UniProtKB - O60343 (TBCD4_HUMAN)
Protein
TBC1 domain family member 4
Gene
TBC1D4
Organism
Homo sapiens (Human)
Status
Functioni
May act as a GTPase-activating protein for RAB2A, RAB8A, RAB10 and RAB14. Isoform 2 promotes insulin-induced glucose transporter SLC2A4/GLUT4 translocation at the plasma membrane, thus increasing glucose uptake.3 Publications
GO - Molecular functioni
- GTPase activator activity Source: GO_Central
GO - Biological processi
- activation of GTPase activity Source: GO_Central
- cellular response to insulin stimulus Source: UniProtKB
- intracellular protein transport Source: GO_Central
- negative regulation of vesicle fusion Source: Ensembl
- vesicle-mediated transport Source: UniProtKB
Keywordsi
Molecular function | GTPase activation |
Enzyme and pathway databases
PathwayCommonsi | O60343 |
Reactomei | R-HSA-1445148, Translocation of SLC2A4 (GLUT4) to the plasma membrane |
SIGNORi | O60343 |
Protein family/group databases
TCDBi | 8.A.87.1.1, the tbc1 domain (tbc1) family |
Names & Taxonomyi
Protein namesi | Recommended name: TBC1 domain family member 4Alternative name(s): Akt substrate of 160 kDa Short name: AS160 |
Gene namesi | Name:TBC1D4 Synonyms:AS160, KIAA0603 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:19165, TBC1D4 |
MIMi | 612465, gene |
neXtProti | NX_O60343 |
VEuPathDBi | HostDB:ENSG00000136111.12 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Note: Isoform 2 shows a cytoplasmic perinuclear localization in a myoblastic cell line in resting and insulin-stimulated cells.
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Involvement in diseasei
Diabetes mellitus, non-insulin-dependent, 5 (NIDDM5)1 Publication
Disease susceptibility is associated with variants affecting the gene represented in this entry.
Disease descriptionA multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to the body's own insulin. Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.
Related information in OMIMMutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 318 | S → A: 80% reduction of insulin-stimulated GLUT4 translocation; when associated with A-588; A-642 and A-751. 1 Publication | 1 | |
Mutagenesisi | 588 | S → A: 80% reduction of insulin-stimulated GLUT4 translocation; when associated with A-318; A-642 and A-751. 1 Publication | 1 | |
Mutagenesisi | 642 | T → A: 80% reduction of insulin-stimulated GLUT4 translocation; when associated with A-318; A-588 and A-751. 1 Publication | 1 | |
Mutagenesisi | 751 | S → A: 80% reduction of insulin-stimulated GLUT4 translocation; when associated with A-318; A-588 and A-642. 1 Publication | 1 | |
Mutagenesisi | 972 | R → K: Loss of Rab GTPase activation. Only 20% reduction of GLUT4 translocation; even when associated with A-318; A-588; A-642 and A-751. 2 Publications | 1 |
Keywords - Diseasei
Diabetes mellitusOrganism-specific databases
DisGeNETi | 9882 |
MalaCardsi | TBC1D4 |
MIMi | 616087, phenotype |
OpenTargetsi | ENSG00000136111 |
PharmGKBi | PA38807 |
Miscellaneous databases
Pharosi | O60343, Tbio |
Genetic variation databases
BioMutai | TBC1D4 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000208026 | 1 – 1298 | TBC1 domain family member 4Add BLAST | 1298 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineCombined sources | 1 | ||
Modified residuei | 262 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 314 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 318 | Phosphoserine; by PKB/AKT1By similarity | 1 | ||
Modified residuei | 341 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 344 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 477 | N6-acetyllysineCombined sources | 1 | ||
Modified residuei | 566 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 568 | PhosphothreonineCombined sources | 1 | ||
Modified residuei | 570 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 577 | Omega-N-methylarginineBy similarity | 1 | ||
Modified residuei | 588 | Phosphoserine; by PKB/AKT1Combined sources1 Publication | 1 | ||
Modified residuei | 591 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 609 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 613 | PhosphothreonineBy similarity | 1 | ||
Modified residuei | 617 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 642 | Phosphothreonine; by PKB/AKT12 Publications | 1 | ||
Modified residuei | 666 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 751 | Phosphoserine; by PKB/AKT1By similarity | 1 | ||
Modified residuei | 754 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 757 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 763 | PhosphothreonineBy similarity | 1 | ||
Isoform 2 (identifier: O60343-2) | |||||
Modified residuei | 666 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 672 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 678 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Phosphorylated by AKT1; insulin-induced. Also phosphorylated by AMPK in response to insulin. Insulin-stimulated phosphorylation is required for SLC2A4/GLUT4 translocation. Has no effect on SLC2A4/GLUT4 internalization. Physiological hyperinsulinemia increases phosphorylation in skeletal muscle. Insulin-stimulated phosphorylation is reduced by 39% in type 2 diabetic patients.3 Publications
Keywords - PTMi
Acetylation, Methylation, PhosphoproteinProteomic databases
EPDi | O60343 |
jPOSTi | O60343 |
MassIVEi | O60343 |
MaxQBi | O60343 |
PaxDbi | O60343 |
PeptideAtlasi | O60343 |
PRIDEi | O60343 |
ProteomicsDBi | 49366 [O60343-1] 49367 [O60343-2] 49368 [O60343-3] 49369 [O60343-4] 49370 [O60343-5] |
PTM databases
iPTMneti | O60343 |
MetOSitei | O60343 |
PhosphoSitePlusi | O60343 |
Expressioni
Tissue specificityi
Widely expressed. Isoform 2 is the highest overexpressed in most tissues. Isoform 1 is highly expressed in skeletal muscle and heart, but was not detectable in the liver nor in adipose tissue. Isoform 2 is strongly expressed in adrenal and thyroid gland, and also in lung, kidney, colon, brain and adipose tissue. Isoform 2 is moderately expressed in skeletal muscle. Expressed in pancreatic Langerhans islets, including beta cells (at protein level). Expression is decreased by twofold in pancreatic islets in type 2 diabetes patients compared to control subjects. Up-regulated in T-cells from patients with atopic dermatitis.3 Publications
Gene expression databases
Bgeei | ENSG00000136111, Expressed in adrenal cortex and 252 other tissues |
ExpressionAtlasi | O60343, baseline and differential |
Genevisiblei | O60343, HS |
Organism-specific databases
HPAi | ENSG00000136111, Low tissue specificity |
Interactioni
Binary interactionsi
O60343
With | #Exp. | IntAct |
---|---|---|
YWHAZ [P63104] | 2 | EBI-522028,EBI-347088 |
Protein-protein interaction databases
BioGRIDi | 115213, 82 interactors |
IntActi | O60343, 52 interactors |
MINTi | O60343 |
STRINGi | 9606.ENSP00000366863 |
Miscellaneous databases
RNActi | O60343, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | O60343 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | O60343 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 53 – 209 | PID 1PROSITE-ProRule annotationAdd BLAST | 157 | |
Domaini | 312 – 468 | PID 2PROSITE-ProRule annotationAdd BLAST | 157 | |
Domaini | 918 – 1112 | Rab-GAP TBCPROSITE-ProRule annotationAdd BLAST | 195 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 672 – 759 | Ser-richAdd BLAST | 88 |
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG4436, Eukaryota |
GeneTreei | ENSGT00940000158486 |
HOGENOMi | CLU_005350_13_2_1 |
InParanoidi | O60343 |
OMAi | CNSLASD |
OrthoDBi | 323342at2759 |
PhylomeDBi | O60343 |
TreeFami | TF317184 |
Family and domain databases
Gene3Di | 2.30.29.30, 2 hits |
InterProi | View protein in InterPro IPR021785, DUF3350 IPR011993, PH-like_dom_sf IPR006020, PTB/PI_dom IPR000195, Rab-GTPase-TBC_dom IPR035969, Rab-GTPase_TBC_sf |
Pfami | View protein in Pfam PF11830, DUF3350, 1 hit PF00640, PID, 2 hits PF00566, RabGAP-TBC, 1 hit |
SMARTi | View protein in SMART SM00462, PTB, 2 hits SM00164, TBC, 1 hit |
SUPFAMi | SSF47923, SSF47923, 2 hits |
PROSITEi | View protein in PROSITE PS01179, PID, 1 hit PS50086, TBC_RABGAP, 1 hit |
s (5+)i Sequence
Sequence statusi: Complete.
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 5 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: O60343-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MEPPSCIQDE PFPHPLEPEP GVSAQPGPGK PSDKRFRLWY VGGSCLDHRT
60 70 80 90 100
TLPMLPWLMA EIRRRSQKPE AGGCGAPAAR EVILVLSAPF LRCVPAPGAG
110 120 130 140 150
ASGGTSPSAT QPNPAVFIFE HKAQHISRFI HNSHDLTYFA YLIKAQPDDP
160 170 180 190 200
ESQMACHVFR ATDPSQVPDV ISSIRQLSKA AMKEDAKPSK DNEDAFYNSQ
210 220 230 240 250
KFEVLYCGKV TVTHKKAPSS LIDDCMEKFS LHEQQRLKIQ GEQRGPDPGE
260 270 280 290 300
DLADLEVVVP GSPGDCLPEE ADGTDTHLGL PAGASQPALT SSRVCFPERI
310 320 330 340 350
LEDSGFDEQQ EFRSRCSSVT GVQRRVHEGS QKSQPRRRHA SAPSHVQPSD
360 370 380 390 400
SEKNRTMLFQ VGRFEINLIS PDTKSVVLEK NFKDISSCSQ GIKHVDHFGF
410 420 430 440 450
ICRESPEPGL SQYICYVFQC ASESLVDEVM LTLKQAFSTA AALQSAKTQI
460 470 480 490 500
KLCEACPMHS LHKLCERIEG LYPPRAKLVI QRHLSSLTDN EQADIFERVQ
510 520 530 540 550
KMKPVSDQEE NELVILHLRQ LCEAKQKTHV HIGEGPSTIS NSTIPENATS
560 570 580 590 600
SGRFKLDILK NKAKRSLTSS LENIFSRGAN RMRGRLGSVD SFERSNSLAS
610 620 630 640 650
EKDYSPGDSP PGTPPASPPS SAWQTFPEED SDSPQFRRRA HTFSHPPSST
660 670 680 690 700
KRKLNLQDGR AQGVRSPLLR QSSSEQCSNL SSVRRMYKES NSSSSLPSLH
710 720 730 740 750
TSFSAPSFTA PSFLKSFYQN SGRLSPQYEN EIRQDTASES SDGEGRKRTS
760 770 780 790 800
STCSNESLSV GGTSVTPRRI SWRQRIFLRV ASPMNKSPSA MQQQDGLDRN
810 820 830 840 850
ELLPLSPLSP TMEEEPLVVF LSGEDDPEKI EERKKSKELR SLWRKAIHQQ
860 870 880 890 900
ILLLRMEKEN QKLEASRDEL QSRKVKLDYE EVGACQKEVL ITWDKKLLNC
910 920 930 940 950
RAKIRCDMED IHTLLKEGVP KSRRGEIWQF LALQYRLRHR LPNKQQPPDI
960 970 980 990 1000
SYKELLKQLT AQQHAILVDL GRTFPTHPYF SVQLGPGQLS LFNLLKAYSL
1010 1020 1030 1040 1050
LDKEVGYCQG ISFVAGVLLL HMSEEQAFEM LKFLMYDLGF RKQYRPDMMS
1060 1070 1080 1090 1100
LQIQMYQLSR LLHDYHRDLY NHLEENEISP SLYAAPWFLT LFASQFSLGF
1110 1120 1130 1140 1150
VARVFDIIFL QGTEVIFKVA LSLLSSQETL IMECESFENI VEFLKNTLPD
1160 1170 1180 1190 1200
MNTSEMEKII TQVFEMDISK QLHAYEVEYH VLQDELQESS YSCEDSETLE
1210 1220 1230 1240 1250
KLERANSQLK RQNMDLLEKL QVAHTKIQAL ESNLENLLTR ETKMKSLIRT
1260 1270 1280 1290
LEQEKMAYQK TVEQLRKLLP ADALVNCDLL LRDLNCNPNN KAKIGNKP
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A3B3IRT3 | A0A3B3IRT3_HUMAN | TBC1 domain family member 4 | TBC1D4 | 1,054 | Annotation score: | ||
Q5JU47 | Q5JU47_HUMAN | TBC1 domain family member 4 | TBC1D4 | 282 | Annotation score: |
Sequence cautioni
The sequence BAA25529 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 644 | S → G in CAH18416 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 845 | K → E in CAH18416 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 864 | E → EG in BAH16628 (PubMed:19077034).Curated | 1 | |
Sequence conflicti | 864 | E → EG in BAA25529 (PubMed:9628581).Curated | 1 | |
Sequence conflicti | 864 | E → EG in AAI51240 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 867 | R → G in CAH18416 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 1137 | F → L in CAH18416 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 1178 | E → G in BAG62187 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_061891 | 619 | P → L. Corresponds to variant dbSNP:rs56223054EnsemblClinVar. | 1 | |
Natural variantiVAR_059855 | 819 | V → ICombined sources4 PublicationsCorresponds to variant dbSNP:rs1062087EnsemblClinVar. | 1 | |
Natural variantiVAR_061892 | 1119 | V → A. Corresponds to variant dbSNP:rs58232698EnsemblClinVar. | 1 | |
Natural variantiVAR_052534 | 1147 | T → M. Corresponds to variant dbSNP:rs9600455EnsemblClinVar. | 1 | |
Natural variantiVAR_052535 | 1275 | V → A3 PublicationsCorresponds to variant dbSNP:rs557337EnsemblClinVar. | 1 | |
Natural variantiVAR_054862 | 1284 | L → I. Corresponds to variant dbSNP:rs11616741Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_036868 | 1 – 783 | Missing in isoform 4 and isoform 5. 1 PublicationAdd BLAST | 783 | |
Alternative sequenceiVSP_036869 | 678 – 740 | Missing in isoform 2. 1 PublicationAdd BLAST | 63 | |
Alternative sequenceiVSP_036870 | 733 – 740 | Missing in isoform 3. 2 Publications | 8 | |
Alternative sequenceiVSP_036871 | 865 – 917 | Missing in isoform 4. 1 PublicationAdd BLAST | 53 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | FM207106 mRNA Translation: CAR62509.1 FM207107 mRNA Translation: CAR62510.1 AB449885 mRNA Translation: BAH16628.1 AB011175 mRNA Translation: BAA25529.2 Different initiation. AK300468 mRNA Translation: BAG62187.1 AK304091 mRNA Translation: BAG64997.1 AL139230 Genomic DNA No translation available. AL162571 Genomic DNA No translation available. BC151239 mRNA Translation: AAI51240.1 CR749622 mRNA Translation: CAH18416.1 |
CCDSi | CCDS41901.1 [O60343-1] CCDS66563.1 [O60343-2] CCDS66564.1 [O60343-3] |
PIRi | T00261 |
RefSeqi | NP_001273587.1, NM_001286658.2 [O60343-3] NP_001273588.1, NM_001286659.2 [O60343-2] NP_055647.2, NM_014832.4 [O60343-1] |
Genome annotation databases
Ensembli | ENST00000377625; ENSP00000366852; ENSG00000136111 [O60343-2] ENST00000377636; ENSP00000366863; ENSG00000136111 [O60343-1] ENST00000431480; ENSP00000395986; ENSG00000136111 [O60343-3] |
GeneIDi | 9882 |
KEGGi | hsa:9882 |
UCSCi | uc001vjl.3, human [O60343-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | FM207106 mRNA Translation: CAR62509.1 FM207107 mRNA Translation: CAR62510.1 AB449885 mRNA Translation: BAH16628.1 AB011175 mRNA Translation: BAA25529.2 Different initiation. AK300468 mRNA Translation: BAG62187.1 AK304091 mRNA Translation: BAG64997.1 AL139230 Genomic DNA No translation available. AL162571 Genomic DNA No translation available. BC151239 mRNA Translation: AAI51240.1 CR749622 mRNA Translation: CAH18416.1 |
CCDSi | CCDS41901.1 [O60343-1] CCDS66563.1 [O60343-2] CCDS66564.1 [O60343-3] |
PIRi | T00261 |
RefSeqi | NP_001273587.1, NM_001286658.2 [O60343-3] NP_001273588.1, NM_001286659.2 [O60343-2] NP_055647.2, NM_014832.4 [O60343-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3QYB | X-ray | 3.50 | A | 874-1170 | [»] | |
SMRi | O60343 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 115213, 82 interactors |
IntActi | O60343, 52 interactors |
MINTi | O60343 |
STRINGi | 9606.ENSP00000366863 |
Protein family/group databases
TCDBi | 8.A.87.1.1, the tbc1 domain (tbc1) family |
PTM databases
iPTMneti | O60343 |
MetOSitei | O60343 |
PhosphoSitePlusi | O60343 |
Genetic variation databases
BioMutai | TBC1D4 |
Proteomic databases
EPDi | O60343 |
jPOSTi | O60343 |
MassIVEi | O60343 |
MaxQBi | O60343 |
PaxDbi | O60343 |
PeptideAtlasi | O60343 |
PRIDEi | O60343 |
ProteomicsDBi | 49366 [O60343-1] 49367 [O60343-2] 49368 [O60343-3] 49369 [O60343-4] 49370 [O60343-5] |
Protocols and materials databases
Antibodypediai | 3177, 471 antibodies |
DNASUi | 9882 |
Genome annotation databases
Ensembli | ENST00000377625; ENSP00000366852; ENSG00000136111 [O60343-2] ENST00000377636; ENSP00000366863; ENSG00000136111 [O60343-1] ENST00000431480; ENSP00000395986; ENSG00000136111 [O60343-3] |
GeneIDi | 9882 |
KEGGi | hsa:9882 |
UCSCi | uc001vjl.3, human [O60343-1] |
Organism-specific databases
CTDi | 9882 |
DisGeNETi | 9882 |
GeneCardsi | TBC1D4 |
HGNCi | HGNC:19165, TBC1D4 |
HPAi | ENSG00000136111, Low tissue specificity |
MalaCardsi | TBC1D4 |
MIMi | 612465, gene 616087, phenotype |
neXtProti | NX_O60343 |
OpenTargetsi | ENSG00000136111 |
PharmGKBi | PA38807 |
VEuPathDBi | HostDB:ENSG00000136111.12 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4436, Eukaryota |
GeneTreei | ENSGT00940000158486 |
HOGENOMi | CLU_005350_13_2_1 |
InParanoidi | O60343 |
OMAi | CNSLASD |
OrthoDBi | 323342at2759 |
PhylomeDBi | O60343 |
TreeFami | TF317184 |
Enzyme and pathway databases
PathwayCommonsi | O60343 |
Reactomei | R-HSA-1445148, Translocation of SLC2A4 (GLUT4) to the plasma membrane |
SIGNORi | O60343 |
Miscellaneous databases
BioGRID-ORCSi | 9882, 4 hits in 993 CRISPR screens |
ChiTaRSi | TBC1D4, human |
EvolutionaryTracei | O60343 |
GeneWikii | TBC1D4 |
GenomeRNAii | 9882 |
Pharosi | O60343, Tbio |
PROi | PR:O60343 |
RNActi | O60343, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000136111, Expressed in adrenal cortex and 252 other tissues |
ExpressionAtlasi | O60343, baseline and differential |
Genevisiblei | O60343, HS |
Family and domain databases
Gene3Di | 2.30.29.30, 2 hits |
InterProi | View protein in InterPro IPR021785, DUF3350 IPR011993, PH-like_dom_sf IPR006020, PTB/PI_dom IPR000195, Rab-GTPase-TBC_dom IPR035969, Rab-GTPase_TBC_sf |
Pfami | View protein in Pfam PF11830, DUF3350, 1 hit PF00640, PID, 2 hits PF00566, RabGAP-TBC, 1 hit |
SMARTi | View protein in SMART SM00462, PTB, 2 hits SM00164, TBC, 1 hit |
SUPFAMi | SSF47923, SSF47923, 2 hits |
PROSITEi | View protein in PROSITE PS01179, PID, 1 hit PS50086, TBC_RABGAP, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TBCD4_HUMAN | |
Accessioni | O60343Primary (citable) accession number: O60343 Secondary accession number(s): A7E2X8 Q68D14 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 10, 2002 |
Last sequence update: | June 7, 2005 | |
Last modified: | April 7, 2021 | |
This is version 182 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 13
Human chromosome 13: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references