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Protein

TBC1 domain family member 12

Gene

TBC1D12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May act as a GTPase-activating protein for Rab family protein(s).

GO - Molecular functioni

  • GTPase activator activity Source: GO_Central
  • Rab GTPase binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionGTPase activation

Names & Taxonomyi

Protein namesi
Recommended name:
TBC1 domain family member 12
Gene namesi
Name:TBC1D12
Synonyms:KIAA0608
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000108239.8
HGNCiHGNC:29082 TBC1D12
neXtProtiNX_O60347

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000108239
PharmGKBiPA134891743

Polymorphism and mutation databases

BioMutaiTBC1D12

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002080371 – 775TBC1 domain family member 12Add BLAST775

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei284PhosphoserineBy similarity1
Modified residuei315PhosphoserineCombined sources1
Modified residuei747PhosphoserineCombined sources1
Modified residuei748PhosphothreonineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO60347
MaxQBiO60347
PaxDbiO60347
PeptideAtlasiO60347
PRIDEiO60347
ProteomicsDBi49377

PTM databases

iPTMnetiO60347
PhosphoSitePlusiO60347

Expressioni

Gene expression databases

BgeeiENSG00000108239 Expressed in 205 organ(s), highest expression level in C1 segment of cervical spinal cord
CleanExiHS_TBC1D12
GenevisibleiO60347 HS

Organism-specific databases

HPAiHPA038277
HPA038645

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi116837, 1 interactor
IntActiO60347, 1 interactor
STRINGi9606.ENSP00000225235

Structurei

3D structure databases

ProteinModelPortaliO60347
SMRiO60347
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini484 – 692Rab-GAP TBCPROSITE-ProRule annotationAdd BLAST209

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili409 – 452Sequence analysisAdd BLAST44

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2223 Eukaryota
COG5210 LUCA
GeneTreeiENSGT00750000117238
HOGENOMiHOG000016604
HOVERGENiHBG061665
InParanoidiO60347
OMAiEPGLCYC
OrthoDBiEOG091G09QI
PhylomeDBiO60347
TreeFamiTF313318

Family and domain databases

InterProiView protein in InterPro
IPR000195 Rab-GTPase-TBC_dom
IPR035969 Rab-GTPase_TBC_sf
PfamiView protein in Pfam
PF00566 RabGAP-TBC, 1 hit
SMARTiView protein in SMART
SM00164 TBC, 1 hit
SUPFAMiSSF47923 SSF47923, 2 hits
PROSITEiView protein in PROSITE
PS50086 TBC_RABGAP, 1 hit

Sequencei

Sequence statusi: Complete.

O60347-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVGPEDAGAC SGRNPKLLPV PAPDPVGQDR KVIRATGGFG GGVGAVEPPE
60 70 80 90 100
EADEEEEADE EEETPPRQLL QRYLAAAGEQ LEPGLCYCPL PAGQAGAPPP
110 120 130 140 150
SAAPRSDACL LGSGSKHRGA EVADGRAPRH EGMTNGDSGF LPGRDCRDLE
160 170 180 190 200
EARGLARAGG RESRRRRPYG RLRLEGPGDE DADGAGSPSD WASPLEDPLR
210 220 230 240 250
SCCLVAADAQ EPEGAGSDSG DSPASSCSSS EDSEQRGVGA GGPEEGAPPA
260 270 280 290 300
TSAERTNGGA EPRLGFSDIH FNSRNTFQVS RGQSARDHLP PAGPPVPLPA
310 320 330 340 350
AEQGPAGASA RARRSGGFAD FFTRNLFPKR TKELKSVVHS APGWKLFGKV
360 370 380 390 400
PPRENLQKTS KIIQQEYEAR TGRTCKPPPQ SSRRKNFEFE PLSTTALILE
410 420 430 440 450
DRPSNLPAKS VEEALRHRQE YDEMVAEAKK REIKEAHKRK RIMKERFKQE
460 470 480 490 500
ENIASAMVIW INEILPNWEV MRSTRRVREL WWQGLPPSVR GKVWSLAVGN
510 520 530 540 550
ELNITPELYE IFLSRAKERW KSFSETSSEN DTEGVSVADR EASLELIKLD
560 570 580 590 600
ISRTFPSLYI FQKGGPYHDV LHSILGAYTC YRPDVGYVQG MSFIAAVLIL
610 620 630 640 650
NLEEADAFIA FANLLNKPCQ LAFFRVDHSM MLKYFATFEV FFEENLSKLF
660 670 680 690 700
LHFKSYSLTP DIYLIDWIFT LYSKSLPLDL ACRVWDVFCR DGEEFLFRTG
710 720 730 740 750
LGILRLYEDI LLQMDFIHIA QFLTKLPEDI TSEKLFSCIA AIQMQNSTKK
760 770
WTQVFASVMK DIKEGDKNSS PALKS
Length:775
Mass (Da):85,626
Last modified:October 3, 2006 - v3
Checksum:i106CD6E788C4C44E
GO

Sequence cautioni

The sequence BAA25534 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAB43225 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti51 – 56Missing in BAA25534 (PubMed:9628581).Curated6
Sequence conflicti357Q → G in CAB43225 (PubMed:17974005).Curated1
Sequence conflicti447F → Y in CAB43225 (PubMed:17974005).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB011180 mRNA Translation: BAA25534.1 Different initiation.
AL138759 Genomic DNA No translation available.
AL355341 Genomic DNA No translation available.
AL049956 mRNA Translation: CAB43225.2 Different initiation.
CCDSiCCDS41553.1
PIRiT08683
RefSeqiNP_056003.1, NM_015188.1
UniGeneiHs.500598

Genome annotation databases

EnsembliENST00000225235; ENSP00000225235; ENSG00000108239
GeneIDi23232
KEGGihsa:23232
UCSCiuc001kjr.3 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB011180 mRNA Translation: BAA25534.1 Different initiation.
AL138759 Genomic DNA No translation available.
AL355341 Genomic DNA No translation available.
AL049956 mRNA Translation: CAB43225.2 Different initiation.
CCDSiCCDS41553.1
PIRiT08683
RefSeqiNP_056003.1, NM_015188.1
UniGeneiHs.500598

3D structure databases

ProteinModelPortaliO60347
SMRiO60347
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116837, 1 interactor
IntActiO60347, 1 interactor
STRINGi9606.ENSP00000225235

PTM databases

iPTMnetiO60347
PhosphoSitePlusiO60347

Polymorphism and mutation databases

BioMutaiTBC1D12

Proteomic databases

EPDiO60347
MaxQBiO60347
PaxDbiO60347
PeptideAtlasiO60347
PRIDEiO60347
ProteomicsDBi49377

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000225235; ENSP00000225235; ENSG00000108239
GeneIDi23232
KEGGihsa:23232
UCSCiuc001kjr.3 human

Organism-specific databases

CTDi23232
EuPathDBiHostDB:ENSG00000108239.8
GeneCardsiTBC1D12
HGNCiHGNC:29082 TBC1D12
HPAiHPA038277
HPA038645
neXtProtiNX_O60347
OpenTargetsiENSG00000108239
PharmGKBiPA134891743
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2223 Eukaryota
COG5210 LUCA
GeneTreeiENSGT00750000117238
HOGENOMiHOG000016604
HOVERGENiHBG061665
InParanoidiO60347
OMAiEPGLCYC
OrthoDBiEOG091G09QI
PhylomeDBiO60347
TreeFamiTF313318

Miscellaneous databases

ChiTaRSiTBC1D12 human
GenomeRNAii23232
PROiPR:O60347

Gene expression databases

BgeeiENSG00000108239 Expressed in 205 organ(s), highest expression level in C1 segment of cervical spinal cord
CleanExiHS_TBC1D12
GenevisibleiO60347 HS

Family and domain databases

InterProiView protein in InterPro
IPR000195 Rab-GTPase-TBC_dom
IPR035969 Rab-GTPase_TBC_sf
PfamiView protein in Pfam
PF00566 RabGAP-TBC, 1 hit
SMARTiView protein in SMART
SM00164 TBC, 1 hit
SUPFAMiSSF47923 SSF47923, 2 hits
PROSITEiView protein in PROSITE
PS50086 TBC_RABGAP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTBC12_HUMAN
AccessioniPrimary (citable) accession number: O60347
Secondary accession number(s): Q5VYA6
, Q8WX26, Q8WX59, Q9UG83
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 21, 2004
Last sequence update: October 3, 2006
Last modified: November 7, 2018
This is version 131 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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