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Entry version 134 (13 Feb 2019)
Sequence version 3 (03 Oct 2006)
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Protein

TBC1 domain family member 12

Gene

TBC1D12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May act as a GTPase-activating protein for Rab family protein(s).

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • GTPase activator activity Source: GO_Central
  • Rab GTPase binding Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGTPase activation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
TBC1 domain family member 12
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TBC1D12
Synonyms:KIAA0608
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000108239.8

Human Gene Nomenclature Database

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HGNCi
HGNC:29082 TBC1D12

neXtProt; the human protein knowledge platform

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neXtProti
NX_O60347

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

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OpenTargetsi
ENSG00000108239

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134891743

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TBC1D12

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002080371 – 775TBC1 domain family member 12Add BLAST775

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
Modified residuei284PhosphoserineBy similarity1
Modified residuei315PhosphoserineCombined sources1
Modified residuei747PhosphoserineCombined sources1
Modified residuei748PhosphothreonineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
O60347

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
O60347

MaxQB - The MaxQuant DataBase

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MaxQBi
O60347

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O60347

PeptideAtlas

More...
PeptideAtlasi
O60347

PRoteomics IDEntifications database

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PRIDEi
O60347

ProteomicsDB human proteome resource

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ProteomicsDBi
49377

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
O60347

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
O60347

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000108239 Expressed in 205 organ(s), highest expression level in C1 segment of cervical spinal cord

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
O60347 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA038277
HPA038645

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
116837, 1 interactor

Protein interaction database and analysis system

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IntActi
O60347, 2 interactors

Molecular INTeraction database

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MINTi
O60347

STRING: functional protein association networks

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STRINGi
9606.ENSP00000225235

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
O60347

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O60347

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini484 – 692Rab-GAP TBCPROSITE-ProRule annotationAdd BLAST209

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili409 – 452Sequence analysisAdd BLAST44

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG2223 Eukaryota
COG5210 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156410

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000016604

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG061665

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
O60347

Identification of Orthologs from Complete Genome Data

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OMAi
EPGLCYC

Database of Orthologous Groups

More...
OrthoDBi
798837at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O60347

TreeFam database of animal gene trees

More...
TreeFami
TF313318

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000195 Rab-GTPase-TBC_dom
IPR035969 Rab-GTPase_TBC_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00566 RabGAP-TBC, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00164 TBC, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47923 SSF47923, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50086 TBC_RABGAP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O60347-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVGPEDAGAC SGRNPKLLPV PAPDPVGQDR KVIRATGGFG GGVGAVEPPE
60 70 80 90 100
EADEEEEADE EEETPPRQLL QRYLAAAGEQ LEPGLCYCPL PAGQAGAPPP
110 120 130 140 150
SAAPRSDACL LGSGSKHRGA EVADGRAPRH EGMTNGDSGF LPGRDCRDLE
160 170 180 190 200
EARGLARAGG RESRRRRPYG RLRLEGPGDE DADGAGSPSD WASPLEDPLR
210 220 230 240 250
SCCLVAADAQ EPEGAGSDSG DSPASSCSSS EDSEQRGVGA GGPEEGAPPA
260 270 280 290 300
TSAERTNGGA EPRLGFSDIH FNSRNTFQVS RGQSARDHLP PAGPPVPLPA
310 320 330 340 350
AEQGPAGASA RARRSGGFAD FFTRNLFPKR TKELKSVVHS APGWKLFGKV
360 370 380 390 400
PPRENLQKTS KIIQQEYEAR TGRTCKPPPQ SSRRKNFEFE PLSTTALILE
410 420 430 440 450
DRPSNLPAKS VEEALRHRQE YDEMVAEAKK REIKEAHKRK RIMKERFKQE
460 470 480 490 500
ENIASAMVIW INEILPNWEV MRSTRRVREL WWQGLPPSVR GKVWSLAVGN
510 520 530 540 550
ELNITPELYE IFLSRAKERW KSFSETSSEN DTEGVSVADR EASLELIKLD
560 570 580 590 600
ISRTFPSLYI FQKGGPYHDV LHSILGAYTC YRPDVGYVQG MSFIAAVLIL
610 620 630 640 650
NLEEADAFIA FANLLNKPCQ LAFFRVDHSM MLKYFATFEV FFEENLSKLF
660 670 680 690 700
LHFKSYSLTP DIYLIDWIFT LYSKSLPLDL ACRVWDVFCR DGEEFLFRTG
710 720 730 740 750
LGILRLYEDI LLQMDFIHIA QFLTKLPEDI TSEKLFSCIA AIQMQNSTKK
760 770
WTQVFASVMK DIKEGDKNSS PALKS
Length:775
Mass (Da):85,626
Last modified:October 3, 2006 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i106CD6E788C4C44E
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA25534 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAB43225 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti51 – 56Missing in BAA25534 (PubMed:9628581).Curated6
Sequence conflicti357Q → G in CAB43225 (PubMed:17974005).Curated1
Sequence conflicti447F → Y in CAB43225 (PubMed:17974005).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AB011180 mRNA Translation: BAA25534.1 Different initiation.
AL138759 Genomic DNA No translation available.
AL355341 Genomic DNA No translation available.
AL049956 mRNA Translation: CAB43225.2 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS41553.1

Protein sequence database of the Protein Information Resource

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PIRi
T08683

NCBI Reference Sequences

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RefSeqi
NP_056003.1, NM_015188.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.500598

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000225235; ENSP00000225235; ENSG00000108239

Database of genes from NCBI RefSeq genomes

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GeneIDi
23232

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:23232

UCSC genome browser

More...
UCSCi
uc001kjr.3 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB011180 mRNA Translation: BAA25534.1 Different initiation.
AL138759 Genomic DNA No translation available.
AL355341 Genomic DNA No translation available.
AL049956 mRNA Translation: CAB43225.2 Different initiation.
CCDSiCCDS41553.1
PIRiT08683
RefSeqiNP_056003.1, NM_015188.1
UniGeneiHs.500598

3D structure databases

ProteinModelPortaliO60347
SMRiO60347
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116837, 1 interactor
IntActiO60347, 2 interactors
MINTiO60347
STRINGi9606.ENSP00000225235

PTM databases

iPTMnetiO60347
PhosphoSitePlusiO60347

Polymorphism and mutation databases

BioMutaiTBC1D12

Proteomic databases

EPDiO60347
jPOSTiO60347
MaxQBiO60347
PaxDbiO60347
PeptideAtlasiO60347
PRIDEiO60347
ProteomicsDBi49377

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000225235; ENSP00000225235; ENSG00000108239
GeneIDi23232
KEGGihsa:23232
UCSCiuc001kjr.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23232
EuPathDBiHostDB:ENSG00000108239.8

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TBC1D12
HGNCiHGNC:29082 TBC1D12
HPAiHPA038277
HPA038645
neXtProtiNX_O60347
OpenTargetsiENSG00000108239
PharmGKBiPA134891743

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2223 Eukaryota
COG5210 LUCA
GeneTreeiENSGT00940000156410
HOGENOMiHOG000016604
HOVERGENiHBG061665
InParanoidiO60347
OMAiEPGLCYC
OrthoDBi798837at2759
PhylomeDBiO60347
TreeFamiTF313318

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
TBC1D12 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
23232

Protein Ontology

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PROi
PR:O60347

Gene expression databases

BgeeiENSG00000108239 Expressed in 205 organ(s), highest expression level in C1 segment of cervical spinal cord
GenevisibleiO60347 HS

Family and domain databases

InterProiView protein in InterPro
IPR000195 Rab-GTPase-TBC_dom
IPR035969 Rab-GTPase_TBC_sf
PfamiView protein in Pfam
PF00566 RabGAP-TBC, 1 hit
SMARTiView protein in SMART
SM00164 TBC, 1 hit
SUPFAMiSSF47923 SSF47923, 2 hits
PROSITEiView protein in PROSITE
PS50086 TBC_RABGAP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTBC12_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O60347
Secondary accession number(s): Q5VYA6
, Q8WX26, Q8WX59, Q9UG83
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 21, 2004
Last sequence update: October 3, 2006
Last modified: February 13, 2019
This is version 134 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
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