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Protein

Glutamate receptor ionotropic, NMDA 3B

Gene

GRIN3B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIon channel, Ligand-gated ion channel, Receptor
Biological processIon transport, Transport
LigandCalcium, Magnesium

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
O60391

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Glutamate receptor ionotropic, NMDA 3B
Short name:
GluN3B
Alternative name(s):
N-methyl-D-aspartate receptor subtype 3B
Short name:
NMDAR3B
Short name:
NR3B
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GRIN3B
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000116032.5

Human Gene Nomenclature Database

More...
HGNCi
HGNC:16768 GRIN3B

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
606651 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O60391

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini23 – 564ExtracellularSequence analysisAdd BLAST542
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei565 – 585HelicalSequence analysisAdd BLAST21
Topological domaini586 – 648CytoplasmicSequence analysisAdd BLAST63
Transmembranei649 – 669HelicalSequence analysisAdd BLAST21
Topological domaini670 – 830ExtracellularSequence analysisAdd BLAST161
Transmembranei831 – 851HelicalSequence analysisAdd BLAST21
Topological domaini852 – 1043CytoplasmicSequence analysisAdd BLAST192

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
116444

Open Targets

More...
OpenTargetsi
ENSG00000116032

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA28984

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2094124

Drug and drug target database

More...
DrugBanki
DB00659 Acamprosate
DB00289 Atomoxetine
DB00996 Gabapentin
DB06741 Gavestinel
DB00145 Glycine
DB01159 Halothane
DB06738 Ketobemidone
DB00142 L-Glutamic Acid
DB04896 Milnacipran
DB01173 Orphenadrine
DB00312 Pentobarbital
DB01174 Phenobarbital
DB01708 Prasterone
DB00418 Secobarbital
DB01520 Tenocyclidine

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
GRIN3B

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 22Sequence analysisAdd BLAST22
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001157023 – 1043Glutamate receptor ionotropic, NMDA 3BAdd BLAST1021

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi69N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi344N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi451N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi465N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi786N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O60391

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O60391

PRoteomics IDEntifications database

More...
PRIDEi
O60391

ProteomicsDB human proteome resource

More...
ProteomicsDBi
49388

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O60391

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O60391

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000116032 Expressed in 71 organ(s), highest expression level in right uterine tube

CleanEx database of gene expression profiles

More...
CleanExi
HS_GRIN3B

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O60391 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B). Does not form functional homomeric channels. Found in a complex containing GRIN1 and GRIN2A (By similarity).By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
125509, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000234389

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
O60391

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O60391

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1053 Eukaryota
ENOG410XNUR LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161021

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231528

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG052634

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O60391

KEGG Orthology (KO)

More...
KOi
K05214

Identification of Orthologs from Complete Genome Data

More...
OMAi
EHPFVFA

Database of Orthologous Groups

More...
OrthoDBi
188544at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O60391

TreeFam database of animal gene trees

More...
TreeFami
TF314731

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR019594 Glu/Gly-bd
IPR001508 Iono_rcpt_met
IPR001320 Iontro_rcpt
IPR028082 Peripla_BP_I

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00060 Lig_chan, 1 hit
PF10613 Lig_chan-Glu_bd, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00177 NMDARECEPTOR

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00918 Lig_chan-Glu_bd, 1 hit
SM00079 PBPe, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53822 SSF53822, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

O60391-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEFVRALWLG LALALGPGSA GGHPQPCGVL ARLGGSVRLG ALLPRAPLAR
60 70 80 90 100
ARARAALARA ALAPRLPHNL SLELVVAAPP ARDPASLTRG LCQALVPPGV
110 120 130 140 150
AALLAFPEAR PELLQLHFLA AATETPVLSL LRREARAPLG APNPFHLQLH
160 170 180 190 200
WASPLETLLD VLVAVLQAHA WEDVGLALCR TQDPGGLVAL WTSRAGRPPQ
210 220 230 240 250
LVLDLSRRDT GDAGLRARLA PMAAPVGGEA PVPAAVLLGC DIARARRVLE
260 270 280 290 300
AVPPGPHWLL GTPLPPKALP TAGLPPGLLA LGEVARPPLE AAIHDIVQLV
310 320 330 340 350
ARALGSAAQV QPKRALLPAP VNCGDLQPAG PESPGRFLAR FLANTSFQGR
360 370 380 390 400
TGPVWVTGSS QVHMSRHFKV WSLRRDPRGA PAWATVGSWR DGQLDLEPGG
410 420 430 440 450
ASARPPPPQG AQVWPKLRVV TLLEHPFVFA RDPDEDGQCP AGQLCLDPGT
460 470 480 490 500
NDSATLDALF AALANGSAPR ALRKCCYGYC IDLLERLAED TPFDFELYLV
510 520 530 540 550
GDGKYGALRD GRWTGLVGDL LAGRAHMAVT SFSINSARSQ VVDFTSPFFS
560 570 580 590 600
TSLGIMVRAR DTASPIGAFM WPLHWSTWLG VFAALHLTAL FLTVYEWRSP
610 620 630 640 650
YGLTPRGRNR STVFSYSSAL NLCYAILFRR TVSSKTPKCP TGRLLMNLWA
660 670 680 690 700
IFCLLVLSSY TANLAAVMVG DKTFEELSGI HDPKLHHPAQ GFRFGTVWES
710 720 730 740 750
SAEAYIKKSF PDMHAHMRRH SAPTTPRGVA MLTSDPPKLN AFIMDKSLLD
760 770 780 790 800
YEVSIDADCK LLTVGKPFAI EGYGIGLPQN SPLTSNLSEF ISRYKSSGFI
810 820 830 840 850
DLLHDKWYKM VPCGKRVFAV TETLQMSIYH FAGLFVLLCL GLGSALLSSL
860 870 880 890 900
GEHAFFRLAL PRIRKGSRLQ YWLHTSQKIH RALNTEPPEG SKEETAEAEP
910 920 930 940 950
SGPEVEQQQQ QQDQPTAPEG WKRARRAVDK ERRVRFLLEP AVVVAPEADA
960 970 980 990 1000
EAEAAPREGP VWLCSYGRPP AARPTGAPQP GELQELERRI EVARERLRQA
1010 1020 1030 1040
LVRRGQLLAQ LGDSARHRPR RLLQARAAPA EAPPHSGRPG SQE
Length:1,043
Mass (Da):112,992
Last modified:July 19, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB7DEB2BEECD6AFEC
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC12680 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_019676157T → M. Corresponds to variant dbSNP:rs2240154Ensembl.1
Natural variantiVAR_079909180R → C1 PublicationCorresponds to variant dbSNP:rs201484790Ensembl.1
Natural variantiVAR_079910194R → W1 PublicationCorresponds to variant dbSNP:rs199717057Ensembl.1
Natural variantiVAR_079911247R → Q1 PublicationCorresponds to variant dbSNP:rs370645758Ensembl.1
Natural variantiVAR_079912247R → W1 PublicationCorresponds to variant dbSNP:rs143106549Ensembl.1
Natural variantiVAR_079913285A → G Found in a patient with autism spectrum disorder; unknown pathological significance. 1 Publication1
Natural variantiVAR_079914332E → K1 PublicationCorresponds to variant dbSNP:rs200777913Ensembl.1
Natural variantiVAR_079915336R → C Found in a patient with schizophrenia; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1043645806Ensembl.1
Natural variantiVAR_079916350R → H1 PublicationCorresponds to variant dbSNP:rs144334537Ensembl.1
Natural variantiVAR_079917381P → L Found in a patient with schizophrenia; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs935843296Ensembl.1
Natural variantiVAR_019677404R → W. Corresponds to variant dbSNP:rs4807399Ensembl.1
Natural variantiVAR_019678414W → R. Corresponds to variant dbSNP:rs2240157Ensembl.1
Natural variantiVAR_079918470R → H Found in a patient with schizophrenia; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1253903191Ensembl.1
Natural variantiVAR_079919472L → P Found in a patient with autism spectrum disorder; unknown pathological significance. 1 Publication1
Natural variantiVAR_079920515G → S1 PublicationCorresponds to variant dbSNP:rs375104717Ensembl.1
Natural variantiVAR_019679577T → M. Corresponds to variant dbSNP:rs2240158Ensembl.1
Natural variantiVAR_079921583A → V1 PublicationCorresponds to variant dbSNP:rs769335041Ensembl.1
Natural variantiVAR_079922598R → C1 PublicationCorresponds to variant dbSNP:rs139187576Ensembl.1
Natural variantiVAR_079923608R → H1 PublicationCorresponds to variant dbSNP:rs540348423Ensembl.1
Natural variantiVAR_061188612T → A. Corresponds to variant dbSNP:rs60621387Ensembl.1
Natural variantiVAR_079924641T → M Found in a patient with autism spectrum disorder; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs778377243Ensembl.1
Natural variantiVAR_079925678S → L1 PublicationCorresponds to variant dbSNP:rs138448790Ensembl.1
Natural variantiVAR_019680845A → T. Corresponds to variant dbSNP:rs2285906Ensembl.1
Natural variantiVAR_079926919E → D Found in a patient with autism spectrum disorder; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs750024778Ensembl.1
Natural variantiVAR_079927928V → M1 PublicationCorresponds to variant dbSNP:rs200419950Ensembl.1
Natural variantiVAR_079928948A → V Found in a patient with schizophrenia; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs769956227Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC004528 Genomic DNA Translation: AAC12680.1 Sequence problems.
BK000070 mRNA Translation: DAA00018.1
BK004079 mRNA Translation: DAA04570.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS32861.1

NCBI Reference Sequences

More...
RefSeqi
NP_619635.1, NM_138690.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.660378

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000234389; ENSP00000234389; ENSG00000116032

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
116444

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:116444

UCSC genome browser

More...
UCSCi
uc002lqo.2 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004528 Genomic DNA Translation: AAC12680.1 Sequence problems.
BK000070 mRNA Translation: DAA00018.1
BK004079 mRNA Translation: DAA04570.1
CCDSiCCDS32861.1
RefSeqiNP_619635.1, NM_138690.2
UniGeneiHs.660378

3D structure databases

ProteinModelPortaliO60391
SMRiO60391
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125509, 2 interactors
STRINGi9606.ENSP00000234389

Chemistry databases

ChEMBLiCHEMBL2094124
DrugBankiDB00659 Acamprosate
DB00289 Atomoxetine
DB00996 Gabapentin
DB06741 Gavestinel
DB00145 Glycine
DB01159 Halothane
DB06738 Ketobemidone
DB00142 L-Glutamic Acid
DB04896 Milnacipran
DB01173 Orphenadrine
DB00312 Pentobarbital
DB01174 Phenobarbital
DB01708 Prasterone
DB00418 Secobarbital
DB01520 Tenocyclidine

PTM databases

iPTMnetiO60391
PhosphoSitePlusiO60391

Polymorphism and mutation databases

BioMutaiGRIN3B

Proteomic databases

jPOSTiO60391
PaxDbiO60391
PRIDEiO60391
ProteomicsDBi49388

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000234389; ENSP00000234389; ENSG00000116032
GeneIDi116444
KEGGihsa:116444
UCSCiuc002lqo.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
116444
DisGeNETi116444
EuPathDBiHostDB:ENSG00000116032.5

GeneCards: human genes, protein and diseases

More...
GeneCardsi
GRIN3B
HGNCiHGNC:16768 GRIN3B
MIMi606651 gene
neXtProtiNX_O60391
OpenTargetsiENSG00000116032
PharmGKBiPA28984

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1053 Eukaryota
ENOG410XNUR LUCA
GeneTreeiENSGT00940000161021
HOGENOMiHOG000231528
HOVERGENiHBG052634
InParanoidiO60391
KOiK05214
OMAiEHPFVFA
OrthoDBi188544at2759
PhylomeDBiO60391
TreeFamiTF314731

Enzyme and pathway databases

SignaLinkiO60391

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
GRIN3B human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
GRIN3B

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
116444

Protein Ontology

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PROi
PR:O60391

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000116032 Expressed in 71 organ(s), highest expression level in right uterine tube
CleanExiHS_GRIN3B
GenevisibleiO60391 HS

Family and domain databases

InterProiView protein in InterPro
IPR019594 Glu/Gly-bd
IPR001508 Iono_rcpt_met
IPR001320 Iontro_rcpt
IPR028082 Peripla_BP_I
PfamiView protein in Pfam
PF00060 Lig_chan, 1 hit
PF10613 Lig_chan-Glu_bd, 1 hit
PRINTSiPR00177 NMDARECEPTOR
SMARTiView protein in SMART
SM00918 Lig_chan-Glu_bd, 1 hit
SM00079 PBPe, 1 hit
SUPFAMiSSF53822 SSF53822, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNMD3B_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O60391
Secondary accession number(s): Q5EAK7, Q7RTW9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: July 19, 2005
Last modified: January 16, 2019
This is version 151 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
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