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Entry version 214 (29 Sep 2021)
Sequence version 2 (16 Aug 2004)
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Protein

Lysine-specific histone demethylase 1A

Gene

KDM1A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Histone demethylase that can demethylate both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context (PubMed:15620353, PubMed:15811342, PubMed:16140033, PubMed:16079794, PubMed:16079795, PubMed:16223729).

Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed (PubMed:15620353, PubMed:15811342, PubMed:16079794, PubMed:21300290).

Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me (PubMed:15620353, PubMed:20389281, PubMed:21300290, PubMed:23721412).

May play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity (PubMed:16140033, PubMed:16079794, PubMed:16885027, PubMed:21300290, PubMed:23721412).

Also acts as a coactivator of androgen receptor (AR)-dependent transcription, by being recruited to AR target genes and mediating demethylation of H3K9me, a specific tag for epigenetic transcriptional repression. The presence of PRKCB in AR-containing complexes, which mediates phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag that prevents demethylation H3K4me, prevents H3K4me demethylase activity of KDM1A (PubMed:16079795).

Demethylates di-methylated 'Lys-370' of p53/TP53 which prevents interaction of p53/TP53 with TP53BP1 and represses p53/TP53-mediated transcriptional activation. Demethylates and stabilizes the DNA methylase DNMT1. Required for gastrulation during embryogenesis. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Effector of SNAI1-mediated transcription repression of E-cadherin/CDH1, CDN7 and KRT8. Required for the maintenance of the silenced state of the SNAI1 target genes E-cadherin/CDH1 and CDN7 (PubMed:20389281).

15 Publications

Caution

Was previously reported to interact with ASXL1. However, this publication has been retracted.2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

FAD5 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

The N-terminal sequences of INSM1 and SNAI1 compete with histone H3 for the same binding site and thereby inhibit histone demethylation (in vitro).2 Publications

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=3.0 µM for H3 monomethyl-K41 Publication
  2. KM=4.2 µM for H3 dimethyl-K41 Publication
  3. KM=3.9 µM for H3 monomethyl-K4-monomethyl-K91 Publication
  4. KM=17.5 µM for monomethyl-K4-acetyl-K91 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei289FADCombined sources4 Publications1
Binding sitei308FADCombined sources4 Publications1
Binding sitei310FADCombined sources4 Publications1
Binding sitei316FADCombined sources4 Publications1
Binding sitei801FADCombined sources4 Publications1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi332 – 333FADCombined sources4 Publications2
Nucleotide bindingi810 – 811FADCombined sources4 Publications2

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator, Developmental protein, Oxidoreductase, Repressor
Biological processTranscription, Transcription regulation
LigandFAD, Flavoprotein

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

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BioCyci
MetaCyc:ENSG00000004487-MONOMER

BRENDA Comprehensive Enzyme Information System

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BRENDAi
1.14.11.65, 2681
1.14.11.66, 2681
1.14.11.67, 2681
1.14.99.66, 2681

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
O60341

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-3214815, HDACs deacetylate histones
R-HSA-3214842, HDMs demethylate histones
R-HSA-5625886, Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
R-HSA-8943724, Regulation of PTEN gene transcription
R-HSA-9018519, Estrogen-dependent gene expression
R-HSA-9029569, NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
R-HSA-9679191, Potential therapeutics for SARS
R-HSA-983231, Factors involved in megakaryocyte development and platelet production

SABIO-RK: Biochemical Reaction Kinetics Database

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SABIO-RKi
O60341

SIGNOR Signaling Network Open Resource

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SIGNORi
O60341

Protein family/group databases

MoonDB Database of extreme multifunctional and moonlighting proteins

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MoonDBi
O60341, Predicted

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Lysine-specific histone demethylase 1ACurated (EC:1.14.99.662 Publications)
Alternative name(s):
BRAF35-HDAC complex protein BHC110
Flavin-containing amine oxidase domain-containing protein 2
[histone H3]-dimethyl-L-lysine(4) FAD-dependent demethylase 1A
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KDM1AImported
Synonyms:AOF2, KDM1, KIAA0601, LSD1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:29079, KDM1A

Online Mendelian Inheritance in Man (OMIM)

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MIMi
609132, gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_O60341

Eukaryotic Pathogen, Vector and Host Database Resources

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VEuPathDBi
HostDB:ENSG00000004487

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Cleft palate, psychomotor retardation, and distinctive facial features (CPRF)3 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA syndrome characterized by cleft palate, developmental delay, psychomotor retardation, and facial dysmorphic features including a prominent forehead, slightly arched eyebrows, elongated palpebral fissures, a wide nasal bridge, thin lips, and widely spaced teeth. Cleft palate is a congenital fissure of the soft and/or hard palate, due to faulty fusion.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_076366379E → K in CPRF. 1 PublicationCorresponds to variant dbSNP:rs864309715Ensembl.1
Natural variantiVAR_076367556D → G in CPRF. 2 PublicationsCorresponds to variant dbSNP:rs864309716Ensembl.1
Natural variantiVAR_076368761Y → H in CPRF. 2 PublicationsCorresponds to variant dbSNP:rs864309714Ensembl.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi503K → R: Loss of polyubiquitination. 1 Publication1
Mutagenesisi535N → A: Strongly reduces demethylase activity. 1 Publication1
Mutagenesisi564H → A: Strongly reduces demethylase activity. 1 Publication1
Mutagenesisi661K → A: Abolishes histone demethylase activity. 1 Publication1
Mutagenesisi761Y → A: Strongly reduces demethylase activity. 1 Publication1

Keywords - Diseasei

Disease variant

Organism-specific databases

DisGeNET

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DisGeNETi
23028

MalaCards human disease database

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MalaCardsi
KDM1A
MIMi616728, phenotype

Open Targets

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OpenTargetsi
ENSG00000004487

Orphanet; a database dedicated to information on rare diseases and orphan drugs

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Orphaneti
477993, Palatal anomalies-widely spaced teeth-facial dysmorphism-developmental delay syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA165751392

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
O60341, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

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ChEMBLi
CHEMBL6136

DrugCentral

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DrugCentrali
O60341

IUPHAR/BPS Guide to PHARMACOLOGY

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GuidetoPHARMACOLOGYi
2669

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
KDM1A

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000998811 – 852Lysine-specific histone demethylase 1AAdd BLAST852

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei59PhosphothreonineCombined sources1
Modified residuei104PhosphothreonineCombined sources1
Modified residuei126PhosphoserineCombined sources1
Modified residuei131PhosphoserineCombined sources1
Modified residuei135PhosphotyrosineCombined sources1
Modified residuei137PhosphoserineCombined sources1
Modified residuei166PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki442Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki469Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki503Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Modified residuei611PhosphoserineCombined sources1
Modified residuei849PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Polyubiquitinated by JADE2; which leads to its proteasomal degradation.1 Publication

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
O60341

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
O60341

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
O60341

MaxQB - The MaxQuant DataBase

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MaxQBi
O60341

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
O60341

PeptideAtlas

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PeptideAtlasi
O60341

PRoteomics IDEntifications database

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PRIDEi
O60341

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
49364 [O60341-1]
49365 [O60341-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
O60341

MetOSite database of methionine sulfoxide sites

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MetOSitei
O60341

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
O60341

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed.1 Publication

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Down-regulated during neural differentiation in neuroblastoma cancer.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000004487, Expressed in subventricular zone (outer) (primate) and 244 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
O60341, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
O60341, HS

Organism-specific databases

Human Protein Atlas

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HPAi
ENSG00000004487, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of a histone demethylase complex with RCOR1 (PubMed:20389281, PubMed:23721412, PubMed:16885027, PubMed:21300290).

Component of a RCOR/GFI/KDM1A/HDAC complex (PubMed:12032298, PubMed:11102443).

Interacts directly with GFI1 and GFI1B.

Interacts with INSM1 (via N-terminus) (PubMed:23721412).

Component of a BHC histone deacetylase complex that contains HDAC1, HDAC2, HMG20B, KDM1A, RCOR1 and PHF21A. The BHC complex may also contain ZMYM2, ZNF217, ZMYM3, GSE1 and GTF2I (PubMed:12493763, PubMed:16140033, PubMed:16885027). In the complex, RCOR1/CoREST strongly enhances the demethylase activity and protects it from the proteasome while PHF21A/BHC80 inhibits the demethylase activity (PubMed:16079794, PubMed:16956976).

Interacts with the androgen receptor (AR) (PubMed:16079795).

Interacts with SNAI1 (via SNAG domain) (PubMed:20389281, PubMed:20562920, PubMed:21300290, PubMed:23721412).

Interacts (via AOD/Tower domain) with JADE2 (via C-terminus) (PubMed:25018020).

Interacts with ESRRB; co-occupes the core set of ESRRB targets (By similarity).

Interacts with SAMD1 (via WH domain); the interaction modulates KDM1A function (PubMed:33980486).

By similarity14 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

O60341
With#Exp.IntAct
AKAP9 [Q99996]2EBI-710124,EBI-1048311
ANKRD23 [Q86SG2]3EBI-710124,EBI-5661893
BIRC2 [Q13490]3EBI-710124,EBI-514538
C8orf74 [Q6P047]2EBI-710124,EBI-8466055
CAGE1 - isoform 4 [Q8TC20-4]3EBI-710124,EBI-11522698
CARD10 [Q9BWT7]3EBI-710124,EBI-3866279
CCDC14 - isoform 3 [Q49A88-3]3EBI-710124,EBI-12105646
CDC5L [Q99459]3EBI-710124,EBI-374880
CDCA4 [Q9BXL8]2EBI-710124,EBI-1773949
CEP57 - isoform 3 [Q86XR8-3]3EBI-710124,EBI-11752486
CEP70 [Q8NHQ1]2EBI-710124,EBI-739624
CEP76 [Q8TAP6]3EBI-710124,EBI-742887
CHD3 [Q12873]4EBI-710124,EBI-523590
COIL [P38432]3EBI-710124,EBI-945751
DNAJA3 [Q96EY1]2EBI-710124,EBI-356767
ELAVL4 - isoform 2 [P26378-2]3EBI-710124,EBI-21603100
EXOC7 - isoform 1 [Q9UPT5-1]3EBI-710124,EBI-6251402
FAM161A [Q3B820]3EBI-710124,EBI-719941
FAM204A [Q9H8W3]3EBI-710124,EBI-8465160
FAM9A [Q8IZU1]2EBI-710124,EBI-8468186
FYCO1 [Q9BQS8]2EBI-710124,EBI-2869338
GAS8 [O95995]3EBI-710124,EBI-1052570
GCC1 [Q96CN9]3EBI-710124,EBI-746252
GOLGA2 [Q08379]3EBI-710124,EBI-618309
GOLGA6A [Q9NYA3]3EBI-710124,EBI-11163335
GSTCD [Q8NEC7]2EBI-710124,EBI-8469616
GTPBP2 [Q9BX10]2EBI-710124,EBI-6115579
H3-4 [Q16695]2EBI-710124,EBI-358900
HAUS1 [Q96CS2]2EBI-710124,EBI-2514791
HDAC3 [O15379]4EBI-710124,EBI-607682
HESX1 [Q9UBX0]2EBI-710124,EBI-8470369
HOMER3 [Q9NSC5]3EBI-710124,EBI-748420
IMMT [Q16891]2EBI-710124,EBI-473801
JRK - isoform 2 [O75564-2]3EBI-710124,EBI-17181882
KIFC3 - isoform 4 [Q9BVG8-5]3EBI-710124,EBI-14069005
KLHDC4 [Q8TBB5]2EBI-710124,EBI-8472352
KRT15 [P19012]3EBI-710124,EBI-739566
KRT31 [Q15323]3EBI-710124,EBI-948001
KRT33B [Q14525]4EBI-710124,EBI-1049638
KRT35 [Q92764]3EBI-710124,EBI-1058674
KRT39 [Q6A163]3EBI-710124,EBI-11958242
KRT40 [Q6A162]3EBI-710124,EBI-10171697
LOXL4 [Q96JB6]2EBI-710124,EBI-749562
LZTS1 [Q9Y250]3EBI-710124,EBI-1216080
MBD3 [O95983]4EBI-710124,EBI-1783068
MYC [P01106]4EBI-710124,EBI-447544
NBPF1 [Q3BBV0]5EBI-710124,EBI-2804530
NECAB2 - isoform 2 [Q7Z6G3-2]3EBI-710124,EBI-10172876
NF2 [P35240]4EBI-710124,EBI-1014472
NFE2L2 [Q16236]5EBI-710124,EBI-2007911
NOTCH1 [P46531]8EBI-710124,EBI-636374
NR1H3 [Q13133]2EBI-710124,EBI-781356
NRBF2 [Q96F24]3EBI-710124,EBI-2362014
ODAD3 [A5D8V7]2EBI-710124,EBI-8466445
OFCC1 [Q8IZS5]2EBI-710124,EBI-8477661
PBX4 [Q9BYU1]3EBI-710124,EBI-10302990
PELP1 [Q8IZL8]6EBI-710124,EBI-716449
PFDN5 [Q99471]3EBI-710124,EBI-357275
PHF19 [Q5T6S3]2EBI-710124,EBI-2339674
PPARD [Q03181]2EBI-710124,EBI-6426768
PSMC1 [P62191]2EBI-710124,EBI-357598
RASSF1 [Q9NS23]2EBI-710124,EBI-367363
RASSF2 [P50749]2EBI-710124,EBI-960081
RASSF3 [Q86WH2]3EBI-710124,EBI-2845202
RBPJ [Q06330]4EBI-710124,EBI-632552
RCOR1 [Q9UKL0]6EBI-710124,EBI-926563
RCOR2 [Q8IZ40]3EBI-710124,EBI-723853
RCOR3 - isoform 2 [Q9P2K3-2]6EBI-710124,EBI-1504830
RPRD1A - isoform 2 [Q96P16-3]3EBI-710124,EBI-12840198
SAMD3 [Q8N6K7]2EBI-710124,EBI-748741
SERGEF [Q9UGK8]2EBI-710124,EBI-465368
SF3B2 [Q13435]2EBI-710124,EBI-749111
SMAD9 [O15198]2EBI-710124,EBI-748763
SNAI1 [O95863]32EBI-710124,EBI-1045459
SNF8 [Q96H20]2EBI-710124,EBI-747719
SPICE1 [Q8N0Z3]4EBI-710124,EBI-2361917
SPSB1 [Q96BD6]2EBI-710124,EBI-2659201
STX19 [Q8N4C7]2EBI-710124,EBI-8484990
TEX9 [Q8N6V9]4EBI-710124,EBI-746341
TFIP11 [Q9UBB9]3EBI-710124,EBI-1105213
TLE5 - isoform 2 [Q08117-2]3EBI-710124,EBI-11741437
TMEM266 [Q2M3C6]3EBI-710124,EBI-12163061
TNNT2 - isoform 11 [P45379-11]3EBI-710124,EBI-17559309
TP53BP2 [Q05BL1]3EBI-710124,EBI-11952721
TRAF4 [Q9BUZ4]4EBI-710124,EBI-3650647
TTC23 - isoform 3 [Q5W5X9-3]3EBI-710124,EBI-9090990
UBASH3B [Q8TF42]3EBI-710124,EBI-1380492
VPS37B [Q9H9H4]3EBI-710124,EBI-4400866
WASHC3 [Q9Y3C0]3EBI-710124,EBI-712969
ZBED1 [O96006]4EBI-710124,EBI-740037
ZBTB39 [O15060]3EBI-710124,EBI-9995672
Isoform 1 [O60341-1]
With#Exp.IntAct
CHD1 [O14646]8EBI-15599570,EBI-1560858
EHMT2 [Q96KQ7]2EBI-15599570,EBI-744366
EHMT2 - isoform 1 [Q96KQ7-1]3EBI-15599570,EBI-15737402
PRKCB - isoform Beta-I [P05771-1]2EBI-15599570,EBI-5774492
RCOR1 [Q9UKL0]6EBI-15599570,EBI-926563
TAL1 [P17542]5EBI-15599570,EBI-1753878
TP53 [P04637]6EBI-15599570,EBI-366083
Tal1 [P22091] from Mus musculus.2EBI-15599570,EBI-8006437

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
116667, 453 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
O60341

Database of interacting proteins

More...
DIPi
DIP-34641N

Protein interaction database and analysis system

More...
IntActi
O60341, 311 interactors

Molecular INTeraction database

More...
MINTi
O60341

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000383042

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
O60341

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
O60341, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1852
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Biological Magnetic Resonance Data Bank

More...
BMRBi
O60341

Small Angle Scattering Biological Data Bank

More...
SASBDBi
O60341

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O60341

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
O60341

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini174 – 273SWIRMPROSITE-ProRule annotationAdd BLAST100

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 176DisorderedSequence analysisAdd BLAST176
Regioni300 – 852Demethylase activityAdd BLAST553

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili110 – 151Sequence analysisAdd BLAST42
Coiled coili428 – 514Sequence analysisAdd BLAST87

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi105 – 151Basic and acidic residuesSequence analysisAdd BLAST47

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The SWIRM domain may act as an anchor site for a histone tail.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the flavin monoamine oxidase family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0029, Eukaryota
KOG0685, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157193

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_004498_5_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O60341

Identification of Orthologs from Complete Genome Data

More...
OMAi
SSRGEMF

Database of Orthologous Groups

More...
OrthoDBi
1034142at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O60341

TreeFam database of animal gene trees

More...
TreeFami
TF312972

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.10.10, 1 hit
3.50.50.60, 2 hits

Intrinsically Disordered proteins with Extensive Annotations and Literature

More...
IDEALi
IID00009

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002937, Amino_oxidase
IPR036188, FAD/NAD-bd_sf
IPR017366, Hist_Lys-spec_deMease
IPR009057, Homeobox-like_sf
IPR007526, SWIRM
IPR036388, WH-like_DNA-bd_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01593, Amino_oxidase, 1 hit
PF04433, SWIRM, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF038051, Histone_Lys-demethylase, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46689, SSF46689, 1 hit
SSF51905, SSF51905, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50934, SWIRM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O60341-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLSGKKAAAA AAAAAAAATG TEAGPGTAGG SENGSEVAAQ PAGLSGPAEV
60 70 80 90 100
GPGAVGERTP RKKEPPRASP PGGLAEPPGS AGPQAGPTVV PGSATPMETG
110 120 130 140 150
IAETPEGRRT SRRKRAKVEY REMDESLANL SEDEYYSEEE RNAKAEKEKK
160 170 180 190 200
LPPPPPQAPP EEENESEPEE PSGVEGAAFQ SRLPHDRMTS QEAACFPDII
210 220 230 240 250
SGPQQTQKVF LFIRNRTLQL WLDNPKIQLT FEATLQQLEA PYNSDTVLVH
260 270 280 290 300
RVHSYLERHG LINFGIYKRI KPLPTKKTGK VIIIGSGVSG LAAARQLQSF
310 320 330 340 350
GMDVTLLEAR DRVGGRVATF RKGNYVADLG AMVVTGLGGN PMAVVSKQVN
360 370 380 390 400
MELAKIKQKC PLYEANGQAV PKEKDEMVEQ EFNRLLEATS YLSHQLDFNV
410 420 430 440 450
LNNKPVSLGQ ALEVVIQLQE KHVKDEQIEH WKKIVKTQEE LKELLNKMVN
460 470 480 490 500
LKEKIKELHQ QYKEASEVKP PRDITAEFLV KSKHRDLTAL CKEYDELAET
510 520 530 540 550
QGKLEEKLQE LEANPPSDVY LSSRDRQILD WHFANLEFAN ATPLSTLSLK
560 570 580 590 600
HWDQDDDFEF TGSHLTVRNG YSCVPVALAE GLDIKLNTAV RQVRYTASGC
610 620 630 640 650
EVIAVNTRST SQTFIYKCDA VLCTLPLGVL KQQPPAVQFV PPLPEWKTSA
660 670 680 690 700
VQRMGFGNLN KVVLCFDRVF WDPSVNLFGH VGSTTASRGE LFLFWNLYKA
710 720 730 740 750
PILLALVAGE AAGIMENISD DVIVGRCLAI LKGIFGSSAV PQPKETVVSR
760 770 780 790 800
WRADPWARGS YSYVAAGSSG NDYDLMAQPI TPGPSIPGAP QPIPRLFFAG
810 820 830 840 850
EHTIRNYPAT VHGALLSGLR EAGRIADQFL GAMYTLPRQA TPGVPAQQSP

SM
Length:852
Mass (Da):92,903
Last modified:August 16, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA61CEDE51E4E0C1D
GO
Isoform 2 (identifier: O60341-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     173-173: G → GQAGGLQDDSSGGYGDGQASG
     369-369: A → ADTVK

Show »
Length:876
Mass (Da):95,155
Checksum:i966CA72A70F68111
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
R4GMQ1R4GMQ1_HUMAN
Lysine-specific histone demethylase
KDM1A
858Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
R4GMP9R4GMP9_HUMAN
Lysine-specific histone demethylase...
KDM1A
301Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA25527 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti78P → Q in AAH40194 (PubMed:15489334).Curated1
Sequence conflicti405P → H in AAH48134 (PubMed:15489334).Curated1
Sequence conflicti669V → A in CAD38675 (PubMed:17974005).Curated1
Sequence conflicti814A → V in AAH16639 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_076366379E → K in CPRF. 1 PublicationCorresponds to variant dbSNP:rs864309715Ensembl.1
Natural variantiVAR_076367556D → G in CPRF. 2 PublicationsCorresponds to variant dbSNP:rs864309716Ensembl.1
Natural variantiVAR_076368761Y → H in CPRF. 2 PublicationsCorresponds to variant dbSNP:rs864309714Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_011198173G → GQAGGLQDDSSGGYGDGQAS G in isoform 2. 1 Publication1
Alternative sequenceiVSP_011199369A → ADTVK in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB011173 mRNA Translation: BAA25527.1 Different initiation.
AL031428 Genomic DNA No translation available.
BC016639 mRNA Translation: AAH16639.1
BC025362 mRNA Translation: AAH25362.1
BC040194 mRNA Translation: AAH40194.3
BC048134 mRNA Translation: AAH48134.2
AL833812 mRNA Translation: CAD38675.2

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS30627.1 [O60341-1]
CCDS53278.1 [O60341-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001009999.1, NM_001009999.2 [O60341-2]
NP_055828.2, NM_015013.3 [O60341-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000356634; ENSP00000349049; ENSG00000004487 [O60341-1]
ENST00000400181; ENSP00000383042; ENSG00000004487 [O60341-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
23028

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:23028

UCSC genome browser

More...
UCSCi
uc001bgi.3, human [O60341-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB011173 mRNA Translation: BAA25527.1 Different initiation.
AL031428 Genomic DNA No translation available.
BC016639 mRNA Translation: AAH16639.1
BC025362 mRNA Translation: AAH25362.1
BC040194 mRNA Translation: AAH40194.3
BC048134 mRNA Translation: AAH48134.2
AL833812 mRNA Translation: CAD38675.2
CCDSiCCDS30627.1 [O60341-1]
CCDS53278.1 [O60341-2]
RefSeqiNP_001009999.1, NM_001009999.2 [O60341-2]
NP_055828.2, NM_015013.3 [O60341-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2COMNMR-A169-279[»]
2DW4X-ray2.30A172-831[»]
2EJRX-ray2.70A172-833[»]
2H94X-ray2.90A172-835[»]
2HKOX-ray2.80A172-835[»]
2IW5X-ray2.57A171-836[»]
2L3DNMR-A174-273[»]
2UXNX-ray2.72A171-836[»]
2UXXX-ray2.74A171-836[»]
2V1DX-ray3.10A123-852[»]
2X0LX-ray3.00A123-852[»]
2XAFX-ray3.25A1-852[»]
2XAGX-ray3.10A1-852[»]
2XAHX-ray3.10A1-852[»]
2XAJX-ray3.30A1-852[»]
2XAQX-ray3.20A1-852[»]
2XASX-ray3.20A1-852[»]
2Y48X-ray3.00A123-852[»]
2Z3YX-ray2.25A172-833[»]
2Z5UX-ray2.25A172-833[»]
3ABTX-ray3.20A172-833[»]
3ABUX-ray3.10A172-833[»]
3ZMSX-ray2.96A1-852[»]
3ZMTX-ray3.10A1-852[»]
3ZMUX-ray3.20A1-852[»]
3ZMVX-ray3.00A1-852[»]
3ZMZX-ray3.00A1-852[»]
3ZN0X-ray2.80A1-852[»]
3ZN1X-ray3.10A1-852[»]
4BAYX-ray3.10A172-852[»]
4CZZX-ray3.00A1-852[»]
4KUMX-ray3.05A171-836[»]
4UV8X-ray2.80A1-852[»]
4UV9X-ray3.00A1-852[»]
4UVAX-ray2.90A1-852[»]
4UVBX-ray2.80A1-852[»]
4UVCX-ray3.10A1-852[»]
4UXNX-ray2.85A1-852[»]
4XBFX-ray2.80A171-836[»]
5AFWX-ray1.60B108-119[»]
5H6QX-ray2.53A172-833[»]
5H6RX-ray2.60A172-833[»]
5IT3X-ray1.40A/B183-267[»]
5L3BX-ray3.30A1-852[»]
5L3CX-ray3.31A1-852[»]
5L3DX-ray2.60A1-852[»]
5L3EX-ray2.80A123-852[»]
5L3FX-ray3.50A123-852[»]
5L3GX-ray3.10A123-852[»]
5LBQX-ray3.30A123-852[»]
5LGNX-ray3.20A172-836[»]
5LGTX-ray3.00A123-852[»]
5LGUX-ray3.20A123-852[»]
5LHGX-ray3.34A1-852[»]
5LHHX-ray3.05A1-852[»]
5LHIX-ray3.40A1-852[»]
5X60X-ray2.69A172-833[»]
5YJBX-ray2.96A172-833[»]
6E1FX-ray1.16A/B/C/D183-267[»]
6K3EX-ray2.87A172-833[»]
6KGKX-ray2.70A172-833[»]
6KGLX-ray2.70A172-833[»]
6KGMX-ray2.62A172-833[»]
6KGNX-ray2.62A172-833[»]
6KGOX-ray2.25A172-833[»]
6KGPX-ray2.25A172-833[»]
6KGQX-ray2.32A172-833[»]
6KGRX-ray2.32A172-833[»]
6NQMX-ray2.90A173-830[»]
6NQUX-ray2.70A173-830[»]
6NR5X-ray2.90A173-830[»]
6S35X-ray3.10A172-833[»]
6TE1X-ray3.11A1-852[»]
6VYPX-ray4.99K/M/k/m171-852[»]
6W4KX-ray2.93A174-832[»]
6WC6X-ray3.10A171-836[»]
C137-151[»]
7CDCX-ray2.64A172-833[»]
7CDDX-ray2.76A172-833[»]
7CDEX-ray2.68A172-833[»]
7CDFX-ray2.68A172-833[»]
7CDGX-ray2.80A172-833[»]
7E0GX-ray2.25A172-833[»]
7JJLX-ray2.60B104-129[»]
7JJMX-ray2.06A104-129[»]
7JK7X-ray1.96A104-129[»]
BMRBiO60341
SASBDBiO60341
SMRiO60341
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi116667, 453 interactors
CORUMiO60341
DIPiDIP-34641N
IntActiO60341, 311 interactors
MINTiO60341
STRINGi9606.ENSP00000383042

Chemistry databases

BindingDBiO60341
ChEMBLiCHEMBL6136
DrugCentraliO60341
GuidetoPHARMACOLOGYi2669

Protein family/group databases

MoonDBiO60341, Predicted

PTM databases

iPTMnetiO60341
MetOSiteiO60341
PhosphoSitePlusiO60341

Genetic variation databases

BioMutaiKDM1A

Proteomic databases

EPDiO60341
jPOSTiO60341
MassIVEiO60341
MaxQBiO60341
PaxDbiO60341
PeptideAtlasiO60341
PRIDEiO60341
ProteomicsDBi49364 [O60341-1]
49365 [O60341-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
3136, 697 antibodies

The DNASU plasmid repository

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DNASUi
23028

Genome annotation databases

EnsembliENST00000356634; ENSP00000349049; ENSG00000004487 [O60341-1]
ENST00000400181; ENSP00000383042; ENSG00000004487 [O60341-2]
GeneIDi23028
KEGGihsa:23028
UCSCiuc001bgi.3, human [O60341-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23028
DisGeNETi23028

GeneCards: human genes, protein and diseases

More...
GeneCardsi
KDM1A
HGNCiHGNC:29079, KDM1A
HPAiENSG00000004487, Low tissue specificity
MalaCardsiKDM1A
MIMi609132, gene
616728, phenotype
neXtProtiNX_O60341
OpenTargetsiENSG00000004487
Orphaneti477993, Palatal anomalies-widely spaced teeth-facial dysmorphism-developmental delay syndrome
PharmGKBiPA165751392
VEuPathDBiHostDB:ENSG00000004487

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0029, Eukaryota
KOG0685, Eukaryota
GeneTreeiENSGT00940000157193
HOGENOMiCLU_004498_5_1_1
InParanoidiO60341
OMAiSSRGEMF
OrthoDBi1034142at2759
PhylomeDBiO60341
TreeFamiTF312972

Enzyme and pathway databases

BioCyciMetaCyc:ENSG00000004487-MONOMER
BRENDAi1.14.11.65, 2681
1.14.11.66, 2681
1.14.11.67, 2681
1.14.99.66, 2681
PathwayCommonsiO60341
ReactomeiR-HSA-3214815, HDACs deacetylate histones
R-HSA-3214842, HDMs demethylate histones
R-HSA-5625886, Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
R-HSA-8943724, Regulation of PTEN gene transcription
R-HSA-9018519, Estrogen-dependent gene expression
R-HSA-9029569, NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
R-HSA-9679191, Potential therapeutics for SARS
R-HSA-983231, Factors involved in megakaryocyte development and platelet production
SABIO-RKiO60341
SIGNORiO60341

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
23028, 92 hits in 1044 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
KDM1A, human
EvolutionaryTraceiO60341

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
23028
PharosiO60341, Tchem

Protein Ontology

More...
PROi
PR:O60341
RNActiO60341, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000004487, Expressed in subventricular zone (outer) (primate) and 244 other tissues
ExpressionAtlasiO60341, baseline and differential
GenevisibleiO60341, HS

Family and domain databases

Gene3Di1.10.10.10, 1 hit
3.50.50.60, 2 hits
IDEALiIID00009
InterProiView protein in InterPro
IPR002937, Amino_oxidase
IPR036188, FAD/NAD-bd_sf
IPR017366, Hist_Lys-spec_deMease
IPR009057, Homeobox-like_sf
IPR007526, SWIRM
IPR036388, WH-like_DNA-bd_sf
PfamiView protein in Pfam
PF01593, Amino_oxidase, 1 hit
PF04433, SWIRM, 1 hit
PIRSFiPIRSF038051, Histone_Lys-demethylase, 1 hit
SUPFAMiSSF46689, SSF46689, 1 hit
SSF51905, SSF51905, 1 hit
PROSITEiView protein in PROSITE
PS50934, SWIRM, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKDM1A_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O60341
Secondary accession number(s): A8MWP9
, Q5TH94, Q5TH95, Q86VT7, Q8IXK4, Q8NDP6, Q8TAZ3, Q96AW4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: August 16, 2004
Last modified: September 29, 2021
This is version 214 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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