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UniProtKB - O60290 (ZN862_HUMAN)

Entry version 141 (07 Apr 2021)
Sequence version 2 (26 Feb 2008)
Previous versions | rss
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Protein

Zinc finger protein 862

Gene

ZNF862

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri135 – 218TTF-type 1Add BLAST84
Zinc fingeri461 – 544TTF-type 2Add BLAST84

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		O60290

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 862
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF862
Synonyms:KIAA0543
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:34519, ZNF862

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O60290

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000106479.10

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		643641

Open Targets

More...OpenTargetsi		ENSG00000106479

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA164727781

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O60290, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ZNF862

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003206441 – 1169Zinc finger protein 862Add BLAST1169

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O60290

PeptideAtlas

More...PeptideAtlasi		O60290

PRoteomics IDEntifications database

More...PRIDEi		O60290

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		49317 [O60290-1]
49318 [O60290-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O60290

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O60290

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000106479, Expressed in lymph node and 219 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O60290, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O60290, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000106479, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		568930, 1 interactor

Protein interaction database and analysis system

More...IntActi		O60290, 4 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000223210

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O60290, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O60290

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini11 – 77KRAB 1PROSITE-ProRule annotationAdd BLAST67
Domaini333 – 404KRAB 2PROSITE-ProRule annotationAdd BLAST72

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri135 – 218TTF-type 1Add BLAST84
Zinc fingeri461 – 544TTF-type 2Add BLAST84

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1721, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000162620

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_283080_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O60290

Identification of Orthologs from Complete Genome Data

More...OMAi		DQACVGI

Database of Orthologous Groups

More...OrthoDBi		82127at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O60290

TreeFam database of animal gene trees

More...TreeFami		TF350866

Family and domain databases

Conserved Domains Database

More...CDDi		cd07765, KRAB_A-box, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR025398, DUF4371
IPR008906, HATC_C_dom
IPR001909, KRAB
IPR036051, KRAB_dom_sf
IPR012337, RNaseH-like_sf
IPR006580, Znf_TTF

Pfam protein domain database

More...Pfami		View protein in Pfam
PF05699, Dimer_Tnp_hAT, 1 hit
PF14291, DUF4371, 1 hit
PF01352, KRAB, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00349, KRAB, 2 hits
SM00597, ZnF_TTF, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF109640, SSF109640, 2 hits
SSF53098, SSF53098, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50805, KRAB, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: O60290-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEPRESGKAP VTFDDITVYL LQEEWVLLSQ QQKELCGSNK LVAPLGPTVA 
        60         70         80         90        100
NPELFRKFGR GPEPWLGSVQ GQRSLLEHHP GKKQMGYMGE MEVQGPTRES 
       110        120        130        140        150
GQSLPPQKKA YLSHLSTGSG HIEGDWAGRN RKLLKPRSIQ KSWFVQFPWL 
       160        170        180        190        200
IMNEEQTALF CSACREYPSI RDKRSRLIEG YTGPFKVETL KYHAKSKAHM 
       210        220        230        240        250
FCVNALAARD PIWAARFRSI RDPPGDVLAS PEPLFTADCP IFYPPGPLGG 
       260        270        280        290        300
FDSMAELLPS SRAELEDPGG DGAIPAMYLD CISDLRQKEI TDGIHSSSDI 
       310        320        330        340        350
NILYNDAVES CIQDPSAEGL SEEVPVVFEE LPVVFEDVAV YFTREEWGML 
       360        370        380        390        400
DKRQKELYRD VMRMNYELLA SLGPAAAKPD LISKLERRAA PWIKDPNGPK 
       410        420        430        440        450
WGKGRPPGNK KMVAVREADT QASAADSALL PGSPVEARAS CCSSSICEEG 
       460        470        480        490        500
DGPRRIKRTY RPRSIQRSWF GQFPWLVIDP KETKLFCSAC IERPNLHDKS 
       510        520        530        540        550
SRLVRGYTGP FKVETLKYHE VSKAHRLCVN TVEIKEDTPH TALVPEISSD 
       560        570        580        590        600
LMANMEHFFN AAYSIAYHSR PLNDFEKILQ LLQSTGTVIL GKYRNRTACT 
       610        620        630        640        650
QFIKYISETL KREILEDVRN SPCVSVLLDS STDASEQACV GIYIRYFKQM 
       660        670        680        690        700
EVKESYITLA PLYSETADGY FETIVSALDE LDIPFRKPGW VVGLGTDGSA 
       710        720        730        740        750
MLSCRGGLVE KFQEVIPQLL PVHCVAHRLH LAVVDACGSI DLVKKCDRHI 
       760        770        780        790        800
RTVFKFYQSS NKRLNELQEG AAPLEQEIIR LKDLNAVRWV ASRRRTLHAL 
       810        820        830        840        850
LVSWPALARH LQRVAEAGGQ IGHRAKGMLK LMRGFHFVKF CHFLLDFLSI 
       860        870        880        890        900
YRPLSEVCQK EIVLITEVNA TLGRAYVALE SLRHQAGPKE EEFNASFKDG 
       910        920        930        940        950
RLHGICLDKL EVAEQRFQAD RERTVLTGIE YLQQRFDADR PPQLKNMEVF 
       960        970        980        990       1000
DTMAWPSGIE LASFGNDDIL NLARYFECSL PTGYSEEALL EEWLGLKTIA 
      1010       1020       1030       1040       1050
QHLPFSMLCK NALAQHCRFP LLSKLMAVVV CVPISTSCCE RGFKAMNRIR 
      1060       1070       1080       1090       1100
TDERTKLSNE VLNMLMMTAV NGVAVTEYDP QPAIQHWYLT SSGRRFSHVY 
      1110       1120       1130       1140       1150
TCAQVPARSP ASARLRKEEM GALYVEEPRT QKPPILPSRE AAEVLKDCIM 
      1160 
EPPERLLYPH TSQEAPGMS
Length:1,169
Mass (Da):131,654
Last modified:February 26, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i76367C6AE1E3C60A
GO
Isoform 2 (identifier: O60290-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-915: Missing.
     916-923: RFQADRER → MGRRWCEW

Show »
Length:254
Mass (Da):28,863
Checksum:i3508B6CFC512DE75
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JB70C9JB70_HUMAN
Zinc finger protein 862
ZNF862
93Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_039248178I → T. Corresponds to variant dbSNP:rs3735328Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0317021 – 915Missing in isoform 2. 1 PublicationAdd BLAST915
Alternative sequenceiVSP_031703916 – 923RFQADRER → MGRRWCEW in isoform 2. 1 Publication8

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AC004877 Genomic DNA No translation available.
BC113087 mRNA Translation: AAI13088.1
AB011115 mRNA Translation: BAA25469.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS47741.1 [O60290-1]

Protein sequence database of the Protein Information Resource

More...PIRi		T00324

NCBI Reference Sequences

More...RefSeqi		NP_001092690.1, NM_001099220.2 [O60290-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000223210; ENSP00000223210; ENSG00000106479 [O60290-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		643641

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:643641

UCSC genome browser

More...UCSCi		uc010lpn.4, human [O60290-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004877 Genomic DNA No translation available.
BC113087 mRNA Translation: AAI13088.1
AB011115 mRNA Translation: BAA25469.1
CCDSiCCDS47741.1 [O60290-1]
PIRiT00324
RefSeqiNP_001092690.1, NM_001099220.2 [O60290-1]

3D structure databases

SMRiO60290
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi568930, 1 interactor
IntActiO60290, 4 interactors
STRINGi9606.ENSP00000223210

PTM databases

iPTMnetiO60290
PhosphoSitePlusiO60290

Genetic variation databases

BioMutaiZNF862

Proteomic databases

PaxDbiO60290
PeptideAtlasiO60290
PRIDEiO60290
ProteomicsDBi49317 [O60290-1]
49318 [O60290-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		10495, 30 antibodies

Genome annotation databases

EnsembliENST00000223210; ENSP00000223210; ENSG00000106479 [O60290-1]
GeneIDi643641
KEGGihsa:643641
UCSCiuc010lpn.4, human [O60290-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		643641
DisGeNETi643641

GeneCards: human genes, protein and diseases

More...GeneCardsi		ZNF862
HGNCiHGNC:34519, ZNF862
HPAiENSG00000106479, Low tissue specificity
neXtProtiNX_O60290
OpenTargetsiENSG00000106479
PharmGKBiPA164727781
VEuPathDBiHostDB:ENSG00000106479.10

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1721, Eukaryota
GeneTreeiENSGT00940000162620
HOGENOMiCLU_283080_0_0_1
InParanoidiO60290
OMAiDQACVGI
OrthoDBi82127at2759
PhylomeDBiO60290
TreeFamiTF350866

Enzyme and pathway databases

PathwayCommonsiO60290

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		643641, 5 hits in 989 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		643641
PharosiO60290, Tdark

Protein Ontology

More...PROi		PR:O60290
RNActiO60290, protein

Gene expression databases

BgeeiENSG00000106479, Expressed in lymph node and 219 other tissues
ExpressionAtlasiO60290, baseline and differential
GenevisibleiO60290, HS

Family and domain databases

CDDicd07765, KRAB_A-box, 2 hits
InterProiView protein in InterPro
IPR025398, DUF4371
IPR008906, HATC_C_dom
IPR001909, KRAB
IPR036051, KRAB_dom_sf
IPR012337, RNaseH-like_sf
IPR006580, Znf_TTF
PfamiView protein in Pfam
PF05699, Dimer_Tnp_hAT, 1 hit
PF14291, DUF4371, 1 hit
PF01352, KRAB, 2 hits
SMARTiView protein in SMART
SM00349, KRAB, 2 hits
SM00597, ZnF_TTF, 2 hits
SUPFAMiSSF109640, SSF109640, 2 hits
SSF53098, SSF53098, 2 hits
PROSITEiView protein in PROSITE
PS50805, KRAB, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN862_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O60290
Secondary accession number(s): A0AUL8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: April 7, 2021
This is version 141 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
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