Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Microtubule-associated serine/threonine-protein kinase 3

Gene

MAST3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Caution

It is uncertain whether Met-1, Met-171 or Met-172 is the initiator.Curated

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei396ATPPROSITE-ProRule annotation1
Active sitei490Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi373 – 381ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Magnesium, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiO60307
SIGNORiO60307

Names & Taxonomyi

Protein namesi
Recommended name:
Microtubule-associated serine/threonine-protein kinase 3 (EC:2.7.11.1)
Gene namesi
Name:MAST3
Synonyms:KIAA0561
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000099308.10
HGNCiHGNC:19036 MAST3
MIMi612258 gene
neXtProtiNX_O60307

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

DisGeNETi23031
OpenTargetsiENSG00000099308
PharmGKBiPA134877725

Chemistry databases

ChEMBLiCHEMBL2417352
GuidetoPHARMACOLOGYi1512

Polymorphism and mutation databases

BioMutaiMAST3

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000863141 – 1309Microtubule-associated serine/threonine-protein kinase 3Add BLAST1309

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei66PhosphoserineCombined sources1
Modified residuei85PhosphoserineCombined sources1
Modified residuei146PhosphoserineCombined sources1
Modified residuei680PhosphoserineCombined sources1
Modified residuei710PhosphoserineBy similarity1
Modified residuei728PhosphoserineBy similarity1
Modified residuei754PhosphoserineCombined sources1
Modified residuei774PhosphoserineCombined sources1
Modified residuei782PhosphoserineCombined sources1
Modified residuei792PhosphoserineCombined sources1
Modified residuei793PhosphoserineCombined sources1
Modified residuei1223PhosphoserineCombined sources1
Modified residuei1273PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO60307
MaxQBiO60307
PaxDbiO60307
PeptideAtlasiO60307
PRIDEiO60307
ProteomicsDBi49334

PTM databases

iPTMnetiO60307
PhosphoSitePlusiO60307

Expressioni

Gene expression databases

BgeeiENSG00000099308 Expressed in 205 organ(s), highest expression level in cerebral cortex
CleanExiHS_MAST3
ExpressionAtlasiO60307 baseline and differential
GenevisibleiO60307 HS

Organism-specific databases

HPAiHPA035061
HPA035062

Interactioni

Subunit structurei

Interacts with PTEN.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
PTENP604843EBI-311420,EBI-696162

Protein-protein interaction databases

BioGridi116670, 108 interactors
IntActiO60307, 41 interactors
STRINGi9606.ENSP00000262811

Chemistry databases

BindingDBiO60307

Structurei

Secondary structure

11309
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO60307
SMRiO60307
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO60307

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini367 – 640Protein kinasePROSITE-ProRule annotationAdd BLAST274
Domaini641 – 712AGC-kinase C-terminalAdd BLAST72
Domaini950 – 1038PDZPROSITE-ProRule annotationAdd BLAST89

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi104 – 109Poly-Ser6
Compositional biasi764 – 767Poly-Ser4
Compositional biasi877 – 941Ser-richAdd BLAST65
Compositional biasi1080 – 1149Ser-richAdd BLAST70

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0606 Eukaryota
ENOG410XPWX LUCA
GeneTreeiENSGT00530000063286
HOGENOMiHOG000046662
HOVERGENiHBG052414
InParanoidiO60307
KOiK08789
OMAiNVAKGRM
OrthoDBiEOG091G00IH
PhylomeDBiO60307
TreeFamiTF313149

Family and domain databases

CDDicd05609 STKc_MAST, 1 hit
Gene3Di1.20.1480.20, 1 hit
InterProiView protein in InterPro
IPR000961 AGC-kinase_C
IPR011009 Kinase-like_dom_sf
IPR015022 MA_Ser/Thr_Kinase_dom
IPR037711 MAST
IPR023142 MAST_pre-PK_dom_sf
IPR001478 PDZ
IPR036034 PDZ_sf
IPR000719 Prot_kinase_dom
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF08926 DUF1908, 1 hit
PF00595 PDZ, 1 hit
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00228 PDZ, 1 hit
SM00220 S_TKc, 1 hit
SUPFAMiSSF140482 SSF140482, 1 hit
SSF50156 SSF50156, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51285 AGC_KINASE_CTER, 1 hit
PS50106 PDZ, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O60307-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDESSLLRRR GLQKELSLPR RGRGCRSGNR KSLVVGTPSP TLSRPLSPLS
60 70 80 90 100
VPTAGSSPLD SPRNFSAASA LNFPFARRAD GRRWSLASLP SSGYGTNTPS
110 120 130 140 150
STLSSSSSSR ERLHQLPFQP TPDELHFLSK HFRSSENVLD EEGGRSPRLR
160 170 180 190 200
PRSRSLSPGR ATGTFDNEIV MMNHVYRERF PKATAQMEGR LQEFLTAYAP
210 220 230 240 250
GARLALADGV LGFIHHQIVE LARDCLAKSG ENLVTSRYFL EMQEKLERLL
260 270 280 290 300
QDAHERSDSE EVSFIVQLVR KLLIIISRPA RLLECLEFDP EEFYHLLEAA
310 320 330 340 350
EGHAREGQGI KTDLPQYIIG QLGLAKDPLE EMVPLSHLEE EQPPAPESPE
360 370 380 390 400
SRALVGQSRR KPCESDFETI KLISNGAYGA VYLVRHRDTR QRFAIKKINK
410 420 430 440 450
QNLILRNQIQ QVFVERDILT FAENPFVVSM FCSFETRRHL CMVMEYVEGG
460 470 480 490 500
DCATLLKNMG PLPVDMARLY FAETVLALEY LHNYGIVHRD LKPDNLLITS
510 520 530 540 550
LGHIKLTDFG LSKIGLMSMA TNLYEGHIEK DAREFIDKQV CGTPEYIAPE
560 570 580 590 600
VIFRQGYGKP VDWWAMGVVL YEFLVGCVPF FGDTPEELFG QVVSDEIMWP
610 620 630 640 650
EGDEALPADA QDLITRLLRQ SPLDRLGTGG THEVKQHPFF LALDWAGLLR
660 670 680 690 700
HKAEFVPQLE AEDDTSYFDT RSERYRHLGS EDDETNDEES STEIPQFSSC
710 720 730 740 750
SHRFSKVYSS SEFLAVQPTP TFAERSFSED REEGWERSEV DYGRRLSADI
760 770 780 790 800
RLRSWTSSGS SCQSSSSQPE RGPSPSLLNT ISLDTMPKFA FSSEDEGVGP
810 820 830 840 850
GPAGPKRPVF ILGEPDPPPA ATPVMPKPSS LSADTAALSH ARLRSNSIGA
860 870 880 890 900
RHSTPRPLDA GRGRRLGGPR DPAPEKSRAS SSGGSGGGSG GRVPKSASVS
910 920 930 940 950
ALSLIITADD GSGGPLMSPL SPRSLSSNPS SRDSSPSRDP SPVCGSLRPP
960 970 980 990 1000
IVIHSSGKKY GFSLRAIRVY MGDSDVYTVH HVVWSVEDGS PAQEAGLRAG
1010 1020 1030 1040 1050
DLITHINGES VLGLVHMDVV ELLLKSGNKI SLRTTALENT SIKVGPARKN
1060 1070 1080 1090 1100
VAKGRMARRS KRSRRRETQD RRKSLFKKIS KQTSVLHTSR SFSSGLHHSL
1110 1120 1130 1140 1150
SSSESLPGSP THSLSPSPTT PCRSPAPDVP ADTTASPPSA SPSSSSPASP
1160 1170 1180 1190 1200
AAAGHTRPSS LHGLAAKLGP PRPKTGRRKS TSSIPPSPLA CPPISAPPPR
1210 1220 1230 1240 1250
SPSPLPGHPP APARSPRLRR GQSADKLGTG ERLDGEAGRR TRGPEAELVV
1260 1270 1280 1290 1300
MRRLHLSERR DSFKKQEAVQ EVSFDEPQEE ATGLPTSVPQ IAVEGEEAVP

VALGPTGRD
Length:1,309
Mass (Da):143,137
Last modified:November 22, 2005 - v2
Checksum:i87E82F2D032ED122
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
V9GYV0V9GYV0_HUMAN
Microtubule-associated serine/threo...
MAST3
86Annotation score:

Sequence cautioni

The sequence AAC62830 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_051646203R → Q. Corresponds to variant dbSNP:rs35945810Ensembl.1
Natural variantiVAR_051647861G → S. Corresponds to variant dbSNP:rs8108738Ensembl.1
Natural variantiVAR_040786883G → S1 PublicationCorresponds to variant dbSNP:rs369960905Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005793 Genomic DNA Translation: AAC62830.1 Different initiation.
AC007192 Genomic DNA Translation: AAD22670.1
AC093054 Genomic DNA No translation available.
AB011133 mRNA Translation: BAA25487.1
CCDSiCCDS46014.1
RefSeqiNP_055831.1, NM_015016.1
UniGeneiHs.466184

Genome annotation databases

EnsembliENST00000262811; ENSP00000262811; ENSG00000099308
GeneIDi23031
KEGGihsa:23031
UCSCiuc002nhz.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005793 Genomic DNA Translation: AAC62830.1 Different initiation.
AC007192 Genomic DNA Translation: AAD22670.1
AC093054 Genomic DNA No translation available.
AB011133 mRNA Translation: BAA25487.1
CCDSiCCDS46014.1
RefSeqiNP_055831.1, NM_015016.1
UniGeneiHs.466184

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1V9VNMR-A181-281[»]
3KHFX-ray1.20A/B948-1040[»]
ProteinModelPortaliO60307
SMRiO60307
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116670, 108 interactors
IntActiO60307, 41 interactors
STRINGi9606.ENSP00000262811

Chemistry databases

BindingDBiO60307
ChEMBLiCHEMBL2417352
GuidetoPHARMACOLOGYi1512

PTM databases

iPTMnetiO60307
PhosphoSitePlusiO60307

Polymorphism and mutation databases

BioMutaiMAST3

Proteomic databases

EPDiO60307
MaxQBiO60307
PaxDbiO60307
PeptideAtlasiO60307
PRIDEiO60307
ProteomicsDBi49334

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262811; ENSP00000262811; ENSG00000099308
GeneIDi23031
KEGGihsa:23031
UCSCiuc002nhz.5 human

Organism-specific databases

CTDi23031
DisGeNETi23031
EuPathDBiHostDB:ENSG00000099308.10
GeneCardsiMAST3
H-InvDBiHIX0014904
HGNCiHGNC:19036 MAST3
HPAiHPA035061
HPA035062
MIMi612258 gene
neXtProtiNX_O60307
OpenTargetsiENSG00000099308
PharmGKBiPA134877725
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0606 Eukaryota
ENOG410XPWX LUCA
GeneTreeiENSGT00530000063286
HOGENOMiHOG000046662
HOVERGENiHBG052414
InParanoidiO60307
KOiK08789
OMAiNVAKGRM
OrthoDBiEOG091G00IH
PhylomeDBiO60307
TreeFamiTF313149

Enzyme and pathway databases

SignaLinkiO60307
SIGNORiO60307

Miscellaneous databases

ChiTaRSiMAST3 human
EvolutionaryTraceiO60307
GenomeRNAii23031
PROiPR:O60307
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000099308 Expressed in 205 organ(s), highest expression level in cerebral cortex
CleanExiHS_MAST3
ExpressionAtlasiO60307 baseline and differential
GenevisibleiO60307 HS

Family and domain databases

CDDicd05609 STKc_MAST, 1 hit
Gene3Di1.20.1480.20, 1 hit
InterProiView protein in InterPro
IPR000961 AGC-kinase_C
IPR011009 Kinase-like_dom_sf
IPR015022 MA_Ser/Thr_Kinase_dom
IPR037711 MAST
IPR023142 MAST_pre-PK_dom_sf
IPR001478 PDZ
IPR036034 PDZ_sf
IPR000719 Prot_kinase_dom
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF08926 DUF1908, 1 hit
PF00595 PDZ, 1 hit
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00228 PDZ, 1 hit
SM00220 S_TKc, 1 hit
SUPFAMiSSF140482 SSF140482, 1 hit
SSF50156 SSF50156, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51285 AGC_KINASE_CTER, 1 hit
PS50106 PDZ, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMAST3_HUMAN
AccessioniPrimary (citable) accession number: O60307
Secondary accession number(s): Q7LDZ8, Q9UPI0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 22, 2005
Last modified: September 12, 2018
This is version 161 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  6. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  7. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again