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Entry version 135 (13 Feb 2019)
Sequence version 1 (01 Aug 1998)
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Protein

Suppression of tumorigenicity 18 protein

Gene

ST18

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Repressor that binds to DNA sequences containing a bipartite element consisting of a direct repeat of the sequence 5'-AAAGTTT-3' separated by 2-9 nucleotides. Represses basal transcription activity from target promoters (By similarity). Inhibits colony formation in cultured breast cancer cells.By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri359 – 402CCHHC-type 1PROSITE-ProRule annotationAdd BLAST44
Zinc fingeri403 – 446CCHHC-type 2PROSITE-ProRule annotationAdd BLAST44
Zinc fingeri715 – 758CCHHC-type 3PROSITE-ProRule annotationAdd BLAST44
Zinc fingeri759 – 802CCHHC-type 4PROSITE-ProRule annotationAdd BLAST44
Zinc fingeri807 – 850CCHHC-type 5PROSITE-ProRule annotationAdd BLAST44
Zinc fingeri860 – 903CCHHC-type 6PROSITE-ProRule annotationAdd BLAST44

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Suppression of tumorigenicity 18 protein
Alternative name(s):
Zinc finger protein 387
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ST18
Synonyms:KIAA0535, ZNF387
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000147488.11

Human Gene Nomenclature Database

More...
HGNCi
HGNC:18695 ST18

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O60284

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
9705

Open Targets

More...
OpenTargetsi
ENSG00000147488

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA38642

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ST18

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002340301 – 1047Suppression of tumorigenicity 18 proteinAdd BLAST1047

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O60284

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O60284

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O60284

PeptideAtlas

More...
PeptideAtlasi
O60284

PRoteomics IDEntifications database

More...
PRIDEi
O60284

ProteomicsDB human proteome resource

More...
ProteomicsDBi
49313

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O60284

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O60284

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected at low levels in heart, liver, kidney, skeletal muscle, pancreas, testis, ovary and prostate. Detected at even lower levels in mammary epithelial cells and breast cancer cells.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000147488 Expressed in 130 organ(s), highest expression level in corpus callosum

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O60284 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O60284 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA044919

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
O60284, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000276480

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11047
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CS8NMR-A812-906[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
O60284

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O60284

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
O60284

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili920 – 992Sequence analysisAdd BLAST73

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MYT1 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri359 – 402CCHHC-type 1PROSITE-ProRule annotationAdd BLAST44
Zinc fingeri403 – 446CCHHC-type 2PROSITE-ProRule annotationAdd BLAST44
Zinc fingeri715 – 758CCHHC-type 3PROSITE-ProRule annotationAdd BLAST44
Zinc fingeri759 – 802CCHHC-type 4PROSITE-ProRule annotationAdd BLAST44
Zinc fingeri807 – 850CCHHC-type 5PROSITE-ProRule annotationAdd BLAST44
Zinc fingeri860 – 903CCHHC-type 6PROSITE-ProRule annotationAdd BLAST44

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IQ4N Eukaryota
ENOG410XNSU LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159905

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000234099

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG006433

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O60284

Identification of Orthologs from Complete Genome Data

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OMAi
AHTQSPC

Database of Orthologous Groups

More...
OrthoDBi
116799at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O60284

TreeFam database of animal gene trees

More...
TreeFami
TF317299

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013681 Myelin_TF
IPR002515 Znf_C2HC
IPR036060 Znf_C2HC_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08474 MYT1, 1 hit
PF01530 zf-C2HC, 6 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF103637 SSF103637, 6 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51802 ZF_CCHHC, 6 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

O60284-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDAEAEDKTL RTRSKGTEVP MDSLIQELSV AYDCSMAKKR TAEDQALGVP
60 70 80 90 100
VNKRKSLLMK PRHYSPKADC QEDRSDRTED DGPLETHGHS TAEEIMIKPM
110 120 130 140 150
DESLLSTAQE NSSRKEDRYS CYQELMVKSL MHLGKFEKNV SVQTVSENLN
160 170 180 190 200
DSGIQSLKAE SDEADECFLI HSDDGRDKID DSQPPFCSSD DNESNSESAE
210 220 230 240 250
NGWDSGSNFS EETKPPRVPK YVLTDHKKDL LEVPEIKTEG DKFIPCENRC
260 270 280 290 300
DSETERKDPQ NALAEPLDGN AQPSFPDVEE EDSESLAVMT EEGSDLEKAK
310 320 330 340 350
GNLSLLEQAI ALQAERGCVF HNTYKELDRF LLEHLAGERR QTKVIDMGGR
360 370 380 390 400
QIFNNKHSPR PEKRETKCPI PGCDGTGHVT GLYPHHRSLS GCPHKVRVPL
410 420 430 440 450
EILAMHENVL KCPTPGCTGR GHVNSNRNTH RSLSGCPIAA AEKLAMSQDK
460 470 480 490 500
NQLDSPQTGQ CPDQAHRTSL VKQIEFNFPS QAITSPRATV SKEQEKFGKV
510 520 530 540 550
PFDYASFDAQ VFGKRPLIQT VQGRKTPPFP ESKHFPNPVK FPNRLPSAGA
560 570 580 590 600
HTQSPGRASS YSYGQCSEDT HIAAAAAILN LSTRCREATD ILSNKPQSLH
610 620 630 640 650
AKGAEIEVDE NGTLDLSMKK NRILDKSAPL TSSNTSIPTP SSSPFKTSSI
660 670 680 690 700
LVNAAFYQAL CDQEGWDTPI NYSKTHGKTE EEKEKDPVSS LENLEEKKFP
710 720 730 740 750
GEASIPSPKP KLHARDLKKE LITCPTPGCD GSGHVTGNYA SHRSVSGCPL
760 770 780 790 800
ADKTLKSLMA ANSQELKCPT PGCDGSGHVT GNYASHRSLS GCPRARKGGV
810 820 830 840 850
KMTPTKEEKE DPELKCPVIG CDGQGHISGK YTSHRTASGC PLAAKRQKEN
860 870 880 890 900
PLNGASLSWK LNKQELPHCP LPGCNGLGHV NNVFVTHRSL SGCPLNAQVI
910 920 930 940 950
KKGKVSEELM TIKLKATGGI ESDEEIRHLD EEIKELNESN LKIEADMMKL
960 970 980 990 1000
QTQITSMESN LKTIEEENKL IEQNNESLLK ELAGLSQALI SSLADIQLPQ
1010 1020 1030 1040
MGPISEQNFE AYVNTLTDMY SNLERDYSPE CKALLESIKQ AVKGIHV
Length:1,047
Mass (Da):115,155
Last modified:August 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4EE28F09AE7C106B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E5RHS3E5RHS3_HUMAN
Suppression of tumorigenicity 18 pr...
ST18
620Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RID0E5RID0_HUMAN
Suppression of tumorigenicity 18 pr...
ST18
364Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RHY1E5RHY1_HUMAN
Suppression of tumorigenicity 18 pr...
ST18
94Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RK88E5RK88_HUMAN
Suppression of tumorigenicity 18 pr...
ST18
12Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RFE8E5RFE8_HUMAN
Suppression of tumorigenicity 18 pr...
ST18
41Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_052732515R → C. Corresponds to variant dbSNP:rs2303460Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB011107 mRNA Translation: BAA25461.1
BC117147 mRNA Translation: AAI17148.1
BC117149 mRNA Translation: AAI17150.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS6149.1

NCBI Reference Sequences

More...
RefSeqi
NP_055497.1, NM_014682.2
XP_006716550.1, XM_006716487.1
XP_011515931.1, XM_011517629.1
XP_011515933.1, XM_011517631.1
XP_011515934.1, XM_011517632.1
XP_011515935.1, XM_011517633.1
XP_011515936.1, XM_011517634.1
XP_011515937.1, XM_011517635.1
XP_011515938.1, XM_011517636.2
XP_011515939.1, XM_011517637.1
XP_011515940.1, XM_011517638.2
XP_016869536.1, XM_017014047.1
XP_016869537.1, XM_017014048.1
XP_016869538.1, XM_017014049.1
XP_016869539.1, XM_017014050.1
XP_016869540.1, XM_017014051.1
XP_016869541.1, XM_017014052.1
XP_016869542.1, XM_017014053.1
XP_016869543.1, XM_017014054.1
XP_016869544.1, XM_017014055.1
XP_016869545.1, XM_017014056.1
XP_016869546.1, XM_017014057.1
XP_016869547.1, XM_017014058.1
XP_016869548.1, XM_017014059.1
XP_016869549.1, XM_017014060.1
XP_016869550.1, XM_017014061.1
XP_016869551.1, XM_017014062.1
XP_016869552.1, XM_017014063.1
XP_016869553.1, XM_017014064.1
XP_016869554.1, XM_017014065.1
XP_016869555.1, XM_017014066.1
XP_016869556.1, XM_017014067.1
XP_016869557.1, XM_017014068.1
XP_016869558.1, XM_017014069.1
XP_016869559.1, XM_017014070.1
XP_016869560.1, XM_017014071.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.655499

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000276480; ENSP00000276480; ENSG00000147488

Database of genes from NCBI RefSeq genomes

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GeneIDi
9705

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:9705

UCSC genome browser

More...
UCSCi
uc003xra.3 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB011107 mRNA Translation: BAA25461.1
BC117147 mRNA Translation: AAI17148.1
BC117149 mRNA Translation: AAI17150.1
CCDSiCCDS6149.1
RefSeqiNP_055497.1, NM_014682.2
XP_006716550.1, XM_006716487.1
XP_011515931.1, XM_011517629.1
XP_011515933.1, XM_011517631.1
XP_011515934.1, XM_011517632.1
XP_011515935.1, XM_011517633.1
XP_011515936.1, XM_011517634.1
XP_011515937.1, XM_011517635.1
XP_011515938.1, XM_011517636.2
XP_011515939.1, XM_011517637.1
XP_011515940.1, XM_011517638.2
XP_016869536.1, XM_017014047.1
XP_016869537.1, XM_017014048.1
XP_016869538.1, XM_017014049.1
XP_016869539.1, XM_017014050.1
XP_016869540.1, XM_017014051.1
XP_016869541.1, XM_017014052.1
XP_016869542.1, XM_017014053.1
XP_016869543.1, XM_017014054.1
XP_016869544.1, XM_017014055.1
XP_016869545.1, XM_017014056.1
XP_016869546.1, XM_017014057.1
XP_016869547.1, XM_017014058.1
XP_016869548.1, XM_017014059.1
XP_016869549.1, XM_017014060.1
XP_016869550.1, XM_017014061.1
XP_016869551.1, XM_017014062.1
XP_016869552.1, XM_017014063.1
XP_016869553.1, XM_017014064.1
XP_016869554.1, XM_017014065.1
XP_016869555.1, XM_017014066.1
XP_016869556.1, XM_017014067.1
XP_016869557.1, XM_017014068.1
XP_016869558.1, XM_017014069.1
XP_016869559.1, XM_017014070.1
XP_016869560.1, XM_017014071.1
UniGeneiHs.655499

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CS8NMR-A812-906[»]
ProteinModelPortaliO60284
SMRiO60284
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO60284, 1 interactor
STRINGi9606.ENSP00000276480

PTM databases

iPTMnetiO60284
PhosphoSitePlusiO60284

Polymorphism and mutation databases

BioMutaiST18

Proteomic databases

jPOSTiO60284
MaxQBiO60284
PaxDbiO60284
PeptideAtlasiO60284
PRIDEiO60284
ProteomicsDBi49313

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000276480; ENSP00000276480; ENSG00000147488
GeneIDi9705
KEGGihsa:9705
UCSCiuc003xra.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9705
DisGeNETi9705
EuPathDBiHostDB:ENSG00000147488.11

GeneCards: human genes, protein and diseases

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GeneCardsi
ST18
HGNCiHGNC:18695 ST18
HPAiHPA044919
neXtProtiNX_O60284
OpenTargetsiENSG00000147488
PharmGKBiPA38642

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IQ4N Eukaryota
ENOG410XNSU LUCA
GeneTreeiENSGT00940000159905
HOGENOMiHOG000234099
HOVERGENiHBG006433
InParanoidiO60284
OMAiAHTQSPC
OrthoDBi116799at2759
PhylomeDBiO60284
TreeFamiTF317299

Miscellaneous databases

EvolutionaryTraceiO60284

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
9705

Protein Ontology

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PROi
PR:O60284

Gene expression databases

BgeeiENSG00000147488 Expressed in 130 organ(s), highest expression level in corpus callosum
ExpressionAtlasiO60284 baseline and differential
GenevisibleiO60284 HS

Family and domain databases

InterProiView protein in InterPro
IPR013681 Myelin_TF
IPR002515 Znf_C2HC
IPR036060 Znf_C2HC_sf
PfamiView protein in Pfam
PF08474 MYT1, 1 hit
PF01530 zf-C2HC, 6 hits
SUPFAMiSSF103637 SSF103637, 6 hits
PROSITEiView protein in PROSITE
PS51802 ZF_CCHHC, 6 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiST18_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O60284
Secondary accession number(s): Q17RY1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: August 1, 1998
Last modified: February 13, 2019
This is version 135 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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