UniProtKB - O60315 (ZEB2_HUMAN)

BLAST

>sp|O60315|ZEB2_HUMAN Zinc finger E-box-binding homeobox 2 OS=Homo sapiens OX=9606 GN=ZEB2 PE=1 SV=1
MKQPIMADGPRCKRRKQANPRRKNVVNYDNVVDTGSETDEEDKLHIAEDDGIANPLDQET
SPASVPNHESSPHVSQALLPREEEEDEIREGGVEHPWHNNEILQASVDGPEEMKEDYDTM
GPEATIQTAINNGTVKNANCTSDFEEYFAKRKLEERDGHAVSIEEYLQRSDTAIIYPEAP
EELSRLGTPEANGQEENDLPPGTPDAFAQLLTCPYCDRGYKRLTSLKEHIKYRHEKNEEN
FSCPLCSYTFAYRTQLERHMVTHKPGTDQHQMLTQGAGNRKFKCTECGKAFKYKHHLKEH
LRIHSGEKPYECPNCKKRFSHSGSYSSHISSKKCIGLISVNGRMRNNIKTGSSPNSVSSS
PTNSAITQLRNKLENGKPLSMSEQTGLLKIKTEPLDFNDYKVLMATHGFSGTSPFMNGGL
GATSPLGVHPSAQSPMQHLGVGMEAPLLGFPTMNSNLSEVQKVLQIVDNTVSRQKMDCKA
EEISKLKGYHMKDPCSQPEEQGVTSPNIPPVGLPVVSHNGATKSIIDYTLEKVNEAKACL
QSLTTDSRRQISNIKKEKLRTLIDLVTDDKMIENHNISTPFSCQFCKESFPGPIPLHQHE
RYLCKMNEEIKAVLQPHENIVPNKAGVFVDNKALLLSSVLSEKGMTSPINPYKDHMSVLK
AYYAMNMEPNSDELLKISIAVGLPQEFVKEWFEQRKVYQYSNSRSPSLERSSKPLAPNSN
PPTKDSLLPRSPVKPMDSITSPSIAELHNSVTNCDPPLRLTKPSHFTNIKPVEKLDHSRS
NTPSPLNLSSTSSKNSHSSSYTPNSFSSEELQAEPLDLSLPKQMKEPKSIIATKNKTKAS
SISLDHNSVSSSSENSDEPLNLTFIKKEFSNSNNLDNKSTNPVFSMNPFSAKPLYTALPP
QSAFPPATFMPPVQTSIPGLRPYPGLDQMSFLPHMAYTYPTGAATFADMQQRRKYQRKQG
FQGELLDGAQDYMSGLDDMTDSDSCLSRKKIKKTESGMYACDLCDKTFQKSSSLLRHKYE
HTGKRPHQCQICKKAFKHKHHLIEHSRLHSGEKPYQCDKCGKRFSHSGSYSQHMNHRYSY
CKREAEEREAAEREAREKGHLEPTELLMNRAYLQSITPQGYSDSEERESMPRDGESEKEH
EKEGEDGYGKLGRQDGDEEFEEEEEESENKSMDTDPETIRDEEETGDHSMDDSSEDGKME
TKSDHEEDNMEDGM

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History
Entry version 196 (07 Nov 2018)
Sequence version 1 (01 Aug 1998)
Previous versions | rss
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Protein

Zinc finger E-box-binding homeobox 2

Gene

ZEB2

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Transcriptional inhibitor that binds to DNA sequence 5'-CACCT-3' in different promoters. Represses transcription of E-cadherin.1 Publication

Regions

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	211 – 234	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	24
Zinc fingerⁱ	241 – 263	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	282 – 304	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	310 – 334	C2H2-type 4; atypicalPROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	581 – 605	C2H2-type 5; atypicalPROSITE-ProRule annotationAdd BLAST	25
DNA bindingⁱ	644 – 703	Homeobox; atypicalAdd BLAST	60
Zinc fingerⁱ	999 – 1021	C2H2-type 6PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	1027 – 1049	C2H2-type 7PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	1055 – 1076	C2H2-type 8; atypicalPROSITE-ProRule annotationAdd BLAST	22

GO - Molecular functionⁱ

distal enhancer DNA-binding transcription activator activity, RNA polymerase II-specific Source: Ensembl
DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
DNA-binding transcription repressor activity, RNA polymerase II-specific
Source: BHF-UCL
Inferred from direct assayⁱ
- 20516212
metal ion binding Source: UniProtKB-KW
phosphatase regulator activity
Source: UniProtKB
Non-traceable author statementⁱ
- 11477103
R-SMAD binding Source: Ensembl
sequence-specific DNA binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 20516212

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell proliferation in forebrain Source: Ensembl
collateral sprouting Source: Ensembl
corpus callosum morphogenesis Source: Ensembl
corticospinal tract morphogenesis Source: Ensembl
developmental pigmentation
Source: BHF-UCL
Inferred from sequence or structural similarityⁱ
- 24769727
hippocampus development Source: Ensembl
mammillary axonal complex development Source: Ensembl
melanocyte migration
Source: BHF-UCL
Inferred from sequence or structural similarityⁱ
- 24769727
negative regulation of transcription by RNA polymerase II
Source: BHF-UCL
Inferred from direct assayⁱ
- 12837246
- 20516212
nervous system development
Source: UniProtKB
Non-traceable author statementⁱ
- 11279515
neural crest cell migration Source: Ensembl
neural tube closure Source: Ensembl
positive regulation of axonogenesis Source: Ensembl
positive regulation of JUN kinase activity Source: Ensembl
positive regulation of lens fiber cell differentiation Source: Ensembl
positive regulation of melanin biosynthetic process
Source: BHF-UCL
Inferred by curatorⁱ
- 24769727
positive regulation of melanocyte differentiation
Source: BHF-UCL
Inferred from sequence or structural similarityⁱ
- 24769727
positive regulation of transcription by RNA polymerase II
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 24769727
positive regulation of Wnt signaling pathway Source: Ensembl
regulation of melanosome organization
Source: BHF-UCL
Inferred from sequence or structural similarityⁱ
- 24769727
somitogenesis Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding, Repressor
Biological process	Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

SignaLinkⁱ	O60315
SIGNORⁱ	O60315

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Zinc finger E-box-binding homeobox 2 Alternative name(s): Smad-interacting protein 1 Short name: SMADIP1 Zinc finger homeobox protein 1b
Gene namesⁱ	Name:ZEB2 Synonyms:KIAA0569, SIP1, ZFHX1B, ZFX1B ORF Names:HRIHFB2411
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 2

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000169554.16
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:14881 ZEB2
MIMⁱ	605802 gene
neXtProtⁱ	NX_O60315

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Mowat-Wilson syndrome (MOWS)4 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA complex developmental disorder characterized by mental retardation, delayed motor development, epilepsy, microcephaly and a wide spectrum of clinically heterogeneous features suggestive of neurocristopathies at the cephalic, cardiac, and vagal levels. Affected patients show an easily recognizable facial appearance with deep set eyes and hypertelorism, medially divergent, broad eyebrows, prominent columella, pointed chin and uplifted, notched ear lobes. Some patients manifest Hirschsprung disease.

Keywords - Diseaseⁱ

Disease mutation, Epilepsy, Hirschsprung disease, Mental retardation

Organism-specific databases

DisGeNET More...DisGeNETⁱ	9839
GeneReviewsⁱ	ZEB2
MalaCards human disease database More...MalaCardsⁱ	ZEB2
MIMⁱ	235730 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000169554
Orphanetⁱ	261552 Mowat-Wilson syndrome due to a ZEB2 point mutation 261537 Mowat-Wilson syndrome due to monosomy 2q22
PharmGKBⁱ	PA162409612

Polymorphism and mutation databases

BioMutaⁱ	ZEB2

BioMutaⁱ

ZEB2

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000047236	1 – 1214	Zinc finger E-box-binding homeobox 2Add BLAST		1214

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	142	PhosphoserineCombined sources	1
Modified residueⁱ	356	PhosphoserineBy similarity	1
Modified residueⁱ	360	PhosphoserineCombined sources	1
Modified residueⁱ	364	PhosphoserineBy similarity	1
Modified residueⁱ	377	N6-acetyllysineCombined sources	1
Cross-linkⁱ	391	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO); alternate
Cross-linkⁱ	391	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Cross-linkⁱ	479	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	555	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	611	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	632	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	647	PhosphoserineCombined sources	1
Cross-linkⁱ	713	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	731	PhosphoserineBy similarity	1
Modified residueⁱ	780	PhosphoserineBy similarity	1
Modified residueⁱ	782	PhosphothreonineCombined sources	1
Modified residueⁱ	784	PhosphoserineCombined sources	1
Cross-linkⁱ	866	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO); alternate
Cross-linkⁱ	866	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residueⁱ	1122	PhosphoserineCombined sources	1
Modified residueⁱ	1124	PhosphoserineBy similarity	1
Modified residueⁱ	1203	PhosphoserineBy similarity	1

Post-translational modificationⁱ

Sumoylation on Lys-391 and Lys-866 is promoted by the E3 SUMO-protein ligase CBX4, and impairs interaction with CTBP1 and transcription repression activity.1 Publication

Keywords - PTMⁱ

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	O60315
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O60315
PaxDbⁱ	O60315
PeptideAtlas More...PeptideAtlasⁱ	O60315
PRIDEⁱ	O60315
ProteomicsDBⁱ	49342

PTM databases

iPTMnetⁱ	O60315
PhosphoSitePlusⁱ	O60315

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000169554 Expressed in 226 organ(s), highest expression level in corpus callosum
CleanExⁱ	HS_SIP1 HS_ZEB2
ExpressionAtlasⁱ	O60315 baseline and differential
Genevisibleⁱ	O60315 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA003456

HPAⁱ

HPA003456

Interactionⁱ

Subunit structureⁱ

Binds activated SMAD1, activated SMAD2 and activated SMAD3; binding with SMAD4 is not detected (By similarity). Interacts with CBX4 and CTBP1.By similarity1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
EHMT2	Q96KQ7	6	EBI-717614,EBI-744366
MTA1	Q13330	12	EBI-717614,EBI-714236
MTA2	O94776	4	EBI-717614,EBI-1783035

GO - Molecular functionⁱ

R-SMAD binding Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	115175, 22 interactors
CORUMⁱ	O60315
ELMⁱ	O60315
IntActⁱ	O60315, 23 interactors
Molecular INTeraction database More...MINTⁱ	O60315
STRINGⁱ	9606.ENSP00000302501

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	654 – 665	Combined sources	12
Helixⁱ	671 – 681	Combined sources	11
Helixⁱ	685 – 700	Combined sources	16

Show more details

3D structure databases

ProteinModelPortalⁱ	O60315
SMRⁱ	O60315
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	O60315

EvolutionaryTraceⁱ

O60315

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	437 – 487	SMAD-MH2 binding domainBy similarityAdd BLAST		51

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	1084 – 1214	Glu-rich (acidic)Add BLAST		131

Sequence similaritiesⁱ

Belongs to the delta-EF1/ZFH-1 C2H2-type zinc-finger family.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	211 – 234	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	24
Zinc fingerⁱ	241 – 263	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	282 – 304	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	310 – 334	C2H2-type 4; atypicalPROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	581 – 605	C2H2-type 5; atypicalPROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	999 – 1021	C2H2-type 6PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	1027 – 1049	C2H2-type 7PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	1055 – 1076	C2H2-type 8; atypicalPROSITE-ProRule annotationAdd BLAST	22

Keywords - Domainⁱ

Homeobox, Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	ENOG410IMF7 Eukaryota ENOG410ZQ40 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00630000089829
HOGENOMⁱ	HOG000264256
HOVERGENⁱ	HBG004697
InParanoidⁱ	O60315
KEGG Orthology (KO) More...KOⁱ	K09299
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0F7Y
PhylomeDBⁱ	O60315
TreeFamⁱ	TF331759

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00086 homeodomain, 1 hit
InterProⁱ	View protein in InterPro IPR008598 Di19_Zn_binding_dom IPR009057 Homeobox-like_sf IPR001356 Homeobox_dom IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00096 zf-C2H2, 3 hits PF05605 zf-Di19, 1 hit
SMARTⁱ	View protein in SMART SM00389 HOX, 1 hit SM00355 ZnF_C2H2, 8 hits
SUPFAMⁱ	SSF46689 SSF46689, 1 hit SSF57667 SSF57667, 4 hits
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 5 hits PS50157 ZINC_FINGER_C2H2_2, 6 hits

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 25 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: O60315-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKQPIMADGP RCKRRKQANP RRKNVVNYDN VVDTGSETDE EDKLHIAEDD 
        60         70         80         90        100
GIANPLDQET SPASVPNHES SPHVSQALLP REEEEDEIRE GGVEHPWHNN 
       110        120        130        140        150
EILQASVDGP EEMKEDYDTM GPEATIQTAI NNGTVKNANC TSDFEEYFAK 
       160        170        180        190        200
RKLEERDGHA VSIEEYLQRS DTAIIYPEAP EELSRLGTPE ANGQEENDLP 
       210        220        230        240        250
PGTPDAFAQL LTCPYCDRGY KRLTSLKEHI KYRHEKNEEN FSCPLCSYTF 
       260        270        280        290        300
AYRTQLERHM VTHKPGTDQH QMLTQGAGNR KFKCTECGKA FKYKHHLKEH 
       310        320        330        340        350
LRIHSGEKPY ECPNCKKRFS HSGSYSSHIS SKKCIGLISV NGRMRNNIKT 
       360        370        380        390        400
GSSPNSVSSS PTNSAITQLR NKLENGKPLS MSEQTGLLKI KTEPLDFNDY 
       410        420        430        440        450
KVLMATHGFS GTSPFMNGGL GATSPLGVHP SAQSPMQHLG VGMEAPLLGF 
       460        470        480        490        500
PTMNSNLSEV QKVLQIVDNT VSRQKMDCKA EEISKLKGYH MKDPCSQPEE 
       510        520        530        540        550
QGVTSPNIPP VGLPVVSHNG ATKSIIDYTL EKVNEAKACL QSLTTDSRRQ 
       560        570        580        590        600
ISNIKKEKLR TLIDLVTDDK MIENHNISTP FSCQFCKESF PGPIPLHQHE 
       610        620        630        640        650
RYLCKMNEEI KAVLQPHENI VPNKAGVFVD NKALLLSSVL SEKGMTSPIN 
       660        670        680        690        700
PYKDHMSVLK AYYAMNMEPN SDELLKISIA VGLPQEFVKE WFEQRKVYQY 
       710        720        730        740        750
SNSRSPSLER SSKPLAPNSN PPTKDSLLPR SPVKPMDSIT SPSIAELHNS 
       760        770        780        790        800
VTNCDPPLRL TKPSHFTNIK PVEKLDHSRS NTPSPLNLSS TSSKNSHSSS 
       810        820        830        840        850
YTPNSFSSEE LQAEPLDLSL PKQMKEPKSI IATKNKTKAS SISLDHNSVS 
       860        870        880        890        900
SSSENSDEPL NLTFIKKEFS NSNNLDNKST NPVFSMNPFS AKPLYTALPP 
       910        920        930        940        950
QSAFPPATFM PPVQTSIPGL RPYPGLDQMS FLPHMAYTYP TGAATFADMQ 
       960        970        980        990       1000
QRRKYQRKQG FQGELLDGAQ DYMSGLDDMT DSDSCLSRKK IKKTESGMYA 
      1010       1020       1030       1040       1050
CDLCDKTFQK SSSLLRHKYE HTGKRPHQCQ ICKKAFKHKH HLIEHSRLHS 
      1060       1070       1080       1090       1100
GEKPYQCDKC GKRFSHSGSY SQHMNHRYSY CKREAEEREA AEREAREKGH 
      1110       1120       1130       1140       1150
LEPTELLMNR AYLQSITPQG YSDSEERESM PRDGESEKEH EKEGEDGYGK 
      1160       1170       1180       1190       1200
LGRQDGDEEF EEEEEESENK SMDTDPETIR DEEETGDHSM DDSSEDGKME 
      1210 
TKSDHEEDNM EDGM

Length:1,214

Mass (Da):136,447

Last modified:August 1, 1998 - v1

Checksum:ⁱB578FD91339C3FDD

Isoform 2 (identifier: O60315-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
111-134: Missing.

« Hide

        10         20         30         40         50
MKQPIMADGP RCKRRKQANP RRKNVVNYDN VVDTGSETDE EDKLHIAEDD 
        60         70         80         90        100
GIANPLDQET SPASVPNHES SPHVSQALLP REEEEDEIRE GGVEHPWHNN 
       110        120        130        140        150
EILQASVDGP VKNANCTSDF EEYFAKRKLE ERDGHAVSIE EYLQRSDTAI 
       160        170        180        190        200
IYPEAPEELS RLGTPEANGQ EENDLPPGTP DAFAQLLTCP YCDRGYKRLT 
       210        220        230        240        250
SLKEHIKYRH EKNEENFSCP LCSYTFAYRT QLERHMVTHK PGTDQHQMLT 
       260        270        280        290        300
QGAGNRKFKC TECGKAFKYK HHLKEHLRIH SGEKPYECPN CKKRFSHSGS 
       310        320        330        340        350
YSSHISSKKC IGLISVNGRM RNNIKTGSSP NSVSSSPTNS AITQLRNKLE 
       360        370        380        390        400
NGKPLSMSEQ TGLLKIKTEP LDFNDYKVLM ATHGFSGTSP FMNGGLGATS 
       410        420        430        440        450
PLGVHPSAQS PMQHLGVGME APLLGFPTMN SNLSEVQKVL QIVDNTVSRQ 
       460        470        480        490        500
KMDCKAEEIS KLKGYHMKDP CSQPEEQGVT SPNIPPVGLP VVSHNGATKS 
       510        520        530        540        550
IIDYTLEKVN EAKACLQSLT TDSRRQISNI KKEKLRTLID LVTDDKMIEN 
       560        570        580        590        600
HNISTPFSCQ FCKESFPGPI PLHQHERYLC KMNEEIKAVL QPHENIVPNK 
       610        620        630        640        650
AGVFVDNKAL LLSSVLSEKG MTSPINPYKD HMSVLKAYYA MNMEPNSDEL 
       660        670        680        690        700
LKISIAVGLP QEFVKEWFEQ RKVYQYSNSR SPSLERSSKP LAPNSNPPTK 
       710        720        730        740        750
DSLLPRSPVK PMDSITSPSI AELHNSVTNC DPPLRLTKPS HFTNIKPVEK 
       760        770        780        790        800
LDHSRSNTPS PLNLSSTSSK NSHSSSYTPN SFSSEELQAE PLDLSLPKQM 
       810        820        830        840        850
KEPKSIIATK NKTKASSISL DHNSVSSSSE NSDEPLNLTF IKKEFSNSNN 
       860        870        880        890        900
LDNKSTNPVF SMNPFSAKPL YTALPPQSAF PPATFMPPVQ TSIPGLRPYP 
       910        920        930        940        950
GLDQMSFLPH MAYTYPTGAA TFADMQQRRK YQRKQGFQGE LLDGAQDYMS 
       960        970        980        990       1000
GLDDMTDSDS CLSRKKIKKT ESGMYACDLC DKTFQKSSSL LRHKYEHTGK 
      1010       1020       1030       1040       1050
RPHQCQICKK AFKHKHHLIE HSRLHSGEKP YQCDKCGKRF SHSGSYSQHM 
      1060       1070       1080       1090       1100
NHRYSYCKRE AEEREAAERE AREKGHLEPT ELLMNRAYLQ SITPQGYSDS 
      1110       1120       1130       1140       1150
EERESMPRDG ESEKEHEKEG EDGYGKLGRQ DGDEEFEEEE EESENKSMDT 
      1160       1170       1180       1190
DPETIRDEEE TGDHSMDDSS EDGKMETKSD HEEDNMEDGM

Note: No experimental confirmation available.

Show »

Length:1,190

Mass (Da):133,806

Checksum:ⁱB9E3278A9EEF8AAC

Computationally mapped potential isoform sequencesⁱ

There are 25 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name	Protein names	Gene names	Length	Annotation

	A0JP08	A0JP08_HUMAN	Zinc finger E-box-binding homeobox ... Zinc finger E-box-binding homeobox 2	ZEB2	1,213	Annotation score:
	A0A1B0GVV8	A0A1B0GVV8_HUMAN	Zinc finger E-box-binding homeobox ... Zinc finger E-box-binding homeobox 2	ZEB2	1,102	Annotation score:
	A0A1B0GV02	A0A1B0GV02_HUMAN	Zinc finger E-box-binding homeobox ... Zinc finger E-box-binding homeobox 2	ZEB2	1,239	Annotation score:
	A0A1B0GWI0	A0A1B0GWI0_HUMAN	Zinc finger E-box-binding homeobox ... Zinc finger E-box-binding homeobox 2	ZEB2	955	Annotation score:
	A0A1B0GW50	A0A1B0GW50_HUMAN	Zinc finger E-box-binding homeobox ... Zinc finger E-box-binding homeobox 2	ZEB2	1,202	Annotation score:
	E7EUW9	E7EUW9_HUMAN	Zinc finger E-box-binding homeobox ... Zinc finger E-box-binding homeobox 2	ZEB2	731	Annotation score:
	U3KQ51	U3KQ51_HUMAN	Zinc finger E-box-binding homeobox ... Zinc finger E-box-binding homeobox 2	ZEB2	423	Annotation score:
	H7C0G0	H7C0G0_HUMAN	Zinc finger E-box-binding homeobox ... Zinc finger E-box-binding homeobox 2	ZEB2	220	Annotation score:
	E7ESP8	E7ESP8_HUMAN	Zinc finger E-box-binding homeobox ... Zinc finger E-box-binding homeobox 2	ZEB2	467	Annotation score:
	A0A1X7SC99	A0A1X7SC99_HUMAN	Zinc finger E-box-binding homeobox ... Zinc finger E-box-binding homeobox 2	ZEB2	612	Annotation score:
There are more potential isoformsShow all

Sequence cautionⁱ

The sequence BAA25495 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	1155	D → G in BAH11928 (PubMed:14702039).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_027016	99	Missing in MOWS. 1 Publication	1
Natural variantⁱVAR_027017	953	R → G in MOWS. 1 Publication	1
Natural variantⁱVAR_035563	983	D → N in a colorectal cancer sample; somatic mutation. 1 Publication	1
Natural variantⁱVAR_027018	1119	Q → R in MOWS. 1 PublicationCorresponds to variant dbSNP:rs137852983EnsemblClinVar.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_044797	111 – 134	Missing in isoform 2. 1 PublicationAdd BLAST		24

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY029472 Genomic DNA Translation: AAK52081.1 AB056507 mRNA Translation: BAB40819.1 AB011141 mRNA Translation: BAA25495.2 Different initiation. AK294928 mRNA Translation: BAH11928.1 AC009951 Genomic DNA No translation available. AC010130 Genomic DNA No translation available. BC127102 mRNA Translation: AAI27103.1 AB015341 mRNA Translation: BAA34798.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS2186.1 [O60315-1] CCDS54403.1 [O60315-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001165124.1, NM_001171653.1 [O60315-2] NP_055610.1, NM_014795.3 [O60315-1] XP_006712944.1, XM_006712881.3 XP_006712945.1, XM_006712882.3
UniGeneⁱ	Hs.34871

Genome annotation databases

Ensemblⁱ	ENST00000409487; ENSP00000386854; ENSG00000169554 [O60315-1] ENST00000539609; ENSP00000443792; ENSG00000169554 [O60315-2] ENST00000558170; ENSP00000454157; ENSG00000169554 [O60315-1] ENST00000627532; ENSP00000487174; ENSG00000169554 [O60315-1]
GeneIDⁱ	9839
KEGGⁱ	hsa:9839
UCSC genome browser More...UCSCⁱ	uc002tvu.4 human [O60315-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O60315	Zinc finger E-box-binding homeobox 2		HUMAN		1102	UniRef100_O60315
Uncharacterized protein ZFHX1B (Fragment)		HUMAN		1079
Zinc finger E-box-binding homeobox 2		HUMAN		955

Protein	Similar proteins		Species	Score	Length	Source
O60315	Zinc finger E-box-binding homeobox 2		MOUSE		1215	UniRef90_O60315
Zinc finger E-box-binding homeobox 2		HUMAN		1102
Uncharacterized protein		MACMU		1253
Uncharacterized protein		CERAT		1253
Uncharacterized protein		MACFA		1253
+527

Protein	Similar proteins		Species	Score	Length	Source
O60315	Zinc finger E-box-binding homeobox 2		MOUSE		1215	UniRef50_O60315
Zinc finger E-box-binding homeobox 2		HUMAN		1102
Zinc finger E-box binding homeobox 2		SAIBB		1253
ZEB2 isoform 34 (Fragment)		PANTR		91
Uncharacterized protein		NOMLE		1253
+532

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY029472 Genomic DNA Translation: AAK52081.1 AB056507 mRNA Translation: BAB40819.1 AB011141 mRNA Translation: BAA25495.2 Different initiation. AK294928 mRNA Translation: BAH11928.1 AC009951 Genomic DNA No translation available. AC010130 Genomic DNA No translation available. BC127102 mRNA Translation: AAI27103.1 AB015341 mRNA Translation: BAA34798.1
CCDSⁱ	CCDS2186.1 [O60315-1] CCDS54403.1 [O60315-2]
RefSeqⁱ	NP_001165124.1, NM_001171653.1 [O60315-2] NP_055610.1, NM_014795.3 [O60315-1] XP_006712944.1, XM_006712881.3 XP_006712945.1, XM_006712882.3
UniGeneⁱ	Hs.34871

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2DA7	NMR	-	A	647-704	[»]
ProteinModelPortalⁱ	O60315
SMRⁱ	O60315
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	115175, 22 interactors
CORUMⁱ	O60315
ELMⁱ	O60315
IntActⁱ	O60315, 23 interactors
MINTⁱ	O60315
STRINGⁱ	9606.ENSP00000302501

PTM databases

iPTMnetⁱ	O60315
PhosphoSitePlusⁱ	O60315

Polymorphism and mutation databases

BioMutaⁱ	ZEB2

BioMutaⁱ

ZEB2

Proteomic databases

EPDⁱ	O60315
MaxQBⁱ	O60315
PaxDbⁱ	O60315
PeptideAtlasⁱ	O60315
PRIDEⁱ	O60315
ProteomicsDBⁱ	49342

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000409487; ENSP00000386854; ENSG00000169554 [O60315-1] ENST00000539609; ENSP00000443792; ENSG00000169554 [O60315-2] ENST00000558170; ENSP00000454157; ENSG00000169554 [O60315-1] ENST00000627532; ENSP00000487174; ENSG00000169554 [O60315-1]
GeneIDⁱ	9839
KEGGⁱ	hsa:9839
UCSCⁱ	uc002tvu.4 human [O60315-1]

Organism-specific databases

CTDⁱ	9839
DisGeNETⁱ	9839
EuPathDBⁱ	HostDB:ENSG00000169554.16
GeneCardsⁱ	ZEB2
GeneReviewsⁱ	ZEB2
HGNCⁱ	HGNC:14881 ZEB2
HPAⁱ	HPA003456
MalaCardsⁱ	ZEB2
MIMⁱ	235730 phenotype 605802 gene
neXtProtⁱ	NX_O60315
OpenTargetsⁱ	ENSG00000169554
Orphanetⁱ	261552 Mowat-Wilson syndrome due to a ZEB2 point mutation 261537 Mowat-Wilson syndrome due to monosomy 2q22
PharmGKBⁱ	PA162409612
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IMF7 Eukaryota ENOG410ZQ40 LUCA
GeneTreeⁱ	ENSGT00630000089829
HOGENOMⁱ	HOG000264256
HOVERGENⁱ	HBG004697
InParanoidⁱ	O60315
KOⁱ	K09299
OrthoDBⁱ	EOG091G0F7Y
PhylomeDBⁱ	O60315
TreeFamⁱ	TF331759

Enzyme and pathway databases

SignaLinkⁱ	O60315
SIGNORⁱ	O60315

Miscellaneous databases

ChiTaRSⁱ	ZEB2 human
EvolutionaryTraceⁱ	O60315
GeneWikiⁱ	ZEB2
GenomeRNAiⁱ	9839
Protein Ontology More...PROⁱ	PR:O60315
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000169554 Expressed in 226 organ(s), highest expression level in corpus callosum
CleanExⁱ	HS_SIP1 HS_ZEB2
ExpressionAtlasⁱ	O60315 baseline and differential
Genevisibleⁱ	O60315 HS

Family and domain databases

CDDⁱ	cd00086 homeodomain, 1 hit
InterProⁱ	View protein in InterPro IPR008598 Di19_Zn_binding_dom IPR009057 Homeobox-like_sf IPR001356 Homeobox_dom IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfamⁱ	View protein in Pfam PF00096 zf-C2H2, 3 hits PF05605 zf-Di19, 1 hit
SMARTⁱ	View protein in SMART SM00389 HOX, 1 hit SM00355 ZnF_C2H2, 8 hits
SUPFAMⁱ	SSF46689 SSF46689, 1 hit SSF57667 SSF57667, 4 hits
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 5 hits PS50157 ZINC_FINGER_C2H2_2, 6 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ZEB2_HUMAN
Accessionⁱ	O60315Primary (citable) accession number: O60315 Secondary accession number(s): A0JP09 , B7Z2P2, F5H814, Q9UED1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 21, 2001
	Last sequence update:	August 1, 1998
	Last modified:	November 7, 2018
	This is version 196 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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UniProtKB - O60315 (ZEB2_HUMAN)

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Zinc finger E-box-binding homeobox 2

ZEB2

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

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GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Cytosol

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ