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Protein

Glutamate receptor ionotropic, NMDA 3B

Gene

GRIN3B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel, Ligand-gated ion channel, Receptor
Biological processIon transport, Transport
LigandCalcium, Magnesium

Enzyme and pathway databases

SignaLinkiO60391

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate receptor ionotropic, NMDA 3B
Short name:
GluN3B
Alternative name(s):
N-methyl-D-aspartate receptor subtype 3B
Short name:
NMDAR3B
Short name:
NR3B
Gene namesi
Name:GRIN3B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000116032.5
HGNCiHGNC:16768 GRIN3B
MIMi606651 gene
neXtProtiNX_O60391

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini23 – 564ExtracellularSequence analysisAdd BLAST542
Transmembranei565 – 585HelicalSequence analysisAdd BLAST21
Topological domaini586 – 648CytoplasmicSequence analysisAdd BLAST63
Transmembranei649 – 669HelicalSequence analysisAdd BLAST21
Topological domaini670 – 830ExtracellularSequence analysisAdd BLAST161
Transmembranei831 – 851HelicalSequence analysisAdd BLAST21
Topological domaini852 – 1043CytoplasmicSequence analysisAdd BLAST192

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Organism-specific databases

DisGeNETi116444
OpenTargetsiENSG00000116032
PharmGKBiPA28984

Chemistry databases

ChEMBLiCHEMBL2094124
DrugBankiDB00659 Acamprosate
DB00289 Atomoxetine
DB00996 Gabapentin
DB06741 Gavestinel
DB00145 Glycine
DB01159 Halothane
DB06738 Ketobemidone
DB00142 L-Glutamic Acid
DB04896 Milnacipran
DB01173 Orphenadrine
DB00312 Pentobarbital
DB01174 Phenobarbital
DB01708 Prasterone
DB00418 Secobarbital
DB01520 Tenocyclidine

Polymorphism and mutation databases

BioMutaiGRIN3B

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000001157023 – 1043Glutamate receptor ionotropic, NMDA 3BAdd BLAST1021

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi69N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi344N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi451N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi465N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi786N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO60391
PRIDEiO60391
ProteomicsDBi49388

PTM databases

iPTMnetiO60391
PhosphoSitePlusiO60391

Expressioni

Gene expression databases

BgeeiENSG00000116032 Expressed in 71 organ(s), highest expression level in right uterine tube
CleanExiHS_GRIN3B
GenevisibleiO60391 HS

Interactioni

Subunit structurei

Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B). Does not form functional homomeric channels. Found in a complex containing GRIN1 and GRIN2A (By similarity).By similarity

Protein-protein interaction databases

BioGridi125509, 2 interactors
STRINGi9606.ENSP00000234389

Structurei

3D structure databases

ProteinModelPortaliO60391
SMRiO60391
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1053 Eukaryota
ENOG410XNUR LUCA
GeneTreeiENSGT00910000143978
HOGENOMiHOG000231528
HOVERGENiHBG052634
InParanoidiO60391
KOiK05214
OMAiEHPFVFA
OrthoDBiEOG091G00PT
PhylomeDBiO60391
TreeFamiTF314731

Family and domain databases

InterProiView protein in InterPro
IPR019594 Glu/Gly-bd
IPR001508 Iono_rcpt_met
IPR001320 Iontro_rcpt
IPR028082 Peripla_BP_I
PfamiView protein in Pfam
PF00060 Lig_chan, 1 hit
PF10613 Lig_chan-Glu_bd, 1 hit
PRINTSiPR00177 NMDARECEPTOR
SMARTiView protein in SMART
SM00918 Lig_chan-Glu_bd, 1 hit
SM00079 PBPe, 1 hit
SUPFAMiSSF53822 SSF53822, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O60391-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEFVRALWLG LALALGPGSA GGHPQPCGVL ARLGGSVRLG ALLPRAPLAR
60 70 80 90 100
ARARAALARA ALAPRLPHNL SLELVVAAPP ARDPASLTRG LCQALVPPGV
110 120 130 140 150
AALLAFPEAR PELLQLHFLA AATETPVLSL LRREARAPLG APNPFHLQLH
160 170 180 190 200
WASPLETLLD VLVAVLQAHA WEDVGLALCR TQDPGGLVAL WTSRAGRPPQ
210 220 230 240 250
LVLDLSRRDT GDAGLRARLA PMAAPVGGEA PVPAAVLLGC DIARARRVLE
260 270 280 290 300
AVPPGPHWLL GTPLPPKALP TAGLPPGLLA LGEVARPPLE AAIHDIVQLV
310 320 330 340 350
ARALGSAAQV QPKRALLPAP VNCGDLQPAG PESPGRFLAR FLANTSFQGR
360 370 380 390 400
TGPVWVTGSS QVHMSRHFKV WSLRRDPRGA PAWATVGSWR DGQLDLEPGG
410 420 430 440 450
ASARPPPPQG AQVWPKLRVV TLLEHPFVFA RDPDEDGQCP AGQLCLDPGT
460 470 480 490 500
NDSATLDALF AALANGSAPR ALRKCCYGYC IDLLERLAED TPFDFELYLV
510 520 530 540 550
GDGKYGALRD GRWTGLVGDL LAGRAHMAVT SFSINSARSQ VVDFTSPFFS
560 570 580 590 600
TSLGIMVRAR DTASPIGAFM WPLHWSTWLG VFAALHLTAL FLTVYEWRSP
610 620 630 640 650
YGLTPRGRNR STVFSYSSAL NLCYAILFRR TVSSKTPKCP TGRLLMNLWA
660 670 680 690 700
IFCLLVLSSY TANLAAVMVG DKTFEELSGI HDPKLHHPAQ GFRFGTVWES
710 720 730 740 750
SAEAYIKKSF PDMHAHMRRH SAPTTPRGVA MLTSDPPKLN AFIMDKSLLD
760 770 780 790 800
YEVSIDADCK LLTVGKPFAI EGYGIGLPQN SPLTSNLSEF ISRYKSSGFI
810 820 830 840 850
DLLHDKWYKM VPCGKRVFAV TETLQMSIYH FAGLFVLLCL GLGSALLSSL
860 870 880 890 900
GEHAFFRLAL PRIRKGSRLQ YWLHTSQKIH RALNTEPPEG SKEETAEAEP
910 920 930 940 950
SGPEVEQQQQ QQDQPTAPEG WKRARRAVDK ERRVRFLLEP AVVVAPEADA
960 970 980 990 1000
EAEAAPREGP VWLCSYGRPP AARPTGAPQP GELQELERRI EVARERLRQA
1010 1020 1030 1040
LVRRGQLLAQ LGDSARHRPR RLLQARAAPA EAPPHSGRPG SQE
Length:1,043
Mass (Da):112,992
Last modified:July 19, 2005 - v2
Checksum:iB7DEB2BEECD6AFEC
GO

Sequence cautioni

The sequence AAC12680 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_019676157T → M. Corresponds to variant dbSNP:rs2240154Ensembl.1
Natural variantiVAR_079909180R → C1 PublicationCorresponds to variant dbSNP:rs201484790Ensembl.1
Natural variantiVAR_079910194R → W1 PublicationCorresponds to variant dbSNP:rs199717057Ensembl.1
Natural variantiVAR_079911247R → Q1 PublicationCorresponds to variant dbSNP:rs370645758Ensembl.1
Natural variantiVAR_079912247R → W1 PublicationCorresponds to variant dbSNP:rs143106549Ensembl.1
Natural variantiVAR_079913285A → G Found in a patient with autism spectrum disorder; unknown pathological significance. 1 Publication1
Natural variantiVAR_079914332E → K1 PublicationCorresponds to variant dbSNP:rs200777913Ensembl.1
Natural variantiVAR_079915336R → C Found in a patient with schizophrenia; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1043645806Ensembl.1
Natural variantiVAR_079916350R → H1 PublicationCorresponds to variant dbSNP:rs144334537Ensembl.1
Natural variantiVAR_079917381P → L Found in a patient with schizophrenia; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs935843296Ensembl.1
Natural variantiVAR_019677404R → W. Corresponds to variant dbSNP:rs4807399Ensembl.1
Natural variantiVAR_019678414W → R. Corresponds to variant dbSNP:rs2240157Ensembl.1
Natural variantiVAR_079918470R → H Found in a patient with schizophrenia; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1253903191Ensembl.1
Natural variantiVAR_079919472L → P Found in a patient with autism spectrum disorder; unknown pathological significance. 1 Publication1
Natural variantiVAR_079920515G → S1 PublicationCorresponds to variant dbSNP:rs375104717Ensembl.1
Natural variantiVAR_019679577T → M. Corresponds to variant dbSNP:rs2240158Ensembl.1
Natural variantiVAR_079921583A → V1 PublicationCorresponds to variant dbSNP:rs769335041Ensembl.1
Natural variantiVAR_079922598R → C1 PublicationCorresponds to variant dbSNP:rs139187576Ensembl.1
Natural variantiVAR_079923608R → H1 PublicationCorresponds to variant dbSNP:rs540348423Ensembl.1
Natural variantiVAR_061188612T → A. Corresponds to variant dbSNP:rs60621387Ensembl.1
Natural variantiVAR_079924641T → M Found in a patient with autism spectrum disorder; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs778377243Ensembl.1
Natural variantiVAR_079925678S → L1 PublicationCorresponds to variant dbSNP:rs138448790Ensembl.1
Natural variantiVAR_019680845A → T. Corresponds to variant dbSNP:rs2285906Ensembl.1
Natural variantiVAR_079926919E → D Found in a patient with autism spectrum disorder; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs750024778Ensembl.1
Natural variantiVAR_079927928V → M1 PublicationCorresponds to variant dbSNP:rs200419950Ensembl.1
Natural variantiVAR_079928948A → V Found in a patient with schizophrenia; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs769956227Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004528 Genomic DNA Translation: AAC12680.1 Sequence problems.
BK000070 mRNA Translation: DAA00018.1
BK004079 mRNA Translation: DAA04570.1
CCDSiCCDS32861.1
RefSeqiNP_619635.1, NM_138690.2
UniGeneiHs.660378

Genome annotation databases

EnsembliENST00000234389; ENSP00000234389; ENSG00000116032
GeneIDi116444
KEGGihsa:116444
UCSCiuc002lqo.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004528 Genomic DNA Translation: AAC12680.1 Sequence problems.
BK000070 mRNA Translation: DAA00018.1
BK004079 mRNA Translation: DAA04570.1
CCDSiCCDS32861.1
RefSeqiNP_619635.1, NM_138690.2
UniGeneiHs.660378

3D structure databases

ProteinModelPortaliO60391
SMRiO60391
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125509, 2 interactors
STRINGi9606.ENSP00000234389

Chemistry databases

ChEMBLiCHEMBL2094124
DrugBankiDB00659 Acamprosate
DB00289 Atomoxetine
DB00996 Gabapentin
DB06741 Gavestinel
DB00145 Glycine
DB01159 Halothane
DB06738 Ketobemidone
DB00142 L-Glutamic Acid
DB04896 Milnacipran
DB01173 Orphenadrine
DB00312 Pentobarbital
DB01174 Phenobarbital
DB01708 Prasterone
DB00418 Secobarbital
DB01520 Tenocyclidine

PTM databases

iPTMnetiO60391
PhosphoSitePlusiO60391

Polymorphism and mutation databases

BioMutaiGRIN3B

Proteomic databases

PaxDbiO60391
PRIDEiO60391
ProteomicsDBi49388

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000234389; ENSP00000234389; ENSG00000116032
GeneIDi116444
KEGGihsa:116444
UCSCiuc002lqo.2 human

Organism-specific databases

CTDi116444
DisGeNETi116444
EuPathDBiHostDB:ENSG00000116032.5
GeneCardsiGRIN3B
HGNCiHGNC:16768 GRIN3B
MIMi606651 gene
neXtProtiNX_O60391
OpenTargetsiENSG00000116032
PharmGKBiPA28984
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1053 Eukaryota
ENOG410XNUR LUCA
GeneTreeiENSGT00910000143978
HOGENOMiHOG000231528
HOVERGENiHBG052634
InParanoidiO60391
KOiK05214
OMAiEHPFVFA
OrthoDBiEOG091G00PT
PhylomeDBiO60391
TreeFamiTF314731

Enzyme and pathway databases

SignaLinkiO60391

Miscellaneous databases

ChiTaRSiGRIN3B human
GeneWikiiGRIN3B
GenomeRNAii116444
PROiPR:O60391
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000116032 Expressed in 71 organ(s), highest expression level in right uterine tube
CleanExiHS_GRIN3B
GenevisibleiO60391 HS

Family and domain databases

InterProiView protein in InterPro
IPR019594 Glu/Gly-bd
IPR001508 Iono_rcpt_met
IPR001320 Iontro_rcpt
IPR028082 Peripla_BP_I
PfamiView protein in Pfam
PF00060 Lig_chan, 1 hit
PF10613 Lig_chan-Glu_bd, 1 hit
PRINTSiPR00177 NMDARECEPTOR
SMARTiView protein in SMART
SM00918 Lig_chan-Glu_bd, 1 hit
SM00079 PBPe, 1 hit
SUPFAMiSSF53822 SSF53822, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNMD3B_HUMAN
AccessioniPrimary (citable) accession number: O60391
Secondary accession number(s): Q5EAK7, Q7RTW9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: July 19, 2005
Last modified: November 7, 2018
This is version 149 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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