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Entry version 156 (13 Nov 2019)
Sequence version 2 (25 Oct 2002)
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Protein

Trafficking kinesin-binding protein 2

Gene

TRAK2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May regulate endosome-to-lysosome trafficking of membrane cargo, including EGFR.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Trafficking kinesin-binding protein 2
Alternative name(s):
Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 3 protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TRAK2
Synonyms:ALS2CR3, KIAA0549
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:13206 TRAK2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
607334 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O60296

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endosome, Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
66008

Open Targets

More...
OpenTargetsi
ENSG00000115993

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA24744

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
O60296

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TRAK2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000645381 – 914Trafficking kinesin-binding protein 2Add BLAST914

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei420PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

O-glycosylated.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O60296

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O60296

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
O60296

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O60296

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O60296

PeptideAtlas

More...
PeptideAtlasi
O60296

PRoteomics IDEntifications database

More...
PRIDEi
O60296

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
18553
49328 [O60296-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O60296

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O60296

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed, with highest expression in heart.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000115993 Expressed in 240 organ(s), highest expression level in spinal cord

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O60296 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O60296 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA015827
HPA062163

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with GABA-A receptor and O-GlcNAc transferase.

Interacts with HGS (By similarity).

Interacts with RHOT1/Miro-1 and RHOT2/Miro-2.

By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
122452, 40 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
O60296

Protein interaction database and analysis system

More...
IntActi
O60296, 30 interactors

Molecular INTeraction database

More...
MINTi
O60296

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000328875

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O60296

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini48 – 353HAP1 N-terminalAdd BLAST306

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni359 – 509Interaction with HGSBy similarityAdd BLAST151

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili134 – 354Sequence analysisAdd BLAST221

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the milton family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4360 Eukaryota
ENOG410XSWD LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158202

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000143414

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O60296

KEGG Orthology (KO)

More...
KOi
K15374

Identification of Orthologs from Complete Genome Data

More...
OMAi
QNFLCER

Database of Orthologous Groups

More...
OrthoDBi
1003820at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O60296

TreeFam database of animal gene trees

More...
TreeFami
TF323495

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006933 HAP1_N
IPR022154 Traffickng_kinesin-bd_prot_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04849 HAP1_N, 1 hit
PF12448 Milton, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: O60296-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSQSQNAIFT SPTGEENLMN SNHRDSESIT DVCSNEDLPE VELVSLLEEQ
60 70 80 90 100
LPQYRLKVDT LFLYENQDWT QSPHQRQHAS DALSPVLAEE TFRYMILGTD
110 120 130 140 150
RVEQMTKTYN DIDMVTHLLA ERDRDLELAA RIGQALLKRN HVLSEQNESL
160 170 180 190 200
EEQLGQAFDQ VNQLQHELCK KDELLRIVSI ASEESETDSS CSTPLRFNES
210 220 230 240 250
FSLSQGLLQL EMLQEKLKEL EEENMALRSK ACHIKTETVT YEEKEQQLVS
260 270 280 290 300
DCVKELRETN AQMSRMTEEL SGKSDELIRY QEELSSLLSQ IVDLQHKLKE
310 320 330 340 350
HVIEKEELKL HLQASKDAQR QLTMELHELQ DRNMECLGML HESQEEIKEL
360 370 380 390 400
RSRSGPTAHL YFSQSYGAFT GESLAAEIEG TMRKKLSLDE ESSLFKQKAQ
410 420 430 440 450
QKRVFDTVRI ANDTRGRSIS FPALLPIPGS NRSSVIMTAK PFESGLQQTE
460 470 480 490 500
DKSLLNQGSS SEEVAGSSQK MGQPGPSGDS DLATALHRLS LRRQNYLSEK
510 520 530 540 550
QFFAEEWQRK IQVLADQKEG VSGCVTPTES LASLCTTQSE ITDLSSASCL
560 570 580 590 600
RGFMPEKLQI VKPLEGSQTL YHWQQLAQPN LGTILDPRPG VITKGFTQLP
610 620 630 640 650
GDAIYHISDL EEDEEEGITF QVQQPLEVEE KLSTSKPVTG IFLPPITSAG
660 670 680 690 700
GPVTVATANP GKCLSCTNST FTFTTCRILH PSDITQVTPS SGFPSLSCGS
710 720 730 740 750
SGSSSSNTAV NSPALSYRLS IGESITNRRD STTTFSSTMS LAKLLQERGI
760 770 780 790 800
SAKVYHSPIS ENPLQPLPKS LAIPSTPPNS PSHSPCPSPL PFEPRVHLSE
810 820 830 840 850
NFLASRPAET FLQEMYGLRP SRNPPDVGQL KMNLVDRLKR LGIARVVKNP
860 870 880 890 900
GAQENGRCQE AEIGPQKPDS AVYLNSGSSL LGGLRRNQSL PVIMGSFAAP
910
VCTSSPKMGV LKED
Length:914
Mass (Da):101,419
Last modified:October 25, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC26525C223A70D6D
GO
Isoform 2 (identifier: O60296-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     301-311: HVIEKEELKLH → VGLFIHSTDIC
     312-914: Missing.

Show »
Length:311
Mass (Da):35,815
Checksum:iBD6C40048A0FFEEB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q53RS6Q53RS6_HUMAN
Trafficking kinesin-binding protein...
TRAK2 ALS2CR3
30Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_014201142V → I2 PublicationsCorresponds to variant dbSNP:rs13022344Ensembl.1
Natural variantiVAR_014434528T → I1 PublicationCorresponds to variant dbSNP:rs2244438Ensembl.1
Natural variantiVAR_051458863I → N1 PublicationCorresponds to variant dbSNP:rs34594680Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_053418301 – 311HVIEKEELKLH → VGLFIHSTDIC in isoform 2. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_053419312 – 914Missing in isoform 2. 1 PublicationAdd BLAST603

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB038964 Genomic DNA Translation: BAB32550.1
AB038951 mRNA Translation: BAB32501.1
AK054763 mRNA Translation: BAB70803.1
AC007256 Genomic DNA No translation available.
AC007282 Genomic DNA No translation available.
AC080069 Genomic DNA No translation available.
AB011121 mRNA Translation: BAA25475.1
BC017999 mRNA Translation: AAH17999.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS2347.1 [O60296-1]

NCBI Reference Sequences

More...
RefSeqi
NP_055864.2, NM_015049.2 [O60296-1]
XP_011509992.1, XM_011511690.1 [O60296-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000332624; ENSP00000328875; ENSG00000115993 [O60296-1]
ENST00000430254; ENSP00000409333; ENSG00000115993 [O60296-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
66008

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:66008

UCSC genome browser

More...
UCSCi
uc002uyb.5 human [O60296-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB038964 Genomic DNA Translation: BAB32550.1
AB038951 mRNA Translation: BAB32501.1
AK054763 mRNA Translation: BAB70803.1
AC007256 Genomic DNA No translation available.
AC007282 Genomic DNA No translation available.
AC080069 Genomic DNA No translation available.
AB011121 mRNA Translation: BAA25475.1
BC017999 mRNA Translation: AAH17999.1
CCDSiCCDS2347.1 [O60296-1]
RefSeqiNP_055864.2, NM_015049.2 [O60296-1]
XP_011509992.1, XM_011511690.1 [O60296-1]

3D structure databases

SMRiO60296
ModBaseiSearch...

Protein-protein interaction databases

BioGridi122452, 40 interactors
CORUMiO60296
IntActiO60296, 30 interactors
MINTiO60296
STRINGi9606.ENSP00000328875

PTM databases

iPTMnetiO60296
PhosphoSitePlusiO60296

Polymorphism and mutation databases

BioMutaiTRAK2

Proteomic databases

EPDiO60296
jPOSTiO60296
MassIVEiO60296
MaxQBiO60296
PaxDbiO60296
PeptideAtlasiO60296
PRIDEiO60296
ProteomicsDBi18553
49328 [O60296-1]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
66008

Genome annotation databases

EnsembliENST00000332624; ENSP00000328875; ENSG00000115993 [O60296-1]
ENST00000430254; ENSP00000409333; ENSG00000115993 [O60296-2]
GeneIDi66008
KEGGihsa:66008
UCSCiuc002uyb.5 human [O60296-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
66008
DisGeNETi66008

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TRAK2
HGNCiHGNC:13206 TRAK2
HPAiHPA015827
HPA062163
MIMi607334 gene
neXtProtiNX_O60296
OpenTargetsiENSG00000115993
PharmGKBiPA24744

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4360 Eukaryota
ENOG410XSWD LUCA
GeneTreeiENSGT00940000158202
HOGENOMiHOG000143414
InParanoidiO60296
KOiK15374
OMAiQNFLCER
OrthoDBi1003820at2759
PhylomeDBiO60296
TreeFamiTF323495

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
TRAK2 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
TRAK2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
66008
PharosiO60296

Protein Ontology

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PROi
PR:O60296

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
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Gene expression databases

BgeeiENSG00000115993 Expressed in 240 organ(s), highest expression level in spinal cord
ExpressionAtlasiO60296 baseline and differential
GenevisibleiO60296 HS

Family and domain databases

InterProiView protein in InterPro
IPR006933 HAP1_N
IPR022154 Traffickng_kinesin-bd_prot_dom
PfamiView protein in Pfam
PF04849 HAP1_N, 1 hit
PF12448 Milton, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTRAK2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O60296
Secondary accession number(s): E7EV21
, Q8WVH7, Q96NS2, Q9C0K5, Q9C0K6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: October 25, 2002
Last modified: November 13, 2019
This is version 156 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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