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UniProtKB - O60343 (TBCD4_HUMAN)

Entry version 177 (22 Apr 2020)
Sequence version 2 (07 Jun 2005)
Previous versions | rss
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Protein

TBC1 domain family member 4

Gene

TBC1D4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May act as a GTPase-activating protein for RAB2A, RAB8A, RAB10 and RAB14. Isoform 2 promotes insulin-induced glucose transporter SLC2A4/GLUT4 translocation at the plasma membrane, thus increasing glucose uptake.3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGTPase activation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane

SIGNOR Signaling Network Open Resource

More...SIGNORi		O60343

Protein family/group databases

Transport Classification Database

More...TCDBi		8.A.87.1.1 the tbc1 domain (tbc1) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
TBC1 domain family member 4
Alternative name(s):
Akt substrate of 160 kDa
Short name:
AS160
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TBC1D4
Synonyms:AS160, KIAA0603
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:19165 TBC1D4

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		612465 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O60343

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Diabetes mellitus, non-insulin-dependent, 5 (NIDDM5)1 Publication
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionA multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to the body's own insulin. Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.
Related information in OMIM

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi318S → A: 80% reduction of insulin-stimulated GLUT4 translocation; when associated with A-588; A-642 and A-751. 1 Publication1
Mutagenesisi588S → A: 80% reduction of insulin-stimulated GLUT4 translocation; when associated with A-318; A-642 and A-751. 1 Publication1
Mutagenesisi642T → A: 80% reduction of insulin-stimulated GLUT4 translocation; when associated with A-318; A-588 and A-751. 1 Publication1
Mutagenesisi751S → A: 80% reduction of insulin-stimulated GLUT4 translocation; when associated with A-318; A-588 and A-642. 1 Publication1
Mutagenesisi972R → K: Loss of Rab GTPase activation. Only 20% reduction of GLUT4 translocation; even when associated with A-318; A-588; A-642 and A-751. 2 Publications1

Keywords - Diseasei

Diabetes mellitus

Organism-specific databases

DisGeNET

More...DisGeNETi		9882

MalaCards human disease database

More...MalaCardsi		TBC1D4
MIMi616087 phenotype

Open Targets

More...OpenTargetsi		ENSG00000136111

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA38807

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O60343 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		TBC1D4

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002080261 – 1298TBC1 domain family member 4Add BLAST1298

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
Modified residuei262PhosphoserineCombined sources1
Modified residuei314PhosphoserineCombined sources1
Modified residuei318Phosphoserine; by PKB/AKT1By similarity1
Modified residuei341PhosphoserineCombined sources1
Modified residuei344PhosphoserineCombined sources1
Modified residuei477N6-acetyllysineCombined sources1
Modified residuei566PhosphoserineCombined sources1
Modified residuei568PhosphothreonineCombined sources1
Modified residuei570PhosphoserineCombined sources1
Modified residuei577Omega-N-methylarginineBy similarity1
Modified residuei588Phosphoserine; by PKB/AKT1Combined sources1 Publication1
Modified residuei591PhosphoserineCombined sources1
Modified residuei609PhosphoserineBy similarity1
Modified residuei613PhosphothreonineBy similarity1
Modified residuei617PhosphoserineBy similarity1
Modified residuei642Phosphothreonine; by PKB/AKT12 Publications1
Modified residuei666PhosphoserineCombined sources1
Modified residuei751Phosphoserine; by PKB/AKT1By similarity1
Modified residuei754PhosphoserineCombined sources1
Modified residuei757PhosphoserineBy similarity1
Modified residuei763PhosphothreonineBy similarity1
Isoform 2 (identifier: O60343-2)
Modified residuei666PhosphoserineCombined sources1
Modified residuei672PhosphoserineCombined sources1
Modified residuei678PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by AKT1; insulin-induced. Also phosphorylated by AMPK in response to insulin. Insulin-stimulated phosphorylation is required for SLC2A4/GLUT4 translocation. Has no effect on SLC2A4/GLUT4 internalization. Physiological hyperinsulinemia increases phosphorylation in skeletal muscle. Insulin-stimulated phosphorylation is reduced by 39% in type 2 diabetic patients.3 Publications

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		O60343

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O60343

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O60343

MaxQB - The MaxQuant DataBase

More...MaxQBi		O60343

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O60343

PeptideAtlas

More...PeptideAtlasi		O60343

PRoteomics IDEntifications database

More...PRIDEi		O60343

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		49366 [O60343-1]
49367 [O60343-2]
49368 [O60343-3]
49369 [O60343-4]
49370 [O60343-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O60343

MetOSite database of methionine sulfoxide sites

More...MetOSitei		O60343

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O60343

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed. Isoform 2 is the highest overexpressed in most tissues. Isoform 1 is highly expressed in skeletal muscle and heart, but was not detectable in the liver nor in adipose tissue. Isoform 2 is strongly expressed in adrenal and thyroid gland, and also in lung, kidney, colon, brain and adipose tissue. Isoform 2 is moderately expressed in skeletal muscle. Expressed in pancreatic Langerhans islets, including beta cells (at protein level). Expression is decreased by twofold in pancreatic islets in type 2 diabetes patients compared to control subjects. Up-regulated in T-cells from patients with atopic dermatitis.3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000136111 Expressed in adrenal cortex and 238 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O60343 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O60343 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000136111 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		115213, 73 interactors

Protein interaction database and analysis system

More...IntActi		O60343, 52 interactors

Molecular INTeraction database

More...MINTi		O60343

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000366863

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O60343 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11298
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O60343

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		O60343

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini53 – 209PID 1PROSITE-ProRule annotationAdd BLAST157
Domaini312 – 468PID 2PROSITE-ProRule annotationAdd BLAST157
Domaini918 – 1112Rab-GAP TBCPROSITE-ProRule annotationAdd BLAST195

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi672 – 759Ser-richAdd BLAST88

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4436 Eukaryota
ENOG410YWJY LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000158486

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_005350_13_2_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O60343

KEGG Orthology (KO)

More...KOi		K17902

Identification of Orthologs from Complete Genome Data

More...OMAi		SSAWHTF

Database of Orthologous Groups

More...OrthoDBi		323342at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O60343

TreeFam database of animal gene trees

More...TreeFami		TF317184

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.30.29.30, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR021785 DUF3350
IPR011993 PH-like_dom_sf
IPR006020 PTB/PI_dom
IPR000195 Rab-GTPase-TBC_dom
IPR035969 Rab-GTPase_TBC_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF11830 DUF3350, 1 hit
PF00640 PID, 2 hits
PF00566 RabGAP-TBC, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00462 PTB, 2 hits
SM00164 TBC, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47923 SSF47923, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS01179 PID, 1 hit
PS50086 TBC_RABGAP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O60343-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEPPSCIQDE PFPHPLEPEP GVSAQPGPGK PSDKRFRLWY VGGSCLDHRT 
        60         70         80         90        100
TLPMLPWLMA EIRRRSQKPE AGGCGAPAAR EVILVLSAPF LRCVPAPGAG 
       110        120        130        140        150
ASGGTSPSAT QPNPAVFIFE HKAQHISRFI HNSHDLTYFA YLIKAQPDDP 
       160        170        180        190        200
ESQMACHVFR ATDPSQVPDV ISSIRQLSKA AMKEDAKPSK DNEDAFYNSQ 
       210        220        230        240        250
KFEVLYCGKV TVTHKKAPSS LIDDCMEKFS LHEQQRLKIQ GEQRGPDPGE 
       260        270        280        290        300
DLADLEVVVP GSPGDCLPEE ADGTDTHLGL PAGASQPALT SSRVCFPERI 
       310        320        330        340        350
LEDSGFDEQQ EFRSRCSSVT GVQRRVHEGS QKSQPRRRHA SAPSHVQPSD 
       360        370        380        390        400
SEKNRTMLFQ VGRFEINLIS PDTKSVVLEK NFKDISSCSQ GIKHVDHFGF 
       410        420        430        440        450
ICRESPEPGL SQYICYVFQC ASESLVDEVM LTLKQAFSTA AALQSAKTQI 
       460        470        480        490        500
KLCEACPMHS LHKLCERIEG LYPPRAKLVI QRHLSSLTDN EQADIFERVQ 
       510        520        530        540        550
KMKPVSDQEE NELVILHLRQ LCEAKQKTHV HIGEGPSTIS NSTIPENATS 
       560        570        580        590        600
SGRFKLDILK NKAKRSLTSS LENIFSRGAN RMRGRLGSVD SFERSNSLAS 
       610        620        630        640        650
EKDYSPGDSP PGTPPASPPS SAWQTFPEED SDSPQFRRRA HTFSHPPSST 
       660        670        680        690        700
KRKLNLQDGR AQGVRSPLLR QSSSEQCSNL SSVRRMYKES NSSSSLPSLH 
       710        720        730        740        750
TSFSAPSFTA PSFLKSFYQN SGRLSPQYEN EIRQDTASES SDGEGRKRTS 
       760        770        780        790        800
STCSNESLSV GGTSVTPRRI SWRQRIFLRV ASPMNKSPSA MQQQDGLDRN 
       810        820        830        840        850
ELLPLSPLSP TMEEEPLVVF LSGEDDPEKI EERKKSKELR SLWRKAIHQQ 
       860        870        880        890        900
ILLLRMEKEN QKLEASRDEL QSRKVKLDYE EVGACQKEVL ITWDKKLLNC 
       910        920        930        940        950
RAKIRCDMED IHTLLKEGVP KSRRGEIWQF LALQYRLRHR LPNKQQPPDI 
       960        970        980        990       1000
SYKELLKQLT AQQHAILVDL GRTFPTHPYF SVQLGPGQLS LFNLLKAYSL 
      1010       1020       1030       1040       1050
LDKEVGYCQG ISFVAGVLLL HMSEEQAFEM LKFLMYDLGF RKQYRPDMMS 
      1060       1070       1080       1090       1100
LQIQMYQLSR LLHDYHRDLY NHLEENEISP SLYAAPWFLT LFASQFSLGF 
      1110       1120       1130       1140       1150
VARVFDIIFL QGTEVIFKVA LSLLSSQETL IMECESFENI VEFLKNTLPD 
      1160       1170       1180       1190       1200
MNTSEMEKII TQVFEMDISK QLHAYEVEYH VLQDELQESS YSCEDSETLE 
      1210       1220       1230       1240       1250
KLERANSQLK RQNMDLLEKL QVAHTKIQAL ESNLENLLTR ETKMKSLIRT 
      1260       1270       1280       1290 
LEQEKMAYQK TVEQLRKLLP ADALVNCDLL LRDLNCNPNN KAKIGNKP
Length:1,298
Mass (Da):146,563
Last modified:June 7, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8DC70CE887C0B311
GO
Isoform 2 (identifier: O60343-2) [UniParc]FASTAAdd to basket
Also known as: AS160_tv2

The sequence of this isoform differs from the canonical sequence as follows:
     678-740: Missing.

Show »
Length:1,235
Mass (Da):139,556
Checksum:i2A688BE2C17FD422
GO
Isoform 3 (identifier: O60343-3) [UniParc]FASTAAdd to basket
Also known as: AS160_tv3

The sequence of this isoform differs from the canonical sequence as follows:
     733-740: Missing.

Show »
Length:1,290
Mass (Da):145,689
Checksum:i38A0D7A205A0D252
GO
Isoform 4 (identifier: O60343-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-783: Missing.
     865-917: Missing.

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Length:462
Mass (Da):53,850
Checksum:iB063DE6885C060DA
GO
Isoform 5 (identifier: O60343-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-783: Missing.

Show »
Length:515
Mass (Da):60,095
Checksum:i18CDA70728CE1CBB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A3B3IRT3A0A3B3IRT3_HUMAN
TBC1 domain family member 4
TBC1D4
1,054Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5JU47Q5JU47_HUMAN
TBC1 domain family member 4
TBC1D4
282Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA25529 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti644S → G in CAH18416 (PubMed:17974005).Curated1
Sequence conflicti845K → E in CAH18416 (PubMed:17974005).Curated1
Sequence conflicti864E → EG in BAH16628 (PubMed:19077034).Curated1
Sequence conflicti864E → EG in BAA25529 (PubMed:9628581).Curated1
Sequence conflicti864E → EG in AAI51240 (PubMed:15489334).Curated1
Sequence conflicti867R → G in CAH18416 (PubMed:17974005).Curated1
Sequence conflicti1137F → L in CAH18416 (PubMed:17974005).Curated1
Sequence conflicti1178E → G in BAG62187 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_061891619P → L. Corresponds to variant dbSNP:rs56223054EnsemblClinVar.1
Natural variantiVAR_059855819V → ICombined sources4 PublicationsCorresponds to variant dbSNP:rs1062087EnsemblClinVar.1
Natural variantiVAR_0618921119V → A. Corresponds to variant dbSNP:rs58232698EnsemblClinVar.1
Natural variantiVAR_0525341147T → M. Corresponds to variant dbSNP:rs9600455EnsemblClinVar.1
Natural variantiVAR_0525351275V → A3 PublicationsCorresponds to variant dbSNP:rs557337EnsemblClinVar.1
Natural variantiVAR_0548621284L → I. Corresponds to variant dbSNP:rs11616741Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0368681 – 783Missing in isoform 4 and isoform 5. 1 PublicationAdd BLAST783
Alternative sequenceiVSP_036869678 – 740Missing in isoform 2. 1 PublicationAdd BLAST63
Alternative sequenceiVSP_036870733 – 740Missing in isoform 3. 2 Publications8
Alternative sequenceiVSP_036871865 – 917Missing in isoform 4. 1 PublicationAdd BLAST53

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
FM207106 mRNA Translation: CAR62509.1
FM207107 mRNA Translation: CAR62510.1
AB449885 mRNA Translation: BAH16628.1
AB011175 mRNA Translation: BAA25529.2 Different initiation.
AK300468 mRNA Translation: BAG62187.1
AK304091 mRNA Translation: BAG64997.1
AL139230 Genomic DNA No translation available.
AL162571 Genomic DNA No translation available.
BC151239 mRNA Translation: AAI51240.1
CR749622 mRNA Translation: CAH18416.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS41901.1 [O60343-1]
CCDS66563.1 [O60343-2]
CCDS66564.1 [O60343-3]

Protein sequence database of the Protein Information Resource

More...PIRi		T00261

NCBI Reference Sequences

More...RefSeqi		NP_001273587.1, NM_001286658.2 [O60343-3]
NP_001273588.1, NM_001286659.2 [O60343-2]
NP_055647.2, NM_014832.4 [O60343-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000377625; ENSP00000366852; ENSG00000136111 [O60343-2]
ENST00000377636; ENSP00000366863; ENSG00000136111 [O60343-1]
ENST00000431480; ENSP00000395986; ENSG00000136111 [O60343-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		9882

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:9882

UCSC genome browser

More...UCSCi		uc001vjl.3 human [O60343-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FM207106 mRNA Translation: CAR62509.1
FM207107 mRNA Translation: CAR62510.1
AB449885 mRNA Translation: BAH16628.1
AB011175 mRNA Translation: BAA25529.2 Different initiation.
AK300468 mRNA Translation: BAG62187.1
AK304091 mRNA Translation: BAG64997.1
AL139230 Genomic DNA No translation available.
AL162571 Genomic DNA No translation available.
BC151239 mRNA Translation: AAI51240.1
CR749622 mRNA Translation: CAH18416.1
CCDSiCCDS41901.1 [O60343-1]
CCDS66563.1 [O60343-2]
CCDS66564.1 [O60343-3]
PIRiT00261
RefSeqiNP_001273587.1, NM_001286658.2 [O60343-3]
NP_001273588.1, NM_001286659.2 [O60343-2]
NP_055647.2, NM_014832.4 [O60343-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3QYBX-ray3.50A874-1170[»]
SMRiO60343
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi115213, 73 interactors
IntActiO60343, 52 interactors
MINTiO60343
STRINGi9606.ENSP00000366863

Protein family/group databases

TCDBi8.A.87.1.1 the tbc1 domain (tbc1) family

PTM databases

iPTMnetiO60343
MetOSiteiO60343
PhosphoSitePlusiO60343

Polymorphism and mutation databases

BioMutaiTBC1D4

Proteomic databases

EPDiO60343
jPOSTiO60343
MassIVEiO60343
MaxQBiO60343
PaxDbiO60343
PeptideAtlasiO60343
PRIDEiO60343
ProteomicsDBi49366 [O60343-1]
49367 [O60343-2]
49368 [O60343-3]
49369 [O60343-4]
49370 [O60343-5]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		3177 449 antibodies

The DNASU plasmid repository

More...DNASUi		9882

Genome annotation databases

EnsembliENST00000377625; ENSP00000366852; ENSG00000136111 [O60343-2]
ENST00000377636; ENSP00000366863; ENSG00000136111 [O60343-1]
ENST00000431480; ENSP00000395986; ENSG00000136111 [O60343-3]
GeneIDi9882
KEGGihsa:9882
UCSCiuc001vjl.3 human [O60343-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		9882
DisGeNETi9882

GeneCards: human genes, protein and diseases

More...GeneCardsi		TBC1D4
HGNCiHGNC:19165 TBC1D4
HPAiENSG00000136111 Low tissue specificity
MalaCardsiTBC1D4
MIMi612465 gene
616087 phenotype
neXtProtiNX_O60343
OpenTargetsiENSG00000136111
PharmGKBiPA38807

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4436 Eukaryota
ENOG410YWJY LUCA
GeneTreeiENSGT00940000158486
HOGENOMiCLU_005350_13_2_1
InParanoidiO60343
KOiK17902
OMAiSSAWHTF
OrthoDBi323342at2759
PhylomeDBiO60343
TreeFamiTF317184

Enzyme and pathway databases

ReactomeiR-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane
SIGNORiO60343

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		TBC1D4 human
EvolutionaryTraceiO60343

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		TBC1D4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		9882
PharosiO60343 Tbio

Protein Ontology

More...PROi		PR:O60343
RNActiO60343 protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000136111 Expressed in adrenal cortex and 238 other tissues
ExpressionAtlasiO60343 baseline and differential
GenevisibleiO60343 HS

Family and domain databases

Gene3Di2.30.29.30, 2 hits
InterProiView protein in InterPro
IPR021785 DUF3350
IPR011993 PH-like_dom_sf
IPR006020 PTB/PI_dom
IPR000195 Rab-GTPase-TBC_dom
IPR035969 Rab-GTPase_TBC_sf
PfamiView protein in Pfam
PF11830 DUF3350, 1 hit
PF00640 PID, 2 hits
PF00566 RabGAP-TBC, 1 hit
SMARTiView protein in SMART
SM00462 PTB, 2 hits
SM00164 TBC, 1 hit
SUPFAMiSSF47923 SSF47923, 2 hits
PROSITEiView protein in PROSITE
PS01179 PID, 1 hit
PS50086 TBC_RABGAP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTBCD4_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O60343
Secondary accession number(s): A7E2X8
, B4DU25, B4E235, B6ETN8, B6ETN9, Q5W0B9, Q68D14
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: June 7, 2005
Last modified: April 22, 2020
This is version 177 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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