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Protein

Protocadherin gamma-A12

Gene

PCDHGA12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

GO - Molecular functioni

GO - Biological processi

  • cell adhesion Source: GO_Central
  • homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro

Keywordsi

Biological processCell adhesion
LigandCalcium

Names & Taxonomyi

Protein namesi
Recommended name:
Protocadherin gamma-A12
Short name:
PCDH-gamma-A12
Alternative name(s):
Cadherin-21
Fibroblast cadherin-3
Gene namesi
Name:PCDHGA12
Synonyms:CDH21, FIB3, KIAA0588
ORF Names:UNQ371/PRO707
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000253159.2
HGNCiHGNC:8699 PCDHGA12
MIMi603059 gene
604968 gene
neXtProtiNX_O60330

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini30 – 692ExtracellularSequence analysisAdd BLAST663
Transmembranei693 – 713HelicalSequence analysisAdd BLAST21
Topological domaini714 – 932CytoplasmicSequence analysisAdd BLAST219

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000253159
PharmGKBiPA33047

Polymorphism and mutation databases

BioMutaiPCDHGA12

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_000000397030 – 932Protocadherin gamma-A12Add BLAST903

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi265N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi419N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi545N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiO60330
MaxQBiO60330
PaxDbiO60330
PeptideAtlasiO60330
PRIDEiO60330
ProteomicsDBi49346
49347 [O60330-2]

PTM databases

iPTMnetiO60330
PhosphoSitePlusiO60330

Expressioni

Gene expression databases

BgeeiENSG00000253159 Expressed in 90 organ(s), highest expression level in putamen
GenevisibleiO60330 HS

Organism-specific databases

HPAiHPA008755
HPA010580

Interactioni

Protein-protein interaction databases

BioGridi117494, 3 interactors

Structurei

3D structure databases

ProteinModelPortaliO60330
SMRiO60330
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 133Cadherin 1PROSITE-ProRule annotationAdd BLAST104
Domaini134 – 242Cadherin 2PROSITE-ProRule annotationAdd BLAST109
Domaini243 – 347Cadherin 3PROSITE-ProRule annotationAdd BLAST105
Domaini348 – 452Cadherin 4PROSITE-ProRule annotationAdd BLAST105
Domaini453 – 562Cadherin 5PROSITE-ProRule annotationAdd BLAST110
Domaini570 – 683Cadherin 6PROSITE-ProRule annotationAdd BLAST114

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594 Eukaryota
ENOG410XQHI LUCA
GeneTreeiENSGT00900000140770
HOGENOMiHOG000220892
HOVERGENiHBG054878
InParanoidiO60330
KOiK16495
OMAiSTQIRYS
OrthoDBiEOG091G024L
PhylomeDBiO60330
TreeFamiTF332299

Family and domain databases

InterProiView protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR032455 Cadherin_C
IPR031904 Cadherin_CBD
IPR020894 Cadherin_CS
IPR013164 Cadherin_N
PfamiView protein in Pfam
PF00028 Cadherin, 5 hits
PF08266 Cadherin_2, 1 hit
PF16492 Cadherin_C_2, 1 hit
PF15974 Cadherin_tail, 1 hit
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 6 hits
SUPFAMiSSF49313 SSF49313, 6 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 5 hits
PS50268 CADHERIN_2, 6 hits

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: O60330-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MIPARLHRDY KGLVLLGILL GTLWETGCTQ IRYSVPEELE KGSRVGDISR
60 70 80 90 100
DLGLEPRELA ERGVRIIPRG RTQLFALNPR SGSLVTAGRI DREELCMGAI
110 120 130 140 150
KCQLNLDILM EDKVKIYGVE VEVRDINDNA PYFRESELEI KISENAATEM
160 170 180 190 200
RFPLPHAWDP DIGKNSLQSY ELSPNTHFSL IVQNGADGSK YPELVLKRAL
210 220 230 240 250
DREEKAAHHL VLTASDGGDP VRTGTARIRV MVLDANDNAP AFAQPEYRAS
260 270 280 290 300
VPENLALGTQ LLVVNATDPD EGVNAEVRYS FRYVDDKAAQ VFKLDCNSGT
310 320 330 340 350
ISTIGELDHE ESGFYQMEVQ AMDNAGYSAR AKVLITVLDV NDNAPEVVLT
360 370 380 390 400
SLASSVPENS PRGTLIALLN VNDQDSEENG QVICFIQGNL PFKLEKSYGN
410 420 430 440 450
YYSLVTDIVL DREQVPSYNI TVTATDRGTP PLSTETHISL NVADTNDNPP
460 470 480 490 500
VFPQASYSAY IPENNPRGVS LVSVTAHDPD CEENAQITYS LAENTIQGAS
510 520 530 540 550
LSSYVSINSD TGVLYALSSF DYEQFRDLQV KVMARDNGHP PLSSNVSLSL
560 570 580 590 600
FVLDQNDNAP EILYPALPTD GSTGVELAPR SAEPGYLVTK VVAVDRDSGQ
610 620 630 640 650
NAWLSYRLLK ASEPGLFSVG LHTGEVRTAR ALLDRDALKQ SLVVAVQDHG
660 670 680 690 700
QPPLSATVTL TVAVADSIPQ VLADLGSLES PANSETSDLT LYLVVAVAAV
710 720 730 740 750
SCVFLAFVIL LLALRLRRWH KSRLLQASGG GLTGAPASHF VGVDGVQAFL
760 770 780 790 800
QTYSHEVSLT TDSRKSHLIF PQPNYADMLV SQESFEKSEP LLLSGDSVFS
810 820 830 840 850
KDSHGLIEQA PPNTDWRFSQ AQRPGTSGSQ NGDDTGTWPN NQFDTEMLQA
860 870 880 890 900
MILASASEAA DGSSTLGGGA GTMGLSARYG PQFTLQHVPD YRQNVYIPGS
910 920 930
NATLTNAAGK RDGKAPAGGN GNKKKSGKKE KK
Length:932
Mass (Da):100,955
Last modified:August 1, 1998 - v1
Checksum:i8BDA90084785D746
GO
Isoform 2 (identifier: O60330-2) [UniParc]FASTAAdd to basket
Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     809-820: QAPPNTDWRFSQ → VSLYQIFFLFFF
     821-932: Missing.

Show »
Length:820
Mass (Da):89,582
Checksum:i5ED08F61B9BA30FB
GO

Sequence cautioni

The sequence AAQ89305 differs from that shown. Probable cloning artifact.Curated
The sequence BAA25514 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti331A → P in BAA21135 (PubMed:9199196).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_008682809 – 820QAPPN…WRFSQ → VSLYQIFFLFFF in isoform 2. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_008683821 – 932Missing in isoform 2. 1 PublicationAdd BLAST112

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF152321 mRNA Translation: AAD43715.1
AF152506 mRNA Translation: AAD43767.1
AB011160 mRNA Translation: BAA25514.2 Different initiation.
AY358946 mRNA Translation: AAQ89305.1 Sequence problems.
AB000897 mRNA Translation: BAA21135.1
CCDSiCCDS4260.1 [O60330-1]
CCDS75346.1 [O60330-2]
PIRiPC4299
RefSeqiNP_003726.1, NM_003735.2 [O60330-1]
NP_115265.1, NM_032094.1 [O60330-2]
UniGeneiHs.368160

Genome annotation databases

EnsembliENST00000252085; ENSP00000252085; ENSG00000253159 [O60330-1]
ENST00000613314; ENSP00000481438; ENSG00000253159 [O60330-2]
GeneIDi26025
KEGGihsa:26025
UCSCiuc003lkt.3 human [O60330-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF152321 mRNA Translation: AAD43715.1
AF152506 mRNA Translation: AAD43767.1
AB011160 mRNA Translation: BAA25514.2 Different initiation.
AY358946 mRNA Translation: AAQ89305.1 Sequence problems.
AB000897 mRNA Translation: BAA21135.1
CCDSiCCDS4260.1 [O60330-1]
CCDS75346.1 [O60330-2]
PIRiPC4299
RefSeqiNP_003726.1, NM_003735.2 [O60330-1]
NP_115265.1, NM_032094.1 [O60330-2]
UniGeneiHs.368160

3D structure databases

ProteinModelPortaliO60330
SMRiO60330
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117494, 3 interactors

PTM databases

iPTMnetiO60330
PhosphoSitePlusiO60330

Polymorphism and mutation databases

BioMutaiPCDHGA12

Proteomic databases

EPDiO60330
MaxQBiO60330
PaxDbiO60330
PeptideAtlasiO60330
PRIDEiO60330
ProteomicsDBi49346
49347 [O60330-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000252085; ENSP00000252085; ENSG00000253159 [O60330-1]
ENST00000613314; ENSP00000481438; ENSG00000253159 [O60330-2]
GeneIDi26025
KEGGihsa:26025
UCSCiuc003lkt.3 human [O60330-1]

Organism-specific databases

CTDi26025
EuPathDBiHostDB:ENSG00000253159.2
GeneCardsiPCDHGA12
HGNCiHGNC:8699 PCDHGA12
HPAiHPA008755
HPA010580
MIMi603059 gene
604968 gene
neXtProtiNX_O60330
OpenTargetsiENSG00000253159
PharmGKBiPA33047
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3594 Eukaryota
ENOG410XQHI LUCA
GeneTreeiENSGT00900000140770
HOGENOMiHOG000220892
HOVERGENiHBG054878
InParanoidiO60330
KOiK16495
OMAiSTQIRYS
OrthoDBiEOG091G024L
PhylomeDBiO60330
TreeFamiTF332299

Miscellaneous databases

GeneWikiiPCDHGA12
GenomeRNAii26025
PROiPR:O60330
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000253159 Expressed in 90 organ(s), highest expression level in putamen
GenevisibleiO60330 HS

Family and domain databases

InterProiView protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR032455 Cadherin_C
IPR031904 Cadherin_CBD
IPR020894 Cadherin_CS
IPR013164 Cadherin_N
PfamiView protein in Pfam
PF00028 Cadherin, 5 hits
PF08266 Cadherin_2, 1 hit
PF16492 Cadherin_C_2, 1 hit
PF15974 Cadherin_tail, 1 hit
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 6 hits
SUPFAMiSSF49313 SSF49313, 6 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 5 hits
PS50268 CADHERIN_2, 6 hits
ProtoNetiSearch...

Entry informationi

Entry nameiPCDGC_HUMAN
AccessioniPrimary (citable) accession number: O60330
Secondary accession number(s): O15100, Q6UW70, Q9Y5D7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: August 1, 1998
Last modified: November 7, 2018
This is version 151 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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