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Protein

Germinal-center associated nuclear protein

Gene

MCM3AP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Isoform GANP: Essential for the generation of high-affinity B-cells against T-cell-dependent antigens by affecting somatic hypermutation at the IgV-regions. May have stimulation-dependent DNA primase activity that would generate extra RNA primers in very rapidely proliferating cells and would support clonal expansion of differentiating B-cells (By similarity). Involved in the nuclear export of poly(A)-containing mRNAs by acting as a scaffold for the TREX-2 complex. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery.By similarity1 Publication
Isoform MCM3AP: Acetyltransferase targeting MCM3. Inhibits initiation of DNA replication, but not elongation.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processImmunity, mRNA transport, Protein transport, Translocation, Transport

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.I.1.1.3 the eukaryotic nuclear pore complex (e-npc) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Germinal-center associated nuclear protein
Short name:
GANP
Alternative name(s):
80 kDa MCM3-associated protein
MCM3 acetylating protein (EC:2.3.1.-)
Short name:
MCM3AP
MCM3 acetyltransferase
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MCM3AP
Synonyms:GANP, KIAA0572, MAP80
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 21

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000160294.10

Human Gene Nomenclature Database

More...
HGNCi
HGNC:6946 MCM3AP

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
603294 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O60318

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nuclear pore complex, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi1730 – 1733HGAG → AAAA: Severely decreased MCM3 acetylating activity. 1 Publication4

Organism-specific databases

DisGeNET

More...
DisGeNETi
8888

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
MCM3AP

MalaCards human disease database

More...
MalaCardsi
MCM3AP

Open Targets

More...
OpenTargetsi
ENSG00000160294

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA30692

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MCM3AP

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000962841 – 1980Germinal-center associated nuclear proteinAdd BLAST1980

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei32Asymmetric dimethylarginineBy similarity1
Modified residuei430PhosphoserineCombined sources1
Modified residuei489N6-acetyllysineBy similarity1
Modified residuei490N6-acetyllysineBy similarity1
Modified residuei508PhosphoserineBy similarity1
Modified residuei538PhosphoserineCombined sources1
Modified residuei557PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation at Ser-508 by CDKs is required for DNA primase activity.By similarity

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O60318

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
O60318

MaxQB - The MaxQuant DataBase

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MaxQBi
O60318

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
O60318

PeptideAtlas

More...
PeptideAtlasi
O60318

PRoteomics IDEntifications database

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PRIDEi
O60318

ProteomicsDB human proteome resource

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ProteomicsDBi
49343

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
O60318

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
O60318

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000160294 Expressed in 222 organ(s), highest expression level in tendon

CleanEx database of gene expression profiles

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CleanExi
HS_MCM3AP

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
O60318 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
O60318 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA021527
HPA032103

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with AICDA/AID (By similarity). Component of the nuclear pore complex (NPC)-associated TREX-2 complex (transcription and export complex 2), composed of at least GANP, two copies of ENY2, PCID2, SEM1, and either centrin CETN2 or CETN3. Isoform MCM3AP interacts with MCM3. Interacts with NXF1 (By via FG-repeats).By similarity3 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
114406, 61 interactors

Database of interacting proteins

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DIPi
DIP-31696N

Protein interaction database and analysis system

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IntActi
O60318, 38 interactors

Molecular INTeraction database

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MINTi
O60318

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000291688

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11980
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4DHXX-ray2.10A/D1163-1235[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
O60318

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O60318

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini775 – 958PCIPROSITE-ProRule annotationAdd BLAST184

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni33 – 340FG-repeatsAdd BLAST308
Regioni421 – 557DNA primaseAdd BLAST137
Regioni1162 – 1256CIDAdd BLAST95
Regioni1658 – 1790AcetyltransferaseAdd BLAST133

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1133 – 1170Sequence analysisAdd BLAST38

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SAC3 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1860 Eukaryota
COG5079 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156322

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000113500

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG102020

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
O60318

Identification of Orthologs from Complete Genome Data

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OMAi
NSSEVKF

Database of Orthologous Groups

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OrthoDBi
1593971at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
O60318

TreeFam database of animal gene trees

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TreeFami
TF105948

Family and domain databases

Conserved Domains Database

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CDDi
cd12443 RRM_MCM3A_like, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR031910 GANP_CID_dom
IPR031907 MCM3AP_GANP
IPR034265 MCM3AP_RRM
IPR031908 NupH_GANP
IPR000717 PCI_dom
IPR035979 RBD_domain_sf
IPR005062 SAC3/GANP/THP3

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16766 CID_GANP, 1 hit
PF16769 MCM3AP_GANP, 1 hit
PF16768 NupH_GANP, 1 hit
PF03399 SAC3_GANP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54928 SSF54928, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50250 PCI, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative promoter usage. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform GANP (identifier: O60318-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNPTNPFSGQ QPSAFSASSS NVGTLPSKPP FRFGQPSLFG QNSTLSGKSS
60 70 80 90 100
GFSQVSSFPA SSGVSHSSSV QTLGFTQTSS VGPFSGLEHT STFVATSGPS
110 120 130 140 150
SSSVLGNTGF SFKSPTSVGA FPSTSAFGQE AGEIVNSGFG KTEFSFKPLE
160 170 180 190 200
NAVFKPILGA ESEPEKTQSQ IASGFFTFSH PISSAPGGLA PFSFPQVTSS
210 220 230 240 250
SATTSNFTFS KPVSSNNSLS AFTPALSNQN VEEEKRGPKS IFGSSNNSFS
260 270 280 290 300
SFPVSSAVLG EPFQASKAGV RQGCEEAVSQ VEPLPSLMKG LKRKEDQDRS
310 320 330 340 350
PRRHGHEPAE DSDPLSRGDH PPDKRPVRLN RPRGGTLFGR TIQDVFKSNK
360 370 380 390 400
EVGRLGNKEA KKETGFVESA ESDHMAIPGG NQSVLAPSRI PGVNKEEETE
410 420 430 440 450
SREKKEDSLR GTPARQSNRS ESTDSLGGLS PSEVTAIQCK NIPDYLNDRT
460 470 480 490 500
ILENHFGKIA KVQRIFTRRS KKLAVVHFFD HASAALARKK GKSLHKDMAI
510 520 530 540 550
FWHRKKISPN KKPFSLKEKK PGDGEVSPST EDAPFQHSPL GKAAGRTGAS
560 570 580 590 600
SLLNKSSPVK KPSLLKAHQF EGDSFDSASE GSEGLGPCVL SLSTLIGTVA
610 620 630 640 650
ETSKEKYRLL DQRDRIMRQA RVKRTDLDKA RTFVGTCLDM CPEKERYMRE
660 670 680 690 700
TRSQLSVFEV VPGTDQVDHA AAVKEYSRSS ADQEEPLPHE LRPLPVLSRT
710 720 730 740 750
MDYLVTQIMD QKEGSLRDWY DFVWNRTRGI RKDITQQHLC DPLTVSLIEK
760 770 780 790 800
CTRFHIHCAH FMCEEPMSSF DAKINNENMT KCLQSLKEMY QDLRNKGVFC
810 820 830 840 850
ASEAEFQGYN VLLSLNKGDI LREVQQFHPA VRNSSEVKFA VQAFAALNSN
860 870 880 890 900
NFVRFFKLVQ SASYLNACLL HCYFSQIRKD ALRALNFAYT VSTQRSTIFP
910 920 930 940 950
LDGVVRMLLF RDCEEATDFL TCHGLTVSDG CVELNRSAFL EPEGLSKTRK
960 970 980 990 1000
SVFITRKLTV SVGEIVNGGP LPPVPRHTPV CSFNSQNKYI GESLAAELPV
1010 1020 1030 1040 1050
STQRPGSDTV GGGRGEECGV EPDAPLSSLP QSLPAPAPSP VPLPPVLALT
1060 1070 1080 1090 1100
PSVAPSLFQL SVQPEPPPPE PVPMYSDEDL AQVVDELIQE ALQRDCEEVG
1110 1120 1130 1140 1150
SAGAAYAAAA LGVSNAAMED LLTAATTGIL RHIAAEEVSK ERERREQERQ
1160 1170 1180 1190 1200
RAEEERLKQE RELVLSELSQ GLAVELMERV MMEFVRETCS QELKNAVETD
1210 1220 1230 1240 1250
QRVRVARCCE DVCAHLVDLF LVEEIFQTAK ETLQELQCFC KYLQRWREAV
1260 1270 1280 1290 1300
TARKKLRRQM RAFPAAPCCV DVSDRLRALA PSAECPIAEE NLARGLLDLG
1310 1320 1330 1340 1350
HAGRLGISCT RLRRLRNKTA HQMKVQHFYQ QLLSDVAWAS LDLPSLVAEH
1360 1370 1380 1390 1400
LPGRQEHVFW KLVLVLPDVE EQSPESCGRI LANWLKVKFM GDEGSVDDTS
1410 1420 1430 1440 1450
SDAGGIQTLS LFNSLSSKGD QMISVNVCIK VAHGALSDGA IDAVETQKDL
1460 1470 1480 1490 1500
LGASGLMLLL PPKMKSEDMA EEDVYWLSAL LQLKQLLQAK PFQPALPLVV
1510 1520 1530 1540 1550
LVPSPGGDAV EKEVEDGLML QDLVSAKLIS DYTVTEIPDT INDLQGSTKV
1560 1570 1580 1590 1600
LQAVQWLVSH CPHSLDLCCQ TLIQYVEDGI GHEFSGRFFH DRRERRLGGL
1610 1620 1630 1640 1650
ASQEPGAIIE LFNSVLQFLA SVVSSEQLCD LSWPVTEFAE AGGSRLLPHL
1660 1670 1680 1690 1700
HWNAPEHLAW LKQAVLGFQL PQMDLPPLGA PWLPVCSMVV QYASQIPSSR
1710 1720 1730 1740 1750
QTQPVLQSQV ENLLHRTYCR WKSKSPSPVH GAGPSVMEIP WDDLIALCIN
1760 1770 1780 1790 1800
HKLRDWTPPR LPVTSEALSE DGQICVYFFK NDLKKYDVPL SWEQARLQTQ
1810 1820 1830 1840 1850
KELQLREGRL AIKPFHPSAN NFPIPLLHMH RNWKRSTECA QEGRIPSTED
1860 1870 1880 1890 1900
LMRGASAEEL LAQCLSSSLL LEKEENKRFE DQLQQWLSED SGAFTDLTSL
1910 1920 1930 1940 1950
PLYLPQTLVS LSHTIEPVMK TSVTTSPQSD MMREQLQLSE ATGTCLGERL
1960 1970 1980
KHLERLIRSS REEEVASELH LSALLDMVDI
Length:1,980
Mass (Da):218,405
Last modified:May 30, 2000 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i503D192686FC38A8
GO
Isoform MCM3AP (identifier: O60318-2) [UniParc]FASTAAdd to basket
Also known as: 80 kDa MCM3-associated protein

The sequence of this isoform differs from the canonical sequence as follows:
     1-1259: Missing.

Note: Produced via an alternative promoter within an intron of GANP. MCM3AP promoter elements are poorly conserved in mice, suggesting that the regulation of MCM3AP may be human specific.
Show »
Length:721
Mass (Da):80,292
Checksum:i6D50E6EEBB6257C1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MSZ7A0A0A0MSZ7_HUMAN
Germinal-center-associated nuclear ...
MCM3AP
94Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_019240102S → L2 PublicationsCorresponds to variant dbSNP:rs9975588Ensembl.1
Natural variantiVAR_019241288M → V1 PublicationCorresponds to variant dbSNP:rs17182545Ensembl.1
Natural variantiVAR_019242333R → L1 PublicationCorresponds to variant dbSNP:rs17182552Ensembl.1
Natural variantiVAR_035472409L → V in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs773228537Ensembl.1
Natural variantiVAR_019243413P → L1 PublicationCorresponds to variant dbSNP:rs17182566Ensembl.1
Natural variantiVAR_070560915E → K Found in a patient with border-line to mild intellectual disability, progressive polyneuropathy and ptosis; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs483352869EnsemblClinVar.1
Natural variantiVAR_0192441051P → L1 PublicationCorresponds to variant dbSNP:rs17182850Ensembl.1
Natural variantiVAR_0192451062V → M1 PublicationCorresponds to variant dbSNP:rs17182857Ensembl.1
Natural variantiVAR_0192461314R → W1 PublicationCorresponds to variant dbSNP:rs17176709Ensembl.1
Natural variantiVAR_0192471449D → E1 PublicationCorresponds to variant dbSNP:rs17183220Ensembl.1
Natural variantiVAR_0192481576V → I2 PublicationsCorresponds to variant dbSNP:rs17183248Ensembl.1
Natural variantiVAR_0192491795A → T1 PublicationCorresponds to variant dbSNP:rs17183290Ensembl.1
Natural variantiVAR_0539731831R → C. Corresponds to variant dbSNP:rs2298697Ensembl.1
Natural variantiVAR_0192501870L → R1 PublicationCorresponds to variant dbSNP:rs17176933Ensembl.1
Natural variantiVAR_0192511941A → V1 PublicationCorresponds to variant dbSNP:rs17183403Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0534381 – 1259Missing in isoform MCM3AP. CuratedAdd BLAST1259

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ010089 mRNA Translation: CAB52687.1
AY590469 Genomic DNA Translation: AAS89300.1
AP000471 Genomic DNA No translation available.
AP001469 Genomic DNA No translation available.
BC013285 mRNA Translation: AAH13285.2
BC004497 mRNA Translation: AAH04497.2
BC104958 mRNA Translation: AAI04959.1
BC104960 mRNA Translation: AAI04961.1
AB011144 mRNA Translation: BAA25498.1
AB005543 mRNA Translation: BAA25170.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS13734.1 [O60318-1]

Protein sequence database of the Protein Information Resource

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PIRi
T00339

NCBI Reference Sequences

More...
RefSeqi
NP_003897.2, NM_003906.4 [O60318-1]
XP_005261260.1, XM_005261203.4 [O60318-1]
XP_005261261.1, XM_005261204.4 [O60318-1]
XP_005261262.1, XM_005261205.3 [O60318-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.389037
Hs.592438

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000291688; ENSP00000291688; ENSG00000160294 [O60318-1]
ENST00000397708; ENSP00000380820; ENSG00000160294 [O60318-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
8888

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:8888

UCSC genome browser

More...
UCSCi
uc002zir.3 human [O60318-1]

Keywords - Coding sequence diversityi

Alternative promoter usage, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ010089 mRNA Translation: CAB52687.1
AY590469 Genomic DNA Translation: AAS89300.1
AP000471 Genomic DNA No translation available.
AP001469 Genomic DNA No translation available.
BC013285 mRNA Translation: AAH13285.2
BC004497 mRNA Translation: AAH04497.2
BC104958 mRNA Translation: AAI04959.1
BC104960 mRNA Translation: AAI04961.1
AB011144 mRNA Translation: BAA25498.1
AB005543 mRNA Translation: BAA25170.1
CCDSiCCDS13734.1 [O60318-1]
PIRiT00339
RefSeqiNP_003897.2, NM_003906.4 [O60318-1]
XP_005261260.1, XM_005261203.4 [O60318-1]
XP_005261261.1, XM_005261204.4 [O60318-1]
XP_005261262.1, XM_005261205.3 [O60318-1]
UniGeneiHs.389037
Hs.592438

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4DHXX-ray2.10A/D1163-1235[»]
ProteinModelPortaliO60318
SMRiO60318
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114406, 61 interactors
DIPiDIP-31696N
IntActiO60318, 38 interactors
MINTiO60318
STRINGi9606.ENSP00000291688

Protein family/group databases

TCDBi1.I.1.1.3 the eukaryotic nuclear pore complex (e-npc) family

PTM databases

iPTMnetiO60318
PhosphoSitePlusiO60318

Polymorphism and mutation databases

BioMutaiMCM3AP

Proteomic databases

EPDiO60318
jPOSTiO60318
MaxQBiO60318
PaxDbiO60318
PeptideAtlasiO60318
PRIDEiO60318
ProteomicsDBi49343

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000291688; ENSP00000291688; ENSG00000160294 [O60318-1]
ENST00000397708; ENSP00000380820; ENSG00000160294 [O60318-1]
GeneIDi8888
KEGGihsa:8888
UCSCiuc002zir.3 human [O60318-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8888
DisGeNETi8888
EuPathDBiHostDB:ENSG00000160294.10

GeneCards: human genes, protein and diseases

More...
GeneCardsi
MCM3AP
GeneReviewsiMCM3AP

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0016189
HGNCiHGNC:6946 MCM3AP
HPAiHPA021527
HPA032103
MalaCardsiMCM3AP
MIMi603294 gene
neXtProtiNX_O60318
OpenTargetsiENSG00000160294
PharmGKBiPA30692

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1860 Eukaryota
COG5079 LUCA
GeneTreeiENSGT00940000156322
HOGENOMiHOG000113500
HOVERGENiHBG102020
InParanoidiO60318
OMAiNSSEVKF
OrthoDBi1593971at2759
PhylomeDBiO60318
TreeFamiTF105948

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
MCM3AP human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
MCM3AP

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
8888

Protein Ontology

More...
PROi
PR:O60318

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000160294 Expressed in 222 organ(s), highest expression level in tendon
CleanExiHS_MCM3AP
ExpressionAtlasiO60318 baseline and differential
GenevisibleiO60318 HS

Family and domain databases

CDDicd12443 RRM_MCM3A_like, 1 hit
InterProiView protein in InterPro
IPR031910 GANP_CID_dom
IPR031907 MCM3AP_GANP
IPR034265 MCM3AP_RRM
IPR031908 NupH_GANP
IPR000717 PCI_dom
IPR035979 RBD_domain_sf
IPR005062 SAC3/GANP/THP3
PfamiView protein in Pfam
PF16766 CID_GANP, 1 hit
PF16769 MCM3AP_GANP, 1 hit
PF16768 NupH_GANP, 1 hit
PF03399 SAC3_GANP, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50250 PCI, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGANP_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O60318
Secondary accession number(s): C9JL56
, Q2M3C1, Q6PJP6, Q9BSY5, Q9UMT4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: January 16, 2019
This is version 161 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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