UniProtKB - O60337 (MARH6_HUMAN)

BLAST

>sp|O60337|MARH6_HUMAN E3 ubiquitin-protein ligase MARCH6 OS=Homo sapiens OX=9606 GN=MARCH6 PE=1 SV=2
MDTAEEDICRVCRSEGTPEKPLYHPCVCTGSIKFIHQECLVQWLKHSRKEYCELCKHRFA
FTPIYSPDMPSRLPIQDIFAGLVTSIGTAIRYWFHYTLVAFAWLGVVPLTACRIYKCLFT
GSVSSLLTLPLDMLSTENLLADCLQGCFVVTCTLCAFISLVWLREQIVHGGAPIWLEHAA
PPFNAAGHHQNEAPAGGNGAENVAADQPANPPAENAVVGENPDAQDDQAEEEEEDNEEED
DAGVEDAADANNGAQDDMNWNALEWDRAAEELTWERMLGLDGSLVFLEHVFWVVSLNTLF
ILVFAFCPYHIGHFSLVGLGFEEHVQASHFEGLITTIVGYILLAITLIICHGLATLVKFH
RSRRLLGVCYIVVKVSLLVVVEIGVFPLICGWWLDICSLEMFDATLKDRELSFQSAPGTT
MFLHWLVGMVYVFYFASFILLLREVLRPGVLWFLRNLNDPDFNPVQEMIHLPIYRHLRRF
ILSVIVFGSIVLLMLWLPIRIIKSVLPNFLPYNVMLYSDAPVSELSLELLLLQVVLPALL
EQGHTRQWLKGLVRAWTVTAGYLLDLHSYLLGDQEENENSANQQVNNNQHARNNNAIPVV
GEGLHAAHQAILQQGGPVGFQPYRRPLNFPLRIFLLIVFMCITLLIASLICLTLPVFAGR
WLMSFWTGTAKIHELYTAACGLYVCWLTIRAVTVMVAWMPQGRRVIFQKVKEWSLMIMKT
LIVAVLLAGVVPLLLGLLFELVIVAPLRVPLDQTPLFYPWQDWALGVLHAKIIAAITLMG
PQWWLKTVIEQVYANGIRNIDLHYIVRKLAAPVISVLLLSLCVPYVIASGVVPLLGVTAE
MQNLVHRRIYPFLLMVVVLMAILSFQVRQFKRLYEHIKNDKYLVGQRLVNYERKSGKQGS
SPPPPQSSQE

Align

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History
Entry version 142 (07 Nov 2018)
Sequence version 2 (06 Feb 2007)
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Protein

E3 ubiquitin-protein ligase MARCH6

Gene

MARCH6

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

E3 ubiquitin-protein ligase that promotes ubiquitination of DIO2, leading to its degradation. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May cooperate with UBE2G1.2 Publications

Catalytic activityⁱ

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N₆-ubiquitinyl-[acceptor protein]-L-lysine.

Pathwayⁱ: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	1 – 62	RING-CH-typePROSITE-ProRule annotationAdd BLAST		62

GO - Molecular functionⁱ

enzyme binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 19651899
ubiquitin conjugating enzyme binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 15673284
ubiquitin protein ligase activity
Source: ParkinsonsUK-UCL
Traceable author statementⁱ
- 16373356
- 25088257
ubiquitin-protein transferase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 15673284
ubiquitin-specific protease binding
Source: ParkinsonsUK-UCL
Inferred from physical interactionⁱ
- 25088257
zinc ion binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

endoplasmic reticulum mannose trimming Source: Reactome
ERAD pathway
Source: ParkinsonsUK-UCL
Traceable author statementⁱ
- 25088257
proteasomal protein catabolic process
Source: ParkinsonsUK-UCL
Inferred from direct assayⁱ
- 15673284
protein K48-linked ubiquitination
Source: UniProtKB
Inferred from direct assayⁱ
- 15673284
ubiquitin-dependent ERAD pathway
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Transferase
Biological process	Ubl conjugation pathway
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

BioCycⁱ	MetaCyc:ENSG00000145495-MONOMER
BRENDAⁱ	2.3.2.B10 2681
Reactomeⁱ	R-HSA-901032 ER Quality Control Compartment (ERQC)
UniPathwayⁱ	UPA00143

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: E3 ubiquitin-protein ligase MARCH6 (EC:2.3.2.27) Alternative name(s): Doa10 homolog Membrane-associated RING finger protein 6 Membrane-associated RING-CH protein VI Short name: MARCH-VI Protein TEB-4 RING finger protein 176 RING-type E3 ubiquitin transferase MARCH6Curated
Gene namesⁱ	Name:MARCH6 Synonyms:KIAA0597, RNF176, TEB4
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 5

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000145495.14
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:30550 MARCH6
MIMⁱ	613297 gene
neXtProtⁱ	NX_O60337

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 91	CytoplasmicSequence analysisAdd BLAST	91
Transmembraneⁱ	92 – 112	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	113 – 142	ExtracellularSequence analysisAdd BLAST	30
Transmembraneⁱ	143 – 163	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	164 – 283	CytoplasmicSequence analysisAdd BLAST	120
Transmembraneⁱ	284 – 304	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	305 – 336	ExtracellularSequence analysisAdd BLAST	32
Transmembraneⁱ	337 – 357	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	358 – 376	CytoplasmicSequence analysisAdd BLAST	19
Transmembraneⁱ	377 – 397	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	398 – 421	ExtracellularSequence analysisAdd BLAST	24
Transmembraneⁱ	422 – 442	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	443 – 480	CytoplasmicSequence analysisAdd BLAST	38
Transmembraneⁱ	481 – 501	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	502 – 519	ExtracellularSequence analysisAdd BLAST	18
Transmembraneⁱ	520 – 540	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	541 – 632	CytoplasmicSequence analysisAdd BLAST	92
Transmembraneⁱ	633 – 653	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	654 – 678	ExtracellularSequence analysisAdd BLAST	25
Transmembraneⁱ	679 – 699	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	700 – 721	CytoplasmicSequence analysisAdd BLAST	22
Transmembraneⁱ	722 – 742	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	743 – 764	ExtracellularSequence analysisAdd BLAST	22
Transmembraneⁱ	765 – 785	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	786 – 815	CytoplasmicSequence analysisAdd BLAST	30
Transmembraneⁱ	816 – 836	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	837 – 848	ExtracellularSequence analysisAdd BLAST	12
Transmembraneⁱ	849 – 869	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	870 – 910	CytoplasmicSequence analysisAdd BLAST	41

Keywords - Cellular componentⁱ

Endoplasmic reticulum, Membrane

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	9	C → A: Abolishes auto-ubiquitination. 1 Publication		1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	10299
Open Targets More...OpenTargetsⁱ	ENSG00000145495
PharmGKBⁱ	PA134869368

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000274298	1 – 910	E3 ubiquitin-protein ligase MARCH6Add BLAST		910

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	1	N-acetylmethionineCombined sources		1

Post-translational modificationⁱ

Auto-ubiquitinated, which results in proteasomal degradation.1 Publication

Keywords - PTMⁱ

Acetylation, Ubl conjugation

Proteomic databases

EPDⁱ	O60337
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O60337
PaxDbⁱ	O60337
PeptideAtlas More...PeptideAtlasⁱ	O60337
PRIDEⁱ	O60337
ProteomicsDBⁱ	49363

PTM databases

iPTMnetⁱ	O60337
PhosphoSitePlusⁱ	O60337

Expressionⁱ

Tissue specificityⁱ

Present in brain (at protein level).1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000145495 Expressed in 240 organ(s), highest expression level in cerebellar vermis
CleanExⁱ	HS_MARCH6
ExpressionAtlasⁱ	O60337 baseline and differential
Genevisibleⁱ	O60337 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA040841 HPA063246

HPAⁱ

HPA040841
HPA063246

Interactionⁱ

Subunit structureⁱ

Interacts with DIO2.1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
RGS2	P41220-1	3	EBI-2684600,EBI-16037474

With

Entry

#Exp.

IntAct

Notes

RGS2

P41220-1

EBI-2684600,EBI-16037474

GO - Molecular functionⁱ

enzyme binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 19651899
ubiquitin conjugating enzyme binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 15673284
ubiquitin-specific protease binding
Source: ParkinsonsUK-UCL
Inferred from physical interactionⁱ
- 25088257

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	115587, 24 interactors
Database of interacting proteins More...DIPⁱ	DIP-56134N
IntActⁱ	O60337, 9 interactors
Molecular INTeraction database More...MINTⁱ	O60337
STRINGⁱ	9606.ENSP00000274140

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O60337
SMRⁱ	O60337
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domainⁱ

The RING-CH-type zinc finger domain is required for E3 ligase activity.

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	1 – 62	RING-CH-typePROSITE-ProRule annotationAdd BLAST		62

Keywords - Domainⁱ

Transmembrane, Transmembrane helix, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG1609 Eukaryota COG5183 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00930000150887
HOGENOMⁱ	HOG000286005
HOVERGENⁱ	HBG080753
InParanoidⁱ	O60337
KEGG Orthology (KO) More...KOⁱ	K10661
OMAⁱ	WLPIRIL
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G02GT
PhylomeDBⁱ	O60337
TreeFamⁱ	TF105777

Family and domain databases

Gene3Dⁱ	3.30.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR011016 Znf_RING-CH IPR013083 Znf_RING/FYVE/PHD
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF12906 RINGv, 1 hit
SMARTⁱ	View protein in SMART SM00744 RINGv, 1 hit
PROSITEⁱ	View protein in PROSITE PS51292 ZF_RING_CH, 1 hit

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: O60337-4) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDTAEEDICR VCRSEGTPEK PLYHPCVCTG SIKFIHQECL VQWLKHSRKE 
        60         70         80         90        100
YCELCKHRFA FTPIYSPDMP SRLPIQDIFA GLVTSIGTAI RYWFHYTLVA 
       110        120        130        140        150
FAWLGVVPLT ACRIYKCLFT GSVSSLLTLP LDMLSTENLL ADCLQGCFVV 
       160        170        180        190        200
TCTLCAFISL VWLREQIVHG GAPIWLEHAA PPFNAAGHHQ NEAPAGGNGA 
       210        220        230        240        250
ENVAADQPAN PPAENAVVGE NPDAQDDQAE EEEEDNEEED DAGVEDAADA 
       260        270        280        290        300
NNGAQDDMNW NALEWDRAAE ELTWERMLGL DGSLVFLEHV FWVVSLNTLF 
       310        320        330        340        350
ILVFAFCPYH IGHFSLVGLG FEEHVQASHF EGLITTIVGY ILLAITLIIC 
       360        370        380        390        400
HGLATLVKFH RSRRLLGVCY IVVKVSLLVV VEIGVFPLIC GWWLDICSLE 
       410        420        430        440        450
MFDATLKDRE LSFQSAPGTT MFLHWLVGMV YVFYFASFIL LLREVLRPGV 
       460        470        480        490        500
LWFLRNLNDP DFNPVQEMIH LPIYRHLRRF ILSVIVFGSI VLLMLWLPIR 
       510        520        530        540        550
IIKSVLPNFL PYNVMLYSDA PVSELSLELL LLQVVLPALL EQGHTRQWLK 
       560        570        580        590        600
GLVRAWTVTA GYLLDLHSYL LGDQEENENS ANQQVNNNQH ARNNNAIPVV 
       610        620        630        640        650
GEGLHAAHQA ILQQGGPVGF QPYRRPLNFP LRIFLLIVFM CITLLIASLI 
       660        670        680        690        700
CLTLPVFAGR WLMSFWTGTA KIHELYTAAC GLYVCWLTIR AVTVMVAWMP 
       710        720        730        740        750
QGRRVIFQKV KEWSLMIMKT LIVAVLLAGV VPLLLGLLFE LVIVAPLRVP 
       760        770        780        790        800
LDQTPLFYPW QDWALGVLHA KIIAAITLMG PQWWLKTVIE QVYANGIRNI 
       810        820        830        840        850
DLHYIVRKLA APVISVLLLS LCVPYVIASG VVPLLGVTAE MQNLVHRRIY 
       860        870        880        890        900
PFLLMVVVLM AILSFQVRQF KRLYEHIKND KYLVGQRLVN YERKSGKQGS 
       910
SPPPPQSSQE

Length:910

Mass (Da):102,545

Last modified:February 6, 2007 - v2

Checksum:ⁱC7A96FEA45B5CA8D

Isoform 2 (identifier: O60337-5) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
64-112: IYSPDMPSRLPIQDIFAGLVTSIGTAIRYWFHYTLVAFAWLGVVPLTAC → S

« Hide

        10         20         30         40         50
MDTAEEDICR VCRSEGTPEK PLYHPCVCTG SIKFIHQECL VQWLKHSRKE 
        60         70         80         90        100
YCELCKHRFA FTPSRIYKCL FTGSVSSLLT LPLDMLSTEN LLADCLQGCF 
       110        120        130        140        150
VVTCTLCAFI SLVWLREQIV HGGAPIWLEH AAPPFNAAGH HQNEAPAGGN 
       160        170        180        190        200
GAENVAADQP ANPPAENAVV GENPDAQDDQ AEEEEEDNEE EDDAGVEDAA 
       210        220        230        240        250
DANNGAQDDM NWNALEWDRA AEELTWERML GLDGSLVFLE HVFWVVSLNT 
       260        270        280        290        300
LFILVFAFCP YHIGHFSLVG LGFEEHVQAS HFEGLITTIV GYILLAITLI 
       310        320        330        340        350
ICHGLATLVK FHRSRRLLGV CYIVVKVSLL VVVEIGVFPL ICGWWLDICS 
       360        370        380        390        400
LEMFDATLKD RELSFQSAPG TTMFLHWLVG MVYVFYFASF ILLLREVLRP 
       410        420        430        440        450
GVLWFLRNLN DPDFNPVQEM IHLPIYRHLR RFILSVIVFG SIVLLMLWLP 
       460        470        480        490        500
IRIIKSVLPN FLPYNVMLYS DAPVSELSLE LLLLQVVLPA LLEQGHTRQW 
       510        520        530        540        550
LKGLVRAWTV TAGYLLDLHS YLLGDQEENE NSANQQVNNN QHARNNNAIP 
       560        570        580        590        600
VVGEGLHAAH QAILQQGGPV GFQPYRRPLN FPLRIFLLIV FMCITLLIAS 
       610        620        630        640        650
LICLTLPVFA GRWLMSFWTG TAKIHELYTA ACGLYVCWLT IRAVTVMVAW 
       660        670        680        690        700
MPQGRRVIFQ KVKEWSLMIM KTLIVAVLLA GVVPLLLGLL FELVIVAPLR 
       710        720        730        740        750
VPLDQTPLFY PWQDWALGVL HAKIIAAITL MGPQWWLKTV IEQVYANGIR 
       760        770        780        790        800
NIDLHYIVRK LAAPVISVLL LSLCVPYVIA SGVVPLLGVT AEMQNLVHRR 
       810        820        830        840        850
IYPFLLMVVV LMAILSFQVR QFKRLYEHIK NDKYLVGQRL VNYERKSGKQ 
       860 
GSSPPPPQSS QE

Show »

Length:862

Mass (Da):97,178

Checksum:ⁱE05382BAE7E49AF3

Isoform 3 (identifier: O60337-6) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
7-112: DICRVCRSEG...WLGVVPLTAC → G

« Hide

        10         20         30         40         50
MDTAEEGRIY KCLFTGSVSS LLTLPLDMLS TENLLADCLQ GCFVVTCTLC 
        60         70         80         90        100
AFISLVWLRE QIVHGGAPIW LEHAAPPFNA AGHHQNEAPA GGNGAENVAA 
       110        120        130        140        150
DQPANPPAEN AVVGENPDAQ DDQAEEEEED NEEEDDAGVE DAADANNGAQ 
       160        170        180        190        200
DDMNWNALEW DRAAEELTWE RMLGLDGSLV FLEHVFWVVS LNTLFILVFA 
       210        220        230        240        250
FCPYHIGHFS LVGLGFEEHV QASHFEGLIT TIVGYILLAI TLIICHGLAT 
       260        270        280        290        300
LVKFHRSRRL LGVCYIVVKV SLLVVVEIGV FPLICGWWLD ICSLEMFDAT 
       310        320        330        340        350
LKDRELSFQS APGTTMFLHW LVGMVYVFYF ASFILLLREV LRPGVLWFLR 
       360        370        380        390        400
NLNDPDFNPV QEMIHLPIYR HLRRFILSVI VFGSIVLLML WLPIRIIKSV 
       410        420        430        440        450
LPNFLPYNVM LYSDAPVSEL SLELLLLQVV LPALLEQGHT RQWLKGLVRA 
       460        470        480        490        500
WTVTAGYLLD LHSYLLGDQE ENENSANQQV NNNQHARNNN AIPVVGEGLH 
       510        520        530        540        550
AAHQAILQQG GPVGFQPYRR PLNFPLRIFL LIVFMCITLL IASLICLTLP 
       560        570        580        590        600
VFAGRWLMSF WTGTAKIHEL YTAACGLYVC WLTIRAVTVM VAWMPQGRRV 
       610        620        630        640        650
IFQKVKEWSL MIMKTLIVAV LLAGVVPLLL GLLFELVIVA PLRVPLDQTP 
       660        670        680        690        700
LFYPWQDWAL GVLHAKIIAA ITLMGPQWWL KTVIEQVYAN GIRNIDLHYI 
       710        720        730        740        750
VRKLAAPVIS VLLLSLCVPY VIASGVVPLL GVTAEMQNLV HRRIYPFLLM 
       760        770        780        790        800
VVVLMAILSF QVRQFKRLYE HIKNDKYLVG QRLVNYERKS GKQGSSPPPP 

QSSQE

Show »

Length:805

Mass (Da):90,413

Checksum:ⁱ1DC90D272E92EDD9

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A0B4J206	A0A0B4J206_HUMAN	E3 ubiquitin-protein ligase MARCH6 E3 ubiquitin-protein ligase MARCH6	MARCH6	608	Annotation score:
D6RHY7	D6RHY7_HUMAN	E3 ubiquitin-protein ligase MARCH6 E3 ubiquitin-protein ligase MARCH6	MARCH6	77	Annotation score:

Sequence cautionⁱ

The sequence AAB66840 differs from that shown. Reason: Frameshift at positions 381, 382, 383, 385, 391, 396 and 418.Curated

The sequence AAB66840 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

The sequence BAA25523 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	380	V → VG in AAB66840 (Ref. 6) Curated	1
Sequence conflictⁱ	384	G → GS in AAB66840 (Ref. 6) Curated	1
Sequence conflictⁱ	390	C → WW in AAB66840 (Ref. 6) Curated	1
Sequence conflictⁱ	395	D → G in AAB66840 (Ref. 6) Curated	1
Sequence conflictⁱ	399	L → LG in AAB66840 (Ref. 6) Curated	1
Sequence conflictⁱ	546	R → K in AAB66840 (Ref. 6) Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_030251	622	P → L1 PublicationCorresponds to variant dbSNP:rs1062914Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_047035	7 – 112	DICRV…PLTAC → G in isoform 3. 1 PublicationAdd BLAST		106
Alternative sequenceⁱVSP_047036	64 – 112	IYSPD…PLTAC → S in isoform 2. 1 PublicationAdd BLAST		49

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB011169 mRNA Translation: BAA25523.1 Different initiation. AK296585 mRNA Translation: BAG59204.1 AK300034 mRNA Translation: BAG61845.1 AC012640 Genomic DNA No translation available. AC092336 Genomic DNA No translation available. CH471102 Genomic DNA Translation: EAX08065.1 CH471102 Genomic DNA Translation: EAX08066.1 BC046148 mRNA Translation: AAH46148.1 BC136461 mRNA Translation: AAI36462.1 BC136462 mRNA Translation: AAI36463.1 BC142679 mRNA Translation: AAI42680.1 BC142694 mRNA Translation: AAI42695.1 AF009301 mRNA Translation: AAB66840.1 Sequence problems.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS34135.1 [O60337-4] CCDS59487.1 [O60337-5] CCDS59488.1 [O60337-6]
PIRⁱ	T00268
NCBI Reference Sequences More...RefSeqⁱ	NP_001257589.1, NM_001270660.1 [O60337-5] NP_001257590.1, NM_001270661.1 [O60337-6] NP_005876.2, NM_005885.3 [O60337-4]
UniGeneⁱ	Hs.432862

Genome annotation databases

Ensemblⁱ	ENST00000274140; ENSP00000274140; ENSG00000145495 [O60337-4] ENST00000449913; ENSP00000414643; ENSG00000145495 [O60337-5] ENST00000503788; ENSP00000425930; ENSG00000145495 [O60337-6]
GeneIDⁱ	10299
KEGGⁱ	hsa:10299
UCSC genome browser More...UCSCⁱ	uc003jet.3 human [O60337-4]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O60337	MARCH6 isoform 1		PANTR		910	UniRef100_O60337
E3 ubiquitin-protein ligase MARCH6		PONAB		910
Uncharacterized protein		PANPA		910
Uncharacterized protein		NOMLE		910
UPI0003E649EB		HUMAN		842
O60337-5	MARCH6 isoform 4		PANTR		862	UniRef100_A0A2I3S5J3
MARCH6 isoform 1		PONAB		862
Uncharacterized protein		PANPA		862
Uncharacterized protein		NOMLE		862
O60337-6	MARCH6 isoform 5		PANTR		805	UniRef100_A0A2I3RGJ7
MARCH6 isoform 4		PONAB		805
Uncharacterized protein		PANPA		805
Uncharacterized protein		NOMLE		805

Protein	Similar proteins		Species	Score	Length	Source
O60337	E3 ubiquitin-protein ligase MARCH6		PONAB		910	UniRef90_O60337
E3 ubiquitin-protein ligase MARCH6		MOUSE		909
MARCH6 isoform 1		PANTR		910
Uncharacterized protein		PANPA		910
Uncharacterized protein		NOMLE		910
+251
O60337-5	Membrane associated ring-CH-type finger 6		RABIT		957	UniRef90_U3KNS9
Uncharacterized protein (Fragment)		MICSU		917
LOC100037143 protein		XENLA		909
Membrane associated ring-CH-type finger 6		TAEGU		904
Uncharacterized protein		PAPAN		886
+52
O60337-6	Membrane associated ring-CH-type finger 6		RABIT		957	UniRef90_U3KNS9
Uncharacterized protein (Fragment)		MICSU		917
LOC100037143 protein		XENLA		909
Membrane associated ring-CH-type finger 6		TAEGU		904
Uncharacterized protein		PAPAN		886
+52

Protein	Similar proteins		Species	Score	Length	Source
O60337	E3 ubiquitin-protein ligase MARCH6		PONAB		910	UniRef50_O60337
E3 ubiquitin-protein ligase MARCH6		MOUSE		909
MARCH6 isoform 1		PANTR		910
Uncharacterized protein		PANPA		910
Uncharacterized protein		NOMLE		910
+339
O60337-5	Membrane associated ring-CH-type finger 6		RABIT		957	UniRef50_U3KNS9
Uncharacterized protein (Fragment)		MICSU		917
LOC100037143 protein		XENLA		909
Membrane associated ring-CH-type finger 6		TAEGU		904
Uncharacterized protein		PAPAN		886
+81
O60337-6	Membrane associated ring-CH-type finger 6		RABIT		957	UniRef50_U3KNS9
Uncharacterized protein (Fragment)		MICSU		917
LOC100037143 protein		XENLA		909
Membrane associated ring-CH-type finger 6		TAEGU		904
Uncharacterized protein		PAPAN		886
+81

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB011169 mRNA Translation: BAA25523.1 Different initiation. AK296585 mRNA Translation: BAG59204.1 AK300034 mRNA Translation: BAG61845.1 AC012640 Genomic DNA No translation available. AC092336 Genomic DNA No translation available. CH471102 Genomic DNA Translation: EAX08065.1 CH471102 Genomic DNA Translation: EAX08066.1 BC046148 mRNA Translation: AAH46148.1 BC136461 mRNA Translation: AAI36462.1 BC136462 mRNA Translation: AAI36463.1 BC142679 mRNA Translation: AAI42680.1 BC142694 mRNA Translation: AAI42695.1 AF009301 mRNA Translation: AAB66840.1 Sequence problems.
CCDSⁱ	CCDS34135.1 [O60337-4] CCDS59487.1 [O60337-5] CCDS59488.1 [O60337-6]
PIRⁱ	T00268
RefSeqⁱ	NP_001257589.1, NM_001270660.1 [O60337-5] NP_001257590.1, NM_001270661.1 [O60337-6] NP_005876.2, NM_005885.3 [O60337-4]
UniGeneⁱ	Hs.432862

3D structure databases

ProteinModelPortalⁱ	O60337
SMRⁱ	O60337
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	115587, 24 interactors
DIPⁱ	DIP-56134N
IntActⁱ	O60337, 9 interactors
MINTⁱ	O60337
STRINGⁱ	9606.ENSP00000274140

PTM databases

iPTMnetⁱ	O60337
PhosphoSitePlusⁱ	O60337

Proteomic databases

EPDⁱ	O60337
MaxQBⁱ	O60337
PaxDbⁱ	O60337
PeptideAtlasⁱ	O60337
PRIDEⁱ	O60337
ProteomicsDBⁱ	49363

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000274140; ENSP00000274140; ENSG00000145495 [O60337-4] ENST00000449913; ENSP00000414643; ENSG00000145495 [O60337-5] ENST00000503788; ENSP00000425930; ENSG00000145495 [O60337-6]
GeneIDⁱ	10299
KEGGⁱ	hsa:10299
UCSCⁱ	uc003jet.3 human [O60337-4]

Organism-specific databases

CTDⁱ	10299
DisGeNETⁱ	10299
EuPathDBⁱ	HostDB:ENSG00000145495.14
GeneCardsⁱ	MARCH6
HGNCⁱ	HGNC:30550 MARCH6
HPAⁱ	HPA040841 HPA063246
MIMⁱ	613297 gene
neXtProtⁱ	NX_O60337
OpenTargetsⁱ	ENSG00000145495
PharmGKBⁱ	PA134869368
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1609 Eukaryota COG5183 LUCA
GeneTreeⁱ	ENSGT00930000150887
HOGENOMⁱ	HOG000286005
HOVERGENⁱ	HBG080753
InParanoidⁱ	O60337
KOⁱ	K10661
OMAⁱ	WLPIRIL
OrthoDBⁱ	EOG091G02GT
PhylomeDBⁱ	O60337
TreeFamⁱ	TF105777

Enzyme and pathway databases

UniPathwayⁱ	UPA00143
BioCycⁱ	MetaCyc:ENSG00000145495-MONOMER
BRENDAⁱ	2.3.2.B10 2681
Reactomeⁱ	R-HSA-901032 ER Quality Control Compartment (ERQC)

Miscellaneous databases

ChiTaRSⁱ	MARCH6 human
GeneWikiⁱ	MARCH6
GenomeRNAiⁱ	10299
Protein Ontology More...PROⁱ	PR:O60337
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000145495 Expressed in 240 organ(s), highest expression level in cerebellar vermis
CleanExⁱ	HS_MARCH6
ExpressionAtlasⁱ	O60337 baseline and differential
Genevisibleⁱ	O60337 HS

Family and domain databases

Gene3Dⁱ	3.30.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR011016 Znf_RING-CH IPR013083 Znf_RING/FYVE/PHD
Pfamⁱ	View protein in Pfam PF12906 RINGv, 1 hit
SMARTⁱ	View protein in SMART SM00744 RINGv, 1 hit
PROSITEⁱ	View protein in PROSITE PS51292 ZF_RING_CH, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	MARH6_HUMAN
Accessionⁱ	O60337Primary (citable) accession number: O60337 Secondary accession number(s): A5PKZ4 , B4DKJ2, B4DT33, D3DTC8, O14670, Q86X77
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 6, 2007
	Last sequence update:	February 6, 2007
	Last modified:	November 7, 2018
	This is version 142 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PATHWAY comments
Index of metabolic and biosynthesis pathways
Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM

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UniProtKB - O60337 (MARH6_HUMAN)

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E3 ubiquitin-protein ligase MARCH6

MARCH6

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

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Endoplasmic reticulum

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Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

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Organism-specific databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

Pathwayⁱ: protein ubiquitination

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ