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UniProtKB - O60290 (ZN862_HUMAN)
Protein
Zinc finger protein 862
Gene
ZNF862
Organism
Homo sapiens (Human)
Status
Functioni
May be involved in transcriptional regulation.
By similarityRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 135 – 218 | TTF-type 1Add BLAST | 84 | |
Zinc fingeri | 461 – 544 | TTF-type 2Add BLAST | 84 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
- protein dimerization activity Source: InterPro
GO - Biological processi
- regulation of transcription, DNA-templated Source: InterPro
Keywordsi
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | O60290 |
SignaLinki | O60290 |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 862 |
Gene namesi | Name:ZNF862 Synonyms:KIAA0543 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:34519, ZNF862 |
neXtProti | NX_O60290 |
VEuPathDBi | HostDB:ENSG00000106479 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nucleus Source: UniProtKB-SubCell
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 643641 |
OpenTargetsi | ENSG00000106479 |
PharmGKBi | PA164727781 |
Miscellaneous databases
Pharosi | O60290, Tdark |
Genetic variation databases
BioMutai | ZNF862 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000320644 | 1 – 1169 | Zinc finger protein 862Add BLAST | 1169 |
Proteomic databases
MassIVEi | O60290 |
PaxDbi | O60290 |
PeptideAtlasi | O60290 |
PRIDEi | O60290 |
ProteomicsDBi | 49317 [O60290-1] |
PTM databases
iPTMneti | O60290 |
PhosphoSitePlusi | O60290 |
Expressioni
Gene expression databases
Bgeei | ENSG00000106479, Expressed in lymph node and 220 other tissues |
ExpressionAtlasi | O60290, baseline and differential |
Genevisiblei | O60290, HS |
Organism-specific databases
HPAi | ENSG00000106479, Low tissue specificity |
Interactioni
GO - Molecular functioni
- protein dimerization activity Source: InterPro
Protein-protein interaction databases
BioGRIDi | 568930, 1 interactor |
IntActi | O60290, 7 interactors |
STRINGi | 9606.ENSP00000223210 |
Miscellaneous databases
RNActi | O60290, protein |
Structurei
3D structure databases
AlphaFoldDBi | O60290 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 11 – 77 | KRAB 1PROSITE-ProRule annotationAdd BLAST | 67 | |
Domaini | 333 – 404 | KRAB 2PROSITE-ProRule annotationAdd BLAST | 72 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 135 – 218 | TTF-type 1Add BLAST | 84 | |
Zinc fingeri | 461 – 544 | TTF-type 2Add BLAST | 84 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000162620 |
HOGENOMi | CLU_283080_0_0_1 |
InParanoidi | O60290 |
OMAi | DQACVGI |
OrthoDBi | 82127at2759 |
PhylomeDBi | O60290 |
TreeFami | TF350866 |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 2 hits |
InterProi | View protein in InterPro IPR025398, DUF4371 IPR008906, HATC_C_dom IPR001909, KRAB IPR036051, KRAB_dom_sf IPR012337, RNaseH-like_sf IPR006580, Znf_TTF |
Pfami | View protein in Pfam PF05699, Dimer_Tnp_hAT, 1 hit PF14291, DUF4371, 1 hit PF01352, KRAB, 2 hits |
SMARTi | View protein in SMART SM00349, KRAB, 2 hits SM00597, ZnF_TTF, 2 hits |
SUPFAMi | SSF109640, SSF109640, 2 hits SSF53098, SSF53098, 2 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 2 hits |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: O60290-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MEPRESGKAP VTFDDITVYL LQEEWVLLSQ QQKELCGSNK LVAPLGPTVA
60 70 80 90 100
NPELFRKFGR GPEPWLGSVQ GQRSLLEHHP GKKQMGYMGE MEVQGPTRES
110 120 130 140 150
GQSLPPQKKA YLSHLSTGSG HIEGDWAGRN RKLLKPRSIQ KSWFVQFPWL
160 170 180 190 200
IMNEEQTALF CSACREYPSI RDKRSRLIEG YTGPFKVETL KYHAKSKAHM
210 220 230 240 250
FCVNALAARD PIWAARFRSI RDPPGDVLAS PEPLFTADCP IFYPPGPLGG
260 270 280 290 300
FDSMAELLPS SRAELEDPGG DGAIPAMYLD CISDLRQKEI TDGIHSSSDI
310 320 330 340 350
NILYNDAVES CIQDPSAEGL SEEVPVVFEE LPVVFEDVAV YFTREEWGML
360 370 380 390 400
DKRQKELYRD VMRMNYELLA SLGPAAAKPD LISKLERRAA PWIKDPNGPK
410 420 430 440 450
WGKGRPPGNK KMVAVREADT QASAADSALL PGSPVEARAS CCSSSICEEG
460 470 480 490 500
DGPRRIKRTY RPRSIQRSWF GQFPWLVIDP KETKLFCSAC IERPNLHDKS
510 520 530 540 550
SRLVRGYTGP FKVETLKYHE VSKAHRLCVN TVEIKEDTPH TALVPEISSD
560 570 580 590 600
LMANMEHFFN AAYSIAYHSR PLNDFEKILQ LLQSTGTVIL GKYRNRTACT
610 620 630 640 650
QFIKYISETL KREILEDVRN SPCVSVLLDS STDASEQACV GIYIRYFKQM
660 670 680 690 700
EVKESYITLA PLYSETADGY FETIVSALDE LDIPFRKPGW VVGLGTDGSA
710 720 730 740 750
MLSCRGGLVE KFQEVIPQLL PVHCVAHRLH LAVVDACGSI DLVKKCDRHI
760 770 780 790 800
RTVFKFYQSS NKRLNELQEG AAPLEQEIIR LKDLNAVRWV ASRRRTLHAL
810 820 830 840 850
LVSWPALARH LQRVAEAGGQ IGHRAKGMLK LMRGFHFVKF CHFLLDFLSI
860 870 880 890 900
YRPLSEVCQK EIVLITEVNA TLGRAYVALE SLRHQAGPKE EEFNASFKDG
910 920 930 940 950
RLHGICLDKL EVAEQRFQAD RERTVLTGIE YLQQRFDADR PPQLKNMEVF
960 970 980 990 1000
DTMAWPSGIE LASFGNDDIL NLARYFECSL PTGYSEEALL EEWLGLKTIA
1010 1020 1030 1040 1050
QHLPFSMLCK NALAQHCRFP LLSKLMAVVV CVPISTSCCE RGFKAMNRIR
1060 1070 1080 1090 1100
TDERTKLSNE VLNMLMMTAV NGVAVTEYDP QPAIQHWYLT SSGRRFSHVY
1110 1120 1130 1140 1150
TCAQVPARSP ASARLRKEEM GALYVEEPRT QKPPILPSRE AAEVLKDCIM
1160
EPPERLLYPH TSQEAPGMS
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketC9JB70 | C9JB70_HUMAN | Zinc finger protein 862 | ZNF862 | 93 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_039248 | 178 | I → T. Corresponds to variant dbSNP:rs3735328Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_031702 | 1 – 915 | Missing in isoform 2. 1 PublicationAdd BLAST | 915 | |
Alternative sequenceiVSP_031703 | 916 – 923 | RFQADRER → MGRRWCEW in isoform 2. 1 Publication | 8 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC004877 Genomic DNA No translation available. BC113087 mRNA Translation: AAI13088.1 AB011115 mRNA Translation: BAA25469.1 |
CCDSi | CCDS47741.1 [O60290-1] |
PIRi | T00324 |
RefSeqi | NP_001092690.1, NM_001099220.2 [O60290-1] |
Genome annotation databases
Ensembli | ENST00000223210.5; ENSP00000223210.4; ENSG00000106479.11 |
GeneIDi | 643641 |
KEGGi | hsa:643641 |
MANE-Selecti | ENST00000223210.5; ENSP00000223210.4; NM_001099220.3; NP_001092690.1 |
UCSCi | uc010lpn.4, human [O60290-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC004877 Genomic DNA No translation available. BC113087 mRNA Translation: AAI13088.1 AB011115 mRNA Translation: BAA25469.1 |
CCDSi | CCDS47741.1 [O60290-1] |
PIRi | T00324 |
RefSeqi | NP_001092690.1, NM_001099220.2 [O60290-1] |
3D structure databases
AlphaFoldDBi | O60290 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 568930, 1 interactor |
IntActi | O60290, 7 interactors |
STRINGi | 9606.ENSP00000223210 |
PTM databases
iPTMneti | O60290 |
PhosphoSitePlusi | O60290 |
Genetic variation databases
BioMutai | ZNF862 |
Proteomic databases
MassIVEi | O60290 |
PaxDbi | O60290 |
PeptideAtlasi | O60290 |
PRIDEi | O60290 |
ProteomicsDBi | 49317 [O60290-1] |
Protocols and materials databases
Antibodypediai | 10495, 29 antibodies from 14 providers |
DNASUi | 643641 |
Genome annotation databases
Ensembli | ENST00000223210.5; ENSP00000223210.4; ENSG00000106479.11 |
GeneIDi | 643641 |
KEGGi | hsa:643641 |
MANE-Selecti | ENST00000223210.5; ENSP00000223210.4; NM_001099220.3; NP_001092690.1 |
UCSCi | uc010lpn.4, human [O60290-1] |
Organism-specific databases
CTDi | 643641 |
DisGeNETi | 643641 |
GeneCardsi | ZNF862 |
HGNCi | HGNC:34519, ZNF862 |
HPAi | ENSG00000106479, Low tissue specificity |
neXtProti | NX_O60290 |
OpenTargetsi | ENSG00000106479 |
PharmGKBi | PA164727781 |
VEuPathDBi | HostDB:ENSG00000106479 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000162620 |
HOGENOMi | CLU_283080_0_0_1 |
InParanoidi | O60290 |
OMAi | DQACVGI |
OrthoDBi | 82127at2759 |
PhylomeDBi | O60290 |
TreeFami | TF350866 |
Enzyme and pathway databases
PathwayCommonsi | O60290 |
SignaLinki | O60290 |
Miscellaneous databases
BioGRID-ORCSi | 643641, 9 hits in 1070 CRISPR screens |
GenomeRNAii | 643641 |
Pharosi | O60290, Tdark |
PROi | PR:O60290 |
RNActi | O60290, protein |
Gene expression databases
Bgeei | ENSG00000106479, Expressed in lymph node and 220 other tissues |
ExpressionAtlasi | O60290, baseline and differential |
Genevisiblei | O60290, HS |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 2 hits |
InterProi | View protein in InterPro IPR025398, DUF4371 IPR008906, HATC_C_dom IPR001909, KRAB IPR036051, KRAB_dom_sf IPR012337, RNaseH-like_sf IPR006580, Znf_TTF |
Pfami | View protein in Pfam PF05699, Dimer_Tnp_hAT, 1 hit PF14291, DUF4371, 1 hit PF01352, KRAB, 2 hits |
SMARTi | View protein in SMART SM00349, KRAB, 2 hits SM00597, ZnF_TTF, 2 hits |
SUPFAMi | SSF109640, SSF109640, 2 hits SSF53098, SSF53098, 2 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | ZN862_HUMAN | |
Accessioni | O60290Primary (citable) accession number: O60290 Secondary accession number(s): A0AUL8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 26, 2008 |
Last sequence update: | February 26, 2008 | |
Last modified: | May 25, 2022 | |
This is version 145 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports