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Entry version 153 (08 May 2019)
Sequence version 3 (01 May 2007)
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Protein

Zinc finger C3H1 domain-containing protein

Gene

ZFC3H1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Subunit of the trimeric poly(A) tail exosome targeting (PAXT) complex, a complex that directs a subset of long and polyadenylated poly(A) RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor MTREX, which links to RNA-binding protein adapters.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri1185 – 1206C3H1-typeAdd BLAST22

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger C3H1 domain-containing protein
Alternative name(s):
Coiled-coil domain-containing protein 131
Proline/serine-rich coiled-coil protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZFC3H1
Synonyms:CCDC131, KIAA0546, PSRC2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:28328 ZFC3H1

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O60293

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
196441

Open Targets

More...
OpenTargetsi
ENSG00000133858

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA164727644

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZFC3H1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002861032 – 1989Zinc finger C3H1 domain-containing proteinAdd BLAST1988

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
Modified residuei15PhosphoserineCombined sources1
Modified residuei28PhosphoserineCombined sources1
Modified residuei34PhosphoserineCombined sources1
Modified residuei128PhosphoserineCombined sources1
Modified residuei251PhosphoserineCombined sources1
Modified residuei352PhosphoserineCombined sources1
Modified residuei383PhosphoserineCombined sources1
Modified residuei662PhosphoserineCombined sources1
Modified residuei714PhosphoserineCombined sources1
Modified residuei717PhosphoserineCombined sources1
Modified residuei719PhosphoserineCombined sources1
Modified residuei766PhosphothreonineCombined sources1
Modified residuei805PhosphoserineCombined sources1
Modified residuei809PhosphoserineCombined sources1
Modified residuei948PhosphoserineCombined sources1
Modified residuei949PhosphoserineCombined sources1
Modified residuei953PhosphoserineCombined sources1
Modified residuei998PhosphoserineCombined sources1
Modified residuei1046PhosphoserineCombined sources1
Modified residuei1301PhosphoserineCombined sources1
Modified residuei1303PhosphoserineCombined sources1
Modified residuei1304PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O60293

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O60293

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O60293

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O60293

PeptideAtlas

More...
PeptideAtlasi
O60293

PRoteomics IDEntifications database

More...
PRIDEi
O60293

ProteomicsDB human proteome resource

More...
ProteomicsDBi
49324
49325 [O60293-2]
49326 [O60293-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O60293

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O60293

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000133858 Expressed in 228 organ(s), highest expression level in epithelium of mammary gland

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O60293 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
O60293 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA007072
HPA007151

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the poly(A) tail exosome targeting (PAXT) complex made of accessory factors, such as PABPN1, ZFC3H1 and MTREX, and which directs a subset of long and polyadenylated poly(A) RNAs for exosomal degradation (PubMed:27871484). Co-localizes with component of the CBC-ARS2 (CBCA) complex. Binds to RNA exosome components. Interacts with NCBP1/CBP80, ZC3H18, MTREX and PABPN1 in a RNase-insensitive manner, and with PABPC4, PABPC1 and ZC3H14 in a RNase-sensitive manner (PubMed:27871484).1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
MYBP102422EBI-746701,EBI-298355

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
128206, 99 interactors

Protein interaction database and analysis system

More...
IntActi
O60293, 33 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000368017

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O60293

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati1361 – 1400TPR 1Add BLAST40
Repeati1401 – 1434TPR 2Add BLAST34
Repeati1438 – 1471TPR 3Add BLAST34
Repeati1478 – 1511TPR 4Add BLAST34
Repeati1602 – 1635TPR 5Add BLAST34
Repeati1636 – 1669TPR 6Add BLAST34
Repeati1745 – 1778TPR 7Add BLAST34

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili219 – 259Sequence analysisAdd BLAST41
Coiled coili358 – 389Sequence analysisAdd BLAST32
Coiled coili432 – 487Sequence analysisAdd BLAST56
Coiled coili847 – 909Sequence analysisAdd BLAST63
Coiled coili965 – 989Sequence analysisAdd BLAST25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi34 – 132Ser-richAdd BLAST99
Compositional biasi542 – 616Pro-richAdd BLAST75

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1185 – 1206C3H1-typeAdd BLAST22

Keywords - Domaini

Coiled coil, Repeat, TPR repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4839 Eukaryota
ENOG410XQ07 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000001116

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000060198

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O60293

Identification of Orthologs from Complete Genome Data

More...
OMAi
KFWRKPV

Database of Orthologous Groups

More...
OrthoDBi
167870at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O60293

TreeFam database of animal gene trees

More...
TreeFami
TF331613

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003107 HAT
IPR019607 Putative_zinc-finger_domain
IPR039278 Red1
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR21563 PTHR21563, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10650 zf-C3H1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00386 HAT, 5 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48452 SSF48452, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50293 TPR_REGION, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: O60293-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MATADTPAPA SSGLSPKEEG ELEDGEISDD DNNSQIRSRS SSSSSGGGLL
60 70 80 90 100
PYPRRRPPHS ARGGGSGGGG GSSSSSSSSQ QQLRNFSRSR HASERGHLRG
110 120 130 140 150
PSSYRPKEPF RSHPPSVRMP SSSLSESSPR PSFWERSHLA LDRFRFRGRP
160 170 180 190 200
YRGGSRWSRG RGVGERGGKP GCRPPLGGGA GSGFSSSQSW REPSPPRKSS
210 220 230 240 250
KSFGRSPSRK QNYSSKNENC VEETFEDLLL KYKQIQLELE CINKDEKLAL
260 270 280 290 300
SSKEENVQED PKTLNFEDQT STDNVSITKD SSKEVAPEEK TQVKTFQAFE
310 320 330 340 350
LKPLRQKLTL PGDKNRLKKV KDGAKPLSLK SDTTDSSQGL QDKEQNLTRR
360 370 380 390 400
ISTSDILSEK KLGEDEEELS ELQLRLLALQ SASKKWQQKE QQVMKESKEK
410 420 430 440 450
LTKTKTVQQK VKTSTKTHSA KKVSTTAKQA LRKQQTKAWK KLQQQKEQER
460 470 480 490 500
QKEEDQRKQA EEEERRKREE EIRKIRDLSN QEEQYNRFMK LVGGKRRSRS
510 520 530 540 550
KSSDPDLRRS LDKQPTDSGG GIYQYDNYEE VAMDTDSETS SPAPSPVQPP
560 570 580 590 600
FFSECSLGYF SPAPSLSLPP PPQVSSLPPL SQPYVEGLCV SLEPLPPLPP
610 620 630 640 650
LPPLPPEDPE QPPKPPFADE EEEEEMLLRE ELLKSLANKR AFKPEETSSN
660 670 680 690 700
SDPPSPPVLN NSHPVPRSNL SIVSINTVSQ PRIQNPKFHR GPRLPRTVIS
710 720 730 740 750
LPKHKSVVVT LNDSDDSESD GEASKSTNSV FGGLESMIKE ARRTAEQASK
760 770 780 790 800
PKVPPKSEKE NDPLRTPEAL PEEKKIEYRL LKEEIANREK QRLIKSDQLK
810 820 830 840 850
TSSSSPANSD VEIDGIGRIA MVTKQVTDAE SKLKKHRILL MKDESVLKNL
860 870 880 890 900
VQQEAKKKES VRNAEAKITK LTEQLQATEK ILNVNRMFLK KLQEQIHRVQ
910 920 930 940 950
QRVTIKKALT LKYGEELARA KAVASKEIGK RKLEQDRFGP NKMMRLDSSP
960 970 980 990 1000
VSSPRKHSAE LIAMEKRRLQ KLEYEYALKI QKLKEARALK AKEQQNISPV
1010 1020 1030 1040 1050
VEEEPEFSLP QPSLHDLTQD KLTLDTEEND VDDEILSGSS RERRRSFLES
1060 1070 1080 1090 1100
NYFTKPNLKH TDTANKECIN KLNKNTVEKP ELFLGLKIGE LQKLYSKADS
1110 1120 1130 1140 1150
LKQLILKTTT GITEKVLHGQ EISVDVDFVT AQSKTMEVKP CPFRPYHSPL
1160 1170 1180 1190 1200
LVFKSYRFSP YYRTKEKLPL SSVSYSNMIE PDQCFCRFDL TGTCNDDDCQ
1210 1220 1230 1240 1250
WQHIQDYTLS RKQLFQDILS YNLSLIGCAE TSTNEEITAS AEKYVEKLFG
1260 1270 1280 1290 1300
VNKDRMSMDQ MAVLLVSNIN ESKGHTPPFT TYKDKRKWKP KFWRKPISDN
1310 1320 1330 1340 1350
SFSSDEEQST GPIKYAFQPE NQINVPALDT VVTPDDVRYF TNETDDIANL
1360 1370 1380 1390 1400
EASVLENPSH VQLWLKLAYK YLNQNEGECS ESLDSALNVL ARALENNKDN
1410 1420 1430 1440 1450
PEIWCHYLRL FSKRGTKDEV QEMCETAVEY APDYQSFWTF LHLESTFEEK
1460 1470 1480 1490 1500
DYVCERMLEF LMGAAKQETS NILSFQLLEA LLFRVQLHIF TGRCQSALAI
1510 1520 1530 1540 1550
LQNALKSAND GIVAEYLKTS DRCLAWLAYI HLIEFNILPS KFYDPSNDNP
1560 1570 1580 1590 1600
SRIVNTESFV MPWQAVQDVK TNPDMLLAVF EDAVKACTDE SLAVEERIEA
1610 1620 1630 1640 1650
CLPLYTNMIA LHQLLERYEA AMELCKSLLE SCPINCQLLE ALVALYLQTN
1660 1670 1680 1690 1700
QHDKARAVWL TAFEKNPQNA EVFYHMCKFF ILQNRGDNLL PFLRKFIASF
1710 1720 1730 1740 1750
FKPGFEKYNN LDLFRYLLNI PGPIDIPSRL CKGNFDDDMF NHQVPYLWLI
1760 1770 1780 1790 1800
YCLCHPLQSS IKETVEAYEA ALGVAMRCDI VQKIWMDYLV FANNRAAGSR
1810 1820 1830 1840 1850
NKVQEFKFFT DLVNRCLVTV PARYPIPFSS ADYWSNYEFH NRVIFFYLSC
1860 1870 1880 1890 1900
VPKTQHSKTL ERFCSVMPAN SGLALRLLQH EWEESNVQIL KLQAKMFTYN
1910 1920 1930 1940 1950
IPTCLATWKI AIAAEIVLKG QREVHRLYQR ALQKLPLCAS LWKDQLLFEA
1960 1970 1980
SEGGKTDNLR KLVSKCQEIG VSLNELLNLN SNKTESKNH
Length:1,989
Mass (Da):226,356
Last modified:May 1, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE5FED04FAE866FDB
GO
Isoform 2 (identifier: O60293-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1910-1989: IAIAAEIVLK...NSNKTESKNH → M

Note: No experimental confirmation available.
Show »
Length:1,910
Mass (Da):217,490
Checksum:i3C18D0452FB02D65
GO
Isoform 4 (identifier: O60293-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     340-346: LQDKEQN → NGIKYFS
     347-1989: Missing.

Note: No experimental confirmation available.
Show »
Length:346
Mass (Da):37,841
Checksum:i1451AF85D85AB236
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V1X1G3V1X1_HUMAN
Proline/serine-rich coiled-coil 2, ...
ZFC3H1 PSRC2, hCG_25411
358Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA25472 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC86028 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0320701006E → K. Corresponds to variant dbSNP:rs1011332Ensembl.1
Natural variantiVAR_0320711807K → R. Corresponds to variant dbSNP:rs11541286Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_024992340 – 346LQDKEQN → NGIKYFS in isoform 4. 1 Publication7
Alternative sequenceiVSP_024993347 – 1989Missing in isoform 4. 1 PublicationAdd BLAST1643
Alternative sequenceiVSP_0249951910 – 1989IAIAA…ESKNH → M in isoform 2. 1 PublicationAdd BLAST80

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AB011118 mRNA Translation: BAA25472.2 Different initiation.
BC064336 mRNA Translation: AAH64336.1 Different termination.
BC073843 mRNA Translation: AAH73843.1
AK125035 mRNA Translation: BAC86028.1 Different initiation.

The Consensus CDS (CCDS) project

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CCDSi
CCDS41813.1 [O60293-1]

Protein sequence database of the Protein Information Resource

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PIRi
T00325

NCBI Reference Sequences

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RefSeqi
NP_659419.3, NM_144982.4 [O60293-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000378743; ENSP00000368017; ENSG00000133858 [O60293-1]
ENST00000548100; ENSP00000450044; ENSG00000133858 [O60293-4]
ENST00000552994; ENSP00000446995; ENSG00000133858 [O60293-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
196441

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:196441

UCSC genome browser

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UCSCi
uc001swo.4 human [O60293-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB011118 mRNA Translation: BAA25472.2 Different initiation.
BC064336 mRNA Translation: AAH64336.1 Different termination.
BC073843 mRNA Translation: AAH73843.1
AK125035 mRNA Translation: BAC86028.1 Different initiation.
CCDSiCCDS41813.1 [O60293-1]
PIRiT00325
RefSeqiNP_659419.3, NM_144982.4 [O60293-1]

3D structure databases

SMRiO60293
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128206, 99 interactors
IntActiO60293, 33 interactors
STRINGi9606.ENSP00000368017

PTM databases

iPTMnetiO60293
PhosphoSitePlusiO60293

Polymorphism and mutation databases

BioMutaiZFC3H1

Proteomic databases

EPDiO60293
jPOSTiO60293
MaxQBiO60293
PaxDbiO60293
PeptideAtlasiO60293
PRIDEiO60293
ProteomicsDBi49324
49325 [O60293-2]
49326 [O60293-4]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
196441
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000378743; ENSP00000368017; ENSG00000133858 [O60293-1]
ENST00000548100; ENSP00000450044; ENSG00000133858 [O60293-4]
ENST00000552994; ENSP00000446995; ENSG00000133858 [O60293-2]
GeneIDi196441
KEGGihsa:196441
UCSCiuc001swo.4 human [O60293-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
196441
DisGeNETi196441

GeneCards: human genes, protein and diseases

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GeneCardsi
ZFC3H1

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0010820
HGNCiHGNC:28328 ZFC3H1
HPAiHPA007072
HPA007151
neXtProtiNX_O60293
OpenTargetsiENSG00000133858
PharmGKBiPA164727644

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4839 Eukaryota
ENOG410XQ07 LUCA
GeneTreeiENSGT00390000001116
HOGENOMiHOG000060198
InParanoidiO60293
OMAiKFWRKPV
OrthoDBi167870at2759
PhylomeDBiO60293
TreeFamiTF331613

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ZFC3H1 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
196441

Protein Ontology

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PROi
PR:O60293

Gene expression databases

BgeeiENSG00000133858 Expressed in 228 organ(s), highest expression level in epithelium of mammary gland
ExpressionAtlasiO60293 baseline and differential
GenevisibleiO60293 HS

Family and domain databases

Gene3Di1.25.40.10, 2 hits
InterProiView protein in InterPro
IPR003107 HAT
IPR019607 Putative_zinc-finger_domain
IPR039278 Red1
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
PANTHERiPTHR21563 PTHR21563, 1 hit
PfamiView protein in Pfam
PF10650 zf-C3H1, 1 hit
SMARTiView protein in SMART
SM00386 HAT, 5 hits
SUPFAMiSSF48452 SSF48452, 2 hits
PROSITEiView protein in PROSITE
PS50293 TPR_REGION, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZC3H1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O60293
Secondary accession number(s): Q6GMU1
, Q6P2S9, Q6ZV36, Q96BE7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: May 1, 2007
Last modified: May 8, 2019
This is version 153 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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