GPRIN2

Functionⁱ

May be involved in neurite outgrowth.1 Publication

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: G protein-regulated inducer of neurite outgrowth 2 Short name: GRIN2
Gene namesⁱ	Name:GPRIN2 Synonyms:KIAA0514
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 10

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000204175.5
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:23730 GPRIN2
MIMⁱ	611240 gene
neXtProtⁱ	NX_O60269

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	9721
Open Targets More...OpenTargetsⁱ	ENSG00000204175
PharmGKBⁱ	PA162390192

Polymorphism and mutation databases

BioMutaⁱ	GPRIN2

BioMutaⁱ

GPRIN2

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000050759	1 – 458	G protein-regulated inducer of neurite outgrowth 2Add BLAST		458

Proteomic databases

EPDⁱ	O60269
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O60269
PaxDbⁱ	O60269
PeptideAtlas More...PeptideAtlasⁱ	O60269
PRIDEⁱ	O60269
ProteomicsDBⁱ	49301

PTM databases

iPTMnetⁱ	O60269
PhosphoSitePlusⁱ	O60269

Expressionⁱ

Tissue specificityⁱ

Expressed specifically in the cerebellum.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000204175
CleanExⁱ	HS_GPRIN2
Genevisibleⁱ	O60269 HS

Interactionⁱ

Subunit structureⁱ

Interacts with activated forms of GNAO1 and GNAZ.1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
SFN	P31947	2	EBI-740397,EBI-476295

With

Entry

#Exp.

IntAct

Notes

SFN

P31947

2

EBI-740397,EBI-476295

Protein-protein interaction databases

BioGridⁱ	115070, 14 interactors
IntActⁱ	O60269, 9 interactors
Molecular INTeraction database More...MINTⁱ	O60269
STRINGⁱ	9606.ENSP00000363433

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O60269
SMRⁱ	O60269
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Phylogenomic databases

eggNOGⁱ	ENOG410IYCC Eukaryota ENOG4111KRR LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00570000079168
HOGENOMⁱ	HOG000112814
InParanoidⁱ	O60269
OMAⁱ	CKAVATS
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G04VZ
PhylomeDBⁱ	O60269
TreeFamⁱ	TF337047

Family and domain databases

InterProⁱ	View protein in InterPro IPR026646 GPRIN2-like/GPRIN3 IPR032745 GRIN_C
PANTHERⁱ	PTHR15718 PTHR15718, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF15235 GRIN_C, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

O60269-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSSSRPEPGP WAPLSPRLQP LSQSSSSLLG EGREQRPELR KTASSTVWQA 
        60         70         80         90        100
QLGEASTRPQ APEEEGNPPE SMKPARASGP KARPSAGGHW WSSTVGNVST 
       110        120        130        140        150
MGGSDLCRLR APSAAAMQRS HSDLVRSTQM RGHSGARKAS LSCSALGSSP 
       160        170        180        190        200
VHRAQLQPGG TSGQGGQAPA GLERDLAPED ETSNSAWMLG ASQLSVPPLD 
       210        220        230        240        250
LGDTTAHSSS AQAEPKAAEQ LATTTCHALP PAALLCGMRE VRAGGCCHAL 
       260        270        280        290        300
PATGILAFPK LVASVSESGL QAQHGVKIHC RLSGGLPGHS HCCAHLWGPA 
       310        320        330        340        350
GLVPEPGSRT KDVWTMTSAN DLAPAEASPL SAQDAGVQAA PVAACKAVAT 
       360        370        380        390        400
SPSLEAPAAL HVFPEVTLGS SLEEVPSPVR DVRWDAEGMT WEVYGAAVDL 
       410        420        430        440        450
EVLGVAIQKH LEMQFEQLQR APASEDSLSV EGRRGPLRAV MQSLRRPSCC 

GCSGAAPE

Length:458

Mass (Da):47,450

Last modified:May 16, 2006 - v2

Checksum:ⁱD6395C187FAD142D

GO

Sequence cautionⁱ

The sequence BAA25440 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	241 – 242	VR → MREVG in BAA25440 (PubMed:9628581).Curated		2
Sequence conflictⁱ	241 – 242	VR → MREVG in AAH11672 (PubMed:15489334).Curated		2

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_059660	5	R → H2 PublicationsCorresponds to variant dbSNP:rs3127817Ensembl.	1
Natural variantⁱVAR_051017	39	L → V. Corresponds to variant dbSNP:rs4926045Ensembl.	1
Natural variantⁱVAR_059661	40	R → H2 PublicationsCorresponds to variant dbSNP:rs3127818Ensembl.	1
Natural variantⁱVAR_059662	47	V → M2 PublicationsCorresponds to variant dbSNP:rs3127819Ensembl.	1
Natural variantⁱVAR_059663	91	W → R2 PublicationsCorresponds to variant dbSNP:rs3127820Ensembl.	1
Natural variantⁱVAR_061656	100	T → P. Corresponds to variant dbSNP:rs7090312Ensembl.	1
Natural variantⁱVAR_051018	104	S → G2 PublicationsCorresponds to variant dbSNP:rs3127679Ensembl.	1
Natural variantⁱVAR_061657	202	G → W. Corresponds to variant dbSNP:rs11204658Ensembl.	1
Natural variantⁱVAR_061658	233	A → S. Corresponds to variant dbSNP:rs11204659Ensembl.	1
Natural variantⁱVAR_061659	241	V → M. Corresponds to variant dbSNP:rs9422022Ensembl.	1
Natural variantⁱVAR_061660	242	R → G. Corresponds to variant dbSNP:rs3127683Ensembl.	1
Natural variantⁱVAR_061661	328	S → C. Corresponds to variant dbSNP:rs4445576Ensembl.	1
Natural variantⁱVAR_061662	375	V → A1 PublicationCorresponds to variant dbSNP:rs3127822Ensembl.	1
Natural variantⁱVAR_059664	400	L → P2 PublicationsCorresponds to variant dbSNP:rs3127823Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB011086 mRNA Translation: BAA25440.2 Different initiation. AL645529 Genomic DNA No translation available. BC011672 mRNA Translation: AAH11672.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS73101.1
NCBI Reference Sequences More...RefSeqⁱ	NP_055511.2, NM_014696.3 XP_005277723.1, XM_005277666.3 XP_011538702.1, XM_011540400.2
UniGeneⁱ	Hs.523375

Genome annotation databases

Ensemblⁱ	ENST00000374314; ENSP00000363433; ENSG00000204175 ENST00000374317; ENSP00000363436; ENSG00000204175
GeneIDⁱ	9721
KEGGⁱ	hsa:9721
UCSC genome browser More...UCSCⁱ	uc057taj.1 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Protein	Similar proteins		Species	Score	Length
O60269	UPI000387C5B3		HUMAN		482
G protein regulated inducer of neurite outgrowth 2		PANTR		482
Uncharacterized protein		PANPA		482
G protein regulated inducer of neurite outgrowth 2		GORGO		458
G protein regulated inducer of neurite outgrowth 2		MACNE		458
+25

Protein	Similar proteins		Species	Score	Length
O60269	UPI000387C5B3		HUMAN		482
G protein regulated inducer of neurite outgrowth 2		PANTR		482
Uncharacterized protein		PANPA		482
G protein-regulated inducer of neurite outgrowth 2		MACFA		458
G protein regulated inducer of neurite outgrowth 2		CHLSB		458
+52

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB011086 mRNA Translation: BAA25440.2 Different initiation. AL645529 Genomic DNA No translation available. BC011672 mRNA Translation: AAH11672.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS73101.1
NCBI Reference Sequences More...RefSeqⁱ	NP_055511.2, NM_014696.3 XP_005277723.1, XM_005277666.3 XP_011538702.1, XM_011540400.2
UniGeneⁱ	Hs.523375

3D structure databases

ProteinModelPortalⁱ	O60269
SMRⁱ	O60269
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	115070, 14 interactors
IntActⁱ	O60269, 9 interactors
Molecular INTeraction database More...MINTⁱ	O60269
STRINGⁱ	9606.ENSP00000363433

PTM databases

iPTMnetⁱ	O60269
PhosphoSitePlusⁱ	O60269

Polymorphism and mutation databases

BioMutaⁱ	GPRIN2

BioMutaⁱ

GPRIN2

Proteomic databases

EPDⁱ	O60269
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O60269
PaxDbⁱ	O60269
PeptideAtlas More...PeptideAtlasⁱ	O60269
PRIDEⁱ	O60269
ProteomicsDBⁱ	49301

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000374314; ENSP00000363433; ENSG00000204175 ENST00000374317; ENSP00000363436; ENSG00000204175
GeneIDⁱ	9721
KEGGⁱ	hsa:9721
UCSC genome browser More...UCSCⁱ	uc057taj.1 human

Organism-specific databases

CTDⁱ	9721
DisGeNET More...DisGeNETⁱ	9721
EuPathDBⁱ	HostDB:ENSG00000204175.5
GeneCardsⁱ	GPRIN2
H-InvDBⁱ	HIX0008795
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:23730 GPRIN2
MIMⁱ	611240 gene
neXtProtⁱ	NX_O60269
Open Targets More...OpenTargetsⁱ	ENSG00000204175
PharmGKBⁱ	PA162390192
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IYCC Eukaryota ENOG4111KRR LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00570000079168
HOGENOMⁱ	HOG000112814
InParanoidⁱ	O60269
OMAⁱ	CKAVATS
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G04VZ
PhylomeDBⁱ	O60269
TreeFamⁱ	TF337047

Miscellaneous databases

GeneWikiⁱ	GPRIN2
GenomeRNAiⁱ	9721
Protein Ontology More...PROⁱ	PR:O60269
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000204175
CleanExⁱ	HS_GPRIN2
Genevisibleⁱ	O60269 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR026646 GPRIN2-like/GPRIN3 IPR032745 GRIN_C
PANTHERⁱ	PTHR15718 PTHR15718, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF15235 GRIN_C, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	GRIN2_HUMAN
Accessionⁱ	O60269Primary (citable) accession number: O60269 Secondary accession number(s): Q5SVF0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
	Last sequence update:	May 16, 2006
	Last modified:	June 20, 2018
	This is version 122 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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UniProtKB - O60269 (GRIN2_HUMAN)

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G protein-regulated inducer of neurite outgrowth 2

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

Names & Taxonomyⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ