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Protein

Sushi domain-containing protein 5

Gene

SUSD5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Sushi domain-containing protein 5
Gene namesi
Name:SUSD5
Synonyms:KIAA0527
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000173705.8
HGNCiHGNC:29061 SUSD5
neXtProtiNX_O60279

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini36 – 574ExtracellularSequence analysisAdd BLAST539
Transmembranei575 – 595HelicalSequence analysisAdd BLAST21
Topological domaini596 – 629CytoplasmicSequence analysisAdd BLAST34

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000173705
PharmGKBiPA143485627

Polymorphism and mutation databases

BioMutaiSUSD5

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 35Sequence analysisAdd BLAST35
ChainiPRO_000027424736 – 629Sushi domain-containing protein 5Add BLAST594

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi61 ↔ 132By similarity
Disulfide bondi140 ↔ 184By similarity
Disulfide bondi167 ↔ 197By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

EPDiO60279
MaxQBiO60279
PaxDbiO60279
PeptideAtlasiO60279
PRIDEiO60279
ProteomicsDBi49308

PTM databases

iPTMnetiO60279
PhosphoSitePlusiO60279
SwissPalmiO60279

Expressioni

Gene expression databases

BgeeiENSG00000173705
CleanExiHS_SUSD5
ExpressionAtlasiO60279 baseline and differential
GenevisibleiO60279 HS

Organism-specific databases

HPAiHPA052788

Interactioni

Protein-protein interaction databases

BioGridi117498, 10 interactors

Structurei

3D structure databases

ProteinModelPortaliO60279
SMRiO60279
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 134LinkPROSITE-ProRule annotationAdd BLAST96
Domaini138 – 199SushiPROSITE-ProRule annotationAdd BLAST62

Keywords - Domaini

Signal, Sushi, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFAC Eukaryota
ENOG410YBQZ LUCA
GeneTreeiENSGT00390000009163
HOGENOMiHOG000154451
HOVERGENiHBG108521
InParanoidiO60279
OMAiHLFWFPA
OrthoDBiEOG091G046R
PhylomeDBiO60279
TreeFamiTF336259

Family and domain databases

CDDicd00033 CCP, 1 hit
Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR016186 C-type_lectin-like/link_sf
IPR016187 CTDL_fold
IPR000538 Link_dom
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom
PfamiView protein in Pfam
PF00193 Xlink, 1 hit
SMARTiView protein in SMART
SM00445 LINK, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit
SSF57535 SSF57535, 1 hit
PROSITEiView protein in PROSITE
PS50963 LINK_2, 1 hit
PS50923 SUSHI, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O60279-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTAEGPSPPA RWHRRLPGLW AAALLLLGLP RLSVRADGKF FVLESQNGSQ
60 70 80 90 100
GLQLEAARLS CKSRGAHLAS ADELRRVVQD CSFAVCTTGW LADGTLGTTV
110 120 130 140 150
CSKGSGEQQI MRAVDVRIES NPVPGGTYSA LCIKDEEKPC GDPPSFPHTI
160 170 180 190 200
LQGRTGLEMG DELLYVCAPG HIMGHRETAF TLLCNSCGEW YGLVQACGKD
210 220 230 240 250
EAEAHIDYED NFPDDRSVSF RELMEDSRTE ADEDRGQGDS SEEAPKQDRL
260 270 280 290 300
VSISVGRENI ARDKVFVPTT GLPGAGSSVP ADSPGSRLLQ KHLFWFPAEA
310 320 330 340 350
FHKPGLEKEV DDDTKKQFSA GDNHSGVKLV PGEPETKVIY GNTDGPSGPF
360 370 380 390 400
VGKNDSKAGD PVVSSSDESW LDGYPVTEGA WRKTEAEEEE DGDRGDGSVG
410 420 430 440 450
LDENVLVTPD QPILVEVKKP KSSTLTPSEG MTHSSVLPSQ MLDVEALALR
460 470 480 490 500
PVNASETEGI GDGDLTKYQS TLPWRFITEE SPMATLSYEL TSSTLEILTV
510 520 530 540 550
NTVKQTPNHI PSTIMATTQP PVETTVPEIQ DSFPYLLSED FFGQEGPGPG
560 570 580 590 600
ASEELHPTLE SCVGDGCPGL SRGPVIATIV TVLCLLLLLA GVGMVWGYRK
610 620
CQHKSSVYKL NVGQRQARHY HQQIEMEKV
Length:629
Mass (Da):68,021
Last modified:April 8, 2008 - v3
Checksum:i51CB3C12D932FD9E
GO

Sequence cautioni

The sequence BAA25453 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti272L → S in BAA25453 (PubMed:9628581).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05139140F → L1 PublicationCorresponds to variant dbSNP:rs9637517Ensembl.1
Natural variantiVAR_03021752L → F. Corresponds to variant dbSNP:rs9637517Ensembl.1
Natural variantiVAR_051392216R → K. Corresponds to variant dbSNP:rs9872477Ensembl.1
Natural variantiVAR_030218228R → K. Corresponds to variant dbSNP:rs9872477Ensembl.1
Natural variantiVAR_051393378E → D1 PublicationCorresponds to variant dbSNP:rs6810039Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB011099 mRNA Translation: BAA25453.1 Different initiation.
AC123900 Genomic DNA No translation available.
CCDSiCCDS46787.1
PIRiT00073
RefSeqiNP_056366.1, NM_015551.1
UniGeneiHs.196647

Genome annotation databases

EnsembliENST00000309558; ENSP00000308727; ENSG00000173705
GeneIDi26032
KEGGihsa:26032
UCSCiuc003cfo.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSUSD5_HUMAN
AccessioniPrimary (citable) accession number: O60279
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: April 8, 2008
Last modified: June 20, 2018
This is version 116 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

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