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UniProtKB - O60269 (GRIN2_HUMAN)

Entry version 130 (16 Oct 2019)
Sequence version 2 (16 May 2006)
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Protein

G protein-regulated inducer of neurite outgrowth 2

Gene

GPRIN2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in neurite outgrowth.1 Publication

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
G protein-regulated inducer of neurite outgrowth 2
Short name:
GRIN2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GPRIN2
Synonyms:KIAA0514
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:23730 GPRIN2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		611240 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O60269

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		9721

Open Targets

More...OpenTargetsi		ENSG00000204175

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA162390192

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O60269

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		GPRIN2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000507591 – 458G protein-regulated inducer of neurite outgrowth 2Add BLAST458

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		O60269

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O60269

MaxQB - The MaxQuant DataBase

More...MaxQBi		O60269

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O60269

PeptideAtlas

More...PeptideAtlasi		O60269

PRoteomics IDEntifications database

More...PRIDEi		O60269

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		49301

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O60269

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O60269

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed specifically in the cerebellum.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000204175 Expressed in 72 organ(s), highest expression level in upper lobe of left lung

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O60269 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with activated forms of GNAO1 and GNAZ.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		115070, 14 interactors

Protein interaction database and analysis system

More...IntActi		O60269, 10 interactors

Molecular INTeraction database

More...MINTi		O60269

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000363436

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O60269

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410IYCC Eukaryota
ENOG4111KRR LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00570000079168

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000112814

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O60269

Identification of Orthologs from Complete Genome Data

More...OMAi		SSTVWQA

Database of Orthologous Groups

More...OrthoDBi		612273at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O60269

TreeFam database of animal gene trees

More...TreeFami		TF337047

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR026646 GPRIN2-like/GPRIN3
IPR032745 GRIN_C

The PANTHER Classification System

More...PANTHERi		PTHR15718 PTHR15718, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF15235 GRIN_C, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O60269-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSSRPEPGP WAPLSPRLQP LSQSSSSLLG EGREQRPELR KTASSTVWQA 
        60         70         80         90        100
QLGEASTRPQ APEEEGNPPE SMKPARASGP KARPSAGGHW WSSTVGNVST 
       110        120        130        140        150
MGGSDLCRLR APSAAAMQRS HSDLVRSTQM RGHSGARKAS LSCSALGSSP 
       160        170        180        190        200
VHRAQLQPGG TSGQGGQAPA GLERDLAPED ETSNSAWMLG ASQLSVPPLD 
       210        220        230        240        250
LGDTTAHSSS AQAEPKAAEQ LATTTCHALP PAALLCGMRE VRAGGCCHAL 
       260        270        280        290        300
PATGILAFPK LVASVSESGL QAQHGVKIHC RLSGGLPGHS HCCAHLWGPA 
       310        320        330        340        350
GLVPEPGSRT KDVWTMTSAN DLAPAEASPL SAQDAGVQAA PVAACKAVAT 
       360        370        380        390        400
SPSLEAPAAL HVFPEVTLGS SLEEVPSPVR DVRWDAEGMT WEVYGAAVDL 
       410        420        430        440        450
EVLGVAIQKH LEMQFEQLQR APASEDSLSV EGRRGPLRAV MQSLRRPSCC 

GCSGAAPE
Length:458
Mass (Da):47,450
Last modified:May 16, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD6395C187FAD142D
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA25440 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti241 – 242VR → MREVG in BAA25440 (PubMed:9628581).Curated2
Sequence conflicti241 – 242VR → MREVG in AAH11672 (PubMed:15489334).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0596605R → H2 PublicationsCorresponds to variant dbSNP:rs3127817Ensembl.1
Natural variantiVAR_05101739L → V. Corresponds to variant dbSNP:rs4926045Ensembl.1
Natural variantiVAR_05966140R → H2 PublicationsCorresponds to variant dbSNP:rs3127818Ensembl.1
Natural variantiVAR_05966247V → M2 PublicationsCorresponds to variant dbSNP:rs3127819Ensembl.1
Natural variantiVAR_05966391W → R2 PublicationsCorresponds to variant dbSNP:rs3127820Ensembl.1
Natural variantiVAR_061656100T → P. Corresponds to variant dbSNP:rs7090312Ensembl.1
Natural variantiVAR_051018104S → G2 PublicationsCorresponds to variant dbSNP:rs3127679Ensembl.1
Natural variantiVAR_061657202G → W. Corresponds to variant dbSNP:rs11204658Ensembl.1
Natural variantiVAR_061658233A → S. Corresponds to variant dbSNP:rs11204659Ensembl.1
Natural variantiVAR_061659241V → M. Corresponds to variant dbSNP:rs9422022Ensembl.1
Natural variantiVAR_061660242R → G. Corresponds to variant dbSNP:rs3127683Ensembl.1
Natural variantiVAR_061661328S → C. Corresponds to variant dbSNP:rs4445576Ensembl.1
Natural variantiVAR_061662375V → A1 PublicationCorresponds to variant dbSNP:rs3127822Ensembl.1
Natural variantiVAR_059664400L → P2 PublicationsCorresponds to variant dbSNP:rs3127823Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB011086 mRNA Translation: BAA25440.2 Different initiation.
AL645529 Genomic DNA No translation available.
BC011672 mRNA Translation: AAH11672.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS73101.1

NCBI Reference Sequences

More...RefSeqi		NP_055511.2, NM_014696.3
XP_005277723.1, XM_005277666.3
XP_011538702.1, XM_011540400.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000374314; ENSP00000363433; ENSG00000204175
ENST00000374317; ENSP00000363436; ENSG00000204175

Database of genes from NCBI RefSeq genomes

More...GeneIDi		9721

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:9721

UCSC genome browser

More...UCSCi		uc057taj.1 human

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB011086 mRNA Translation: BAA25440.2 Different initiation.
AL645529 Genomic DNA No translation available.
BC011672 mRNA Translation: AAH11672.1
CCDSiCCDS73101.1
RefSeqiNP_055511.2, NM_014696.3
XP_005277723.1, XM_005277666.3
XP_011538702.1, XM_011540400.2

3D structure databases

SMRiO60269
ModBaseiSearch...

Protein-protein interaction databases

BioGridi115070, 14 interactors
IntActiO60269, 10 interactors
MINTiO60269
STRINGi9606.ENSP00000363436

PTM databases

iPTMnetiO60269
PhosphoSitePlusiO60269

Polymorphism and mutation databases

BioMutaiGPRIN2

Proteomic databases

EPDiO60269
jPOSTiO60269
MaxQBiO60269
PaxDbiO60269
PeptideAtlasiO60269
PRIDEiO60269
ProteomicsDBi49301

Genome annotation databases

EnsembliENST00000374314; ENSP00000363433; ENSG00000204175
ENST00000374317; ENSP00000363436; ENSG00000204175
GeneIDi9721
KEGGihsa:9721
UCSCiuc057taj.1 human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		9721
DisGeNETi9721

GeneCards: human genes, protein and diseases

More...GeneCardsi		GPRIN2
HGNCiHGNC:23730 GPRIN2
MIMi611240 gene
neXtProtiNX_O60269
OpenTargetsiENSG00000204175
PharmGKBiPA162390192

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG410IYCC Eukaryota
ENOG4111KRR LUCA
GeneTreeiENSGT00570000079168
HOGENOMiHOG000112814
InParanoidiO60269
OMAiSSTVWQA
OrthoDBi612273at2759
PhylomeDBiO60269
TreeFamiTF337047

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		GPRIN2 human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		GPRIN2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		9721
PharosiO60269

Protein Ontology

More...PROi		PR:O60269

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000204175 Expressed in 72 organ(s), highest expression level in upper lobe of left lung
GenevisibleiO60269 HS

Family and domain databases

InterProiView protein in InterPro
IPR026646 GPRIN2-like/GPRIN3
IPR032745 GRIN_C
PANTHERiPTHR15718 PTHR15718, 1 hit
PfamiView protein in Pfam
PF15235 GRIN_C, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGRIN2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O60269
Secondary accession number(s): Q5SVF0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: May 16, 2006
Last modified: October 16, 2019
This is version 130 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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