Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 151 (08 May 2019)
Sequence version 4 (25 Nov 2008)
Previous versions | rss
Other tutorials and videosHelp videoFeedback
Protein

Mitogen-activated protein kinase-binding protein 1

Gene

MAPKBP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Negative regulator of NOD2 function. It down-regulates NOD2-induced processes such as activation of NF-kappa-B signaling, IL8 secretion and antibacterial response (PubMed:22700971). Involved in JNK signaling pathway (By similarity).By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
O60336

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Mitogen-activated protein kinase-binding protein 1
Alternative name(s):
JNK-binding protein 1
Short name:
JNKBP-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MAPKBP1
Synonyms:JNKBP1, KIAA0596
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:29536 MAPKBP1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
616786 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O60336

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Nephronophthisis 20 (NPHP20)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of nephronophthisis, an autosomal recessive chronic tubulo-interstitial nephritis that progresses to end-stage renal failure. Some patients have cystic kidneys of normal size and no extrarenal manifestations, whereas others have enlarged renal size and severe extrarenal defects, including hypertrophic obstructive cardiomyopathy, aortic stenosis, pulmonary stenosis, patent ductus arteriosus, situs inversus, and periportal liver fibrosis. NPHP20 patients do not show extrarenal manifestations or evidence of a ciliopathy, such as situs inversus or polydactyly.
See also OMIM:617271
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_077958544R → Q in NPHP20; unknown pathological significance; no effect on localization at the spindle pole; no effect on interaction with WDR62; no effect on interaction with MAPK9. 1 PublicationCorresponds to variant dbSNP:rs1057519305EnsemblClinVar.1

Keywords - Diseasei

Disease mutation, Nephronophthisis

Organism-specific databases

DisGeNET

More...
DisGeNETi
23005

MalaCards human disease database

More...
MalaCardsi
MAPKBP1
MIMi617271 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000137802

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
93592 Juvenile nephronophthisis
93589 Late-onset nephronophthisis

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142671479

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MAPKBP1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003341582 – 1514Mitogen-activated protein kinase-binding protein 1Add BLAST1513

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
Modified residuei1198PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O60336

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O60336

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O60336

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O60336

PeptideAtlas

More...
PeptideAtlasi
O60336

PRoteomics IDEntifications database

More...
PRIDEi
O60336

ProteomicsDB human proteome resource

More...
ProteomicsDBi
49357
49358 [O60336-2]
49359 [O60336-3]
49360 [O60336-4]
49361 [O60336-5]
49362 [O60336-6]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O60336

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O60336

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in intestinal mucosa, where it is detected in epithelial cells, endothelial cells, smooth muscle cells and immune cells, such as lymphocytes (PubMed:22700971). Expressed in kidney (PubMed:28089251).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000137802 Expressed in 203 organ(s), highest expression level in right hemisphere of cerebellum

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O60336 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O60336 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA030832
HPA030833

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Can form homodimers (via C-terminus) (PubMed:23341463). Interacts (via C-terminus) with WDR62 (via C-terminus) (PubMed:23341463, PubMed:28089251). Interacts with MAPK9 (PubMed:28089251). Interacts (via N-terminus) with NOD2; the interaction is enhanced in presence of muramyl dipeptide (MDP) (PubMed:22700971). Interacts with MAPK10 (By similarity).By similarity3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
116650, 31 interactors

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
O60336

Protein interaction database and analysis system

More...
IntActi
O60336, 59 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000393099

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati88 – 129WD 1Add BLAST42
Repeati132 – 173WD 2Add BLAST42
Repeati175 – 213WD 3Add BLAST39
Repeati276 – 315WD 4Add BLAST40
Repeati342 – 381WD 5Add BLAST40
Repeati387 – 436WD 6Add BLAST50
Repeati477 – 516WD 7Add BLAST40
Repeati519 – 561WD 8Add BLAST43
Repeati565 – 606WD 9Add BLAST42
Repeati614 – 653WD 10Add BLAST40
Repeati659 – 698WD 11Add BLAST40
Repeati701 – 740WD 12Add BLAST40

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1041 – 1047Poly-Glu7
Compositional biasi1114 – 1119Poly-Ser6
Compositional biasi1387 – 1390Poly-Pro4

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The N-terminal WD40 domain is necessary for the interaction with NOD2 and down-regulation of NOD2 function.1 Publication

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1408 Eukaryota
ENOG410Y87A LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160664

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O60336

KEGG Orthology (KO)

More...
KOi
K21763

Identification of Orthologs from Complete Genome Data

More...
OMAi
SCPHIIR

Database of Orthologous Groups

More...
OrthoDBi
1017450at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O60336

TreeFam database of animal gene trees

More...
TreeFami
TF323254

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00400 WD40, 7 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00320 WD40, 12 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50978 SSF50978, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50082 WD_REPEATS_2, 1 hit
PS50294 WD_REPEATS_REGION, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 6 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O60336-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAVEGSTITS RIKNLLRSPS IKLRRSKAGN RREDLSSKVT LEKVLGITVS
60 70 80 90 100
GGRGLACDPR SGLVAYPAGC VVVLFNPRKH KQHHILNSSR KTITALAFSP
110 120 130 140 150
DGKYLVTGES GHMPAVRVWD VAEHSQVAEL QEHKYGVACV AFSPSAKYIV
160 170 180 190 200
SVGYQHDMIV NVWAWKKNIV VASNKVSSRV TAVSFSEDCS YFVTAGNRHI
210 220 230 240 250
KFWYLDDSKT SKVNATVPLL GRSGLLGELR NNLFTDVACG RGKKADSTFC
260 270 280 290 300
ITSSGLLCEF SDRRLLDKWV ELRNIDSFTT TVAHCISVSQ DYIFCGCADG
310 320 330 340 350
TVRLFNPSNL HFLSTLPRPH ALGTDIASVT EASRLFSGVA NARYPDTIAL
360 370 380 390 400
TFDPTNQWLS CVYNDHSIYV WDVRDPKKVG KVYSALYHSS CVWSVEVYPE
410 420 430 440 450
VKDSNQACLP PSSFITCSSD NTIRLWNTES SGVHGSTLHR NILSSDLIKI
460 470 480 490 500
IYVDGNTQAL LDTELPGGDK ADASLLDPRV GIRSVCVSPN GQHLASGDRM
510 520 530 540 550
GTLRVHELQS LSEMLKVEAH DSEILCLEYS KPDTGLKLLA SASRDRLIHV
560 570 580 590 600
LDAGREYSLQ QTLDEHSSSI TAVKFAASDG QVRMISCGAD KSIYFRTAQK
610 620 630 640 650
SGDGVQFTRT HHVVRKTTLY DMDVEPSWKY TAIGCQDRNI RIFNISSGKQ
660 670 680 690 700
KKLFKGSQGE DGTLIKVQTD PSGIYIATSC SDKNLSIFDF SSGECVATMF
710 720 730 740 750
GHSEIVTGMK FSNDCKHLIS VSGDSCIFVW RLSSEMTISM RQRLAELRQR
760 770 780 790 800
QRGGKQQGPS SPQRASGPNR HQAPSMLSPG PALSSDSDKE GEDEGTEEEL
810 820 830 840 850
PALPVLAKST KKALASVPSP ALPRSLSHWE MSRAQESVGF LDPAPAANPG
860 870 880 890 900
PRRRGRWVQP GVELSVRSML DLRQLETLAP SLQDPSQDSL AIIPSGPRKH
910 920 930 940 950
GQEALETSLT SQNEKPPRPQ ASQPCSYPHI IRLLSQEEGV FAQDLEPAPI
960 970 980 990 1000
EDGIVYPEPS DNPTMDTSEF QVQAPARGTL GRVYPGSRSS EKHSPDSACS
1010 1020 1030 1040 1050
VDYSSSCLSS PEHPTEDSES TEPLSVDGIS SDLEEPAEGD EEEEEEEGGM
1060 1070 1080 1090 1100
GPYGLQEGSP QTPDQEQFLK QHFETLASGA APGAPVQVPE RSESRSISSR
1110 1120 1130 1140 1150
FLLQVQTRPL REPSPSSSSL ALMSRPAQVP QASGEQPRGN GANPPGAPPE
1160 1170 1180 1190 1200
VEPSSGNPSP QQAASVLLPR CRLNPDSSWA PKRVATASPF SGLQKAQSVH
1210 1220 1230 1240 1250
SLVPQERHEA SLQAPSPGAL LSREIEAQDG LGSLPPADGR PSRPHSYQNP
1260 1270 1280 1290 1300
TTSSMAKISR SISVGENLGL VAEPQAHAPI RVSPLSKLAL PSRAHLVLDI
1310 1320 1330 1340 1350
PKPLPDRPTL AAFSPVTKGR APGEAEKPGF PVGLGKAHST TERWACLGEG
1360 1370 1380 1390 1400
TTPKPRTECQ AHPGPSSPCA QQLPVSSLFQ GPENLQPPPP EKTPNPMECT
1410 1420 1430 1440 1450
KPGAALSQDS EPAVSLEQCE QLVAELRGSV RQAVRLYHSV AGCKMPSAEQ
1460 1470 1480 1490 1500
SRIAQLLRDT FSSVRQELEA VAGAVLSSPG SSPGAVGAEQ TQALLEQYSE
1510
LLLRAVERRM ERKL
Length:1,514
Mass (Da):163,818
Last modified:November 25, 2008 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i13FD125E44CABBFD
GO
Isoform 2 (identifier: O60336-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     274-279: Missing.
     1134-1410: Missing.

Note: No experimental confirmation available.
Show »
Length:1,231
Mass (Da):134,309
Checksum:i562B680D20C616B0
GO
Isoform 3 (identifier: O60336-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     274-396: Missing.
     1411-1412: Missing.

Show »
Length:1,389
Mass (Da):149,945
Checksum:i3AD9E18431DA7614
GO
Isoform 4 (identifier: O60336-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-499: Missing.

Note: No experimental confirmation available.
Show »
Length:1,015
Mass (Da):109,155
Checksum:i2E47B6DD20087E6E
GO
Isoform 5 (identifier: O60336-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     214-215: NA → RC
     216-1514: Missing.

Note: No experimental confirmation available.
Show »
Length:215
Mass (Da):23,707
Checksum:i5FFAA575381E3C07
GO
Isoform 6 (identifier: O60336-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     274-279: Missing.

Note: No experimental confirmation available.
Show »
Length:1,508
Mass (Da):163,141
Checksum:i332C0E0E9ABD2B91
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RHX7D6RHX7_HUMAN
Mitogen-activated protein kinase-bi...
MAPKBP1
331Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6R9F7D6R9F7_HUMAN
Mitogen-activated protein kinase-bi...
MAPKBP1
156Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RAI2D6RAI2_HUMAN
Mitogen-activated protein kinase-bi...
MAPKBP1
69Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA25522 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti843P → S in AAH36660 (PubMed:15489334).Curated1
Sequence conflicti1444K → R in AL833267 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_043343204Y → S. Corresponds to variant dbSNP:rs4354909Ensembl.1
Natural variantiVAR_043344313L → V. Corresponds to variant dbSNP:rs1201689Ensembl.1
Natural variantiVAR_077958544R → Q in NPHP20; unknown pathological significance; no effect on localization at the spindle pole; no effect on interaction with WDR62; no effect on interaction with MAPK9. 1 PublicationCorresponds to variant dbSNP:rs1057519305EnsemblClinVar.1
Natural variantiVAR_0433451240R → P4 PublicationsCorresponds to variant dbSNP:rs3959569Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0336291 – 499Missing in isoform 4. 1 PublicationAdd BLAST499
Alternative sequenceiVSP_033630214 – 215NA → RC in isoform 5. 1 Publication2
Alternative sequenceiVSP_033631216 – 1514Missing in isoform 5. 1 PublicationAdd BLAST1299
Alternative sequenceiVSP_033632274 – 396Missing in isoform 3. 2 PublicationsAdd BLAST123
Alternative sequenceiVSP_033633274 – 279Missing in isoform 2 and isoform 6. 2 Publications6
Alternative sequenceiVSP_0336341134 – 1410Missing in isoform 2. 1 PublicationAdd BLAST277
Alternative sequenceiVSP_0336351411 – 1412Missing in isoform 3. 2 Publications2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB177850 mRNA Translation: BAD66828.1
AB011168 mRNA Translation: BAA25522.2 Different initiation.
AK292414 mRNA Translation: BAF85103.1
AL833267 mRNA No translation available.
AC020659 Genomic DNA No translation available.
AC073657 Genomic DNA No translation available.
CH471125 Genomic DNA Translation: EAW92516.1
BC036660 mRNA Translation: AAH36660.1
BC113983 mRNA Translation: AAI13984.1
BC114493 mRNA Translation: AAI14494.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS32201.1 [O60336-6]
CCDS45239.1 [O60336-1]
CCDS58359.1 [O60336-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
T00270

NCBI Reference Sequences

More...
RefSeqi
NP_001122080.1, NM_001128608.1 [O60336-1]
NP_001252540.1, NM_001265611.1 [O60336-2]
NP_055809.2, NM_014994.2 [O60336-6]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000456763; ENSP00000393099; ENSG00000137802 [O60336-1]
ENST00000457542; ENSP00000397570; ENSG00000137802 [O60336-6]
ENST00000514566; ENSP00000426154; ENSG00000137802 [O60336-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
23005

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:23005

UCSC genome browser

More...
UCSCi
uc001zoj.4 human [O60336-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB177850 mRNA Translation: BAD66828.1
AB011168 mRNA Translation: BAA25522.2 Different initiation.
AK292414 mRNA Translation: BAF85103.1
AL833267 mRNA No translation available.
AC020659 Genomic DNA No translation available.
AC073657 Genomic DNA No translation available.
CH471125 Genomic DNA Translation: EAW92516.1
BC036660 mRNA Translation: AAH36660.1
BC113983 mRNA Translation: AAI13984.1
BC114493 mRNA Translation: AAI14494.1
CCDSiCCDS32201.1 [O60336-6]
CCDS45239.1 [O60336-1]
CCDS58359.1 [O60336-2]
PIRiT00270
RefSeqiNP_001122080.1, NM_001128608.1 [O60336-1]
NP_001252540.1, NM_001265611.1 [O60336-2]
NP_055809.2, NM_014994.2 [O60336-6]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi116650, 31 interactors
ELMiO60336
IntActiO60336, 59 interactors
STRINGi9606.ENSP00000393099

PTM databases

iPTMnetiO60336
PhosphoSitePlusiO60336

Polymorphism and mutation databases

BioMutaiMAPKBP1

Proteomic databases

EPDiO60336
jPOSTiO60336
MaxQBiO60336
PaxDbiO60336
PeptideAtlasiO60336
PRIDEiO60336
ProteomicsDBi49357
49358 [O60336-2]
49359 [O60336-3]
49360 [O60336-4]
49361 [O60336-5]
49362 [O60336-6]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000456763; ENSP00000393099; ENSG00000137802 [O60336-1]
ENST00000457542; ENSP00000397570; ENSG00000137802 [O60336-6]
ENST00000514566; ENSP00000426154; ENSG00000137802 [O60336-2]
GeneIDi23005
KEGGihsa:23005
UCSCiuc001zoj.4 human [O60336-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23005
DisGeNETi23005

GeneCards: human genes, protein and diseases

More...
GeneCardsi
MAPKBP1

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0022002
HGNCiHGNC:29536 MAPKBP1
HPAiHPA030832
HPA030833
MalaCardsiMAPKBP1
MIMi616786 gene
617271 phenotype
neXtProtiNX_O60336
OpenTargetsiENSG00000137802
Orphaneti93592 Juvenile nephronophthisis
93589 Late-onset nephronophthisis
PharmGKBiPA142671479

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1408 Eukaryota
ENOG410Y87A LUCA
GeneTreeiENSGT00940000160664
InParanoidiO60336
KOiK21763
OMAiSCPHIIR
OrthoDBi1017450at2759
PhylomeDBiO60336
TreeFamiTF323254

Enzyme and pathway databases

SignaLinkiO60336

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
MAPKBP1 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
23005

Protein Ontology

More...
PROi
PR:O60336

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000137802 Expressed in 203 organ(s), highest expression level in right hemisphere of cerebellum
ExpressionAtlasiO60336 baseline and differential
GenevisibleiO60336 HS

Family and domain databases

Gene3Di2.130.10.10, 2 hits
InterProiView protein in InterPro
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF00400 WD40, 7 hits
SMARTiView protein in SMART
SM00320 WD40, 12 hits
SUPFAMiSSF50978 SSF50978, 2 hits
PROSITEiView protein in PROSITE
PS50082 WD_REPEATS_2, 1 hit
PS50294 WD_REPEATS_REGION, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMABP1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O60336
Secondary accession number(s): A6NM93
, A8K8P9, Q14CB5, Q14CD8, Q49AJ8, Q5W9G9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: November 25, 2008
Last modified: May 8, 2019
This is version 151 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again