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Protein

Signal-induced proliferation-associated 1-like protein 3

Gene

SIPA1L3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a critical role in epithelial cell morphogenesis, polarity, adhesion and cytoskeletal organization in the lens (PubMed:26231217).1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGTPase activation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Signal-induced proliferation-associated 1-like protein 3
Short name:
SIPA1-like protein 3
Alternative name(s):
SPA-1-like protein 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SIPA1L3
Synonyms:KIAA0545, SPAL3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000105738.10

Human Gene Nomenclature Database

More...
HGNCi
HGNC:23801 SIPA1L3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
616655 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O60292

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

A chromosomal translocation involving SIPA1L3 is found in a patient with bilateral severe ocular abnormalities including congenital cataracts, corneal clouding, iridocorneal and lenticular adhesions and microphthalmia. Chromosomal translocation t(2;19)(q37.3;q13.1). In addition to translocation, missense variant has been found in patient with bilateral congenital cataracts (PubMed:26231217).1 Publication
Cataract 45 (CTRCT45)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn opacification of the crystalline lens of the eye that frequently results in visual impairment or blindness. Opacities vary in morphology, are often confined to a portion of the lens, and may be static or progressive. In general, the more posteriorly located and dense an opacity, the greater the impact on visual function.
See also OMIM:616851

Keywords - Diseasei

Cataract

Organism-specific databases

DisGeNET

More...
DisGeNETi
23094

MalaCards human disease database

More...
MalaCardsi
SIPA1L3
MIMi616851 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000105738

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
98994 Total early-onset cataract

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134866783

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SIPA1L3

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000567521 – 1781Signal-induced proliferation-associated 1-like protein 3Add BLAST1781

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei100PhosphoserineBy similarity1
Modified residuei146PhosphoserineBy similarity1
Modified residuei401PhosphoserineCombined sources1
Modified residuei1364PhosphoserineCombined sources1
Modified residuei1387PhosphothreonineBy similarity1
Modified residuei1448N6-acetyllysineCombined sources1
Modified residuei1544PhosphoserineCombined sources1
Modified residuei1547PhosphoserineBy similarity1
Modified residuei1619PhosphoserineBy similarity1
Modified residuei1622PhosphoserineBy similarity1
Modified residuei1677PhosphoserineBy similarity1
Modified residuei1699PhosphothreonineCombined sources1
Modified residuei1703PhosphothreonineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O60292

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O60292

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O60292

PeptideAtlas

More...
PeptideAtlasi
O60292

PRoteomics IDEntifications database

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PRIDEi
O60292

ProteomicsDB human proteome resource

More...
ProteomicsDBi
49323

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O60292

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O60292

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000105738 Expressed in 222 organ(s), highest expression level in intestine

CleanEx database of gene expression profiles

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CleanExi
HS_SIPA1L3

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
O60292 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O60292 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA042072
HPA045480

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
116722, 51 interactors

Protein interaction database and analysis system

More...
IntActi
O60292, 34 interactors

Molecular INTeraction database

More...
MINTi
O60292

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000222345

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
O60292

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O60292

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini611 – 828Rap-GAPPROSITE-ProRule annotationAdd BLAST218
Domaini966 – 1042PDZPROSITE-ProRule annotationAdd BLAST77

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1720 – 1774Sequence analysisAdd BLAST55

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3686 Eukaryota
ENOG410XTIX LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159183

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000154319

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG056135

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O60292

KEGG Orthology (KO)

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KOi
K17703

Identification of Orthologs from Complete Genome Data

More...
OMAi
KDQYQYR

Database of Orthologous Groups

More...
OrthoDBi
EOG091G016P

Database for complete collections of gene phylogenies

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PhylomeDBi
O60292

TreeFam database of animal gene trees

More...
TreeFami
TF318626

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.40.50.11210, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR001478 PDZ
IPR036034 PDZ_sf
IPR035974 Rap/Ran-GAP_sf
IPR000331 Rap_GAP_dom
IPR031204 SIPA1L3
IPR021818 SIPA1L_C

The PANTHER Classification System

More...
PANTHERi
PTHR15711:SF15 PTHR15711:SF15, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02145 Rap_GAP, 1 hit
PF11881 SPAR_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00228 PDZ, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF111347 SSF111347, 1 hit
SSF50156 SSF50156, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50106 PDZ, 1 hit
PS50085 RAPGAP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

O60292-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTTYRAIPSD GVDLAASCGA RVGDVLPGPH TGDYAPLGFW AQNGSMSQPL
60 70 80 90 100
GESPATATAT ATATTRPSPT TPAMPKMGVR ARVADWPPKR EALREHSNPS
110 120 130 140 150
PSQDTDGTKA TKMAHSMRSI QNGQPPTSTP ASSGSKAFHR LSRRRSKDVE
160 170 180 190 200
FQDGWPRSPG RAFLPLRHRS SSEITLSECD AEDAGEPRGA RHTGALPLFR
210 220 230 240 250
EYGSTSSIDV QGMPEQSFFD ILNEFRSEQP DARGCQALTE LLRADPGPHL
260 270 280 290 300
MGGGGGAKGD SHNGQPAKDS LLPLQPTKEK EKARKKPARG LGGGDTVDSS
310 320 330 340 350
IFRKLRSSKP EGEAGRSPGE ADEGRSPPEA SRPWVCQKSF AHFDVQSMLF
360 370 380 390 400
DLNEAAANRV SVSQRRNTTT GASAASAASA MASLTASRAH SLGGLDPAFT
410 420 430 440 450
STEDLNCKEN LEQDLGDDNS NDLLLSCPHF RNEIGGECER NVSFSRASVG
460 470 480 490 500
SPSSGEGHLA EPALSAYRTN ASISVLEVPK EQQRTQSRPR QYSIEHVDLG
510 520 530 540 550
ARYYQDYFVG KEHANYFGVD EKLGPVAVSI KREKLEDHKE HGPQYQYRII
560 570 580 590 600
FRTRELITLR GSILEDATPT ATKHGTGRGL PLKDALEYVI PELNIHCLRL
610 620 630 640 650
ALNTPKVTEQ LLKLDEQGLC RKHKVGILYC KAGQSSEEEM YNNEEAGPAF
660 670 680 690 700
EEFLSLIGEK VCLKGFTKYA AQLDVKTDST GTHSLYTMYQ DYEIMFHVST
710 720 730 740 750
LLPYTPNNRQ QLLRKRHIGN DIVTIIFQEP GALPFTPKNI RSHFQHVFII
760 770 780 790 800
VRVHNPCTDN VCYSMAVTRS KDAPPFGPPI PSGTTFRKSD VFRDFLLAKV
810 820 830 840 850
INAENAAHKS DKFHTMATRT RQEYLKDLAE NCVSNTPIDS TGKFNLISLT
860 870 880 890 900
SKKKEKTKAR AGAEQHSAGA IAWRVVAQDY AQGVEIDCIL GISNEFVVLL
910 920 930 940 950
DLRTKEVVFN CYCGDVIGWT PDSSTLKIFY GRGDHIFLQA TEGSVEDIRE
960 970 980 990 1000
IVQRLKVMTS GWETVDMTLR RNGLGQLGFH VKYDGTVAEV EDYGFAWQAG
1010 1020 1030 1040 1050
LRQGSRLVEI CKVAVVTLTH DQMIDLLRTS VTVKVVIIPP FEDGTPRRGW
1060 1070 1080 1090 1100
PETYDMNTSE PKTEQESITP GGRPPYRSNA PWQWSGPASH NSLPASKWAT
1110 1120 1130 1140 1150
PTTPGHAQSL SRPLKQTPIV PFRESQPLHS KRPVSFPETP YTVSPAGADR
1160 1170 1180 1190 1200
VPPYRQPSGS FSTPGSATYV RYKPSPERYT AAPHPLLSLD PHFSHDGTSS
1210 1220 1230 1240 1250
GDSSSGGLTS QESTMERQKP EPLWHVPAQA RLSAIAGSSG NKHPSRQDAA
1260 1270 1280 1290 1300
GKDSPNRHSK GEPQYSSHSS SNTLSSNASS SHSDDRWFDP LDPLEPEQDP
1310 1320 1330 1340 1350
LSKGGSSDSG IDTTLYTSSP SCMSLAKAPR PAKPHKPPGS MGLCGGGREA
1360 1370 1380 1390 1400
AGRSHHADRR REVSPAPAVA GQSKGYRPKL YSSGSSTPTG LAGGSRDPPR
1410 1420 1430 1440 1450
QPSDMGSRVG YPAQVYKTAS AETPRPSQLA QPSPFQLSAS VPKSFFSKQP
1460 1470 1480 1490 1500
VRNKHPTGWK RTEEPPPRPL PFSDPKKQVD TNTKNVFGQP RLRASLRDLR
1510 1520 1530 1540 1550
SPRKNYKSTI EDDLKKLIIM DNLGPEQERD TGQSPQKGLQ RTLSDESLCS
1560 1570 1580 1590 1600
GRREPSFASP AGLEPGLPSD VLFTSTCAFP SSTLPARRQH QHPHPPVGPG
1610 1620 1630 1640 1650
ATPAAGSGFP EKKSTISASE LSLADGRDRP LRRLDPGLMP LPDTAAGLEW
1660 1670 1680 1690 1700
SSLVNAAKAY EVQRAVSLFS LNDPALSPDI PPAHSPVHSH LSLERGPPTP
1710 1720 1730 1740 1750
RTTPTMSEEP PLDLTGKVYQ LEVMLKQLHT DLQKEKQDKV VLQSEVASLR
1760 1770 1780
QNNQRLQEES QAASEQLRKF AEIFCREKKE L
Length:1,781
Mass (Da):194,610
Last modified:March 7, 2006 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6A91F43B5BC3E175
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0QX89M0QX89_HUMAN
Signal-induced proliferation-associ...
SIPA1L3
165Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R2Q7M0R2Q7_HUMAN
Signal-induced proliferation-associ...
SIPA1L3
184Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_075045148D → Y Found in a patient with bilateral congenital cataracts; unknown pathological significance; lack of normal basal actin stress fiber formation; absence of SIPA1L3 and F-actin colocalization. 1 PublicationCorresponds to variant dbSNP:rs138476311EnsemblClinVar.1
Natural variantiVAR_0254761371G → S. Corresponds to variant dbSNP:rs2304133Ensembl.1
Natural variantiVAR_0254771450P → A. Corresponds to variant dbSNP:rs3745945Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY168880 mRNA Translation: AAO12531.1
AB011117 mRNA Translation: BAA25471.2
AC011465 Genomic DNA No translation available.
AC011479 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS33007.1

NCBI Reference Sequences

More...
RefSeqi
NP_055888.1, NM_015073.2
XP_005258728.1, XM_005258671.4
XP_011524959.1, XM_011526657.2
XP_016882006.1, XM_017026517.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.655502

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000222345; ENSP00000222345; ENSG00000105738

Database of genes from NCBI RefSeq genomes

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GeneIDi
23094

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:23094

UCSC genome browser

More...
UCSCi
uc002ohk.4 human

Keywords - Coding sequence diversityi

Chromosomal rearrangement, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY168880 mRNA Translation: AAO12531.1
AB011117 mRNA Translation: BAA25471.2
AC011465 Genomic DNA No translation available.
AC011479 Genomic DNA No translation available.
CCDSiCCDS33007.1
RefSeqiNP_055888.1, NM_015073.2
XP_005258728.1, XM_005258671.4
XP_011524959.1, XM_011526657.2
XP_016882006.1, XM_017026517.1
UniGeneiHs.655502

3D structure databases

ProteinModelPortaliO60292
SMRiO60292
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116722, 51 interactors
IntActiO60292, 34 interactors
MINTiO60292
STRINGi9606.ENSP00000222345

PTM databases

iPTMnetiO60292
PhosphoSitePlusiO60292

Polymorphism and mutation databases

BioMutaiSIPA1L3

Proteomic databases

EPDiO60292
MaxQBiO60292
PaxDbiO60292
PeptideAtlasiO60292
PRIDEiO60292
ProteomicsDBi49323

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000222345; ENSP00000222345; ENSG00000105738
GeneIDi23094
KEGGihsa:23094
UCSCiuc002ohk.4 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
23094
DisGeNETi23094
EuPathDBiHostDB:ENSG00000105738.10

GeneCards: human genes, protein and diseases

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GeneCardsi
SIPA1L3
HGNCiHGNC:23801 SIPA1L3
HPAiHPA042072
HPA045480
MalaCardsiSIPA1L3
MIMi616655 gene
616851 phenotype
neXtProtiNX_O60292
OpenTargetsiENSG00000105738
Orphaneti98994 Total early-onset cataract
PharmGKBiPA134866783

Human Unidentified Gene-Encoded large proteins database

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HUGEi
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GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG3686 Eukaryota
ENOG410XTIX LUCA
GeneTreeiENSGT00940000159183
HOGENOMiHOG000154319
HOVERGENiHBG056135
InParanoidiO60292
KOiK17703
OMAiKDQYQYR
OrthoDBiEOG091G016P
PhylomeDBiO60292
TreeFamiTF318626

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SIPA1L3 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
23094

Protein Ontology

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PROi
PR:O60292

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000105738 Expressed in 222 organ(s), highest expression level in intestine
CleanExiHS_SIPA1L3
ExpressionAtlasiO60292 baseline and differential
GenevisibleiO60292 HS

Family and domain databases

Gene3Di3.40.50.11210, 1 hit
InterProiView protein in InterPro
IPR001478 PDZ
IPR036034 PDZ_sf
IPR035974 Rap/Ran-GAP_sf
IPR000331 Rap_GAP_dom
IPR031204 SIPA1L3
IPR021818 SIPA1L_C
PANTHERiPTHR15711:SF15 PTHR15711:SF15, 1 hit
PfamiView protein in Pfam
PF02145 Rap_GAP, 1 hit
PF11881 SPAR_C, 1 hit
SMARTiView protein in SMART
SM00228 PDZ, 1 hit
SUPFAMiSSF111347 SSF111347, 1 hit
SSF50156 SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS50106 PDZ, 1 hit
PS50085 RAPGAP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSI1L3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O60292
Secondary accession number(s): Q2TV87
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: March 7, 2006
Last modified: December 5, 2018
This is version 146 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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