Zinc finger E-box-binding homeobox 2

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• DNA-binding transcription activator activity, RNA polymerase II-specific Source: Ensembl
• DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
• DNA-binding transcription repressor activity, RNA polymerase II-specific Source: BHF-UCL <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Regulation of the expression and activity of the antiangiogenic homeobox gene GAX/MEOX2 by ZEB2 and microRNA-221."
    Chen Y., Banda M., Speyer C.L., Smith J.S., Rabson A.B., Gorski D.H.
    Mol. Cell. Biol. 30:3902-3913(2010) [PubMed] [Europe PMC] [Abstract]
• metal ion binding Source: UniProtKB-KW
• phosphatase regulator activity Source: UniProtKB <p>Non-traceable Author Statement</p> <p>Used for statements in the abstract, introduction or discussion of a paper that cannot be traced back to another publication.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#nas">GO evidence code guide</a></p> Non-traceable author statementⁱ
  • "Smad-interacting protein 1 is a repressor of liver/bone/kidney alkaline phosphatase transcription in bone morphogenetic protein-induced osteogenic differentiation of C2C12 cells."
    Tylzanowski P., Verschueren K., Huylebroeck D., Luyten F.P.
    J. Biol. Chem. 276:40001-40007(2001) [PubMed] [Europe PMC] [Abstract]
• R-SMAD binding Source: Ensembl
• sequence-specific DNA binding Source: BHF-UCLInferred from direct assayⁱ
  • "Regulation of the expression and activity of the antiangiogenic homeobox gene GAX/MEOX2 by ZEB2 and microRNA-221."
    Chen Y., Banda M., Speyer C.L., Smith J.S., Rabson A.B., Gorski D.H.
    Mol. Cell. Biol. 30:3902-3913(2010) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• cell proliferation in forebrain Source: Ensembl
• collateral sprouting Source: Ensembl
• corpus callosum morphogenesis Source: Ensembl
• corticospinal tract morphogenesis Source: Ensembl
• developmental pigmentation Source: BHF-UCL <p>Inferred from Sequence or Structural Similarity <br />Used for any analysis based on sequence alignment, structure comparison, or evaluation of sequence features such as composition.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iss">GO evidence code guide</a></p> Inferred from sequence or structural similarityⁱ
  • "Identification of a ZEB2-MITF-ZEB1 transcriptional network that controls melanogenesis and melanoma progression."
    Denecker G., Vandamme N., Akay O., Koludrovic D., Taminau J., Lemeire K., Gheldof A., De Craene B., Van Gele M., Brochez L., Udupi G.M., Rafferty M., Balint B., Gallagher W.M., Ghanem G., Huylebroeck D., Haigh J., van den Oord J.

    , Larue L., Davidson I., Marine J.C., Berx G.
    Cell Death Differ. 21:1250-1261(2014) [PubMed] [Europe PMC] [Abstract]
• hippocampus development Source: Ensembl
• mammillary axonal complex development Source: Ensembl
• melanocyte migration Source: BHF-UCLInferred from sequence or structural similarityⁱ
  • "Identification of a ZEB2-MITF-ZEB1 transcriptional network that controls melanogenesis and melanoma progression."
    Denecker G., Vandamme N., Akay O., Koludrovic D., Taminau J., Lemeire K., Gheldof A., De Craene B., Van Gele M., Brochez L., Udupi G.M., Rafferty M., Balint B., Gallagher W.M., Ghanem G., Huylebroeck D., Haigh J., van den Oord J.

    , Larue L., Davidson I., Marine J.C., Berx G.
    Cell Death Differ. 21:1250-1261(2014) [PubMed] [Europe PMC] [Abstract]
• negative regulation of transcription by RNA polymerase II Source: BHF-UCLInferred from direct assayⁱ
  • "Multiple tumor suppressor pathways negatively regulate telomerase."
    Lin S.Y., Elledge S.J.
    Cell 113:881-889(2003) [PubMed] [Europe PMC] [Abstract]
  • "Regulation of the expression and activity of the antiangiogenic homeobox gene GAX/MEOX2 by ZEB2 and microRNA-221."
    Chen Y., Banda M., Speyer C.L., Smith J.S., Rabson A.B., Gorski D.H.
    Mol. Cell. Biol. 30:3902-3913(2010) [PubMed] [Europe PMC] [Abstract]
• nervous system development Source: UniProtKBNon-traceable author statementⁱ
  • Ref.2

    "Mutations in SIP1, encoding Smad interacting protein 1, cause a form of Hirschsprung disease."
    Wakamatsu N., Yamada Y., Yamada K., Ono T., Nomura N., Taniguchi H., Kitoh H., Mutoh N., Yamanaka T., Mushiake K., Kato K., Sonta S., Nagaya M.
    Nat. Genet. 27:369-370(2001) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
• neural crest cell migration Source: Ensembl
• neural tube closure Source: Ensembl
• positive regulation of axonogenesis Source: Ensembl
• positive regulation of JUN kinase activity Source: Ensembl
• positive regulation of lens fiber cell differentiation Source: Ensembl
• positive regulation of melanin biosynthetic process Source: BHF-UCL <p>Inferred by Curator</p> <p>Used for cases where an annotation is not supported by any evidence but can be reasonably inferred by a curator from other GO annotations for which evidence <br />is available.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ic">GO evidence code guide</a></p> Inferred by curatorⁱ
  • "Identification of a ZEB2-MITF-ZEB1 transcriptional network that controls melanogenesis and melanoma progression."
    Denecker G., Vandamme N., Akay O., Koludrovic D., Taminau J., Lemeire K., Gheldof A., De Craene B., Van Gele M., Brochez L., Udupi G.M., Rafferty M., Balint B., Gallagher W.M., Ghanem G., Huylebroeck D., Haigh J., van den Oord J.

    , Larue L., Davidson I., Marine J.C., Berx G.
    Cell Death Differ. 21:1250-1261(2014) [PubMed] [Europe PMC] [Abstract]
• positive regulation of melanocyte differentiation Source: BHF-UCLInferred from sequence or structural similarityⁱ
  • "Identification of a ZEB2-MITF-ZEB1 transcriptional network that controls melanogenesis and melanoma progression."
    Denecker G., Vandamme N., Akay O., Koludrovic D., Taminau J., Lemeire K., Gheldof A., De Craene B., Van Gele M., Brochez L., Udupi G.M., Rafferty M., Balint B., Gallagher W.M., Ghanem G., Huylebroeck D., Haigh J., van den Oord J.

    , Larue L., Davidson I., Marine J.C., Berx G.
    Cell Death Differ. 21:1250-1261(2014) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription by RNA polymerase II Source: BHF-UCL <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Identification of a ZEB2-MITF-ZEB1 transcriptional network that controls melanogenesis and melanoma progression."
    Denecker G., Vandamme N., Akay O., Koludrovic D., Taminau J., Lemeire K., Gheldof A., De Craene B., Van Gele M., Brochez L., Udupi G.M., Rafferty M., Balint B., Gallagher W.M., Ghanem G., Huylebroeck D., Haigh J., van den Oord J.

    , Larue L., Davidson I., Marine J.C., Berx G.
    Cell Death Differ. 21:1250-1261(2014) [PubMed] [Europe PMC] [Abstract]
• positive regulation of Wnt signaling pathway Source: Ensembl
• regulation of melanosome organization Source: BHF-UCLInferred from sequence or structural similarityⁱ
  • "Identification of a ZEB2-MITF-ZEB1 transcriptional network that controls melanogenesis and melanoma progression."
    Denecker G., Vandamme N., Akay O., Koludrovic D., Taminau J., Lemeire K., Gheldof A., De Craene B., Van Gele M., Brochez L., Udupi G.M., Rafferty M., Balint B., Gallagher W.M., Ghanem G., Huylebroeck D., Haigh J., van den Oord J.

    , Larue L., Davidson I., Marine J.C., Berx G.
    Cell Death Differ. 21:1250-1261(2014) [PubMed] [Europe PMC] [Abstract]
• somitogenesis Source: Ensembl

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseaseⁱ

Keywords - Diseaseⁱ

Organism-specific databases

Miscellaneous databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• R-SMAD binding Source: Ensembl

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Region

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Zinc finger

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 2 described isoforms and 25 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MKQPIMADGP RCKRRKQANP RRKNVVNYDN VVDTGSETDE EDKLHIAEDD 
        60         70         80         90        100
GIANPLDQET SPASVPNHES SPHVSQALLP REEEEDEIRE GGVEHPWHNN 
       110        120        130        140        150
EILQASVDGP EEMKEDYDTM GPEATIQTAI NNGTVKNANC TSDFEEYFAK 
       160        170        180        190        200
RKLEERDGHA VSIEEYLQRS DTAIIYPEAP EELSRLGTPE ANGQEENDLP 
       210        220        230        240        250
PGTPDAFAQL LTCPYCDRGY KRLTSLKEHI KYRHEKNEEN FSCPLCSYTF 
       260        270        280        290        300
AYRTQLERHM VTHKPGTDQH QMLTQGAGNR KFKCTECGKA FKYKHHLKEH 
       310        320        330        340        350
LRIHSGEKPY ECPNCKKRFS HSGSYSSHIS SKKCIGLISV NGRMRNNIKT 
       360        370        380        390        400
GSSPNSVSSS PTNSAITQLR NKLENGKPLS MSEQTGLLKI KTEPLDFNDY 
       410        420        430        440        450
KVLMATHGFS GTSPFMNGGL GATSPLGVHP SAQSPMQHLG VGMEAPLLGF 
       460        470        480        490        500
PTMNSNLSEV QKVLQIVDNT VSRQKMDCKA EEISKLKGYH MKDPCSQPEE 
       510        520        530        540        550
QGVTSPNIPP VGLPVVSHNG ATKSIIDYTL EKVNEAKACL QSLTTDSRRQ 
       560        570        580        590        600
ISNIKKEKLR TLIDLVTDDK MIENHNISTP FSCQFCKESF PGPIPLHQHE 
       610        620        630        640        650
RYLCKMNEEI KAVLQPHENI VPNKAGVFVD NKALLLSSVL SEKGMTSPIN 
       660        670        680        690        700
PYKDHMSVLK AYYAMNMEPN SDELLKISIA VGLPQEFVKE WFEQRKVYQY 
       710        720        730        740        750
SNSRSPSLER SSKPLAPNSN PPTKDSLLPR SPVKPMDSIT SPSIAELHNS 
       760        770        780        790        800
VTNCDPPLRL TKPSHFTNIK PVEKLDHSRS NTPSPLNLSS TSSKNSHSSS 
       810        820        830        840        850
YTPNSFSSEE LQAEPLDLSL PKQMKEPKSI IATKNKTKAS SISLDHNSVS 
       860        870        880        890        900
SSSENSDEPL NLTFIKKEFS NSNNLDNKST NPVFSMNPFS AKPLYTALPP 
       910        920        930        940        950
QSAFPPATFM PPVQTSIPGL RPYPGLDQMS FLPHMAYTYP TGAATFADMQ 
       960        970        980        990       1000
QRRKYQRKQG FQGELLDGAQ DYMSGLDDMT DSDSCLSRKK IKKTESGMYA 
      1010       1020       1030       1040       1050
CDLCDKTFQK SSSLLRHKYE HTGKRPHQCQ ICKKAFKHKH HLIEHSRLHS 
      1060       1070       1080       1090       1100
GEKPYQCDKC GKRFSHSGSY SQHMNHRYSY CKREAEEREA AEREAREKGH 
      1110       1120       1130       1140       1150
LEPTELLMNR AYLQSITPQG YSDSEERESM PRDGESEKEH EKEGEDGYGK 
      1160       1170       1180       1190       1200
LGRQDGDEEF EEEEEESENK SMDTDPETIR DEEETGDHSM DDSSEDGKME 
      1210 
TKSDHEEDNM EDGM                                        

        10         20         30         40         50
MKQPIMADGP RCKRRKQANP RRKNVVNYDN VVDTGSETDE EDKLHIAEDD 
        60         70         80         90        100
GIANPLDQET SPASVPNHES SPHVSQALLP REEEEDEIRE GGVEHPWHNN 
       110        120        130        140        150
EILQASVDGP VKNANCTSDF EEYFAKRKLE ERDGHAVSIE EYLQRSDTAI 
       160        170        180        190        200
IYPEAPEELS RLGTPEANGQ EENDLPPGTP DAFAQLLTCP YCDRGYKRLT 
       210        220        230        240        250
SLKEHIKYRH EKNEENFSCP LCSYTFAYRT QLERHMVTHK PGTDQHQMLT 
       260        270        280        290        300
QGAGNRKFKC TECGKAFKYK HHLKEHLRIH SGEKPYECPN CKKRFSHSGS 
       310        320        330        340        350
YSSHISSKKC IGLISVNGRM RNNIKTGSSP NSVSSSPTNS AITQLRNKLE 
       360        370        380        390        400
NGKPLSMSEQ TGLLKIKTEP LDFNDYKVLM ATHGFSGTSP FMNGGLGATS 
       410        420        430        440        450
PLGVHPSAQS PMQHLGVGME APLLGFPTMN SNLSEVQKVL QIVDNTVSRQ 
       460        470        480        490        500
KMDCKAEEIS KLKGYHMKDP CSQPEEQGVT SPNIPPVGLP VVSHNGATKS 
       510        520        530        540        550
IIDYTLEKVN EAKACLQSLT TDSRRQISNI KKEKLRTLID LVTDDKMIEN 
       560        570        580        590        600
HNISTPFSCQ FCKESFPGPI PLHQHERYLC KMNEEIKAVL QPHENIVPNK 
       610        620        630        640        650
AGVFVDNKAL LLSSVLSEKG MTSPINPYKD HMSVLKAYYA MNMEPNSDEL 
       660        670        680        690        700
LKISIAVGLP QEFVKEWFEQ RKVYQYSNSR SPSLERSSKP LAPNSNPPTK 
       710        720        730        740        750
DSLLPRSPVK PMDSITSPSI AELHNSVTNC DPPLRLTKPS HFTNIKPVEK 
       760        770        780        790        800
LDHSRSNTPS PLNLSSTSSK NSHSSSYTPN SFSSEELQAE PLDLSLPKQM 
       810        820        830        840        850
KEPKSIIATK NKTKASSISL DHNSVSSSSE NSDEPLNLTF IKKEFSNSNN 
       860        870        880        890        900
LDNKSTNPVF SMNPFSAKPL YTALPPQSAF PPATFMPPVQ TSIPGLRPYP 
       910        920        930        940        950
GLDQMSFLPH MAYTYPTGAA TFADMQQRRK YQRKQGFQGE LLDGAQDYMS 
       960        970        980        990       1000
GLDDMTDSDS CLSRKKIKKT ESGMYACDLC DKTFQKSSSL LRHKYEHTGK 
      1010       1020       1030       1040       1050
RPHQCQICKK AFKHKHHLIE HSRLHSGEKP YQCDKCGKRF SHSGSYSQHM 
      1060       1070       1080       1090       1100
NHRYSYCKRE AEEREAAERE AREKGHLEPT ELLMNRAYLQ SITPQGYSDS 
      1110       1120       1130       1140       1150
EERESMPRDG ESEKEHEKEG EDGYGKLGRQ DGDEEFEEEE EESENKSMDT 
      1160       1170       1180       1190
DPETIRDEEE TGDHSMDDSS EDGKMETKSD HEEDNMEDGM            

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautionⁱ

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. Human entries with polymorphisms or disease mutations
   List of human entries with polymorphisms or disease mutations
2. SIMILARITY comments
   Index of protein domains and families
3. Human chromosome 2
   Human chromosome 2: entries, gene names and cross-references to MIM
4. Human polymorphisms and disease mutations
   Index of human polymorphisms and disease mutations
5. MIM cross-references
   Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
6. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references