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UniProtKB - O60333 (KIF1B_HUMAN)

Entry version 215 (02 Dec 2020)
Sequence version 5 (17 Oct 2006)
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Protein

Kinesin-like protein KIF1B

Gene

KIF1B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Motor for anterograde transport of mitochondria. Has a microtubule plus end-directed motility. Isoform 2 is required for induction of neuronal apoptosis.1 Publication
Isoform 1 mediates the transport of synaptic vesicles in neuronal cells.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi97 – 104ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMotor protein
Biological processApoptosis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		O60333

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-6811434, COPI-dependent Golgi-to-ER retrograde traffic
R-HSA-983189, Kinesins

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Kinesin-like protein KIF1B
Short name:
Klp
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KIF1B
Synonyms:KIAA0591, KIAA1448
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000054523.17

Human Gene Nomenclature Database

More...HGNCi		HGNC:16636, KIF1B

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		605995, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O60333

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Microtubule, Mitochondrion, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Charcot-Marie-Tooth disease 2A1 (CMT2A1)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA dominant axonal form of Charcot-Marie-Tooth disease, a disorder of the peripheral nervous system, characterized by progressive weakness and atrophy, initially of the peroneal muscles and later of the distal muscles of the arms. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathies (designated CMT1 when they are dominantly inherited) and primary peripheral axonal neuropathies (CMT2). Neuropathies of the CMT2 group are characterized by signs of axonal degeneration in the absence of obvious myelin alterations, normal or slightly reduced nerve conduction velocities, and progressive distal muscle weakness and atrophy.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01151598Q → L in CMT2A1. 1 PublicationCorresponds to variant dbSNP:rs121908160EnsemblClinVar.1
Neuroblastoma 1 (NBLST1)
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionA common neoplasm of early childhood arising from embryonic cells that form the primitive neural crest and give rise to the adrenal medulla and the sympathetic nervous system.
Related information in OMIM
Pheochromocytoma (PCC)1 Publication
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionA catecholamine-producing tumor of chromaffin tissue of the adrenal medulla or sympathetic paraganglia. The cardinal symptom, reflecting the increased secretion of epinephrine and norepinephrine, is hypertension, which may be persistent or intermittent.
Related information in OMIM

Keywords - Diseasei

Charcot-Marie-Tooth disease, Disease mutation, Neurodegeneration, Neuropathy

Organism-specific databases

DisGeNET

More...DisGeNETi		23095

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...GeneReviewsi		KIF1B

MalaCards human disease database

More...MalaCardsi		KIF1B
MIMi118210, phenotype
171300, phenotype
256700, phenotype

Open Targets

More...OpenTargetsi		ENSG00000054523

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		99946, Autosomal dominant Charcot-Marie-Tooth disease type 2A1
29072, Hereditary pheochromocytoma-paraganglioma

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA38176

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O60333, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL5889

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		KIF1B

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001254072 – 1816Kinesin-like protein KIF1BAdd BLAST1815

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserineCombined sources1
Modified residuei647PhosphothreonineBy similarity1
Modified residuei652PhosphothreonineBy similarity1
Modified residuei1054PhosphoserineCombined sources1
Modified residuei1057PhosphoserineCombined sources1
Modified residuei1075PhosphothreonineCombined sources1
Modified residuei1416PhosphoserineCombined sources1
Modified residuei1454PhosphoserineCombined sources1
Modified residuei1487PhosphoserineCombined sources1
Modified residuei1573PhosphoserineCombined sources1
Modified residuei1603PhosphoserineCombined sources1
Modified residuei1610PhosphoserineCombined sources1
Modified residuei1613PhosphoserineCombined sources1
Isoform 3 (identifier: O60333-3)
Modified residuei663PhosphoserineCombined sources1
Modified residuei665PhosphoserineCombined sources1
Modified residuei1141PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		O60333

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O60333

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O60333

MaxQB - The MaxQuant DataBase

More...MaxQBi		O60333

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O60333

PeptideAtlas

More...PeptideAtlasi		O60333

PRoteomics IDEntifications database

More...PRIDEi		O60333

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		49353 [O60333-1]
49354 [O60333-2]
49355 [O60333-3]
49356 [O60333-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O60333

MetOSite database of methionine sulfoxide sites

More...MetOSitei		O60333

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O60333

SwissPalm database of S-palmitoylation events

More...SwissPalmi		O60333

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 3 is abundant in the skeletal muscle. It is also expressed in fetal brain, lung and kidney, and adult heart, placenta, testis, ovary and small intestine. Isoform 2 is abundant in the brain and also expressed in fetal heart, lung, liver and kidney, and adult skeletal muscle, placenta, liver, kidney, heart, spleen, thymus, prostate, testis, ovary, small intestine, colon and pancreas.3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000054523, Expressed in skeletal muscle tissue of rectus abdominis and 235 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O60333, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O60333, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000054523, Tissue enhanced (skeletal)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer (By similarity).

Interacts (via C-terminus end of the kinesin-motor domain) with CHP1; the interaction occurs in a calcium-dependent manner (By similarity).

Interacts with KIFBP (PubMed:16225668).

By similarity1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		116723, 71 interactors

Database of interacting proteins

More...DIPi		DIP-33015N

Protein interaction database and analysis system

More...IntActi		O60333, 64 interactors

Molecular INTeraction database

More...MINTi		O60333

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000263934

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		O60333

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O60333, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11816
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O60333

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		O60333

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini5 – 354Kinesin motorPROSITE-ProRule annotationAdd BLAST350
Domaini556 – 612FHAPROSITE-ProRule annotationAdd BLAST57
Domaini1702 – 1799PHPROSITE-ProRule annotationAdd BLAST98

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni270 – 350Interaction with KBP1 PublicationAdd BLAST81

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili365 – 386Sequence analysisAdd BLAST22
Coiled coili470 – 502Sequence analysisAdd BLAST33
Coiled coili668 – 737Sequence analysisAdd BLAST70
Coiled coili841 – 869Sequence analysisAdd BLAST29

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Unc-104 subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0245, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000157445

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_009645_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O60333

Identification of Orthologs from Complete Genome Data

More...OMAi		LHQEDEF

Database of Orthologous Groups

More...OrthoDBi		76316at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O60333

TreeFam database of animal gene trees

More...TreeFami		TF105221

Family and domain databases

Conserved Domains Database

More...CDDi		cd00060, FHA, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.30.29.30, 1 hit
3.40.850.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000253, FHA_dom
IPR022164, Kinesin-like
IPR027640, Kinesin-like_fam
IPR022140, Kinesin-like_KIF1-typ
IPR032405, Kinesin_assoc
IPR019821, Kinesin_motor_CS
IPR001752, Kinesin_motor_dom
IPR036961, Kinesin_motor_dom_sf
IPR027417, P-loop_NTPase
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
IPR008984, SMAD_FHA_dom_sf

The PANTHER Classification System

More...PANTHERi		PTHR24115, PTHR24115, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF12473, DUF3694, 1 hit
PF00498, FHA, 1 hit
PF12423, KIF1B, 1 hit
PF00225, Kinesin, 1 hit
PF16183, Kinesin_assoc, 1 hit
PF00169, PH, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00380, KINESINHEAVY

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00240, FHA, 1 hit
SM00129, KISc, 1 hit
SM00233, PH, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF49879, SSF49879, 1 hit
SSF52540, SSF52540, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50006, FHA_DOMAIN, 1 hit
PS00411, KINESIN_MOTOR_1, 1 hit
PS50067, KINESIN_MOTOR_2, 1 hit
PS50003, PH_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O60333-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSGASVKVAV RVRPFNSRET SKESKCIIQM QGNSTSIINP KNPKEAPKSF 
        60         70         80         90        100
SFDYSYWSHT SPEDPCFASQ NRVYNDIGKE MLLHAFEGYN VCIFAYGQTG 
       110        120        130        140        150
AGKSYTMMGK QEESQAGIIP QLCEELFEKI NDNCNEEMSY SVEVSYMEIY 
       160        170        180        190        200
CERVRDLLNP KNKGNLRVRE HPLLGPYVED LSKLAVTSYT DIADLMDAGN 
       210        220        230        240        250
KARTVAATNM NETSSRSHAV FTIVFTQKKH DNETNLSTEK VSKISLVDLA 
       260        270        280        290        300
GSERADSTGA KGTRLKEGAN INKSLTTLGK VISALAEVDN CTSKSKKKKK 
       310        320        330        340        350
TDFIPYRDSV LTWLLRENLG GNSRTAMVAA LSPADINYDE TLSTLRYADR 
       360        370        380        390        400
AKQIKCNAVI NEDPNAKLVR ELKEEVTRLK DLLRAQGLGD IIDIDPLIDD 
       410        420        430        440        450
YSGSGSKYLK DFQNNKHRYL LASENQRPGH FSTASMGSLT SSPSSCSLSS 
       460        470        480        490        500
QVGLTSVTSI QERIMSTPGG EEAIERLKES EKIIAELNET WEEKLRKTEA 
       510        520        530        540        550
IRMEREALLA EMGVAIREDG GTLGVFSPKK TPHLVNLNED PLMSECLLYY 
       560        570        580        590        600
IKDGITRVGQ ADAERRQDIV LSGAHIKEEH CIFRSERSNS GEVIVTLEPC 
       610        620        630        640        650
ERSETYVNGK RVSQPVQLRS GNRIIMGKNH VFRFNHPEQA RAEREKTPSA 
       660        670        680        690        700
ETPSEPVDWT FAQRELLEKQ GIDMKQEMEK RLQEMEILYK KEKEEADLLL 
       710        720        730        740        750
EQQRLDYESK LQALQKQVET RSLAAETTEE EEEEEEVPWT QHEFELAQWA 
       760        770        780        790        800
FRKWKSHQFT SLRDLLWGNA VYLKEANAIS VELKKKVQFQ FVLLTDTLYS 
       810        820        830        840        850
PLPPELLPTE MEKTHEDRPF PRTVVAVEVQ DLKNGATHYW SLEKLKQRLD 
       860        870        880        890        900
LMREMYDRAG EMASSAQDES ETTVTGSDPF YDRFHWFKLV GSSPIFHGCV 
       910        920        930        940        950
NERLADRTPS PTFSTADSDI TELADEQQDE MEDFDDEAFV DDAGSDAGTE 
       960        970        980        990       1000
EGSDLFSDGH DPFYDRSPWF ILVGRAFVYL SNLLYPVPLI HRVAIVSEKG 
      1010       1020       1030       1040       1050
EVRGFLRVAV QAIAADEEAP DYGSGIRQSG TAKISFDNEY FNQSDFSSVA 
      1060       1070       1080       1090       1100
MTRSGLSLEE LRIVEGQGQS SEVITPPEEI SRINDLDLKS STLLDGKMVM 
      1110       1120       1130       1140       1150
EGFSEEIGNH LKLGSAFTFR VTVLQASGIL PEYADIFCQF NFLHRHDEAF 
      1160       1170       1180       1190       1200
STEPLKNNGR GSPLAFYHVQ NIAVEITESF VDYIKTKPIV FEVFGHYQQH 
      1210       1220       1230       1240       1250
PLHLQGQELN SPPQPCRRFF PPPMPLSKPV PATKLNTMSK TSLGQSMSKY 
      1260       1270       1280       1290       1300
DLLVWFEISE LEPTGEYIPA VVDHTAGLPC QGTFLLHQGI QRRITVTIIH 
      1310       1320       1330       1340       1350
EKGSELHWKD VRELVVGRIR NKPEVDEAAV DAILSLNIIS AKYLKSSHNS 
      1360       1370       1380       1390       1400
SRTFYRFEAV WDSSLHNSLL LNRVTPYGEK IYMTLSAYLE LDHCIQPAVI 
      1410       1420       1430       1440       1450
TKDVCMVFYS RDAKISPPRS LRSLFGSGYS KSPDSNRVTG IYELSLCKMS 
      1460       1470       1480       1490       1500
DTGSPGMQRR RRKILDTSVA YVRGEENLAG WRPRGDSLIL EHQWELEKLE 
      1510       1520       1530       1540       1550
LLHEVEKTRH FLLLRERLGD SIPKSLSDSL SPSLSSGTLS TSTSISSQIS 
      1560       1570       1580       1590       1600
TTTFESAITP SESSGYDSGD IESLVDREKE LATKCLQLLT HTFNREFSQV 
      1610       1620       1630       1640       1650
HGSVSDCKLS DISPIGRDPS ESSFSSATLT PSSTCPSLVD SRSNSLDQKT 
      1660       1670       1680       1690       1700
PEANSRASSP CPEFEQFQIV PAVETPYLAR AGKNEFLNLV PDIEEIRPSS 
      1710       1720       1730       1740       1750
VVSKKGYLHF KEPLYSNWAK HFVVVRRPYV FIYNSDKDPV ERGIINLSTA 
      1760       1770       1780       1790       1800
QVEYSEDQQA MVKTPNTFAV CTKHRGVLLQ ALNDKDMNDW LYAFNPLLAG 
      1810 
TIRSKLSRRC PSQSKY
Length:1,816
Mass (Da):204,476
Last modified:October 17, 2006 - v5
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAD62F0515978C783
GO
Isoform 2 (identifier: O60333-2) [UniParc]FASTAAdd to basket
Also known as: Beta

The sequence of this isoform differs from the canonical sequence as follows:
     289-294: Missing.
     394-434: IDPLIDDYSGSGSKYLKDFQNNKHRYLLASENQRPGHFSTA → T

Show »
Length:1,770
Mass (Da):199,263
Checksum:i8AE6BB2665AF702C
GO
Isoform 3 (identifier: O60333-3) [UniParc]FASTAAdd to basket
Also known as: Alpha

The sequence of this isoform differs from the canonical sequence as follows:
     289-294: Missing.
     394-434: IDPLIDDYSGSGSKYLKDFQNNKHRYLLASENQRPGHFSTA → T
     707-1196: YESKLQALQK...KPIVFEVFGH → ADSDSGDDSD...NLKAGRETTV
     1197-1816: Missing.

Show »
Length:1,153
Mass (Da):130,363
Checksum:i6F0D8846CD283811
GO
Isoform 4 (identifier: O60333-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1804-1816: SKLSRRCPSQSKY → PGHLASEIIREDKSVSFSCQ

Show »
Length:1,823
Mass (Da):205,140
Checksum:iA53CAAD5693880E7
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q4R9M9Q4R9M9_HUMAN
Kinesin family member 1Bbeta isofor...
KIF1B KIF1Bbeta
1,809Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WWA3A0A087WWA3_HUMAN
Kinesin-like protein KIF1B
KIF1B
1,797Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0U1RQL3A0A0U1RQL3_HUMAN
Kinesin-like protein KIF1B
KIF1B
498Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH01415 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAP35838 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAA25517 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence BAA95972 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence BAB69038 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti87E → G in BAA25517 (PubMed:10819331).Curated1
Sequence conflicti129 – 131KIN → TNH in AAK49332 (PubMed:11526494).Curated3
Sequence conflicti129 – 131KIN → TNH in AAK85155 (Ref. 4) Curated3
Sequence conflicti129 – 131KIN → TNH in AAN17742 (Ref. 5) Curated3
Sequence conflicti170E → D in AAK49332 (PubMed:11526494).Curated1
Sequence conflicti170E → D in AAK85155 (Ref. 4) Curated1
Sequence conflicti170E → D in AAN17742 (Ref. 5) Curated1
Sequence conflicti174L → R in AAK49332 (PubMed:11526494).Curated1
Sequence conflicti174L → R in AAK85155 (Ref. 4) Curated1
Sequence conflicti174L → R in AAN17742 (Ref. 5) Curated1
Sequence conflicti219 – 221AVF → VVY in AAK49332 (PubMed:11526494).Curated3
Sequence conflicti219 – 221AVF → VVY in AAK85155 (Ref. 4) Curated3
Sequence conflicti219 – 221AVF → VVY in AAN17742 (Ref. 5) Curated3
Sequence conflicti235 – 239NLSTE → ILATV in AAK49332 (PubMed:11526494).Curated5
Sequence conflicti235 – 239NLSTE → ILATV in AAK85155 (Ref. 4) Curated5
Sequence conflicti235 – 239NLSTE → ILATV in AAN17742 (Ref. 5) Curated5
Sequence conflicti244I → T in AAK49332 (PubMed:11526494).Curated1
Sequence conflicti244I → T in AAK85155 (Ref. 4) Curated1
Sequence conflicti244I → T in AAN17742 (Ref. 5) Curated1
Sequence conflicti253E → D in AAK49332 (PubMed:11526494).Curated1
Sequence conflicti253E → D in AAK85155 (Ref. 4) Curated1
Sequence conflicti253E → D in AAN17742 (Ref. 5) Curated1
Sequence conflicti256D → A in AAK49332 (PubMed:11526494).Curated1
Sequence conflicti256D → A in AAK85155 (Ref. 4) Curated1
Sequence conflicti256D → A in AAN17742 (Ref. 5) Curated1
Sequence conflicti270N → I in AAK49332 (PubMed:11526494).Curated1
Sequence conflicti270N → I in AAK85155 (Ref. 4) Curated1
Sequence conflicti270N → I in AAN17742 (Ref. 5) Curated1
Sequence conflicti363D → G in BAB69038 (PubMed:10762626).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06353134S → L in a medulloblastoma sample; somatic mutation; loss of ability to induce apoptosis. 1 PublicationCorresponds to variant dbSNP:rs1269940164Ensembl.1
Natural variantiVAR_01151598Q → L in CMT2A1. 1 PublicationCorresponds to variant dbSNP:rs121908160EnsemblClinVar.1
Natural variantiVAR_063532692E → V Confers susceptibility to neuroblastoma; found as germline mutation in a neuroblastoma patient; loss of ability to induce apoptosis. 1 PublicationCorresponds to variant dbSNP:rs121908161Ensembl.1
Natural variantiVAR_063533873T → I Confers susceptibility to neuroblastoma; found as germline mutation in a neuroblastoma patient; loss of ability to induce apoptosis. 1 PublicationCorresponds to variant dbSNP:rs121908162Ensembl.1
Natural variantiVAR_0635341133Y → C1 PublicationCorresponds to variant dbSNP:rs2297881Ensembl.1
Natural variantiVAR_0635351263P → S Confers susceptibility to neuroblastoma; found as germline mutation in a neuroblastoma patient; loss of ability to induce apoptosis. 1 PublicationCorresponds to variant dbSNP:rs121908163Ensembl.1
Natural variantiVAR_0635361527S → N Confers susceptibility to pheochromocytoma; found as germline mutation in a pheochromocytoma family; loss of ability to induce apoptosis. 1 PublicationCorresponds to variant dbSNP:rs121908164Ensembl.1
Natural variantiVAR_0635371600V → M1 PublicationCorresponds to variant dbSNP:rs77172218Ensembl.1
Natural variantiVAR_0635381674E → K in a pheochromocytoma sample; loss of ability to induce apoptosis. 1 PublicationCorresponds to variant dbSNP:rs143669846Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_002858289 – 294Missing in isoform 2 and isoform 3. 4 Publications6
Alternative sequenceiVSP_002859394 – 434IDPLI…HFSTA → T in isoform 2 and isoform 3. 4 PublicationsAdd BLAST41
Alternative sequenceiVSP_002860707 – 1196YESKL…EVFGH → ADSDSGDDSDKRSCEESWKL ITSLREKLPPSKLQTIVKKC GLPSSGKKREPIKMYQIPQR RRLSKDSKWVTISDLKIQAV KEICYEVALNDFRHSRQEIE ALAIVKMKELCAMYGKKDPN ERDSWRAVARDVWDTVGVGD EKIEDVMATGKGSTDVDDLK VHIDKLEDILQEVKKQNNMK DEEIKVLRNKMLKMEKVLPL IGSQEQKSPGSHKAKEPVGA GVSSTSENNVSKGDNGELAK EERVSQLMNGDPAFRRGRLR WMRQEQIRFKNLQQQEITKQ LRRQNVPHRFIPPENRKPRF PFKSNPKHRNSWSPGTHIII TEDEVIELRIPKDDEARKGN KEESQEKGGKGAFKDPQFPW GSQGMRSQDHIQVSKQHINN QQQPPQLRWRSNSLNNGQPK STRCQASASAESLNSHSGHP TADVQTFQAKRHIHQHRQSY CNYNTGGQLEGNAATSYQKQ TDKPSHCSQFVTPPRMRRQF SAPNLKAGRETTV in isoform 3. 4 PublicationsAdd BLAST490
Alternative sequenceiVSP_0028611197 – 1816Missing in isoform 3. 4 PublicationsAdd BLAST620
Alternative sequenceiVSP_0093811804 – 1816SKLSR…SQSKY → PGHLASEIIREDKSVSFSCQ in isoform 4. 2 PublicationsAdd BLAST13

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AX039604 Genomic DNA Translation: CAC16629.1
AB017133 mRNA Translation: BAB69038.1 Different initiation.
AF257176 mRNA Translation: AAK49332.1
AY043362 mRNA Translation: AAK85155.1
AB088210 mRNA Translation: BAE02543.1
AY139835 mRNA Translation: AAN17742.1
AB011163 mRNA Translation: BAA25517.2 Different initiation.
AB040881 mRNA Translation: BAA95972.2 Different initiation.
AL139424 Genomic DNA No translation available.
AL358013 Genomic DNA No translation available.
BC001415 mRNA Translation: AAH01415.1 Different initiation.
BC115395 mRNA Translation: AAI15396.1
BT007174 mRNA Translation: AAP35838.1 Different initiation.
AK022977 mRNA Translation: BAB14341.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS111.1 [O60333-2]
CCDS112.1 [O60333-3]

NCBI Reference Sequences

More...RefSeqi		NP_055889.2, NM_015074.3 [O60333-2]
NP_904325.2, NM_183416.3 [O60333-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000263934; ENSP00000263934; ENSG00000054523 [O60333-2]
ENST00000377081; ENSP00000366284; ENSG00000054523 [O60333-4]
ENST00000377083; ENSP00000366287; ENSG00000054523 [O60333-3]
ENST00000377086; ENSP00000366290; ENSG00000054523 [O60333-1]
ENST00000377093; ENSP00000366297; ENSG00000054523 [O60333-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		23095

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:23095

UCSC genome browser

More...UCSCi		uc001aqv.5, human [O60333-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Inherited peripheral neuropathies mutation db

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AX039604 Genomic DNA Translation: CAC16629.1
AB017133 mRNA Translation: BAB69038.1 Different initiation.
AF257176 mRNA Translation: AAK49332.1
AY043362 mRNA Translation: AAK85155.1
AB088210 mRNA Translation: BAE02543.1
AY139835 mRNA Translation: AAN17742.1
AB011163 mRNA Translation: BAA25517.2 Different initiation.
AB040881 mRNA Translation: BAA95972.2 Different initiation.
AL139424 Genomic DNA No translation available.
AL358013 Genomic DNA No translation available.
BC001415 mRNA Translation: AAH01415.1 Different initiation.
BC115395 mRNA Translation: AAI15396.1
BT007174 mRNA Translation: AAP35838.1 Different initiation.
AK022977 mRNA Translation: BAB14341.1
CCDSiCCDS111.1 [O60333-2]
CCDS112.1 [O60333-3]
RefSeqiNP_055889.2, NM_015074.3 [O60333-2]
NP_904325.2, NM_183416.3 [O60333-3]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2EH0NMR-A531-647[»]
SMRiO60333
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi116723, 71 interactors
DIPiDIP-33015N
IntActiO60333, 64 interactors
MINTiO60333
STRINGi9606.ENSP00000263934

Chemistry databases

BindingDBiO60333
ChEMBLiCHEMBL5889

PTM databases

iPTMnetiO60333
MetOSiteiO60333
PhosphoSitePlusiO60333
SwissPalmiO60333

Polymorphism and mutation databases

BioMutaiKIF1B

Proteomic databases

EPDiO60333
jPOSTiO60333
MassIVEiO60333
MaxQBiO60333
PaxDbiO60333
PeptideAtlasiO60333
PRIDEiO60333
ProteomicsDBi49353 [O60333-1]
49354 [O60333-2]
49355 [O60333-3]
49356 [O60333-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		4196, 104 antibodies

The DNASU plasmid repository

More...DNASUi		23095

Genome annotation databases

EnsembliENST00000263934; ENSP00000263934; ENSG00000054523 [O60333-2]
ENST00000377081; ENSP00000366284; ENSG00000054523 [O60333-4]
ENST00000377083; ENSP00000366287; ENSG00000054523 [O60333-3]
ENST00000377086; ENSP00000366290; ENSG00000054523 [O60333-1]
ENST00000377093; ENSP00000366297; ENSG00000054523 [O60333-3]
GeneIDi23095
KEGGihsa:23095
UCSCiuc001aqv.5, human [O60333-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		23095
DisGeNETi23095
EuPathDBiHostDB:ENSG00000054523.17

GeneCards: human genes, protein and diseases

More...GeneCardsi		KIF1B
GeneReviewsiKIF1B
HGNCiHGNC:16636, KIF1B
HPAiENSG00000054523, Tissue enhanced (skeletal)
MalaCardsiKIF1B
MIMi118210, phenotype
171300, phenotype
256700, phenotype
605995, gene
neXtProtiNX_O60333
OpenTargetsiENSG00000054523
Orphaneti99946, Autosomal dominant Charcot-Marie-Tooth disease type 2A1
29072, Hereditary pheochromocytoma-paraganglioma
PharmGKBiPA38176

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...
Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0245, Eukaryota
GeneTreeiENSGT00940000157445
HOGENOMiCLU_009645_0_0_1
InParanoidiO60333
OMAiLHQEDEF
OrthoDBi76316at2759
PhylomeDBiO60333
TreeFamiTF105221

Enzyme and pathway databases

PathwayCommonsiO60333
ReactomeiR-HSA-6811434, COPI-dependent Golgi-to-ER retrograde traffic
R-HSA-983189, Kinesins

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		23095, 3 hits in 842 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		KIF1B, human
EvolutionaryTraceiO60333

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		KIF1B

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		23095
PharosiO60333, Tbio

Protein Ontology

More...PROi		PR:O60333
RNActiO60333, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000054523, Expressed in skeletal muscle tissue of rectus abdominis and 235 other tissues
ExpressionAtlasiO60333, baseline and differential
GenevisibleiO60333, HS

Family and domain databases

CDDicd00060, FHA, 1 hit
Gene3Di2.30.29.30, 1 hit
3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR000253, FHA_dom
IPR022164, Kinesin-like
IPR027640, Kinesin-like_fam
IPR022140, Kinesin-like_KIF1-typ
IPR032405, Kinesin_assoc
IPR019821, Kinesin_motor_CS
IPR001752, Kinesin_motor_dom
IPR036961, Kinesin_motor_dom_sf
IPR027417, P-loop_NTPase
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
IPR008984, SMAD_FHA_dom_sf
PANTHERiPTHR24115, PTHR24115, 1 hit
PfamiView protein in Pfam
PF12473, DUF3694, 1 hit
PF00498, FHA, 1 hit
PF12423, KIF1B, 1 hit
PF00225, Kinesin, 1 hit
PF16183, Kinesin_assoc, 1 hit
PF00169, PH, 1 hit
PRINTSiPR00380, KINESINHEAVY
SMARTiView protein in SMART
SM00240, FHA, 1 hit
SM00129, KISc, 1 hit
SM00233, PH, 1 hit
SUPFAMiSSF49879, SSF49879, 1 hit
SSF52540, SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50006, FHA_DOMAIN, 1 hit
PS00411, KINESIN_MOTOR_1, 1 hit
PS50067, KINESIN_MOTOR_2, 1 hit
PS50003, PH_DOMAIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKIF1B_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O60333
Secondary accession number(s): A6NFS8
, A6NKQ4, Q4VXC3, Q4VXC4, Q4VXC5, Q4VXC6, Q96Q94, Q9BV80, Q9P280
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: October 17, 2006
Last modified: December 2, 2020
This is version 215 of the entry and version 5 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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