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Entry version 185 (07 Oct 2020)
Sequence version 3 (23 Mar 2010)
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Protein

Zinc finger protein 292

Gene

ZNF292

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri569 – 591C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri681 – 705C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri722 – 744C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri750 – 774C2H2-type 4PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri779 – 803C2H2-type 5PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri807 – 831C2H2-type 6PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri1098 – 1123C2H2-type 7PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri1375 – 1397C2H2-type 8; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1902 – 1927C2H2-type 9PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri1947 – 1972C2H2-type 10PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri2114 – 2139C2H2-type 11PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri2172 – 2197C2H2-type 12PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri2216 – 2241C2H2-type 13PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri2256 – 2281C2H2-type 14PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri2386 – 2410C2H2-type 15PROSITE-ProRule annotationAdd BLAST25

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
O60281

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 292
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF292
Synonyms:KIAA0530
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000188994.12

Human Gene Nomenclature Database

More...
HGNCi
HGNC:18410, ZNF292

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O60281

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
23036

MalaCards human disease database

More...
MalaCardsi
ZNF292

Open Targets

More...
OpenTargetsi
ENSG00000188994

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134945416

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
O60281, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZNF292

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000475141 – 2723Zinc finger protein 292Add BLAST2723

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei654PhosphoserineBy similarity1
Modified residuei1117N6-acetyllysineBy similarity1
Modified residuei1159PhosphoserineCombined sources1
Modified residuei2042N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O60281

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O60281

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
O60281

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O60281

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O60281

PeptideAtlas

More...
PeptideAtlasi
O60281

PRoteomics IDEntifications database

More...
PRIDEi
O60281

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
49309 [O60281-1]
49310 [O60281-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O60281

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O60281

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000188994, Expressed in placenta and 255 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O60281, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O60281, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000188994, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
116675, 16 interactors

Protein interaction database and analysis system

More...
IntActi
O60281, 16 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000358590

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
O60281, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

12723
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Biological Magnetic Resonance Data Bank

More...
BMRBi
O60281

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O60281

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
O60281

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1827 – 1854Sequence analysisAdd BLAST28

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri569 – 591C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri681 – 705C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri722 – 744C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri750 – 774C2H2-type 4PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri779 – 803C2H2-type 5PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri807 – 831C2H2-type 6PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri1098 – 1123C2H2-type 7PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri1375 – 1397C2H2-type 8; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1902 – 1927C2H2-type 9PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri1947 – 1972C2H2-type 10PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri2114 – 2139C2H2-type 11PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri2172 – 2197C2H2-type 12PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri2216 – 2241C2H2-type 13PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri2256 – 2281C2H2-type 14PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri2386 – 2410C2H2-type 15PROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000183034

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000520_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O60281

Identification of Orthologs from Complete Genome Data

More...
OMAi
SHVSTGC

Database of Orthologous Groups

More...
OrthoDBi
1318335at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O60281

TreeFam database of animal gene trees

More...
TreeFami
TF350813

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00096, zf-C2H2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00355, ZnF_C2H2, 16 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57667, SSF57667, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00028, ZINC_FINGER_C2H2_1, 13 hits
PS50157, ZINC_FINGER_C2H2_2, 11 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O60281-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MADEEAEQER LSCGEGGCVA ELQRLGERLQ ELELQLRESR VPAVEAATDY
60 70 80 90 100
CQQLCQTLLE YAEKWKTSED PLPLLEVYTV AIQSYVKARP YLTSECENVA
110 120 130 140 150
LVLERLALSC VELLLCLPVE LSDKQWEQFQ TLVQVAHEKL MENGSCELHF
160 170 180 190 200
LATLAQETGV WKNPVLCTIL SQEPLDKDKV NEFLAFEGPI LLDMRIKHLI
210 220 230 240 250
KTNQLSQATA LAKLCSDHPE IGIKGSFKQT YLVCLCTSSP NGKLIEEISE
260 270 280 290 300
VDCKDALEMI CNLESEGDEK SALVLCTAFL SRQLQQGDMY CAWELTLFWS
310 320 330 340 350
KLQQRVEPSI QVYLERCRQL SLLTKTVYHI FFLIKVINSE TEGAGLATCI
360 370 380 390 400
ELCVKALRLE STENTEVKIS ICKTISCLLP DDLEVKRACQ LSEFLIEPTV
410 420 430 440 450
DAYYAVEMLY NQPDQKYDEE NLPIPNSLRC ELLLVLKTQW PFDPEFWDWK
460 470 480 490 500
TLKRQCLALM GEEASIVSSI DELNDSEVYE KVVDYQEESK ETSMNGLSGG
510 520 530 540 550
VGANSGLLKD IGDEKQKKRE IKQLRERGFI SARFRNWQAY MQYCVLCDKE
560 570 580 590 600
FLGHRIVRHA QKHYKDGIYS CPICAKNFNS KETFVPHVTL HVKQSSKERL
610 620 630 640 650
AAMKPLRRLG RPPKITTTNE NQKTNTVAKQ EQRPIKKNSL YSTDFIVFND
660 670 680 690 700
NDGSDDENDD KDKSYEPEVI PVQKPVPVNE FNCPVTFCKK GFKYFKNLIA
710 720 730 740 750
HVKGHKDNED AKRFLEMQSK KVICQYCRRH FVSVTHLNDH LQMHCGSKPY
760 770 780 790 800
ICIQMKCKAG FNSYAELLTH RKEHQVFRAK CMFPKCGRIF SEAYLLYDHE
810 820 830 840 850
AQHYNTYTCK FTGCGKVYRS QGELEKHLDD HSTPPEKVLP PEAQLNSSGD
860 870 880 890 900
SIQPSEVNQN TAENIEKERS MLPSENNIEN SLLADRSDAW DKSKAESAVT
910 920 930 940 950
KQDQISASEL RQANGPLSNG LENPATTPLL QSSEVAVSIK VSLNQGIEDN
960 970 980 990 1000
FGKQENSTVE GSGEALVTDL HTPVEDTCND LCHPGFQERK EQDCFNDAHV
1010 1020 1030 1040 1050
TQNSLVNSET LKIGDLTPQN LERQVNNLMT FSVQNQAAFQ NNLPTSKFEC
1060 1070 1080 1090 1100
GDNVKTSSNL YNLPLKTLES IAFVPPQSDL SNSLGTPSVP PKAPVQKFSC
1110 1120 1130 1140 1150
QVEGCTRTYN SSQSIGKHMK TAHPDQYAAF KMQRKSKKGQ KANNLNTPNN
1160 1170 1180 1190 1200
GKFVYFLPSP VNSSNPFFTS QTKANGNPAC SAQLQHVSPP IFPAHLASVS
1210 1220 1230 1240 1250
TPLLSSMESV INPNITSQDK NEQGGMLCSQ MENLPSTALP AQMEDLTKTV
1260 1270 1280 1290 1300
LPLNIDSGSD PFLPLPAESS SMSLFPSPAD SGTNSVFSQL ENNTNHYSSQ
1310 1320 1330 1340 1350
IEGNTNSSFL KGGNGENAVF PSQVNVANNF SSTNAQQSAP EKVKKDRGRG
1360 1370 1380 1390 1400
PNGKERKPKH NKRAKWPAII RDGKFICSRC YRAFTNPRSL GGHLSKRSYC
1410 1420 1430 1440 1450
KPLDGAEIAQ ELLQSNGQPS LLASMILSTN AVNLQQPQQS TFNPEACFKD
1460 1470 1480 1490 1500
PSFLQLLAEN RSPAFLPNTF PRSGVTNFNT SVSQEGSEII KQALETAGIP
1510 1520 1530 1540 1550
STFEGAEMLS HVSTGCVSDA SQVNATVMPN PTVPPLLHTV CHPNTLLTNQ
1560 1570 1580 1590 1600
NRTSNSKTSS IEECSSLPVF PTNDLLLKTV ENGLCSSSFP NSGGPSQNFT
1610 1620 1630 1640 1650
SNSSRVSVIS GPQNTRSSHL NKKGNSASKR RKKVAPPLIA PNASQNLVTS
1660 1670 1680 1690 1700
DLTTMGLIAK SVEIPTTNLH SNVIPTCEPQ SLVENLTQKL NNVNNQLFMT
1710 1720 1730 1740 1750
DVKENFKTSL ESHTVLAPLT LKTENGDSQM MALNSCTTSI NSDLQISEDN
1760 1770 1780 1790 1800
VIQNFEKTLE IIKTAMNSQI LEVKSGSQGA GETSQNAQIN YNIQLPSVNT
1810 1820 1830 1840 1850
VQNNKLPDSS PFSSFISVMP TKSNIPQSEV SHKEDQIQEI LEGLQKLKLE
1860 1870 1880 1890 1900
NDLSTPASQC VLINTSVTLT PTPVKSTADI TVIQPVSEMI NIQFNDKVNK
1910 1920 1930 1940 1950
PFVCQNQGCN YSAMTKDALF KHYGKIHQYT PEMILEIKKN QLKFAPFKCV
1960 1970 1980 1990 2000
VPTCTKTFTR NSNLRAHCQL VHHFTTEEMV KLKIKRPYGR KSQSENVPAS
2010 2020 2030 2040 2050
RSTQVKKQLA MTEENKKESQ PALELRAETQ NTHSNVAVIP EKQLVEKKSP
2060 2070 2080 2090 2100
DKTESSLQVI TVTSEQCNTN ALTNTQTKGR KIRRHKKEKE EKKRKKPVSQ
2110 2120 2130 2140 2150
SLEFPTRYSP YRPYRCVHQG CFAAFTIQQN LILHYQAVHK SDLPAFSAEV
2160 2170 2180 2190 2200
EEESEAGKES EETETKQTLK EFRCQVSDCS RIFQAITGLI QHYMKLHEMT
2210 2220 2230 2240 2250
PEEIESMTAS VDVGKFPCDQ LECKSSFTTY LNYVVHLEAD HGIGLRASKT
2260 2270 2280 2290 2300
EEDGVYKCDC EGCDRIYATR SNLLRHIFNK HNDKHKAHLI RPRRLTPGQE
2310 2320 2330 2340 2350
NMSSKANQEK SKSKHRGTKH SRCGKEGIKM PKTKRKKKNN LENKNAKIVQ
2360 2370 2380 2390 2400
IEENKPYSLK RGKHVYSIKA RNDALSECTS RFVTQYPCMI KGCTSVVTSE
2410 2420 2430 2440 2450
SNIIRHYKCH KLSKAFTSQH RNLLIVFKRC CNSQVKETSE QEGAKNDVKD
2460 2470 2480 2490 2500
SDTCVSESND NSRTTATVSQ KEVEKNEKDE MDELTELFIT KLINEDSTSV
2510 2520 2530 2540 2550
ETQANTSSNV SNDFQEDNLC QSERQKASNL KRVNKEKNVS QNKKRKVEKA
2560 2570 2580 2590 2600
EPASAAELSS VRKEEETAVA IQTIEEHPAS FDWSSFKPMG FEVSFLKFLE
2610 2620 2630 2640 2650
ESAVKQKKNT DKDHPNTGNK KGSHSNSRKN IDKTAVTSGN HVCPCKESET
2660 2670 2680 2690 2700
FVQFANPSQL QCSDNVKIVL DKNLKDCTEL VLKQLQEMKP TVSLKKLEVH
2710 2720
SNDPDMSVMK DISIGKATGR GQY
Length:2,723
Mass (Da):304,816
Last modified:March 23, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA9E05072E9B64303
GO
Isoform 2 (identifier: O60281-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-140: Missing.
     180-184: Missing.

Show »
Length:2,578
Mass (Da):288,286
Checksum:i503D04918A8F8F34
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KNV1J3KNV1_HUMAN
Zinc finger protein 292
ZNF292
2,718Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YB79H0YB79_HUMAN
Zinc finger protein 292
ZNF292
256Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RFE6E5RFE6_HUMAN
Zinc finger protein 292
ZNF292
87Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RJG2E5RJG2_HUMAN
Zinc finger protein 292
ZNF292
66Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YAU0H0YAU0_HUMAN
Zinc finger protein 292
ZNF292
132Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB14622 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB14654 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAD97823 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence CAD97823 differs from that shown. Reason: Frameshift.Curated
The sequence CAD97823 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti896E → V in BAB14622 (PubMed:14702039).Curated1
Sequence conflicti1003N → D in BAB14622 (PubMed:14702039).Curated1
Sequence conflicti1217S → P in CAD97823 (Ref. 2) Curated1
Sequence conflicti1355E → K in BAB14622 (PubMed:14702039).Curated1
Sequence conflicti1530N → S in BAB14622 (PubMed:14702039).Curated1
Sequence conflicti1846K → E in CAD97823 (Ref. 2) Curated1
Sequence conflicti1953T → A in CAD97823 (Ref. 2) Curated1
Sequence conflicti2162E → K in BAB14654 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0629721740I → V2 PublicationsCorresponds to variant dbSNP:rs9362415Ensembl.1
Natural variantiVAR_0629732045V → I1 PublicationCorresponds to variant dbSNP:rs6910541Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0388571 – 140Missing in isoform 2. CuratedAdd BLAST140
Alternative sequenceiVSP_038858180 – 184Missing in isoform 2. Curated5

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AL139274 Genomic DNA No translation available.
BX537746 mRNA Translation: CAD97823.1 Sequence problems.
AK023626 mRNA Translation: BAB14622.1 Different initiation.
AK023712 mRNA Translation: BAB14654.1 Different initiation.
AB011102 mRNA Translation: BAA25456.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS47457.1 [O60281-1]

NCBI Reference Sequences

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RefSeqi
NP_055836.1, NM_015021.1 [O60281-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000369577; ENSP00000358590; ENSG00000188994 [O60281-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
23036

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:23036

UCSC genome browser

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UCSCi
uc003plm.5, human [O60281-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL139274 Genomic DNA No translation available.
BX537746 mRNA Translation: CAD97823.1 Sequence problems.
AK023626 mRNA Translation: BAB14622.1 Different initiation.
AK023712 mRNA Translation: BAB14654.1 Different initiation.
AB011102 mRNA Translation: BAA25456.1
CCDSiCCDS47457.1 [O60281-1]
RefSeqiNP_055836.1, NM_015021.1 [O60281-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1X3CNMR-A2094-2153[»]
BMRBiO60281
SMRiO60281
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi116675, 16 interactors
IntActiO60281, 16 interactors
STRINGi9606.ENSP00000358590

PTM databases

iPTMnetiO60281
PhosphoSitePlusiO60281

Polymorphism and mutation databases

BioMutaiZNF292

Proteomic databases

EPDiO60281
jPOSTiO60281
MassIVEiO60281
MaxQBiO60281
PaxDbiO60281
PeptideAtlasiO60281
PRIDEiO60281
ProteomicsDBi49309 [O60281-1]
49310 [O60281-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
31770, 50 antibodies

Genome annotation databases

EnsembliENST00000369577; ENSP00000358590; ENSG00000188994 [O60281-1]
GeneIDi23036
KEGGihsa:23036
UCSCiuc003plm.5, human [O60281-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
23036
DisGeNETi23036
EuPathDBiHostDB:ENSG00000188994.12

GeneCards: human genes, protein and diseases

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GeneCardsi
ZNF292
HGNCiHGNC:18410, ZNF292
HPAiENSG00000188994, Low tissue specificity
MalaCardsiZNF292
neXtProtiNX_O60281
OpenTargetsiENSG00000188994
PharmGKBiPA134945416

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1721, Eukaryota
GeneTreeiENSGT00950000183034
HOGENOMiCLU_000520_0_0_1
InParanoidiO60281
OMAiSHVSTGC
OrthoDBi1318335at2759
PhylomeDBiO60281
TreeFamiTF350813

Enzyme and pathway databases

PathwayCommonsiO60281

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
23036, 7 hits in 894 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ZNF292, human
EvolutionaryTraceiO60281

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
23036
PharosiO60281, Tbio

Protein Ontology

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PROi
PR:O60281
RNActiO60281, protein

Gene expression databases

BgeeiENSG00000188994, Expressed in placenta and 255 other tissues
ExpressionAtlasiO60281, baseline and differential
GenevisibleiO60281, HS

Family and domain databases

InterProiView protein in InterPro
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
PfamiView protein in Pfam
PF00096, zf-C2H2, 1 hit
SMARTiView protein in SMART
SM00355, ZnF_C2H2, 16 hits
SUPFAMiSSF57667, SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028, ZINC_FINGER_C2H2_1, 13 hits
PS50157, ZINC_FINGER_C2H2_2, 11 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN292_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O60281
Secondary accession number(s): Q5W0B2
, Q7Z3L7, Q9H8G3, Q9H8J4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: March 23, 2010
Last modified: October 7, 2020
This is version 185 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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