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Protein

G protein-regulated inducer of neurite outgrowth 2

Gene

GPRIN2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in neurite outgrowth.1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
G protein-regulated inducer of neurite outgrowth 2
Short name:
GRIN2
Gene namesi
Name:GPRIN2
Synonyms:KIAA0514
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000204175.5
HGNCiHGNC:23730 GPRIN2
MIMi611240 gene
neXtProtiNX_O60269

Pathology & Biotechi

Organism-specific databases

DisGeNETi9721
OpenTargetsiENSG00000204175
PharmGKBiPA162390192

Polymorphism and mutation databases

BioMutaiGPRIN2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000507591 – 458G protein-regulated inducer of neurite outgrowth 2Add BLAST458

Proteomic databases

EPDiO60269
MaxQBiO60269
PaxDbiO60269
PeptideAtlasiO60269
PRIDEiO60269
ProteomicsDBi49301

PTM databases

iPTMnetiO60269
PhosphoSitePlusiO60269

Expressioni

Tissue specificityi

Expressed specifically in the cerebellum.1 Publication

Gene expression databases

BgeeiENSG00000204175
CleanExiHS_GPRIN2
GenevisibleiO60269 HS

Interactioni

Subunit structurei

Interacts with activated forms of GNAO1 and GNAZ.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
SFNP319472EBI-740397,EBI-476295

Protein-protein interaction databases

BioGridi115070, 14 interactors
IntActiO60269, 9 interactors
MINTiO60269
STRINGi9606.ENSP00000363433

Structurei

3D structure databases

ProteinModelPortaliO60269
SMRiO60269
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IYCC Eukaryota
ENOG4111KRR LUCA
GeneTreeiENSGT00570000079168
HOGENOMiHOG000112814
InParanoidiO60269
OMAiCKAVATS
OrthoDBiEOG091G04VZ
PhylomeDBiO60269
TreeFamiTF337047

Family and domain databases

InterProiView protein in InterPro
IPR026646 GPRIN2-like/GPRIN3
IPR032745 GRIN_C
PANTHERiPTHR15718 PTHR15718, 1 hit
PfamiView protein in Pfam
PF15235 GRIN_C, 1 hit

Sequencei

Sequence statusi: Complete.

O60269-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSSRPEPGP WAPLSPRLQP LSQSSSSLLG EGREQRPELR KTASSTVWQA
60 70 80 90 100
QLGEASTRPQ APEEEGNPPE SMKPARASGP KARPSAGGHW WSSTVGNVST
110 120 130 140 150
MGGSDLCRLR APSAAAMQRS HSDLVRSTQM RGHSGARKAS LSCSALGSSP
160 170 180 190 200
VHRAQLQPGG TSGQGGQAPA GLERDLAPED ETSNSAWMLG ASQLSVPPLD
210 220 230 240 250
LGDTTAHSSS AQAEPKAAEQ LATTTCHALP PAALLCGMRE VRAGGCCHAL
260 270 280 290 300
PATGILAFPK LVASVSESGL QAQHGVKIHC RLSGGLPGHS HCCAHLWGPA
310 320 330 340 350
GLVPEPGSRT KDVWTMTSAN DLAPAEASPL SAQDAGVQAA PVAACKAVAT
360 370 380 390 400
SPSLEAPAAL HVFPEVTLGS SLEEVPSPVR DVRWDAEGMT WEVYGAAVDL
410 420 430 440 450
EVLGVAIQKH LEMQFEQLQR APASEDSLSV EGRRGPLRAV MQSLRRPSCC

GCSGAAPE
Length:458
Mass (Da):47,450
Last modified:May 16, 2006 - v2
Checksum:iD6395C187FAD142D
GO

Sequence cautioni

The sequence BAA25440 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti241 – 242VR → MREVG in BAA25440 (PubMed:9628581).Curated2
Sequence conflicti241 – 242VR → MREVG in AAH11672 (PubMed:15489334).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0596605R → H2 PublicationsCorresponds to variant dbSNP:rs3127817Ensembl.1
Natural variantiVAR_05101739L → V. Corresponds to variant dbSNP:rs4926045Ensembl.1
Natural variantiVAR_05966140R → H2 PublicationsCorresponds to variant dbSNP:rs3127818Ensembl.1
Natural variantiVAR_05966247V → M2 PublicationsCorresponds to variant dbSNP:rs3127819Ensembl.1
Natural variantiVAR_05966391W → R2 PublicationsCorresponds to variant dbSNP:rs3127820Ensembl.1
Natural variantiVAR_061656100T → P. Corresponds to variant dbSNP:rs7090312Ensembl.1
Natural variantiVAR_051018104S → G2 PublicationsCorresponds to variant dbSNP:rs3127679Ensembl.1
Natural variantiVAR_061657202G → W. Corresponds to variant dbSNP:rs11204658Ensembl.1
Natural variantiVAR_061658233A → S. Corresponds to variant dbSNP:rs11204659Ensembl.1
Natural variantiVAR_061659241V → M. Corresponds to variant dbSNP:rs9422022Ensembl.1
Natural variantiVAR_061660242R → G. Corresponds to variant dbSNP:rs3127683Ensembl.1
Natural variantiVAR_061661328S → C. Corresponds to variant dbSNP:rs4445576Ensembl.1
Natural variantiVAR_061662375V → A1 PublicationCorresponds to variant dbSNP:rs3127822Ensembl.1
Natural variantiVAR_059664400L → P2 PublicationsCorresponds to variant dbSNP:rs3127823Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB011086 mRNA Translation: BAA25440.2 Different initiation.
AL645529 Genomic DNA No translation available.
BC011672 mRNA Translation: AAH11672.1
CCDSiCCDS73101.1
RefSeqiNP_055511.2, NM_014696.3
XP_005277723.1, XM_005277666.3
XP_011538702.1, XM_011540400.2
UniGeneiHs.523375

Genome annotation databases

EnsembliENST00000374314; ENSP00000363433; ENSG00000204175
ENST00000374317; ENSP00000363436; ENSG00000204175
GeneIDi9721
KEGGihsa:9721
UCSCiuc057taj.1 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiGRIN2_HUMAN
AccessioniPrimary (citable) accession number: O60269
Secondary accession number(s): Q5SVF0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: May 16, 2006
Last modified: June 20, 2018
This is version 122 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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