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Entry version 167 (02 Jun 2021)
Sequence version 2 (25 Oct 2005)
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Protein

Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma

Gene

PIP5K1C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the phosphorylation of phosphatidylinositol 4-phosphate (PtdIns4P/PI4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2/PIP2), a lipid second messenger that regulates several cellular processes such as signal transduction, vesicle trafficking, actin cytoskeleton dynamics, cell adhesion, and cell motility (PubMed:12422219, PubMed:22942276).

PtdIns(4,5)P2 can directly act as a second messenger or can be utilized as a precursor to generate other second messengers: inositol 1,4,5-trisphosphate (IP3), diacylglycerol (DAG) or phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3/PIP3) (Probable). PIP5K1A-mediated phosphorylation of PtdIns4P is the predominant pathway for PtdIns(4,5)P2 synthesis (By similarity).

Together with PIP5K1A, is required for phagocytosis, both enzymes regulating different types of actin remodeling at sequential steps (By similarity).

Promotes particle attachment by generating the pool of PtdIns(4,5)P2 that induces controlled actin depolymerization to facilitate Fc-gamma-R clustering. Mediates RAC1-dependent reorganization of actin filaments. Required for synaptic vesicle transport (By similarity).

Controls the plasma membrane pool of PtdIns(4,5)P2 implicated in synaptic vesicle endocytosis and exocytosis (PubMed:12847086).

Plays a role in endocytosis mediated by clathrin and AP-2 (adaptor protein complex 2) (PubMed:12847086).

Required for clathrin-coated pits assembly at the synapse (PubMed:17261850).

Participates in cell junction assembly (PubMed:17261850).

Modulates adherens junctions formation by facilitating CDH1/cadherin trafficking (PubMed:17261850).

Required for focal adhesion dynamics. Modulates the targeting of talins (TLN1 and TLN2) to the plasma membrane and their efficient assembly into focal adhesions (PubMed:12422219).

Regulates the interaction between talins (TLN1 and TLN2) and beta-integrins (PubMed:12422219).

Required for uropodium formation and retraction of the cell rear during directed migration (By similarity).

Has a role in growth factor-stimulated directional cell migration and adhesion (By similarity).

Required for talin assembly into nascent adhesions forming at the leading edge toward the direction of the growth factor (PubMed:17635937).

Negative regulator of T-cell activation and adhesion (By similarity).

Negatively regulates integrin alpha-L/beta-2 (LFA-1) polarization and adhesion induced by T-cell receptor (By similarity).

Together with PIP5K1A has a role during embryogenesis and together with PIP5K1B may have a role immediately after birth (By similarity).

By similarity1 Publication5 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=1.6 µM for 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 4-phosphate1 Publication
  2. KM=15 µM for 1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho-1D-myo-inositol 4-phosphate1 Publication

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionKinase, Transferase
    Biological processCell adhesion, Chemotaxis, Endocytosis, Exocytosis, Phagocytosis
    LigandATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyc Collection of Pathway/Genome Databases

    More...
    BioCyci
    MetaCyc:HS02710-MONOMER

    BRENDA Comprehensive Enzyme Information System

    More...
    BRENDAi
    2.7.1.68, 2681

    Pathway Commons web resource for biological pathway data

    More...
    PathwayCommonsi
    O60331

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-1660499, Synthesis of PIPs at the plasma membrane
    R-HSA-399955, SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
    R-HSA-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
    R-HSA-8856828, Clathrin-mediated endocytosis

    SIGNOR Signaling Network Open Resource

    More...
    SIGNORi
    O60331

    Chemistry databases

    SwissLipids knowledge resource for lipid biology

    More...
    SwissLipidsi
    SLP:000000551 [O60331-4]

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma1 Publication (EC:2.7.1.682 Publications)
    Short name:
    PIP5K1gamma1 Publication
    Short name:
    PtdIns(4)P-5-kinase 1 gamma1 Publication
    Alternative name(s):
    Type I phosphatidylinositol 4-phosphate 5-kinase gammaBy similarity
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:PIP5K1CImported
    Synonyms:KIAA0589
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

    Organism-specific databases

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:8996, PIP5K1C

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    606102, gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_O60331

    Eukaryotic Pathogen, Vector and Host Database Resources

    More...
    VEuPathDBi
    HostDB:ENSG00000186111.8

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Cell projection, Cytoplasm, Membrane, Nucleus

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    <p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

    Lethal congenital contracture syndrome 3 (LCCS3)1 Publication
    The disease is caused by variants affecting the gene represented in this entry.
    Disease descriptionA form of lethal congenital contracture syndrome, an autosomal recessive disorder characterized by degeneration of anterior horn neurons, extreme skeletal muscle atrophy, and congenital non-progressive joint contractures (arthrogryposis). The contractures can involve the upper or lower limbs and/or the vertebral column, leading to various degrees of flexion or extension limitations evident at birth. LCCS3 patients present at birth with severe multiple joint contractures and severe muscle wasting and atrophy, mainly in the legs. Death occurs minutes to hours after birth due to respiratory insufficiency. The phenotype can be distinguished from that of LCCS1 by the absence of hydrops, fractures and multiple pterygia, and from LCCS2 by the absence of neurogenic bladder defect.
    Related information in OMIM
    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_036996253D → N in LCCS3; loss of activity. 1 PublicationCorresponds to variant dbSNP:rs121908315EnsemblClinVar.1

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi650S → D: Abolishes binding to TLN2. Affects localization to focal adhesions. 1 Publication1
    Mutagenesisi650S → N: Does not affect binding to TLN2 and localization to focal adhesions. 1 Publication1

    Keywords - Diseasei

    Disease variant

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    23396

    MalaCards human disease database

    More...
    MalaCardsi
    PIP5K1C
    MIMi611369, phenotype

    Open Targets

    More...
    OpenTargetsi
    ENSG00000186111

    Orphanet; a database dedicated to information on rare diseases and orphan drugs

    More...
    Orphaneti
    137783, Lethal congenital contracture syndrome type 3

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA33329

    Miscellaneous databases

    Pharos NIH Druggable Genome Knowledgebase

    More...
    Pharosi
    O60331, Tchem

    Chemistry databases

    ChEMBL database of bioactive drug-like small molecules

    More...
    ChEMBLi
    CHEMBL1908383

    DrugCentral

    More...
    DrugCentrali
    O60331

    Genetic variation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    PIP5K1C

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001854621 – 668Phosphatidylinositol 4-phosphate 5-kinase type-1 gammaAdd BLAST668

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei265N6-acetyllysine1 Publication1
    Modified residuei268N6-acetyllysine1 Publication1
    Modified residuei459Asymmetric dimethylarginine; alternateBy similarity1
    Modified residuei459Omega-N-methylarginine; alternateBy similarity1
    Modified residuei555PhosphoserineBy similarity1
    Modified residuei639Phosphotyrosine; by EGFRBy similarity1
    Modified residuei649Phosphotyrosine; by CSK1 Publication1
    Modified residuei650Phosphoserine; by CDK5, MAPK1 and CDK11 Publication1
    Modified residuei662PhosphoserineBy similarity1
    Modified residuei666PhosphoserineBy similarity1
    Modified residuei668PhosphothreonineBy similarity1

    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

    Phosphorylation on Ser-650 negatively regulates binding to TLN2 and is strongly stimulated in mitosis. Phosphorylation on Tyr-649 is necessary for targeting to focal adhesions. Phosphorylation on Ser-650 and Tyr-649 are mutually exclusive. Phosphorylated by SYK and CSK (By similarity). Tyrosine phosphorylation is enhanced by PTK2 signaling. Phosphorylated at Tyr-639 upon EGF stimulation. Some studies suggest that phosphorylation on Tyr-649 enhances binding to tailins (TLN1 and TLN2). According to PubMed:15738269 phosphorylation at Tyr-649 does not directly enhance binding to tailins (TLN1 and TLN2) but may act indirectly by inhibiting phosphorylation at Ser-650.By similarity1 Publication
    Acetylation at Lys-265 and Lys-268 seems to decrease lipid 1-phosphatidylinositol-4-phosphate 5-kinase activity. Deacetylation of these sites by SIRT1 positively regulates the exocytosis of TSH-containing granules from pituitary cells.1 Publication

    Keywords - PTMi

    Acetylation, Methylation, Phosphoprotein

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...
    EPDi
    O60331

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    O60331

    MassIVE - Mass Spectrometry Interactive Virtual Environment

    More...
    MassIVEi
    O60331

    MaxQB - The MaxQuant DataBase

    More...
    MaxQBi
    O60331

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    O60331

    PeptideAtlas

    More...
    PeptideAtlasi
    O60331

    PRoteomics IDEntifications database

    More...
    PRIDEi
    O60331

    ProteomicsDB: a multi-organism proteome resource

    More...
    ProteomicsDBi
    49349 [O60331-1]
    49350 [O60331-2]
    49351 [O60331-3]
    49352 [O60331-4]

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    O60331

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    O60331

    SwissPalm database of S-palmitoylation events

    More...
    SwissPalmi
    O60331

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Isoform 1 is strongly expressed in brain and also detected in heart and lung.1 Publication
    Isoform 2 is strongly expressed in pancreas and liver and in lesser quantities in brain, heart, lung and kidney.1 Publication
    Isoform 3 is detected in large amounts in heart and large intestine, is also present in lung, pancreas and thyroid, and to a lesser extent in brain, stomach and kidney.1 Publication

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000186111, Expressed in right hemisphere of cerebellum and 242 other tissues

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    O60331, HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    ENSG00000186111, Low tissue specificity

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Interacts with TLN1 (By similarity).

    Interacts with TLN2; interaction stimulates 1-phosphatidylinositol-4-phosphate 5-kinase activity (PubMed:12422219). May compete with beta-integrins for the same binding site on TLN1 and TLN2.

    Interacts with ARF6; interaction stimulates 1-phosphatidylinositol-4-phosphate 5-kinase activity.

    Interacts with AP2B1.

    Interacts with AP2M1; phosphorylation of PIP5K1C by CSK disrupts the interaction; clathrin competes with PIP5K1C (By similarity).

    Interacts with CDH1.

    Interacts with CSK (By similarity).

    Interacts with PLCG1; interaction is abolished upon EGF stimulation (By similarity).

    Interacts with LAPTM4B; promotes SNX5 association with LAPTM4B; kinase activity of PIP5K1C is required; interaction is regulated by phosphatidylinositol 4,5-bisphosphate generated by PIP5K1C (PubMed:25588945).

    By similarity2 Publications

    <p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGRID)

    More...
    BioGRIDi
    116969, 30 interactors

    Database of interacting proteins

    More...
    DIPi
    DIP-39809N

    Protein interaction database and analysis system

    More...
    IntActi
    O60331, 9 interactors

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000466363

    Chemistry databases

    BindingDB database of measured binding affinities

    More...
    BindingDBi
    O60331

    Miscellaneous databases

    RNAct, Protein-RNA interaction predictions for model organisms.

    More...
    RNActi
    O60331, protein

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1668
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    O60331

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    Protein Data Bank in Europe - Knowledge Base

    More...
    PDBe-KBi
    Search...

    Miscellaneous databases

    Relative evolutionary importance of amino acids within a protein sequence

    More...
    EvolutionaryTracei
    O60331

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini75 – 443PIPKPROSITE-ProRule annotationAdd BLAST369

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni45 – 67DisorderedSequence analysisAdd BLAST23
    Regioni526 – 578DisorderedSequence analysisAdd BLAST53
    Regioni593 – 642DisorderedSequence analysisAdd BLAST50
    Regioni641 – 668Mediates interaction with TLN21 PublicationAdd BLAST28

    Compositional bias

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi526 – 542Polar residuesSequence analysisAdd BLAST17
    Compositional biasi543 – 568Basic and acidic residuesSequence analysisAdd BLAST26

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG0229, Eukaryota

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00940000159258

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    CLU_004312_5_1_1

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    O60331

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    DIYFFPD

    Database of Orthologous Groups

    More...
    OrthoDBi
    296899at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    O60331

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF319618

    Family and domain databases

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    3.30.800.10, 1 hit
    3.30.810.10, 2 hits

    Intrinsically Disordered proteins with Extensive Annotations and Literature

    More...
    IDEALi
    IID00359

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR023610, PInositol-4-P-5-kinase
    IPR027483, PInositol-4-P-5-kinase_C
    IPR002498, PInositol-4-P-5-kinase_core
    IPR027484, PInositol-4-P-5-kinase_N

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR23086, PTHR23086, 1 hit

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF01504, PIP5K, 1 hit

    Simple Modular Architecture Research Tool; a protein domain database

    More...
    SMARTi
    View protein in SMART
    SM00330, PIPKc, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS51455, PIPK, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

    This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

    Isoform 1 (identifier: O60331-1) [UniParc]FASTAAdd to basket
    Also known as: PIPKIgamma-90, PIPKIgamma-668, PIPkinIgamma-a, PIPKIgamma_i2

    This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MELEVPDEAE SAEAGAVPSE AAWAAESGAA AGLAQKKAAP TEVLSMTAQP
    60 70 80 90 100
    GPGHGKKLGH RGVDASGETT YKKTTSSTLK GAIQLGIGYT VGHLSSKPER
    110 120 130 140 150
    DVLMQDFYVV ESIFFPSEGS NLTPAHHFQD FRFKTYAPVA FRYFRELFGI
    160 170 180 190 200
    RPDDYLYSLC NEPLIELSNP GASGSLFYVT SDDEFIIKTV MHKEAEFLQK
    210 220 230 240 250
    LLPGYYMNLN QNPRTLLPKF YGLYCVQSGG KNIRVVVMNN ILPRVVKMHL
    260 270 280 290 300
    KFDLKGSTYK RRASKKEKEK SFPTYKDLDF MQDMPEGLLL DADTFSALVK
    310 320 330 340 350
    TLQRDCLVLE SFKIMDYSLL LGVHNIDQHE RERQAQGAQS TSDEKRPVGQ
    360 370 380 390 400
    KALYSTAMES IQGGAARGEA IESDDTMGGI PAVNGRGERL LLHIGIIDIL
    410 420 430 440 450
    QSYRFIKKLE HTWKALVHDG DTVSVHRPSF YAERFFKFMS NTVFRKNSSL
    460 470 480 490 500
    KSSPSKKGRG GALLAVKPLG PTAAFSASQI PSEREEAQYD LRGARSYPTL
    510 520 530 540 550
    EDEGRPDLLP CTPPSFEEAT TASIATTLSS TSLSIPERSP SETSEQPRYR
    560 570 580 590 600
    RRTQSSGQDG RPQEEPPAEE DLQQITVQVE PACSVEIVVP KEEDAGVEAS
    610 620 630 640 650
    PAGASAAVEV ETASQASDEE GAPASQASDE EDAPATDIYF PTDERSWVYS
    660
    PLHYSAQAPP ASDGESDT
    Length:668
    Mass (Da):73,260
    Last modified:October 25, 2005 - v2
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i45A9FB32B4E43083
    GO
    Isoform 2 (identifier: O60331-2) [UniParc]FASTAAdd to basket
    Also known as: variant 700, PIPKIgamma-700, PIPKIgamma_i4

    The sequence of this isoform differs from the canonical sequence as follows:
         640-668: FPTDERSWVYSPLHYSAQAPPASDGESDT → FWRLWGPHAP...GAMSCCVSVS

    Show »
    Length:700
    Mass (Da):76,620
    Checksum:iD3E3DC89BDF2E868
    GO
    Isoform 3 (identifier: O60331-3) [UniParc]FASTAAdd to basket
    Also known as: variant 707, PIPKIgamma-707, PIPKIgamma_i5

    The sequence of this isoform differs from the canonical sequence as follows:
         641-668: PTDERSWVYSPLHYSAQAPPASDGESDT → FTDGRYWIYS...TSVVFQKGFG

    Show »
    Length:707
    Mass (Da):77,484
    Checksum:i42BC87A1C20A5037
    GO
    Isoform 4 (identifier: O60331-4) [UniParc]FASTAAdd to basket
    Also known as: PIPKIgamma-87, PIPKIgamma-640, PIPkinIgamma-b, PIPKIgamma_i1

    The sequence of this isoform differs from the canonical sequence as follows:
         641-668: Missing.

    Show »
    Length:640
    Mass (Da):70,214
    Checksum:i197B427BF16392C8
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    A0A7P0T808A0A7P0T808_HUMAN
    Phosphatidylinositol 4-phosphate 5-...
    PIP5K1C
    694Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A0A7P0TAE7A0A7P0TAE7_HUMAN
    Phosphatidylinositol 4-phosphate 5-...
    PIP5K1C
    204Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    <p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

    The sequence BAA25515 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti236V → M in BAH14283 (PubMed:14702039).Curated1

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Natural variantiVAR_036996253D → N in LCCS3; loss of activity. 1 PublicationCorresponds to variant dbSNP:rs121908315EnsemblClinVar.1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_042078640 – 668FPTDE…GESDT → FWRLWGPHAPTWPWRREGRA ACLCPYPPHVVTPFPGTGLC ASWSPDGTGGLGAMSCCVSV S in isoform 2. 1 PublicationAdd BLAST29
    Alternative sequenceiVSP_042080641 – 668PTDER…GESDT → FTDGRYWIYSPRHRRLRAVT LSASGTVSDRSRPPWGEGAV PLGQQGAAGPRPEAQCLTSV VFQKGFG in isoform 3. 1 PublicationAdd BLAST28
    Alternative sequenceiVSP_042079641 – 668Missing in isoform 4. 1 PublicationAdd BLAST28

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    FJ965536 mRNA Translation: ACS73483.1
    FJ965537 mRNA Translation: ACS73484.1
    AB011161 mRNA Translation: BAA25515.1 Different initiation.
    AK315912 mRNA Translation: BAH14283.1
    AC005542 Genomic DNA Translation: AAC32904.1
    AC093071 Genomic DNA No translation available.
    AC004637 Genomic DNA No translation available.

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS32872.1 [O60331-1]
    CCDS56074.1 [O60331-4]
    CCDS74257.1 [O60331-3]

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_001182662.1, NM_001195733.1 [O60331-4]
    NP_001287778.1, NM_001300849.1 [O60331-3]
    NP_036530.1, NM_012398.2 [O60331-1]

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000335312; ENSP00000335333; ENSG00000186111 [O60331-1]
    ENST00000537021; ENSP00000444779; ENSG00000186111 [O60331-2]
    ENST00000539785; ENSP00000445992; ENSG00000186111 [O60331-4]
    ENST00000589578; ENSP00000466363; ENSG00000186111 [O60331-3]

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    23396

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:23396

    UCSC genome browser

    More...
    UCSCi
    uc002lyj.3, human [O60331-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    FJ965536 mRNA Translation: ACS73483.1
    FJ965537 mRNA Translation: ACS73484.1
    AB011161 mRNA Translation: BAA25515.1 Different initiation.
    AK315912 mRNA Translation: BAH14283.1
    AC005542 Genomic DNA Translation: AAC32904.1
    AC093071 Genomic DNA No translation available.
    AC004637 Genomic DNA No translation available.
    CCDSiCCDS32872.1 [O60331-1]
    CCDS56074.1 [O60331-4]
    CCDS74257.1 [O60331-3]
    RefSeqiNP_001182662.1, NM_001195733.1 [O60331-4]
    NP_001287778.1, NM_001300849.1 [O60331-3]
    NP_036530.1, NM_012398.2 [O60331-1]

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...
    PDBei

    Protein Data Bank RCSB

    More...
    RCSB PDBi

    Protein Data Bank Japan

    More...
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    2G35NMR-B646-653[»]
    3H1ZX-ray1.83P639-653[»]
    3H85X-ray2.60P646-653[»]
    SMRiO60331
    ModBaseiSearch...
    PDBe-KBiSearch...

    Protein-protein interaction databases

    BioGRIDi116969, 30 interactors
    DIPiDIP-39809N
    IntActiO60331, 9 interactors
    STRINGi9606.ENSP00000466363

    Chemistry databases

    BindingDBiO60331
    ChEMBLiCHEMBL1908383
    DrugCentraliO60331
    SwissLipidsiSLP:000000551 [O60331-4]

    PTM databases

    iPTMnetiO60331
    PhosphoSitePlusiO60331
    SwissPalmiO60331

    Genetic variation databases

    BioMutaiPIP5K1C

    Proteomic databases

    EPDiO60331
    jPOSTiO60331
    MassIVEiO60331
    MaxQBiO60331
    PaxDbiO60331
    PeptideAtlasiO60331
    PRIDEiO60331
    ProteomicsDBi49349 [O60331-1]
    49350 [O60331-2]
    49351 [O60331-3]
    49352 [O60331-4]

    Protocols and materials databases

    Antibodypedia a portal for validated antibodies

    More...
    Antibodypediai
    2779, 230 antibodies

    The DNASU plasmid repository

    More...
    DNASUi
    23396

    Genome annotation databases

    EnsembliENST00000335312; ENSP00000335333; ENSG00000186111 [O60331-1]
    ENST00000537021; ENSP00000444779; ENSG00000186111 [O60331-2]
    ENST00000539785; ENSP00000445992; ENSG00000186111 [O60331-4]
    ENST00000589578; ENSP00000466363; ENSG00000186111 [O60331-3]
    GeneIDi23396
    KEGGihsa:23396
    UCSCiuc002lyj.3, human [O60331-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    23396
    DisGeNETi23396

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    PIP5K1C
    HGNCiHGNC:8996, PIP5K1C
    HPAiENSG00000186111, Low tissue specificity
    MalaCardsiPIP5K1C
    MIMi606102, gene
    611369, phenotype
    neXtProtiNX_O60331
    OpenTargetsiENSG00000186111
    Orphaneti137783, Lethal congenital contracture syndrome type 3
    PharmGKBiPA33329
    VEuPathDBiHostDB:ENSG00000186111.8

    Human Unidentified Gene-Encoded large proteins database

    More...
    HUGEi
    Search...

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG0229, Eukaryota
    GeneTreeiENSGT00940000159258
    HOGENOMiCLU_004312_5_1_1
    InParanoidiO60331
    OMAiDIYFFPD
    OrthoDBi296899at2759
    PhylomeDBiO60331
    TreeFamiTF319618

    Enzyme and pathway databases

    BioCyciMetaCyc:HS02710-MONOMER
    BRENDAi2.7.1.68, 2681
    PathwayCommonsiO60331
    ReactomeiR-HSA-1660499, Synthesis of PIPs at the plasma membrane
    R-HSA-399955, SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
    R-HSA-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
    R-HSA-8856828, Clathrin-mediated endocytosis
    SIGNORiO60331

    Miscellaneous databases

    BioGRID ORCS database of CRISPR phenotype screens

    More...
    BioGRID-ORCSi
    23396, 13 hits in 996 CRISPR screens

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...
    ChiTaRSi
    PIP5K1C, human
    EvolutionaryTraceiO60331

    The Gene Wiki collection of pages on human genes and proteins

    More...
    GeneWikii
    PIP5K1C

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    23396
    PharosiO60331, Tchem

    Protein Ontology

    More...
    PROi
    PR:O60331
    RNActiO60331, protein

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000186111, Expressed in right hemisphere of cerebellum and 242 other tissues
    GenevisibleiO60331, HS

    Family and domain databases

    Gene3Di3.30.800.10, 1 hit
    3.30.810.10, 2 hits
    IDEALiIID00359
    InterProiView protein in InterPro
    IPR023610, PInositol-4-P-5-kinase
    IPR027483, PInositol-4-P-5-kinase_C
    IPR002498, PInositol-4-P-5-kinase_core
    IPR027484, PInositol-4-P-5-kinase_N
    PANTHERiPTHR23086, PTHR23086, 1 hit
    PfamiView protein in Pfam
    PF01504, PIP5K, 1 hit
    SMARTiView protein in SMART
    SM00330, PIPKc, 1 hit
    PROSITEiView protein in PROSITE
    PS51455, PIPK, 1 hit

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPI51C_HUMAN
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O60331
    Secondary accession number(s): B7Z9E7
    , C6GIJ7, C6GIJ8, Q7LE07
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2005
    Last sequence update: October 25, 2005
    Last modified: June 2, 2021
    This is version 167 of the entry and version 2 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with genetic variants
      List of human entries with genetic variants
    3. Human variants curated from literature reports
      Index of human variants curated from literature reports
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
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