Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Leucine zipper putative tumor suppressor 3

Gene

LZTS3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in promoting the maturation of dendritic spines, probably via regulating SIPA1L1 levels at the postsynaptic density of synapses.By similarity

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine zipper putative tumor suppressor 3Curated
Alternative name(s):
ProSAP-interacting protein 1By similarity
Short name:
ProSAPiP1By similarity
Gene namesi
Name:LZTS3Imported
Synonyms:KIAA0552Imported, PROSAPIP1By similarity
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000088899.14
HGNCiHGNC:30139 LZTS3
MIMi610484 gene
neXtProtiNX_O60299

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Cytoskeleton, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000088899

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000507601 – 673Leucine zipper putative tumor suppressor 3Add BLAST673

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei316PhosphoserineBy similarity1
Modified residuei318PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO60299
MaxQBiO60299
PaxDbiO60299
PeptideAtlasiO60299
PRIDEiO60299
ProteomicsDBi49329
49330 [O60299-2]

PTM databases

iPTMnetiO60299
PhosphoSitePlusiO60299

Expressioni

Gene expression databases

BgeeiENSG00000088899 Expressed in 220 organ(s), highest expression level in cerebellar vermis
GenevisibleiO60299 HS

Organism-specific databases

HPAiHPA031008
HPA031009

Interactioni

Subunit structurei

Interacts (via C-terminus) with SHANK3 (via PDZ domain). Interacts (via coiled coil) with SIPA1L1. Can form homooligomers.By similarity

Protein-protein interaction databases

BioGridi115109, 6 interactors
IntActiO60299, 5 interactors
STRINGi9606.ENSP00000332123

Structurei

3D structure databases

ProteinModelPortaliO60299
SMRiO60299
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili317 – 496Sequence analysisAdd BLAST180
Coiled coili571 – 639Sequence analysisAdd BLAST69

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi60 – 63Poly-Gly4
Compositional biasi122 – 125Poly-Ser4
Compositional biasi282 – 290Poly-Ser9
Compositional biasi298 – 306Poly-Gly9
Compositional biasi550 – 553Poly-Ala4

Sequence similaritiesi

Belongs to the LZTS3 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IFZY Eukaryota
ENOG410Z2V9 LUCA
GeneTreeiENSGT00510000046769
HOGENOMiHOG000230889
HOVERGENiHBG052381
InParanoidiO60299
OMAiVGYNGIS
OrthoDBiEOG091G03L2
PhylomeDBiO60299

Family and domain databases

InterProiView protein in InterPro
IPR033295 LZTS3
PANTHERiPTHR19354:SF6 PTHR19354:SF6, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: O60299-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAKLETLPVR ADPGRDPLLA FAPRPSELGP PDPRLAMGSV GSGVAHAQEF
60 70 80 90 100
AMKSVGTRTG GGGSQGSFPG PRGSGSGASR ERPGRYPSED KGLANSLYLN
110 120 130 140 150
GELRGSDHTD VCGNVVGSSG GSSSSGGSDK APPQYREPSH PPKLLATSGK
160 170 180 190 200
LDQCSEPLVR PSAFKPVVPK NFHSMQNLCP PQTNGTPEGR QGPGGLKGGL
210 220 230 240 250
DKSRTMTPAG GSGSGLSDSG RNSLTSLPTY SSSYSQHLAP LSASTSHINR
260 270 280 290 300
IGTASYGSGS GGSSGGGSGY QDLGTSDSGR ASSKSGSSSS MGRPGHLGSG
310 320 330 340 350
EGGGGGLPFA ACSPPSPSAL IQELEERLWE KEQEVAALRR SLEQSEAAVA
360 370 380 390 400
QVLEERQKAW ERELAELRQG CSGKLQQVAR RAQRAQQGLQ LQVLRLQQDK
410 420 430 440 450
KQLQEEAARL MRQREELEDK VAACQKEQAD FLPRIEETKW EVCQKAGEIS
460 470 480 490 500
LLKQQLKDSQ ADVSQKLSEI VGLRSQLREG RASLREKEEQ LLSLRDSFSS
510 520 530 540 550
KQASLELGEG ELPAACLKPA LTPVDPAEPQ DALATCESDE AKMRRQAGVA
560 570 580 590 600
AAASLVSVDG EAEAGGESGT RALRREVGRL QAELAAERRA RERQGASFAE
610 620 630 640 650
ERRVWLEEKE KVIEYQKQLQ LSYVEMYQRN QQLERRLRER GAAGGASTPT
660 670
PQHGEEKKAW TPSRLERIES TEI
Length:673
Mass (Da):71,791
Last modified:August 1, 1998 - v1
Checksum:i3E548EC03A01F770
GO
Isoform 2 (identifier: O60299-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     351-396: Missing.

Show »
Length:627
Mass (Da):66,409
Checksum:i5747A212FD997D81
GO

Sequence cautioni

The sequence BAA25478 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti557S → Y in AAH38860 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_039202351 – 396Missing in isoform 2. 1 PublicationAdd BLAST46

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB011124 mRNA Translation: BAA25478.2 Different initiation.
AL121891 Genomic DNA No translation available.
CH471133 Genomic DNA Translation: EAX10545.1
CH471133 Genomic DNA Translation: EAX10546.1
CH471133 Genomic DNA Translation: EAX10547.1
BC038860 mRNA Translation: AAH38860.1
CCDSiCCDS63218.1 [O60299-2]
PIRiT00328
RefSeqiNP_001269462.1, NM_001282533.1 [O60299-2]
XP_005260949.1, XM_005260892.1 [O60299-1]
XP_005260950.1, XM_005260893.2 [O60299-1]
UniGeneiHs.90232

Genome annotation databases

EnsembliENST00000329152; ENSP00000332123; ENSG00000088899 [O60299-1]
ENST00000337576; ENSP00000338166; ENSG00000088899 [O60299-1]
ENST00000360342; ENSP00000353496; ENSG00000088899 [O60299-2]
ENST00000645462; ENSP00000495241; ENSG00000088899 [O60299-2]
GeneIDi9762
KEGGihsa:9762
UCSCiuc002wia.3 human [O60299-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB011124 mRNA Translation: BAA25478.2 Different initiation.
AL121891 Genomic DNA No translation available.
CH471133 Genomic DNA Translation: EAX10545.1
CH471133 Genomic DNA Translation: EAX10546.1
CH471133 Genomic DNA Translation: EAX10547.1
BC038860 mRNA Translation: AAH38860.1
CCDSiCCDS63218.1 [O60299-2]
PIRiT00328
RefSeqiNP_001269462.1, NM_001282533.1 [O60299-2]
XP_005260949.1, XM_005260892.1 [O60299-1]
XP_005260950.1, XM_005260893.2 [O60299-1]
UniGeneiHs.90232

3D structure databases

ProteinModelPortaliO60299
SMRiO60299
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115109, 6 interactors
IntActiO60299, 5 interactors
STRINGi9606.ENSP00000332123

PTM databases

iPTMnetiO60299
PhosphoSitePlusiO60299

Proteomic databases

EPDiO60299
MaxQBiO60299
PaxDbiO60299
PeptideAtlasiO60299
PRIDEiO60299
ProteomicsDBi49329
49330 [O60299-2]

Protocols and materials databases

DNASUi9762
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000329152; ENSP00000332123; ENSG00000088899 [O60299-1]
ENST00000337576; ENSP00000338166; ENSG00000088899 [O60299-1]
ENST00000360342; ENSP00000353496; ENSG00000088899 [O60299-2]
ENST00000645462; ENSP00000495241; ENSG00000088899 [O60299-2]
GeneIDi9762
KEGGihsa:9762
UCSCiuc002wia.3 human [O60299-1]

Organism-specific databases

CTDi9762
EuPathDBiHostDB:ENSG00000088899.14
GeneCardsiLZTS3
H-InvDBiHIX0015590
HGNCiHGNC:30139 LZTS3
HPAiHPA031008
HPA031009
MIMi610484 gene
neXtProtiNX_O60299
OpenTargetsiENSG00000088899
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFZY Eukaryota
ENOG410Z2V9 LUCA
GeneTreeiENSGT00510000046769
HOGENOMiHOG000230889
HOVERGENiHBG052381
InParanoidiO60299
OMAiVGYNGIS
OrthoDBiEOG091G03L2
PhylomeDBiO60299

Miscellaneous databases

ChiTaRSiLZTS3 human
GenomeRNAii9762
PROiPR:O60299
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000088899 Expressed in 220 organ(s), highest expression level in cerebellar vermis
GenevisibleiO60299 HS

Family and domain databases

InterProiView protein in InterPro
IPR033295 LZTS3
PANTHERiPTHR19354:SF6 PTHR19354:SF6, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLZTS3_HUMAN
AccessioniPrimary (citable) accession number: O60299
Secondary accession number(s): A2A2Q7, D3DVX6, Q8IXX8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: August 1, 1998
Last modified: November 7, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again