UniProtKB - O60333 (KIF1B_HUMAN)
Kinesin-like protein KIF1B
KIF1B
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 97 – 104 | ATPPROSITE-ProRule annotation | 8 |
GO - Molecular functioni
- ATPase activity Source: UniProtKB
- ATP binding Source: UniProtKB-KW
- ATP-dependent microtubule motor activity, plus-end-directed Source: GO_Central
- kinase binding Source: Ensembl
- kinesin binding Source: UniProtKB
- microtubule binding Source: GO_Central
- microtubule motor activity Source: UniProtKB
- scaffold protein binding Source: Ensembl
GO - Biological processi
- anterograde axonal transport Source: UniProtKB
- anterograde neuronal dense core vesicle transport Source: Ensembl
- apoptotic process Source: UniProtKB-KW
- cellular response to nerve growth factor stimulus Source: Ensembl
- cytoskeleton-dependent intracellular transport Source: UniProtKB
- lysosome localization Source: Ensembl
- microtubule-based movement Source: UniProtKB
- mitochondrion transport along microtubule Source: Ensembl
- neuromuscular synaptic transmission Source: UniProtKB
- neuron-neuron synaptic transmission Source: UniProtKB
- positive regulation of gene expression Source: Ensembl
- protein localization to cell periphery Source: Ensembl
- response to rotenone Source: Ensembl
- retrograde neuronal dense core vesicle transport Source: Ensembl
- vesicle-mediated transport Source: GO_Central
Keywordsi
Molecular function | Motor protein |
Biological process | Apoptosis |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | O60333 |
Reactomei | R-HSA-6811434, COPI-dependent Golgi-to-ER retrograde traffic R-HSA-983189, Kinesins |
Names & Taxonomyi
Protein namesi | Recommended name: Kinesin-like protein KIF1BShort name: Klp |
Gene namesi | Name:KIF1B Synonyms:KIAA0591, KIAA1448 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:16636, KIF1B |
MIMi | 605995, gene |
neXtProti | NX_O60333 |
VEuPathDBi | HostDB:ENSG00000054523.17 |
Subcellular locationi
Mitochondrion
- Mitochondrion 1 Publication
Cytoskeleton
Other locations
- synaptic vesicle By similarity
Cytoskeleton
- kinesin complex Source: GO_Central
- microtubule Source: GO_Central
- microtubule associated complex Source: UniProtKB
Mitochondrion
- mitochondrion Source: UniProtKB-SubCell
Other locations
- axon Source: GO_Central
- axon cytoplasm Source: GOC
- cytoplasmic vesicle Source: UniProtKB
- cytoplasmic vesicle membrane Source: UniProtKB
- dendrite Source: GO_Central
- neuron projection Source: UniProtKB
- synaptic vesicle Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cell junction, Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Microtubule, Mitochondrion, SynapsePathology & Biotechi
Involvement in diseasei
Charcot-Marie-Tooth disease 2A1 (CMT2A1)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_011515 | 98 | Q → L in CMT2A1. 1 PublicationCorresponds to variant dbSNP:rs121908160EnsemblClinVar. | 1 |
Neuroblastoma 1 (NBLST1)
Pheochromocytoma (PCC)1 Publication
Keywords - Diseasei
Charcot-Marie-Tooth disease, Disease variant, Neurodegeneration, NeuropathyOrganism-specific databases
DisGeNETi | 23095 |
GeneReviewsi | KIF1B |
MalaCardsi | KIF1B |
MIMi | 118210, phenotype 171300, phenotype 256700, phenotype |
OpenTargetsi | ENSG00000054523 |
Orphaneti | 99946, Autosomal dominant Charcot-Marie-Tooth disease type 2A1 29072, Hereditary pheochromocytoma-paraganglioma |
PharmGKBi | PA38176 |
Miscellaneous databases
Pharosi | O60333, Tbio |
Chemistry databases
ChEMBLi | CHEMBL5889 |
Genetic variation databases
BioMutai | KIF1B |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000125407 | 2 – 1816 | Kinesin-like protein KIF1BAdd BLAST | 1815 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Modified residuei | 2 | N-acetylserineCombined sources | 1 | ||
Modified residuei | 647 | PhosphothreonineBy similarity | 1 | ||
Modified residuei | 652 | PhosphothreonineBy similarity | 1 | ||
Modified residuei | 1054 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 1057 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 1075 | PhosphothreonineCombined sources | 1 | ||
Modified residuei | 1416 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 1454 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 1487 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 1573 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 1603 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 1610 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 1613 | PhosphoserineCombined sources | 1 | ||
Isoform 3 (identifier: O60333-3) | |||||
Modified residuei | 663 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 665 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 1141 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | O60333 |
jPOSTi | O60333 |
MassIVEi | O60333 |
MaxQBi | O60333 |
PaxDbi | O60333 |
PeptideAtlasi | O60333 |
PRIDEi | O60333 |
ProteomicsDBi | 49353 [O60333-1] 49354 [O60333-2] 49355 [O60333-3] 49356 [O60333-4] |
PTM databases
iPTMneti | O60333 |
MetOSitei | O60333 |
PhosphoSitePlusi | O60333 |
SwissPalmi | O60333 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000054523, Expressed in skeletal muscle tissue of rectus abdominis and 235 other tissues |
ExpressionAtlasi | O60333, baseline and differential |
Genevisiblei | O60333, HS |
Organism-specific databases
HPAi | ENSG00000054523, Tissue enhanced (skeletal) |
Interactioni
Subunit structurei
Monomer (By similarity).
Interacts (via C-terminus end of the kinesin-motor domain) with CHP1; the interaction occurs in a calcium-dependent manner (By similarity).
Interacts with KIFBP (PubMed:16225668).
By similarity1 PublicationBinary interactionsi
O60333
With | #Exp. | IntAct |
---|---|---|
CLASP1 [Q7Z460] | 3 | EBI-465633,EBI-913476 |
SIAH1 [Q8IUQ4] | 3 | EBI-465633,EBI-747107 |
Isoform 2 [O60333-2]
Isoform 3 [O60333-3]
With | #Exp. | IntAct |
---|---|---|
DLG1 [Q12959] | 4 | EBI-465669,EBI-357481 |
DLG4 [P78352] | 4 | EBI-465669,EBI-80389 |
MAGI1 [Q96QZ7] | 3 | EBI-465669,EBI-924464 |
Dlg2 [Q63622] from Rattus norvegicus. | 3 | EBI-465669,EBI-396947 |
GO - Molecular functioni
- kinase binding Source: Ensembl
- kinesin binding Source: UniProtKB
- microtubule binding Source: GO_Central
- scaffold protein binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 116723, 72 interactors |
DIPi | DIP-33015N |
IntActi | O60333, 336 interactors |
MINTi | O60333 |
STRINGi | 9606.ENSP00000263934 |
Chemistry databases
BindingDBi | O60333 |
Miscellaneous databases
RNActi | O60333, protein |
Structurei
Secondary structure
3D structure databases
SMRi | O60333 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | O60333 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 5 – 354 | Kinesin motorPROSITE-ProRule annotationAdd BLAST | 350 | |
Domaini | 556 – 612 | FHAPROSITE-ProRule annotationAdd BLAST | 57 | |
Domaini | 1702 – 1799 | PHPROSITE-ProRule annotationAdd BLAST | 98 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 270 – 350 | Interaction with KBP1 PublicationAdd BLAST | 81 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 365 – 386 | Sequence analysisAdd BLAST | 22 | |
Coiled coili | 470 – 502 | Sequence analysisAdd BLAST | 33 | |
Coiled coili | 668 – 737 | Sequence analysisAdd BLAST | 70 | |
Coiled coili | 841 – 869 | Sequence analysisAdd BLAST | 29 |
Sequence similaritiesi
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG0245, Eukaryota |
GeneTreei | ENSGT00940000157445 |
HOGENOMi | CLU_009645_0_0_1 |
InParanoidi | O60333 |
OMAi | LHQEDEF |
OrthoDBi | 76316at2759 |
PhylomeDBi | O60333 |
TreeFami | TF105221 |
Family and domain databases
CDDi | cd00060, FHA, 1 hit |
Gene3Di | 2.30.29.30, 1 hit 3.40.850.10, 1 hit |
InterProi | View protein in InterPro IPR000253, FHA_dom IPR022164, Kinesin-like IPR027640, Kinesin-like_fam IPR022140, Kinesin-like_KIF1-typ IPR032405, Kinesin_assoc IPR019821, Kinesin_motor_CS IPR001752, Kinesin_motor_dom IPR036961, Kinesin_motor_dom_sf IPR027417, P-loop_NTPase IPR011993, PH-like_dom_sf IPR001849, PH_domain IPR008984, SMAD_FHA_dom_sf |
PANTHERi | PTHR24115, PTHR24115, 1 hit |
Pfami | View protein in Pfam PF12473, DUF3694, 1 hit PF00498, FHA, 1 hit PF12423, KIF1B, 1 hit PF00225, Kinesin, 1 hit PF16183, Kinesin_assoc, 1 hit PF00169, PH, 1 hit |
PRINTSi | PR00380, KINESINHEAVY |
SMARTi | View protein in SMART SM00240, FHA, 1 hit SM00129, KISc, 1 hit SM00233, PH, 1 hit |
SUPFAMi | SSF49879, SSF49879, 1 hit SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS50006, FHA_DOMAIN, 1 hit PS00411, KINESIN_MOTOR_1, 1 hit PS50067, KINESIN_MOTOR_2, 1 hit PS50003, PH_DOMAIN, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSGASVKVAV RVRPFNSRET SKESKCIIQM QGNSTSIINP KNPKEAPKSF
60 70 80 90 100
SFDYSYWSHT SPEDPCFASQ NRVYNDIGKE MLLHAFEGYN VCIFAYGQTG
110 120 130 140 150
AGKSYTMMGK QEESQAGIIP QLCEELFEKI NDNCNEEMSY SVEVSYMEIY
160 170 180 190 200
CERVRDLLNP KNKGNLRVRE HPLLGPYVED LSKLAVTSYT DIADLMDAGN
210 220 230 240 250
KARTVAATNM NETSSRSHAV FTIVFTQKKH DNETNLSTEK VSKISLVDLA
260 270 280 290 300
GSERADSTGA KGTRLKEGAN INKSLTTLGK VISALAEVDN CTSKSKKKKK
310 320 330 340 350
TDFIPYRDSV LTWLLRENLG GNSRTAMVAA LSPADINYDE TLSTLRYADR
360 370 380 390 400
AKQIKCNAVI NEDPNAKLVR ELKEEVTRLK DLLRAQGLGD IIDIDPLIDD
410 420 430 440 450
YSGSGSKYLK DFQNNKHRYL LASENQRPGH FSTASMGSLT SSPSSCSLSS
460 470 480 490 500
QVGLTSVTSI QERIMSTPGG EEAIERLKES EKIIAELNET WEEKLRKTEA
510 520 530 540 550
IRMEREALLA EMGVAIREDG GTLGVFSPKK TPHLVNLNED PLMSECLLYY
560 570 580 590 600
IKDGITRVGQ ADAERRQDIV LSGAHIKEEH CIFRSERSNS GEVIVTLEPC
610 620 630 640 650
ERSETYVNGK RVSQPVQLRS GNRIIMGKNH VFRFNHPEQA RAEREKTPSA
660 670 680 690 700
ETPSEPVDWT FAQRELLEKQ GIDMKQEMEK RLQEMEILYK KEKEEADLLL
710 720 730 740 750
EQQRLDYESK LQALQKQVET RSLAAETTEE EEEEEEVPWT QHEFELAQWA
760 770 780 790 800
FRKWKSHQFT SLRDLLWGNA VYLKEANAIS VELKKKVQFQ FVLLTDTLYS
810 820 830 840 850
PLPPELLPTE MEKTHEDRPF PRTVVAVEVQ DLKNGATHYW SLEKLKQRLD
860 870 880 890 900
LMREMYDRAG EMASSAQDES ETTVTGSDPF YDRFHWFKLV GSSPIFHGCV
910 920 930 940 950
NERLADRTPS PTFSTADSDI TELADEQQDE MEDFDDEAFV DDAGSDAGTE
960 970 980 990 1000
EGSDLFSDGH DPFYDRSPWF ILVGRAFVYL SNLLYPVPLI HRVAIVSEKG
1010 1020 1030 1040 1050
EVRGFLRVAV QAIAADEEAP DYGSGIRQSG TAKISFDNEY FNQSDFSSVA
1060 1070 1080 1090 1100
MTRSGLSLEE LRIVEGQGQS SEVITPPEEI SRINDLDLKS STLLDGKMVM
1110 1120 1130 1140 1150
EGFSEEIGNH LKLGSAFTFR VTVLQASGIL PEYADIFCQF NFLHRHDEAF
1160 1170 1180 1190 1200
STEPLKNNGR GSPLAFYHVQ NIAVEITESF VDYIKTKPIV FEVFGHYQQH
1210 1220 1230 1240 1250
PLHLQGQELN SPPQPCRRFF PPPMPLSKPV PATKLNTMSK TSLGQSMSKY
1260 1270 1280 1290 1300
DLLVWFEISE LEPTGEYIPA VVDHTAGLPC QGTFLLHQGI QRRITVTIIH
1310 1320 1330 1340 1350
EKGSELHWKD VRELVVGRIR NKPEVDEAAV DAILSLNIIS AKYLKSSHNS
1360 1370 1380 1390 1400
SRTFYRFEAV WDSSLHNSLL LNRVTPYGEK IYMTLSAYLE LDHCIQPAVI
1410 1420 1430 1440 1450
TKDVCMVFYS RDAKISPPRS LRSLFGSGYS KSPDSNRVTG IYELSLCKMS
1460 1470 1480 1490 1500
DTGSPGMQRR RRKILDTSVA YVRGEENLAG WRPRGDSLIL EHQWELEKLE
1510 1520 1530 1540 1550
LLHEVEKTRH FLLLRERLGD SIPKSLSDSL SPSLSSGTLS TSTSISSQIS
1560 1570 1580 1590 1600
TTTFESAITP SESSGYDSGD IESLVDREKE LATKCLQLLT HTFNREFSQV
1610 1620 1630 1640 1650
HGSVSDCKLS DISPIGRDPS ESSFSSATLT PSSTCPSLVD SRSNSLDQKT
1660 1670 1680 1690 1700
PEANSRASSP CPEFEQFQIV PAVETPYLAR AGKNEFLNLV PDIEEIRPSS
1710 1720 1730 1740 1750
VVSKKGYLHF KEPLYSNWAK HFVVVRRPYV FIYNSDKDPV ERGIINLSTA
1760 1770 1780 1790 1800
QVEYSEDQQA MVKTPNTFAV CTKHRGVLLQ ALNDKDMNDW LYAFNPLLAG
1810
TIRSKLSRRC PSQSKY
The sequence of this isoform differs from the canonical sequence as follows:
289-294: Missing.
394-434: IDPLIDDYSGSGSKYLKDFQNNKHRYLLASENQRPGHFSTA → T
707-1196: YESKLQALQK...KPIVFEVFGH → ADSDSGDDSD...NLKAGRETTV
1197-1816: Missing.
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ4R9M9 | Q4R9M9_HUMAN | Kinesin family member 1Bbeta isofor... | KIF1B KIF1Bbeta | 1,809 | Annotation score: | ||
A0A087WWA3 | A0A087WWA3_HUMAN | Kinesin-like protein KIF1B | KIF1B | 1,797 | Annotation score: | ||
A0A0U1RQL3 | A0A0U1RQL3_HUMAN | Kinesin-like protein KIF1B | KIF1B | 498 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 87 | E → G in BAA25517 (PubMed:10819331).Curated | 1 | |
Sequence conflicti | 129 – 131 | KIN → TNH in AAK49332 (PubMed:11526494).Curated | 3 | |
Sequence conflicti | 129 – 131 | KIN → TNH in AAK85155 (Ref. 4) Curated | 3 | |
Sequence conflicti | 129 – 131 | KIN → TNH in AAN17742 (Ref. 5) Curated | 3 | |
Sequence conflicti | 170 | E → D in AAK49332 (PubMed:11526494).Curated | 1 | |
Sequence conflicti | 170 | E → D in AAK85155 (Ref. 4) Curated | 1 | |
Sequence conflicti | 170 | E → D in AAN17742 (Ref. 5) Curated | 1 | |
Sequence conflicti | 174 | L → R in AAK49332 (PubMed:11526494).Curated | 1 | |
Sequence conflicti | 174 | L → R in AAK85155 (Ref. 4) Curated | 1 | |
Sequence conflicti | 174 | L → R in AAN17742 (Ref. 5) Curated | 1 | |
Sequence conflicti | 219 – 221 | AVF → VVY in AAK49332 (PubMed:11526494).Curated | 3 | |
Sequence conflicti | 219 – 221 | AVF → VVY in AAK85155 (Ref. 4) Curated | 3 | |
Sequence conflicti | 219 – 221 | AVF → VVY in AAN17742 (Ref. 5) Curated | 3 | |
Sequence conflicti | 235 – 239 | NLSTE → ILATV in AAK49332 (PubMed:11526494).Curated | 5 | |
Sequence conflicti | 235 – 239 | NLSTE → ILATV in AAK85155 (Ref. 4) Curated | 5 | |
Sequence conflicti | 235 – 239 | NLSTE → ILATV in AAN17742 (Ref. 5) Curated | 5 | |
Sequence conflicti | 244 | I → T in AAK49332 (PubMed:11526494).Curated | 1 | |
Sequence conflicti | 244 | I → T in AAK85155 (Ref. 4) Curated | 1 | |
Sequence conflicti | 244 | I → T in AAN17742 (Ref. 5) Curated | 1 | |
Sequence conflicti | 253 | E → D in AAK49332 (PubMed:11526494).Curated | 1 | |
Sequence conflicti | 253 | E → D in AAK85155 (Ref. 4) Curated | 1 | |
Sequence conflicti | 253 | E → D in AAN17742 (Ref. 5) Curated | 1 | |
Sequence conflicti | 256 | D → A in AAK49332 (PubMed:11526494).Curated | 1 | |
Sequence conflicti | 256 | D → A in AAK85155 (Ref. 4) Curated | 1 | |
Sequence conflicti | 256 | D → A in AAN17742 (Ref. 5) Curated | 1 | |
Sequence conflicti | 270 | N → I in AAK49332 (PubMed:11526494).Curated | 1 | |
Sequence conflicti | 270 | N → I in AAK85155 (Ref. 4) Curated | 1 | |
Sequence conflicti | 270 | N → I in AAN17742 (Ref. 5) Curated | 1 | |
Sequence conflicti | 363 | D → G in BAB69038 (PubMed:10762626).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_063531 | 34 | S → L in a medulloblastoma sample; somatic mutation; loss of ability to induce apoptosis. 1 PublicationCorresponds to variant dbSNP:rs1269940164Ensembl. | 1 | |
Natural variantiVAR_011515 | 98 | Q → L in CMT2A1. 1 PublicationCorresponds to variant dbSNP:rs121908160EnsemblClinVar. | 1 | |
Natural variantiVAR_063532 | 692 | E → V Confers susceptibility to neuroblastoma; found as germline mutation in a neuroblastoma patient; loss of ability to induce apoptosis. 1 PublicationCorresponds to variant dbSNP:rs121908161Ensembl. | 1 | |
Natural variantiVAR_063533 | 873 | T → I Confers susceptibility to neuroblastoma; found as germline mutation in a neuroblastoma patient; loss of ability to induce apoptosis. 1 PublicationCorresponds to variant dbSNP:rs121908162Ensembl. | 1 | |
Natural variantiVAR_063534 | 1133 | Y → C1 PublicationCorresponds to variant dbSNP:rs2297881Ensembl. | 1 | |
Natural variantiVAR_063535 | 1263 | P → S Confers susceptibility to neuroblastoma; found as germline mutation in a neuroblastoma patient; loss of ability to induce apoptosis. 1 PublicationCorresponds to variant dbSNP:rs121908163Ensembl. | 1 | |
Natural variantiVAR_063536 | 1527 | S → N Confers susceptibility to pheochromocytoma; found as germline mutation in a pheochromocytoma family; loss of ability to induce apoptosis. 1 PublicationCorresponds to variant dbSNP:rs121908164Ensembl. | 1 | |
Natural variantiVAR_063537 | 1600 | V → M1 PublicationCorresponds to variant dbSNP:rs77172218Ensembl. | 1 | |
Natural variantiVAR_063538 | 1674 | E → K in a pheochromocytoma sample; loss of ability to induce apoptosis. 1 PublicationCorresponds to variant dbSNP:rs143669846Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_002858 | 289 – 294 | Missing in isoform 2 and isoform 3. 4 Publications | 6 | |
Alternative sequenceiVSP_002859 | 394 – 434 | IDPLI…HFSTA → T in isoform 2 and isoform 3. 4 PublicationsAdd BLAST | 41 | |
Alternative sequenceiVSP_002860 | 707 – 1196 | YESKL…EVFGH → ADSDSGDDSDKRSCEESWKL ITSLREKLPPSKLQTIVKKC GLPSSGKKREPIKMYQIPQR RRLSKDSKWVTISDLKIQAV KEICYEVALNDFRHSRQEIE ALAIVKMKELCAMYGKKDPN ERDSWRAVARDVWDTVGVGD EKIEDVMATGKGSTDVDDLK VHIDKLEDILQEVKKQNNMK DEEIKVLRNKMLKMEKVLPL IGSQEQKSPGSHKAKEPVGA GVSSTSENNVSKGDNGELAK EERVSQLMNGDPAFRRGRLR WMRQEQIRFKNLQQQEITKQ LRRQNVPHRFIPPENRKPRF PFKSNPKHRNSWSPGTHIII TEDEVIELRIPKDDEARKGN KEESQEKGGKGAFKDPQFPW GSQGMRSQDHIQVSKQHINN QQQPPQLRWRSNSLNNGQPK STRCQASASAESLNSHSGHP TADVQTFQAKRHIHQHRQSY CNYNTGGQLEGNAATSYQKQ TDKPSHCSQFVTPPRMRRQF SAPNLKAGRETTV in isoform 3. 4 PublicationsAdd BLAST | 490 | |
Alternative sequenceiVSP_002861 | 1197 – 1816 | Missing in isoform 3. 4 PublicationsAdd BLAST | 620 | |
Alternative sequenceiVSP_009381 | 1804 – 1816 | SKLSR…SQSKY → PGHLASEIIREDKSVSFSCQ in isoform 4. 2 PublicationsAdd BLAST | 13 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AX039604 Genomic DNA Translation: CAC16629.1 AB017133 mRNA Translation: BAB69038.1 Different initiation. AF257176 mRNA Translation: AAK49332.1 AY043362 mRNA Translation: AAK85155.1 AB088210 mRNA Translation: BAE02543.1 AY139835 mRNA Translation: AAN17742.1 AB011163 mRNA Translation: BAA25517.2 Different initiation. AB040881 mRNA Translation: BAA95972.2 Different initiation. AL139424 Genomic DNA No translation available. AL358013 Genomic DNA No translation available. BC001415 mRNA Translation: AAH01415.1 Different initiation. BC115395 mRNA Translation: AAI15396.1 BT007174 mRNA Translation: AAP35838.1 Different initiation. AK022977 mRNA Translation: BAB14341.1 |
CCDSi | CCDS111.1 [O60333-2] CCDS112.1 [O60333-3] |
RefSeqi | NP_055889.2, NM_015074.3 [O60333-2] NP_904325.2, NM_183416.3 [O60333-3] |
Genome annotation databases
Ensembli | ENST00000263934; ENSP00000263934; ENSG00000054523 [O60333-2] ENST00000377081; ENSP00000366284; ENSG00000054523 [O60333-4] ENST00000377083; ENSP00000366287; ENSG00000054523 [O60333-3] ENST00000377086; ENSP00000366290; ENSG00000054523 [O60333-1] ENST00000377093; ENSP00000366297; ENSG00000054523 [O60333-3] ENST00000676179; ENSP00000502065; ENSG00000054523 [O60333-1] |
GeneIDi | 23095 |
KEGGi | hsa:23095 |
UCSCi | uc001aqv.5, human [O60333-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Inherited peripheral neuropathies mutation db |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AX039604 Genomic DNA Translation: CAC16629.1 AB017133 mRNA Translation: BAB69038.1 Different initiation. AF257176 mRNA Translation: AAK49332.1 AY043362 mRNA Translation: AAK85155.1 AB088210 mRNA Translation: BAE02543.1 AY139835 mRNA Translation: AAN17742.1 AB011163 mRNA Translation: BAA25517.2 Different initiation. AB040881 mRNA Translation: BAA95972.2 Different initiation. AL139424 Genomic DNA No translation available. AL358013 Genomic DNA No translation available. BC001415 mRNA Translation: AAH01415.1 Different initiation. BC115395 mRNA Translation: AAI15396.1 BT007174 mRNA Translation: AAP35838.1 Different initiation. AK022977 mRNA Translation: BAB14341.1 |
CCDSi | CCDS111.1 [O60333-2] CCDS112.1 [O60333-3] |
RefSeqi | NP_055889.2, NM_015074.3 [O60333-2] NP_904325.2, NM_183416.3 [O60333-3] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2EH0 | NMR | - | A | 531-647 | [»] | |
SMRi | O60333 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 116723, 72 interactors |
DIPi | DIP-33015N |
IntActi | O60333, 336 interactors |
MINTi | O60333 |
STRINGi | 9606.ENSP00000263934 |
Chemistry databases
BindingDBi | O60333 |
ChEMBLi | CHEMBL5889 |
PTM databases
iPTMneti | O60333 |
MetOSitei | O60333 |
PhosphoSitePlusi | O60333 |
SwissPalmi | O60333 |
Genetic variation databases
BioMutai | KIF1B |
Proteomic databases
EPDi | O60333 |
jPOSTi | O60333 |
MassIVEi | O60333 |
MaxQBi | O60333 |
PaxDbi | O60333 |
PeptideAtlasi | O60333 |
PRIDEi | O60333 |
ProteomicsDBi | 49353 [O60333-1] 49354 [O60333-2] 49355 [O60333-3] 49356 [O60333-4] |
Protocols and materials databases
Antibodypediai | 4196, 104 antibodies |
DNASUi | 23095 |
Genome annotation databases
Ensembli | ENST00000263934; ENSP00000263934; ENSG00000054523 [O60333-2] ENST00000377081; ENSP00000366284; ENSG00000054523 [O60333-4] ENST00000377083; ENSP00000366287; ENSG00000054523 [O60333-3] ENST00000377086; ENSP00000366290; ENSG00000054523 [O60333-1] ENST00000377093; ENSP00000366297; ENSG00000054523 [O60333-3] ENST00000676179; ENSP00000502065; ENSG00000054523 [O60333-1] |
GeneIDi | 23095 |
KEGGi | hsa:23095 |
UCSCi | uc001aqv.5, human [O60333-1] |
Organism-specific databases
CTDi | 23095 |
DisGeNETi | 23095 |
GeneCardsi | KIF1B |
GeneReviewsi | KIF1B |
HGNCi | HGNC:16636, KIF1B |
HPAi | ENSG00000054523, Tissue enhanced (skeletal) |
MalaCardsi | KIF1B |
MIMi | 118210, phenotype 171300, phenotype 256700, phenotype 605995, gene |
neXtProti | NX_O60333 |
OpenTargetsi | ENSG00000054523 |
Orphaneti | 99946, Autosomal dominant Charcot-Marie-Tooth disease type 2A1 29072, Hereditary pheochromocytoma-paraganglioma |
PharmGKBi | PA38176 |
VEuPathDBi | HostDB:ENSG00000054523.17 |
HUGEi | Search... Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0245, Eukaryota |
GeneTreei | ENSGT00940000157445 |
HOGENOMi | CLU_009645_0_0_1 |
InParanoidi | O60333 |
OMAi | LHQEDEF |
OrthoDBi | 76316at2759 |
PhylomeDBi | O60333 |
TreeFami | TF105221 |
Enzyme and pathway databases
PathwayCommonsi | O60333 |
Reactomei | R-HSA-6811434, COPI-dependent Golgi-to-ER retrograde traffic R-HSA-983189, Kinesins |
Miscellaneous databases
BioGRID-ORCSi | 23095, 3 hits in 872 CRISPR screens |
ChiTaRSi | KIF1B, human |
EvolutionaryTracei | O60333 |
GeneWikii | KIF1B |
GenomeRNAii | 23095 |
Pharosi | O60333, Tbio |
PROi | PR:O60333 |
RNActi | O60333, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000054523, Expressed in skeletal muscle tissue of rectus abdominis and 235 other tissues |
ExpressionAtlasi | O60333, baseline and differential |
Genevisiblei | O60333, HS |
Family and domain databases
CDDi | cd00060, FHA, 1 hit |
Gene3Di | 2.30.29.30, 1 hit 3.40.850.10, 1 hit |
InterProi | View protein in InterPro IPR000253, FHA_dom IPR022164, Kinesin-like IPR027640, Kinesin-like_fam IPR022140, Kinesin-like_KIF1-typ IPR032405, Kinesin_assoc IPR019821, Kinesin_motor_CS IPR001752, Kinesin_motor_dom IPR036961, Kinesin_motor_dom_sf IPR027417, P-loop_NTPase IPR011993, PH-like_dom_sf IPR001849, PH_domain IPR008984, SMAD_FHA_dom_sf |
PANTHERi | PTHR24115, PTHR24115, 1 hit |
Pfami | View protein in Pfam PF12473, DUF3694, 1 hit PF00498, FHA, 1 hit PF12423, KIF1B, 1 hit PF00225, Kinesin, 1 hit PF16183, Kinesin_assoc, 1 hit PF00169, PH, 1 hit |
PRINTSi | PR00380, KINESINHEAVY |
SMARTi | View protein in SMART SM00240, FHA, 1 hit SM00129, KISc, 1 hit SM00233, PH, 1 hit |
SUPFAMi | SSF49879, SSF49879, 1 hit SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS50006, FHA_DOMAIN, 1 hit PS00411, KINESIN_MOTOR_1, 1 hit PS50067, KINESIN_MOTOR_2, 1 hit PS50003, PH_DOMAIN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | KIF1B_HUMAN | |
Accessioni | O60333Primary (citable) accession number: O60333 Secondary accession number(s): A6NFS8 Q9P280 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 11, 2001 |
Last sequence update: | October 17, 2006 | |
Last modified: | February 10, 2021 | |
This is version 216 of the entry and version 5 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants