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Entry version 136 (13 Feb 2019)
Sequence version 2 (06 Dec 2005)
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Protein

Leucine-rich repeat-containing protein 37A3

Gene

LRRC37A3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Leucine-rich repeat-containing protein 37A3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LRRC37A3
Synonyms:KIAA0563
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000176809.10

Human Gene Nomenclature Database

More...
HGNCi
HGNC:32427 LRRC37A3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
616557 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O60309

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini36 – 1581ExtracellularSequence analysisAdd BLAST1546
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1582 – 1602HelicalSequence analysisAdd BLAST21
Topological domaini1603 – 1634CytoplasmicSequence analysisAdd BLAST32

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
374819

Open Targets

More...
OpenTargetsi
ENSG00000176809

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162394563

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
LRRC37A3

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 35Sequence analysisAdd BLAST35
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000007624436 – 1634Leucine-rich repeat-containing protein 37A3Add BLAST1599

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi296N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1079N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
O60309

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O60309

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O60309

PeptideAtlas

More...
PeptideAtlasi
O60309

PRoteomics IDEntifications database

More...
PRIDEi
O60309

ProteomicsDB human proteome resource

More...
ProteomicsDBi
49338

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O60309

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O60309

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000176809 Expressed in 179 organ(s), highest expression level in testis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O60309 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O60309 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA042121
HPA042701
HPA043056
HPA045090

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000325713

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
O60309

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati137 – 160LRR 1Add BLAST24
Repeati230 – 253LRR 2Add BLAST24
Repeati267 – 290LRR 3Add BLAST24
Repeati864 – 887LRR 4Add BLAST24
Repeati888 – 911LRR 5Add BLAST24
Repeati912 – 935LRR 6Add BLAST24
Repeati937 – 959LRR 7Add BLAST23
Repeati963 – 987LRR 8Add BLAST25
Repeati1002 – 1027LRR 9Add BLAST26
Repeati1124 – 1146LRR 10Add BLAST23
Repeati1151 – 1176LRR 11Add BLAST26
Repeati1359 – 1384LRR 12Add BLAST26

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the LRRC37A family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IJNR Eukaryota
ENOG410YV94 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000063282

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000113269

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG100009

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O60309

Identification of Orthologs from Complete Genome Data

More...
OMAi
PENTINQ

Database of Orthologous Groups

More...
OrthoDBi
181606at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O60309

TreeFam database of animal gene trees

More...
TreeFami
TF341959

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.80.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR015753 LRRC37
IPR032754 LRRC37_N
IPR029423 LRRC37AB_C

The PANTHER Classification System

More...
PANTHERi
PTHR23045 PTHR23045, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13855 LRR_8, 1 hit
PF15779 LRRC37, 6 hits
PF14914 LRRC37AB_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00369 LRR_TYP, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51450 LRR, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All

O60309-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTSAQCPALA CVMSPLRFWG PWPLLMWQLL WLLVKEAQPL EWVKDPLQLT
60 70 80 90 100
SNPLGPPEPW SSHSSHFPRE SPHAPTLPAD PWDFDHLGPS ASSEMPAPPQ
110 120 130 140 150
ESTENLVPFL DTWDSAGELP LEPEQFLASQ QDLKDKLSPQ ERLPVSPKKL
160 170 180 190 200
KKDPAQRWSL AEIIGIIHQL STPQSQKQTL QNEYSSTDTP YPGSLPPELR
210 220 230 240 250
VKSDEPPGPS EQVGPSQFHL EPETQNPETL EDIQSSSLQQ EAPAQLPQLL
260 270 280 290 300
EEEPSSMQQE APALPPESSM ESLTLPNHEV SVQPPGEDQA YYHLPNITVK
310 320 330 340 350
PADVEVTITS EPTNETESSQ AQQETPIQFP EEVEPSATQQ EAPIEPPVPP
360 370 380 390 400
MEHELSISEQ QQPVQPSESS REVESSPTQQ ETPGQPPEHH EVTVSPPGHH
410 420 430 440 450
QTHHLASPSV SVKPPDVQLT IAAEPSAEVG TSLVHQEATT RLSGSGNDVE
460 470 480 490 500
PPAIQHGGPP LLPESSEEAG PLAVQQETSF QSPEPINNEN PSPTQQEAAA
510 520 530 540 550
EHPQTAEEGE SSLTHQEAPA QTPEFPNVVV AQPPEHSHLT QATVQPLDLG
560 570 580 590 600
FTITPESMTE VELSPTMKET PTQPPKKVVP QLRVYQGVTN PTPGQDQAQH
610 620 630 640 650
PVSPSVTVQL LDLGLTITPE PTTEVGHSTP PKRTIVSPKH PEVTLPHPDQ
660 670 680 690 700
VQTQHSHLTR ATVQPLDLGF TITPKSMTEV EPSTALMTTA PPPGHPEVTL
710 720 730 740 750
PPSDKGQAQH SHLTQATVQP LDLELTITTK PTTEVKPSPT TEETSTQLPD
760 770 780 790 800
LGLAIIPEPT TETGHSTALE KTTAPRPDRV QTLHRSLTEV TGPPTELEPA
810 820 830 840 850
QDSLVQSESY TQNKALTAPE EHKASTSTNI CELCTCGDEM LSCIDLNPEQ
860 870 880 890 900
RLRQVPVPEP NTHNGTFTIL NFQGNYISYI DGNVWKAYSW TEKLILRENN
910 920 930 940 950
LTELHKDSFE GLLSLQYLDL SCNKIQSIER HTFEPLPFLK FINLSCNVIT
960 970 980 990 1000
ELSFGTFQAW HGMQFLHKLI LNHNPLTTVE DPYLFKLPAL KYLDMGTTLV
1010 1020 1030 1040 1050
PLTTLKNILM MTVELEKLIV PSHMACCLCQ FKNSIEAVCK TVKLHCNSAC
1060 1070 1080 1090 1100
LTNTTHCPEE ASVGNPEGAF MKVLQARKNY TSTELIIEPE EPSDSSGINL
1110 1120 1130 1140 1150
SGFGSEQLDT NDESDVTSTL SYILPYFSAV NLDVKSLLLP FIKLPTTGNS
1160 1170 1180 1190 1200
LAKIQTVGKN RQRLNRVLMG PRSIQKRHFK EVGRQSIRRE QGAQASVENT
1210 1220 1230 1240 1250
AEEKRLGSPA PRELKQPHTQ QGPEKLAGNA VYTKPSFTQE HKAAVSVLKP
1260 1270 1280 1290 1300
FSKGAPSTSS PAKALPQVRD RWKDLTHAIS ILESAKARVT NMKTSKPIVH
1310 1320 1330 1340 1350
SRKKYRFHKT RSRMTHRTPK VKKSPKVRKK SYLSRLMLSN RLPFSAAKSL
1360 1370 1380 1390 1400
INSPSQGAFS SLRDLSPQEN PFLEVSAPSE HFIENNNTKD TTARNAFEEN
1410 1420 1430 1440 1450
VFMENTNMPE GTISENTNYN HPPEADSAGT AFNLGPTVKQ TETKWEYNNV
1460 1470 1480 1490 1500
GTDLSPEPKS FNYPLLSSPG DQFEIQLTQQ LQSVIPNNNV RRLIAHVIRT
1510 1520 1530 1540 1550
LKMDCSGAHV QVTCAKLVSR TGHLMKLLSG QQEVKASKIE WDTDQWKTEN
1560 1570 1580 1590 1600
YINESTEAQS EQKEKSLEFT KELPGYGYTK KLILALIVTG ILTILIILLC
1610 1620 1630
LIEICCHRRS LQEDEEGFSR DSEAPTEEES EALP
Length:1,634
Mass (Da):180,621
Last modified:December 6, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i84C8F93290B29EB1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3QTJ5J3QTJ5_HUMAN
Leucine-rich repeat-containing prot...
LRRC37A3
752Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B4DSF2B4DSF2_HUMAN
Leucine-rich repeat-containing prot...
LRRC37A3
672Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W7X0F8W7X0_HUMAN
Leucine-rich repeat-containing prot...
LRRC37A3
611Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QL27J3QL27_HUMAN
Leucine-rich repeat-containing prot...
LRRC37A3
236Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KT91J3KT91_HUMAN
Leucine-rich repeat-containing prot...
LRRC37A3
231Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KT96J3KT96_HUMAN
Leucine-rich repeat-containing prot...
LRRC37A3
93Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QKQ2J3QKQ2_HUMAN
Leucine-rich repeat-containing prot...
LRRC37A3
197Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA25489 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC03710 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti51S → P in AAH43145 (PubMed:15489334).Curated1
Sequence conflicti1086I → T in AAH43145 (PubMed:15489334).Curated1
Sequence conflicti1417T → A in AAH43145 (PubMed:15489334).Curated1
Sequence conflicti1419Y → H in BAC03710 (PubMed:14702039).Curated1
Sequence conflicti1619S → P in BAC03710 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0510881215K → E. Corresponds to variant dbSNP:rs9893710Ensembl.1
Natural variantiVAR_0616721590G → A. Corresponds to variant dbSNP:rs28532307Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB011135 mRNA Translation: BAA25489.3 Different initiation.
BC043145 mRNA Translation: AAH43145.1
AK091625 mRNA Translation: BAC03710.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS32708.1

NCBI Reference Sequences

More...
RefSeqi
NP_955372.2, NM_199340.3

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.551962
Hs.744157
Hs.744758

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000319651; ENSP00000325713; ENSG00000176809
ENST00000584306; ENSP00000464535; ENSG00000176809

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
374819

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:374819

UCSC genome browser

More...
UCSCi
uc002jey.3 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB011135 mRNA Translation: BAA25489.3 Different initiation.
BC043145 mRNA Translation: AAH43145.1
AK091625 mRNA Translation: BAC03710.1 Different initiation.
CCDSiCCDS32708.1
RefSeqiNP_955372.2, NM_199340.3
UniGeneiHs.551962
Hs.744157
Hs.744758

3D structure databases

ProteinModelPortaliO60309
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000325713

PTM databases

iPTMnetiO60309
PhosphoSitePlusiO60309

Polymorphism and mutation databases

BioMutaiLRRC37A3

Proteomic databases

EPDiO60309
jPOSTiO60309
PaxDbiO60309
PeptideAtlasiO60309
PRIDEiO60309
ProteomicsDBi49338

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000319651; ENSP00000325713; ENSG00000176809
ENST00000584306; ENSP00000464535; ENSG00000176809
GeneIDi374819
KEGGihsa:374819
UCSCiuc002jey.3 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
374819
DisGeNETi374819
EuPathDBiHostDB:ENSG00000176809.10

GeneCards: human genes, protein and diseases

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GeneCardsi
LRRC37A3

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0026017
HIX0027304
HIX0027323
HGNCiHGNC:32427 LRRC37A3
HPAiHPA042121
HPA042701
HPA043056
HPA045090
MIMi616557 gene
neXtProtiNX_O60309
OpenTargetsiENSG00000176809
PharmGKBiPA162394563

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IJNR Eukaryota
ENOG410YV94 LUCA
GeneTreeiENSGT00530000063282
HOGENOMiHOG000113269
HOVERGENiHBG100009
InParanoidiO60309
OMAiPENTINQ
OrthoDBi181606at2759
PhylomeDBiO60309
TreeFamiTF341959

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
LRRC37A3 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
374819

Protein Ontology

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PROi
PR:O60309

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000176809 Expressed in 179 organ(s), highest expression level in testis
ExpressionAtlasiO60309 baseline and differential
GenevisibleiO60309 HS

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR015753 LRRC37
IPR032754 LRRC37_N
IPR029423 LRRC37AB_C
PANTHERiPTHR23045 PTHR23045, 2 hits
PfamiView protein in Pfam
PF13855 LRR_8, 1 hit
PF15779 LRRC37, 6 hits
PF14914 LRRC37AB_C, 1 hit
SMARTiView protein in SMART
SM00369 LRR_TYP, 4 hits
PROSITEiView protein in PROSITE
PS51450 LRR, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiL37A3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O60309
Secondary accession number(s): Q49A01, Q49A80, Q8NB33
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: December 6, 2005
Last modified: February 13, 2019
This is version 136 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
UniProt is an ELIXIR core data resource
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