UniProtKB - O60315 (ZEB2_HUMAN)
Protein
Zinc finger E-box-binding homeobox 2
Gene
ZEB2
Organism
Homo sapiens (Human)
Status
Functioni
Transcriptional inhibitor that binds to DNA sequence 5'-CACCT-3' in different promoters (PubMed:16061479, PubMed:20516212). Represses transcription of E-cadherin (PubMed:16061479). Represses expression of MEOX2 (PubMed:20516212).2 Publications
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 211 – 234 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 241 – 263 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 282 – 304 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 310 – 334 | C2H2-type 4; atypicalPROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 581 – 605 | C2H2-type 5; atypicalPROSITE-ProRule annotationAdd BLAST | 25 | |
DNA bindingi | 644 – 703 | Homeobox; atypicalAdd BLAST | 60 | |
Zinc fingeri | 999 – 1021 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 1027 – 1049 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 1055 – 1076 | C2H2-type 8; atypicalPROSITE-ProRule annotationAdd BLAST | 22 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: BHF-UCL
- metal ion binding Source: UniProtKB-KW
- phosphatase regulator activity Source: UniProtKB
- sequence-specific DNA binding Source: BHF-UCL
GO - Biological processi
- developmental pigmentation Source: BHF-UCL
- melanocyte migration Source: BHF-UCL
- negative regulation of transcription by RNA polymerase II Source: BHF-UCL
- nervous system development Source: UniProtKB
- positive regulation of melanin biosynthetic process Source: BHF-UCL
- positive regulation of melanocyte differentiation Source: BHF-UCL
- positive regulation of transcription by RNA polymerase II Source: BHF-UCL
- regulation of melanosome organization Source: BHF-UCL
Keywordsi
Molecular function | DNA-binding, Repressor |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | O60315 |
SignaLinki | O60315 |
SIGNORi | O60315 |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger E-box-binding homeobox 2Alternative name(s): Smad-interacting protein 11 Publication Short name: SMADIP11 Publication Zinc finger homeobox protein 1b |
Gene namesi | ORF Names:HRIHFB2411 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:14881, ZEB2 |
MIMi | 605802, gene |
neXtProti | NX_O60315 |
VEuPathDBi | HostDB:ENSG00000169554.16 |
Subcellular locationi
Nucleus
- Nucleus 2 Publications
Other locations
- Chromosome 1 Publication
Cytosol
- cytosol Source: HPA
Nucleus
- nuclear chromatin Source: BHF-UCL
- nucleolus Source: HPA
- nucleoplasm Source: HPA
- nucleus Source: BHF-UCL
Keywords - Cellular componenti
Chromosome, NucleusPathology & Biotechi
Involvement in diseasei
Mowat-Wilson syndrome (MOWS)4 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA complex developmental disorder characterized by mental retardation, delayed motor development, epilepsy, microcephaly and a wide spectrum of clinically heterogeneous features suggestive of neurocristopathies at the cephalic, cardiac, and vagal levels. Affected patients show an easily recognizable facial appearance with deep set eyes and hypertelorism, medially divergent, broad eyebrows, prominent columella, pointed chin and uplifted, notched ear lobes. Some patients manifest Hirschsprung disease.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_027016 | 99 | Missing in MOWS. 1 Publication | 1 | |
Natural variantiVAR_027017 | 953 | R → G in MOWS. 1 Publication | 1 | |
Natural variantiVAR_027018 | 1119 | Q → R in MOWS. 1 PublicationCorresponds to variant dbSNP:rs137852983EnsemblClinVar. | 1 |
Keywords - Diseasei
Disease variant, Epilepsy, Hirschsprung disease, Mental retardationOrganism-specific databases
DisGeNETi | 9839 |
GeneReviewsi | ZEB2 |
MalaCardsi | ZEB2 |
MIMi | 235730, phenotype |
OpenTargetsi | ENSG00000169554 |
Orphaneti | 261552, Mowat-Wilson syndrome due to a ZEB2 point mutation 261537, Mowat-Wilson syndrome due to monosomy 2q22 |
PharmGKBi | PA162409612 |
Miscellaneous databases
Pharosi | O60315, Tbio |
Genetic variation databases
BioMutai | ZEB2 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047236 | 1 – 1214 | Zinc finger E-box-binding homeobox 2Add BLAST | 1214 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 142 | PhosphoserineCombined sources | 1 | |
Modified residuei | 356 | PhosphoserineBy similarity | 1 | |
Modified residuei | 360 | PhosphoserineCombined sources | 1 | |
Modified residuei | 364 | PhosphoserineBy similarity | 1 | |
Modified residuei | 377 | N6-acetyllysineCombined sources | 1 | |
Cross-linki | 391 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO); alternate | ||
Cross-linki | 391 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources | ||
Cross-linki | 479 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 555 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 611 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 632 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 647 | PhosphoserineCombined sources | 1 | |
Cross-linki | 713 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 731 | PhosphoserineBy similarity | 1 | |
Modified residuei | 780 | PhosphoserineBy similarity | 1 | |
Modified residuei | 782 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 784 | PhosphoserineCombined sources | 1 | |
Cross-linki | 866 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO); alternate | ||
Cross-linki | 866 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources | ||
Modified residuei | 1122 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1124 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1203 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Sumoylation on Lys-391 and Lys-866 is promoted by the E3 SUMO-protein ligase CBX4, and impairs interaction with CTBP1 and transcription repression activity.1 Publication
Keywords - PTMi
Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | O60315 |
jPOSTi | O60315 |
MassIVEi | O60315 |
MaxQBi | O60315 |
PaxDbi | O60315 |
PeptideAtlasi | O60315 |
PRIDEi | O60315 |
ProteomicsDBi | 27650 49342 [O60315-1] |
PTM databases
iPTMneti | O60315 |
PhosphoSitePlusi | O60315 |
Expressioni
Inductioni
Down-regulated by microRNA-221 (miR-221).1 Publication
Gene expression databases
Bgeei | ENSG00000169554, Expressed in corpus callosum and 238 other tissues |
ExpressionAtlasi | O60315, baseline and differential |
Genevisiblei | O60315, HS |
Organism-specific databases
HPAi | ENSG00000169554, Tissue enhanced (brain) |
Interactioni
Subunit structurei
Binds activated SMAD1, activated SMAD2 and activated SMAD3; binding with SMAD4 is not detected (By similarity).
Interacts with CBX4 and CTBP1.
By similarity1 PublicationBinary interactionsi
Hide detailsO60315
With | #Exp. | IntAct |
---|---|---|
EHMT2 [Q96KQ7] | 6 | EBI-717614,EBI-744366 |
MTA1 [Q13330] | 12 | EBI-717614,EBI-714236 |
MTA2 [O94776] | 4 | EBI-717614,EBI-1783035 |
Protein-protein interaction databases
BioGRIDi | 115175, 26 interactors |
CORUMi | O60315 |
ELMi | O60315 |
IntActi | O60315, 25 interactors |
MINTi | O60315 |
STRINGi | 9606.ENSP00000454157 |
Miscellaneous databases
RNActi | O60315, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
BMRBi | O60315 |
SMRi | O60315 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | O60315 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 437 – 487 | SMAD-MH2 binding domainBy similarityAdd BLAST | 51 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1084 – 1214 | Glu-rich (acidic)Add BLAST | 131 |
Sequence similaritiesi
Belongs to the delta-EF1/ZFH-1 C2H2-type zinc-finger family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 211 – 234 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 241 – 263 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 282 – 304 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 310 – 334 | C2H2-type 4; atypicalPROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 581 – 605 | C2H2-type 5; atypicalPROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 999 – 1021 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 1027 – 1049 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 1055 – 1076 | C2H2-type 8; atypicalPROSITE-ProRule annotationAdd BLAST | 22 |
Keywords - Domaini
Homeobox, Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG3623, Eukaryota |
GeneTreei | ENSGT00950000183208 |
HOGENOMi | CLU_005890_0_1_1 |
InParanoidi | O60315 |
OrthoDBi | 890458at2759 |
PhylomeDBi | O60315 |
TreeFami | TF331759 |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR008598, Di19_Zn-bd IPR009057, Homeobox-like_sf IPR001356, Homeobox_dom IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 3 hits PF05605, zf-Di19, 1 hit |
SMARTi | View protein in SMART SM00389, HOX, 1 hit SM00355, ZnF_C2H2, 8 hits |
SUPFAMi | SSF46689, SSF46689, 1 hit SSF57667, SSF57667, 4 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 5 hits PS50157, ZINC_FINGER_C2H2_2, 6 hits |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 25 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: O60315-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MKQPIMADGP RCKRRKQANP RRKNVVNYDN VVDTGSETDE EDKLHIAEDD
60 70 80 90 100
GIANPLDQET SPASVPNHES SPHVSQALLP REEEEDEIRE GGVEHPWHNN
110 120 130 140 150
EILQASVDGP EEMKEDYDTM GPEATIQTAI NNGTVKNANC TSDFEEYFAK
160 170 180 190 200
RKLEERDGHA VSIEEYLQRS DTAIIYPEAP EELSRLGTPE ANGQEENDLP
210 220 230 240 250
PGTPDAFAQL LTCPYCDRGY KRLTSLKEHI KYRHEKNEEN FSCPLCSYTF
260 270 280 290 300
AYRTQLERHM VTHKPGTDQH QMLTQGAGNR KFKCTECGKA FKYKHHLKEH
310 320 330 340 350
LRIHSGEKPY ECPNCKKRFS HSGSYSSHIS SKKCIGLISV NGRMRNNIKT
360 370 380 390 400
GSSPNSVSSS PTNSAITQLR NKLENGKPLS MSEQTGLLKI KTEPLDFNDY
410 420 430 440 450
KVLMATHGFS GTSPFMNGGL GATSPLGVHP SAQSPMQHLG VGMEAPLLGF
460 470 480 490 500
PTMNSNLSEV QKVLQIVDNT VSRQKMDCKA EEISKLKGYH MKDPCSQPEE
510 520 530 540 550
QGVTSPNIPP VGLPVVSHNG ATKSIIDYTL EKVNEAKACL QSLTTDSRRQ
560 570 580 590 600
ISNIKKEKLR TLIDLVTDDK MIENHNISTP FSCQFCKESF PGPIPLHQHE
610 620 630 640 650
RYLCKMNEEI KAVLQPHENI VPNKAGVFVD NKALLLSSVL SEKGMTSPIN
660 670 680 690 700
PYKDHMSVLK AYYAMNMEPN SDELLKISIA VGLPQEFVKE WFEQRKVYQY
710 720 730 740 750
SNSRSPSLER SSKPLAPNSN PPTKDSLLPR SPVKPMDSIT SPSIAELHNS
760 770 780 790 800
VTNCDPPLRL TKPSHFTNIK PVEKLDHSRS NTPSPLNLSS TSSKNSHSSS
810 820 830 840 850
YTPNSFSSEE LQAEPLDLSL PKQMKEPKSI IATKNKTKAS SISLDHNSVS
860 870 880 890 900
SSSENSDEPL NLTFIKKEFS NSNNLDNKST NPVFSMNPFS AKPLYTALPP
910 920 930 940 950
QSAFPPATFM PPVQTSIPGL RPYPGLDQMS FLPHMAYTYP TGAATFADMQ
960 970 980 990 1000
QRRKYQRKQG FQGELLDGAQ DYMSGLDDMT DSDSCLSRKK IKKTESGMYA
1010 1020 1030 1040 1050
CDLCDKTFQK SSSLLRHKYE HTGKRPHQCQ ICKKAFKHKH HLIEHSRLHS
1060 1070 1080 1090 1100
GEKPYQCDKC GKRFSHSGSY SQHMNHRYSY CKREAEEREA AEREAREKGH
1110 1120 1130 1140 1150
LEPTELLMNR AYLQSITPQG YSDSEERESM PRDGESEKEH EKEGEDGYGK
1160 1170 1180 1190 1200
LGRQDGDEEF EEEEEESENK SMDTDPETIR DEEETGDHSM DDSSEDGKME
1210
TKSDHEEDNM EDGM
Computationally mapped potential isoform sequencesi
There are 25 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A1B0GV02 | A0A1B0GV02_HUMAN | Zinc finger E-box-binding homeobox ... | ZEB2 | 1,239 | Annotation score: | ||
A0JP08 | A0JP08_HUMAN | Zinc finger E-box-binding homeobox ... | ZEB2 | 1,213 | Annotation score: | ||
A0A1B0GVV8 | A0A1B0GVV8_HUMAN | Zinc finger E-box-binding homeobox ... | ZEB2 | 1,102 | Annotation score: | ||
A0A1B0GW50 | A0A1B0GW50_HUMAN | Zinc finger E-box-binding homeobox ... | ZEB2 | 1,202 | Annotation score: | ||
E7EUW9 | E7EUW9_HUMAN | Zinc finger E-box-binding homeobox ... | ZEB2 | 731 | Annotation score: | ||
H7C0G0 | H7C0G0_HUMAN | Zinc finger E-box-binding homeobox ... | ZEB2 | 220 | Annotation score: | ||
U3KQ51 | U3KQ51_HUMAN | Zinc finger E-box-binding homeobox ... | ZEB2 | 955 | Annotation score: | ||
E7ESP8 | E7ESP8_HUMAN | Zinc finger E-box-binding homeobox ... | ZEB2 | 467 | Annotation score: | ||
A0A1X7SC99 | A0A1X7SC99_HUMAN | Zinc finger E-box-binding homeobox ... | ZEB2 | 612 | Annotation score: | ||
C9JUQ1 | C9JUQ1_HUMAN | Zinc finger E-box-binding homeobox ... | ZEB2 | 63 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence cautioni
The sequence BAA25495 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 1155 | D → G in BAH11928 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_027016 | 99 | Missing in MOWS. 1 Publication | 1 | |
Natural variantiVAR_027017 | 953 | R → G in MOWS. 1 Publication | 1 | |
Natural variantiVAR_035563 | 983 | D → N in a colorectal cancer sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_027018 | 1119 | Q → R in MOWS. 1 PublicationCorresponds to variant dbSNP:rs137852983EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_044797 | 111 – 134 | Missing in isoform 2. 1 PublicationAdd BLAST | 24 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY029472 Genomic DNA Translation: AAK52081.1 AB056507 mRNA Translation: BAB40819.1 AB011141 mRNA Translation: BAA25495.2 Different initiation. AK294928 mRNA Translation: BAH11928.1 AC009951 Genomic DNA No translation available. AC010130 Genomic DNA No translation available. BC127102 mRNA Translation: AAI27103.1 AB015341 mRNA Translation: BAA34798.1 |
CCDSi | CCDS2186.1 [O60315-1] CCDS54403.1 [O60315-2] |
RefSeqi | NP_001165124.1, NM_001171653.1 [O60315-2] NP_055610.1, NM_014795.3 [O60315-1] XP_006712944.1, XM_006712881.3 XP_006712945.1, XM_006712882.3 |
Genome annotation databases
Ensembli | ENST00000409487; ENSP00000386854; ENSG00000169554 [O60315-1] ENST00000539609; ENSP00000443792; ENSG00000169554 [O60315-2] ENST00000558170; ENSP00000454157; ENSG00000169554 [O60315-1] ENST00000627532; ENSP00000487174; ENSG00000169554 [O60315-1] |
GeneIDi | 9839 |
KEGGi | hsa:9839 |
UCSCi | uc002tvu.4, human [O60315-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY029472 Genomic DNA Translation: AAK52081.1 AB056507 mRNA Translation: BAB40819.1 AB011141 mRNA Translation: BAA25495.2 Different initiation. AK294928 mRNA Translation: BAH11928.1 AC009951 Genomic DNA No translation available. AC010130 Genomic DNA No translation available. BC127102 mRNA Translation: AAI27103.1 AB015341 mRNA Translation: BAA34798.1 |
CCDSi | CCDS2186.1 [O60315-1] CCDS54403.1 [O60315-2] |
RefSeqi | NP_001165124.1, NM_001171653.1 [O60315-2] NP_055610.1, NM_014795.3 [O60315-1] XP_006712944.1, XM_006712881.3 XP_006712945.1, XM_006712882.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2DA7 | NMR | - | A | 647-704 | [»] | |
BMRBi | O60315 | |||||
SMRi | O60315 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 115175, 26 interactors |
CORUMi | O60315 |
ELMi | O60315 |
IntActi | O60315, 25 interactors |
MINTi | O60315 |
STRINGi | 9606.ENSP00000454157 |
PTM databases
iPTMneti | O60315 |
PhosphoSitePlusi | O60315 |
Genetic variation databases
BioMutai | ZEB2 |
Proteomic databases
EPDi | O60315 |
jPOSTi | O60315 |
MassIVEi | O60315 |
MaxQBi | O60315 |
PaxDbi | O60315 |
PeptideAtlasi | O60315 |
PRIDEi | O60315 |
ProteomicsDBi | 27650 49342 [O60315-1] |
Protocols and materials databases
Antibodypediai | 18810, 625 antibodies |
CPTCi | O60315, 1 antibody |
Genome annotation databases
Ensembli | ENST00000409487; ENSP00000386854; ENSG00000169554 [O60315-1] ENST00000539609; ENSP00000443792; ENSG00000169554 [O60315-2] ENST00000558170; ENSP00000454157; ENSG00000169554 [O60315-1] ENST00000627532; ENSP00000487174; ENSG00000169554 [O60315-1] |
GeneIDi | 9839 |
KEGGi | hsa:9839 |
UCSCi | uc002tvu.4, human [O60315-1] |
Organism-specific databases
CTDi | 9839 |
DisGeNETi | 9839 |
GeneCardsi | ZEB2 |
GeneReviewsi | ZEB2 |
HGNCi | HGNC:14881, ZEB2 |
HPAi | ENSG00000169554, Tissue enhanced (brain) |
MalaCardsi | ZEB2 |
MIMi | 235730, phenotype 605802, gene |
neXtProti | NX_O60315 |
OpenTargetsi | ENSG00000169554 |
Orphaneti | 261552, Mowat-Wilson syndrome due to a ZEB2 point mutation 261537, Mowat-Wilson syndrome due to monosomy 2q22 |
PharmGKBi | PA162409612 |
VEuPathDBi | HostDB:ENSG00000169554.16 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3623, Eukaryota |
GeneTreei | ENSGT00950000183208 |
HOGENOMi | CLU_005890_0_1_1 |
InParanoidi | O60315 |
OrthoDBi | 890458at2759 |
PhylomeDBi | O60315 |
TreeFami | TF331759 |
Enzyme and pathway databases
PathwayCommonsi | O60315 |
SignaLinki | O60315 |
SIGNORi | O60315 |
Miscellaneous databases
BioGRID-ORCSi | 9839, 102 hits in 910 CRISPR screens |
ChiTaRSi | ZEB2, human |
EvolutionaryTracei | O60315 |
GeneWikii | ZEB2 |
GenomeRNAii | 9839 |
Pharosi | O60315, Tbio |
PROi | PR:O60315 |
RNActi | O60315, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000169554, Expressed in corpus callosum and 238 other tissues |
ExpressionAtlasi | O60315, baseline and differential |
Genevisiblei | O60315, HS |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR008598, Di19_Zn-bd IPR009057, Homeobox-like_sf IPR001356, Homeobox_dom IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 3 hits PF05605, zf-Di19, 1 hit |
SMARTi | View protein in SMART SM00389, HOX, 1 hit SM00355, ZnF_C2H2, 8 hits |
SUPFAMi | SSF46689, SSF46689, 1 hit SSF57667, SSF57667, 4 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 5 hits PS50157, ZINC_FINGER_C2H2_2, 6 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ZEB2_HUMAN | |
Accessioni | O60315Primary (citable) accession number: O60315 Secondary accession number(s): A0JP09 Q9UED1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 21, 2001 |
Last sequence update: | August 1, 1998 | |
Last modified: | February 10, 2021 | |
This is version 214 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families