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UniProtKB - O60269 (GRIN2_HUMAN)
Protein
G protein-regulated inducer of neurite outgrowth 2
Gene
GPRIN2
Organism
Homo sapiens (Human)
Status
Functioni
May be involved in neurite outgrowth.
1 PublicationGO - Biological processi
- neuron projection development Source: GO_Central
Enzyme and pathway databases
PathwayCommonsi | O60269 |
SignaLinki | O60269 |
Names & Taxonomyi
Protein namesi | Recommended name: G protein-regulated inducer of neurite outgrowth 2Short name: GRIN2 |
Gene namesi | Name:GPRIN2 Synonyms:KIAA0514 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:23730, GPRIN2 |
MIMi | 611240, gene |
neXtProti | NX_O60269 |
VEuPathDBi | HostDB:ENSG00000204175 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 9721 |
OpenTargetsi | ENSG00000204175 |
PharmGKBi | PA162390192 |
Miscellaneous databases
Pharosi | O60269, Tbio |
Genetic variation databases
BioMutai | GPRIN2 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000050759 | 1 – 458 | G protein-regulated inducer of neurite outgrowth 2Add BLAST | 458 |
Proteomic databases
EPDi | O60269 |
jPOSTi | O60269 |
MassIVEi | O60269 |
MaxQBi | O60269 |
PaxDbi | O60269 |
PeptideAtlasi | O60269 |
PRIDEi | O60269 |
ProteomicsDBi | 49301 |
PTM databases
iPTMneti | O60269 |
PhosphoSitePlusi | O60269 |
Expressioni
Tissue specificityi
Expressed specifically in the cerebellum.1 Publication
Gene expression databases
Bgeei | ENSG00000204175, Expressed in muscle tissue and 92 other tissues |
Genevisiblei | O60269, HS |
Organism-specific databases
HPAi | ENSG00000204175, Tissue enhanced (lung, skin) |
Interactioni
Subunit structurei
Interacts with activated forms of GNAO1 and GNAZ.
1 PublicationBinary interactionsi
Protein-protein interaction databases
BioGRIDi | 115070, 28 interactors |
IntActi | O60269, 10 interactors |
MINTi | O60269 |
STRINGi | 9606.ENSP00000363436 |
Miscellaneous databases
RNActi | O60269, protein |
Structurei
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 94 | DisorderedSequence analysisAdd BLAST | 94 | |
Regioni | 118 – 172 | DisorderedSequence analysisAdd BLAST | 55 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 17 – 31 | Polar residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 41 – 56 | Polar residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 120 – 164 | Polar residuesSequence analysisAdd BLAST | 45 |
Phylogenomic databases
eggNOGi | ENOG502SG81, Eukaryota |
GeneTreei | ENSGT00570000079168 |
HOGENOMi | CLU_038162_0_0_1 |
InParanoidi | O60269 |
OMAi | CCAHPWG |
OrthoDBi | 612273at2759 |
PhylomeDBi | O60269 |
TreeFami | TF337047 |
Family and domain databases
InterProi | View protein in InterPro IPR026646, GPRIN2-like/GPRIN3 IPR032745, GRIN_C |
PANTHERi | PTHR15718, PTHR15718, 1 hit |
Pfami | View protein in Pfam PF15235, GRIN_C, 1 hit |
i Sequence
Sequence statusi: Complete.
O60269-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSSSRPEPGP WAPLSPRLQP LSQSSSSLLG EGREQRPELR KTASSTVWQA
60 70 80 90 100
QLGEASTRPQ APEEEGNPPE SMKPARASGP KARPSAGGHW WSSTVGNVST
110 120 130 140 150
MGGSDLCRLR APSAAAMQRS HSDLVRSTQM RGHSGARKAS LSCSALGSSP
160 170 180 190 200
VHRAQLQPGG TSGQGGQAPA GLERDLAPED ETSNSAWMLG ASQLSVPPLD
210 220 230 240 250
LGDTTAHSSS AQAEPKAAEQ LATTTCHALP PAALLCGMRE VRAGGCCHAL
260 270 280 290 300
PATGILAFPK LVASVSESGL QAQHGVKIHC RLSGGLPGHS HCCAHLWGPA
310 320 330 340 350
GLVPEPGSRT KDVWTMTSAN DLAPAEASPL SAQDAGVQAA PVAACKAVAT
360 370 380 390 400
SPSLEAPAAL HVFPEVTLGS SLEEVPSPVR DVRWDAEGMT WEVYGAAVDL
410 420 430 440 450
EVLGVAIQKH LEMQFEQLQR APASEDSLSV EGRRGPLRAV MQSLRRPSCC
GCSGAAPE
Sequence cautioni
The sequence BAA25440 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 241 – 242 | VR → MREVG in BAA25440 (PubMed:9628581).Curated | 2 | |
Sequence conflicti | 241 – 242 | VR → MREVG in AAH11672 (PubMed:15489334).Curated | 2 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_059660 | 5 | R → H2 PublicationsCorresponds to variant dbSNP:rs3127817Ensembl. | 1 | |
Natural variantiVAR_051017 | 39 | L → V. Corresponds to variant dbSNP:rs4926045Ensembl. | 1 | |
Natural variantiVAR_059661 | 40 | R → H2 PublicationsCorresponds to variant dbSNP:rs3127818Ensembl. | 1 | |
Natural variantiVAR_059662 | 47 | V → M2 PublicationsCorresponds to variant dbSNP:rs3127819Ensembl. | 1 | |
Natural variantiVAR_059663 | 91 | W → R2 PublicationsCorresponds to variant dbSNP:rs3127820Ensembl. | 1 | |
Natural variantiVAR_061656 | 100 | T → P. Corresponds to variant dbSNP:rs7090312Ensembl. | 1 | |
Natural variantiVAR_051018 | 104 | S → G2 PublicationsCorresponds to variant dbSNP:rs3127679Ensembl. | 1 | |
Natural variantiVAR_061657 | 202 | G → W. Corresponds to variant dbSNP:rs11204658Ensembl. | 1 | |
Natural variantiVAR_061658 | 233 | A → S. Corresponds to variant dbSNP:rs11204659Ensembl. | 1 | |
Natural variantiVAR_061659 | 241 | V → M. Corresponds to variant dbSNP:rs9422022Ensembl. | 1 | |
Natural variantiVAR_061660 | 242 | R → G. Corresponds to variant dbSNP:rs3127683Ensembl. | 1 | |
Natural variantiVAR_061661 | 328 | S → C. Corresponds to variant dbSNP:rs4445576Ensembl. | 1 | |
Natural variantiVAR_061662 | 375 | V → A1 PublicationCorresponds to variant dbSNP:rs3127822Ensembl. | 1 | |
Natural variantiVAR_059664 | 400 | L → P2 PublicationsCorresponds to variant dbSNP:rs3127823Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB011086 mRNA Translation: BAA25440.2 Different initiation. AL645529 Genomic DNA No translation available. BC011672 mRNA Translation: AAH11672.1 |
CCDSi | CCDS73101.1 |
RefSeqi | NP_055511.2, NM_014696.3 XP_005277723.1, XM_005277666.3 XP_011538702.1, XM_011540400.2 |
Genome annotation databases
Ensembli | ENST00000374314; ENSP00000363433; ENSG00000204175 ENST00000374317; ENSP00000363436; ENSG00000204175 |
GeneIDi | 9721 |
KEGGi | hsa:9721 |
MANE-Selecti | ENST00000374314.6; ENSP00000363433.4; NM_001385282.1; NP_001372211.1 |
UCSCi | uc057taj.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB011086 mRNA Translation: BAA25440.2 Different initiation. AL645529 Genomic DNA No translation available. BC011672 mRNA Translation: AAH11672.1 |
CCDSi | CCDS73101.1 |
RefSeqi | NP_055511.2, NM_014696.3 XP_005277723.1, XM_005277666.3 XP_011538702.1, XM_011540400.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 115070, 28 interactors |
IntActi | O60269, 10 interactors |
MINTi | O60269 |
STRINGi | 9606.ENSP00000363436 |
PTM databases
iPTMneti | O60269 |
PhosphoSitePlusi | O60269 |
Genetic variation databases
BioMutai | GPRIN2 |
Proteomic databases
EPDi | O60269 |
jPOSTi | O60269 |
MassIVEi | O60269 |
MaxQBi | O60269 |
PaxDbi | O60269 |
PeptideAtlasi | O60269 |
PRIDEi | O60269 |
ProteomicsDBi | 49301 |
Protocols and materials databases
Antibodypediai | 27207, 123 antibodies from 23 providers |
DNASUi | 9721 |
Genome annotation databases
Ensembli | ENST00000374314; ENSP00000363433; ENSG00000204175 ENST00000374317; ENSP00000363436; ENSG00000204175 |
GeneIDi | 9721 |
KEGGi | hsa:9721 |
MANE-Selecti | ENST00000374314.6; ENSP00000363433.4; NM_001385282.1; NP_001372211.1 |
UCSCi | uc057taj.1, human |
Organism-specific databases
CTDi | 9721 |
DisGeNETi | 9721 |
GeneCardsi | GPRIN2 |
HGNCi | HGNC:23730, GPRIN2 |
HPAi | ENSG00000204175, Tissue enhanced (lung, skin) |
MIMi | 611240, gene |
neXtProti | NX_O60269 |
OpenTargetsi | ENSG00000204175 |
PharmGKBi | PA162390192 |
VEuPathDBi | HostDB:ENSG00000204175 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502SG81, Eukaryota |
GeneTreei | ENSGT00570000079168 |
HOGENOMi | CLU_038162_0_0_1 |
InParanoidi | O60269 |
OMAi | CCAHPWG |
OrthoDBi | 612273at2759 |
PhylomeDBi | O60269 |
TreeFami | TF337047 |
Enzyme and pathway databases
PathwayCommonsi | O60269 |
SignaLinki | O60269 |
Miscellaneous databases
BioGRID-ORCSi | 9721, 29 hits in 1027 CRISPR screens |
ChiTaRSi | GPRIN2, human |
GeneWikii | GPRIN2 |
GenomeRNAii | 9721 |
Pharosi | O60269, Tbio |
PROi | PR:O60269 |
RNActi | O60269, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000204175, Expressed in muscle tissue and 92 other tissues |
Genevisiblei | O60269, HS |
Family and domain databases
InterProi | View protein in InterPro IPR026646, GPRIN2-like/GPRIN3 IPR032745, GRIN_C |
PANTHERi | PTHR15718, PTHR15718, 1 hit |
Pfami | View protein in Pfam PF15235, GRIN_C, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | GRIN2_HUMAN | |
Accessioni | O60269Primary (citable) accession number: O60269 Secondary accession number(s): Q5SVF0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1999 |
Last sequence update: | May 16, 2006 | |
Last modified: | February 23, 2022 | |
This is version 142 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot