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Protein

Trafficking kinesin-binding protein 2

Gene

TRAK2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May regulate endosome-to-lysosome trafficking of membrane cargo, including EGFR.By similarity

GO - Molecular functioni

  • enzyme binding Source: Ensembl
  • GABA receptor binding Source: GO_Central
  • kinesin binding Source: Ensembl
  • myosin binding Source: GO_Central
  • signaling receptor binding Source: UniProtKB
  • TPR domain binding Source: Ensembl

GO - Biological processi

Keywordsi

Biological processTransport

Names & Taxonomyi

Protein namesi
Recommended name:
Trafficking kinesin-binding protein 2
Alternative name(s):
Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 3 protein
Gene namesi
Name:TRAK2
Synonyms:ALS2CR3, KIAA0549
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000115993.11
HGNCiHGNC:13206 TRAK2
MIMi607334 gene
neXtProtiNX_O60296

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endosome, Mitochondrion

Pathology & Biotechi

Organism-specific databases

DisGeNETi66008
OpenTargetsiENSG00000115993
PharmGKBiPA24744

Polymorphism and mutation databases

BioMutaiTRAK2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000645381 – 914Trafficking kinesin-binding protein 2Add BLAST914

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei420PhosphoserineCombined sources1

Post-translational modificationi

O-glycosylated.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiO60296
MaxQBiO60296
PaxDbiO60296
PeptideAtlasiO60296
PRIDEiO60296
ProteomicsDBi49328

PTM databases

iPTMnetiO60296
PhosphoSitePlusiO60296

Expressioni

Tissue specificityi

Widely expressed, with highest expression in heart.

Gene expression databases

BgeeiENSG00000115993 Expressed in 240 organ(s), highest expression level in spinal cord
CleanExiHS_TRAK2
ExpressionAtlasiO60296 baseline and differential
GenevisibleiO60296 HS

Organism-specific databases

HPAiHPA015827
HPA062163

Interactioni

Subunit structurei

Interacts with GABA-A receptor and O-GlcNAc transferase. Interacts with HGS (By similarity). Interacts with RHOT1/Miro-1 and RHOT2/Miro-2.By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi122452, 37 interactors
CORUMiO60296
IntActiO60296, 4 interactors
STRINGi9606.ENSP00000328875

Structurei

3D structure databases

ProteinModelPortaliO60296
SMRiO60296
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini48 – 353HAP1 N-terminalAdd BLAST306

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni359 – 509Interaction with HGSBy similarityAdd BLAST151

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili134 – 354Sequence analysisAdd BLAST221

Sequence similaritiesi

Belongs to the milton family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG4360 Eukaryota
ENOG410XSWD LUCA
GeneTreeiENSGT00390000003132
HOGENOMiHOG000143414
HOVERGENiHBG069248
InParanoidiO60296
KOiK15374
OMAiTSNPGKC
OrthoDBiEOG091G0LLD
PhylomeDBiO60296
TreeFamiTF323495

Family and domain databases

InterProiView protein in InterPro
IPR006933 HAP1_N
IPR022154 Traffickng_kinesin-bd_prot_dom
PfamiView protein in Pfam
PF04849 HAP1_N, 1 hit
PF12448 Milton, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: O60296-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSQSQNAIFT SPTGEENLMN SNHRDSESIT DVCSNEDLPE VELVSLLEEQ
60 70 80 90 100
LPQYRLKVDT LFLYENQDWT QSPHQRQHAS DALSPVLAEE TFRYMILGTD
110 120 130 140 150
RVEQMTKTYN DIDMVTHLLA ERDRDLELAA RIGQALLKRN HVLSEQNESL
160 170 180 190 200
EEQLGQAFDQ VNQLQHELCK KDELLRIVSI ASEESETDSS CSTPLRFNES
210 220 230 240 250
FSLSQGLLQL EMLQEKLKEL EEENMALRSK ACHIKTETVT YEEKEQQLVS
260 270 280 290 300
DCVKELRETN AQMSRMTEEL SGKSDELIRY QEELSSLLSQ IVDLQHKLKE
310 320 330 340 350
HVIEKEELKL HLQASKDAQR QLTMELHELQ DRNMECLGML HESQEEIKEL
360 370 380 390 400
RSRSGPTAHL YFSQSYGAFT GESLAAEIEG TMRKKLSLDE ESSLFKQKAQ
410 420 430 440 450
QKRVFDTVRI ANDTRGRSIS FPALLPIPGS NRSSVIMTAK PFESGLQQTE
460 470 480 490 500
DKSLLNQGSS SEEVAGSSQK MGQPGPSGDS DLATALHRLS LRRQNYLSEK
510 520 530 540 550
QFFAEEWQRK IQVLADQKEG VSGCVTPTES LASLCTTQSE ITDLSSASCL
560 570 580 590 600
RGFMPEKLQI VKPLEGSQTL YHWQQLAQPN LGTILDPRPG VITKGFTQLP
610 620 630 640 650
GDAIYHISDL EEDEEEGITF QVQQPLEVEE KLSTSKPVTG IFLPPITSAG
660 670 680 690 700
GPVTVATANP GKCLSCTNST FTFTTCRILH PSDITQVTPS SGFPSLSCGS
710 720 730 740 750
SGSSSSNTAV NSPALSYRLS IGESITNRRD STTTFSSTMS LAKLLQERGI
760 770 780 790 800
SAKVYHSPIS ENPLQPLPKS LAIPSTPPNS PSHSPCPSPL PFEPRVHLSE
810 820 830 840 850
NFLASRPAET FLQEMYGLRP SRNPPDVGQL KMNLVDRLKR LGIARVVKNP
860 870 880 890 900
GAQENGRCQE AEIGPQKPDS AVYLNSGSSL LGGLRRNQSL PVIMGSFAAP
910
VCTSSPKMGV LKED
Length:914
Mass (Da):101,419
Last modified:October 25, 2002 - v2
Checksum:iC26525C223A70D6D
GO
Isoform 2 (identifier: O60296-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     301-311: HVIEKEELKLH → VGLFIHSTDIC
     312-914: Missing.

Show »
Length:311
Mass (Da):35,815
Checksum:iBD6C40048A0FFEEB
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q53RS6Q53RS6_HUMAN
Trafficking kinesin-binding protein...
TRAK2 ALS2CR3
30Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_014201142V → I2 PublicationsCorresponds to variant dbSNP:rs13022344Ensembl.1
Natural variantiVAR_014434528T → I1 PublicationCorresponds to variant dbSNP:rs2244438Ensembl.1
Natural variantiVAR_051458863I → N1 PublicationCorresponds to variant dbSNP:rs34594680Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_053418301 – 311HVIEKEELKLH → VGLFIHSTDIC in isoform 2. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_053419312 – 914Missing in isoform 2. 1 PublicationAdd BLAST603

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB038964 Genomic DNA Translation: BAB32550.1
AB038951 mRNA Translation: BAB32501.1
AK054763 mRNA Translation: BAB70803.1
AC007256 Genomic DNA No translation available.
AC007282 Genomic DNA No translation available.
AC080069 Genomic DNA No translation available.
AB011121 mRNA Translation: BAA25475.1
BC017999 mRNA Translation: AAH17999.1
CCDSiCCDS2347.1 [O60296-1]
RefSeqiNP_055864.2, NM_015049.2 [O60296-1]
XP_011509992.1, XM_011511690.1 [O60296-1]
UniGeneiHs.152774

Genome annotation databases

EnsembliENST00000332624; ENSP00000328875; ENSG00000115993 [O60296-1]
ENST00000430254; ENSP00000409333; ENSG00000115993 [O60296-2]
GeneIDi66008
KEGGihsa:66008
UCSCiuc002uyb.5 human [O60296-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB038964 Genomic DNA Translation: BAB32550.1
AB038951 mRNA Translation: BAB32501.1
AK054763 mRNA Translation: BAB70803.1
AC007256 Genomic DNA No translation available.
AC007282 Genomic DNA No translation available.
AC080069 Genomic DNA No translation available.
AB011121 mRNA Translation: BAA25475.1
BC017999 mRNA Translation: AAH17999.1
CCDSiCCDS2347.1 [O60296-1]
RefSeqiNP_055864.2, NM_015049.2 [O60296-1]
XP_011509992.1, XM_011511690.1 [O60296-1]
UniGeneiHs.152774

3D structure databases

ProteinModelPortaliO60296
SMRiO60296
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122452, 37 interactors
CORUMiO60296
IntActiO60296, 4 interactors
STRINGi9606.ENSP00000328875

PTM databases

iPTMnetiO60296
PhosphoSitePlusiO60296

Polymorphism and mutation databases

BioMutaiTRAK2

Proteomic databases

EPDiO60296
MaxQBiO60296
PaxDbiO60296
PeptideAtlasiO60296
PRIDEiO60296
ProteomicsDBi49328

Protocols and materials databases

DNASUi66008
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000332624; ENSP00000328875; ENSG00000115993 [O60296-1]
ENST00000430254; ENSP00000409333; ENSG00000115993 [O60296-2]
GeneIDi66008
KEGGihsa:66008
UCSCiuc002uyb.5 human [O60296-1]

Organism-specific databases

CTDi66008
DisGeNETi66008
EuPathDBiHostDB:ENSG00000115993.11
GeneCardsiTRAK2
H-InvDBiHIX0002738
HGNCiHGNC:13206 TRAK2
HPAiHPA015827
HPA062163
MIMi607334 gene
neXtProtiNX_O60296
OpenTargetsiENSG00000115993
PharmGKBiPA24744
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4360 Eukaryota
ENOG410XSWD LUCA
GeneTreeiENSGT00390000003132
HOGENOMiHOG000143414
HOVERGENiHBG069248
InParanoidiO60296
KOiK15374
OMAiTSNPGKC
OrthoDBiEOG091G0LLD
PhylomeDBiO60296
TreeFamiTF323495

Miscellaneous databases

ChiTaRSiTRAK2 human
GeneWikiiTRAK2
GenomeRNAii66008
PROiPR:O60296
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000115993 Expressed in 240 organ(s), highest expression level in spinal cord
CleanExiHS_TRAK2
ExpressionAtlasiO60296 baseline and differential
GenevisibleiO60296 HS

Family and domain databases

InterProiView protein in InterPro
IPR006933 HAP1_N
IPR022154 Traffickng_kinesin-bd_prot_dom
PfamiView protein in Pfam
PF04849 HAP1_N, 1 hit
PF12448 Milton, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTRAK2_HUMAN
AccessioniPrimary (citable) accession number: O60296
Secondary accession number(s): E7EV21
, Q8WVH7, Q96NS2, Q9C0K5, Q9C0K6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: October 25, 2002
Last modified: November 7, 2018
This is version 147 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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