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Protein

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7

Gene

GNG7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Plays a role in the regulation of adenylyl cyclase signaling in certain regions of the brain. Plays a role in the formation or stabilzation of a G protein heterotrimer (G(olf) subunit alpha-beta-gamma-7) that is required for adenylyl cyclase activity in the striatum (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransducer

Enzyme and pathway databases

ReactomeiR-HSA-1296041 Activation of G protein gated Potassium channels
R-HSA-163359 Glucagon signaling in metabolic regulation
R-HSA-202040 G-protein activation
R-HSA-381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
R-HSA-392170 ADP signalling through P2Y purinoceptor 12
R-HSA-392451 G beta:gamma signalling through PI3Kgamma
R-HSA-392851 Prostacyclin signalling through prostacyclin receptor
R-HSA-400042 Adrenaline,noradrenaline inhibits insulin secretion
R-HSA-4086398 Ca2+ pathway
R-HSA-416476 G alpha (q) signalling events
R-HSA-416482 G alpha (12/13) signalling events
R-HSA-418217 G beta:gamma signalling through PLC beta
R-HSA-418555 G alpha (s) signalling events
R-HSA-418592 ADP signalling through P2Y purinoceptor 1
R-HSA-418594 G alpha (i) signalling events
R-HSA-418597 G alpha (z) signalling events
R-HSA-420092 Glucagon-type ligand receptors
R-HSA-428930 Thromboxane signalling through TP receptor
R-HSA-432040 Vasopressin regulates renal water homeostasis via Aquaporins
R-HSA-456926 Thrombin signalling through proteinase activated receptors (PARs)
R-HSA-500657 Presynaptic function of Kainate receptors
R-HSA-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
R-HSA-997272 Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
SignaLinkiO60262

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
Gene namesi
Name:GNG7
Synonyms:GNGT7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000176533.12
HGNCiHGNC:4410 GNG7
MIMi604430 gene
neXtProtiNX_O60262

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi2788
OpenTargetsiENSG00000176533
PharmGKBiPA28789

Polymorphism and mutation databases

BioMutaiGNG7

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000126352 – 65Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7Add BLAST64
PropeptideiPRO_000001263666 – 68Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei65Cysteine methyl esterBy similarity1
Lipidationi65S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Prenylation

Proteomic databases

EPDiO60262
MaxQBiO60262
PaxDbiO60262
PeptideAtlasiO60262
PRIDEiO60262
ProteomicsDBi49296

PTM databases

iPTMnetiO60262
PhosphoSitePlusiO60262

Expressioni

Tissue specificityi

Expressed in a variety of tissues. Down-regulated in pancreatic and esophageal cancer.1 Publication

Gene expression databases

BgeeiENSG00000176533
CleanExiHS_GNG7
ExpressionAtlasiO60262 baseline and differential
GenevisibleiO60262 HS

Organism-specific databases

HPAiHPA057790

Interactioni

Subunit structurei

G proteins are composed of 3 units, alpha, beta and gamma.

Protein-protein interaction databases

BioGridi109050, 16 interactors
IntActiO60262, 4 interactors
STRINGi9606.ENSP00000371594

Structurei

3D structure databases

ProteinModelPortaliO60262
SMRiO60262
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G protein gamma family.Curated

Phylogenomic databases

eggNOGiKOG4119 Eukaryota
ENOG41122JF LUCA
GeneTreeiENSGT00760000119218
HOGENOMiHOG000231034
HOVERGENiHBG014983
InParanoidiO60262
KOiK04543
OMAiSELMNYC
OrthoDBiEOG091G17J0
PhylomeDBiO60262
TreeFamiTF319909

Family and domain databases

CDDicd00068 GGL, 1 hit
Gene3Di4.10.260.10, 1 hit
InterProiView protein in InterPro
IPR015898 G-protein_gamma-like_dom
IPR036284 GGL_sf
IPR001770 Gprotein-gamma
PANTHERiPTHR13809 PTHR13809, 1 hit
PfamiView protein in Pfam
PF00631 G-gamma, 1 hit
PRINTSiPR00321 GPROTEING
SMARTiView protein in SMART
SM00224 GGL, 1 hit
SUPFAMiSSF48670 SSF48670, 1 hit
PROSITEiView protein in PROSITE
PS50058 G_PROTEIN_GAMMA, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O60262-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSATNNIAQA RKLVEQLRIE AGIERIKVSK AASDLMSYCE QHARNDPLLV
60
GVPASENPFK DKKPCIIL
Length:68
Mass (Da):7,522
Last modified:August 1, 1998 - v1
Checksum:i704133C7BEC7FD72
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB010414 mRNA Translation: BAA28348.1
AF493874 mRNA Translation: AAM12588.1
AK311750 mRNA Translation: BAG34693.1
AC005512 Genomic DNA Translation: AAC32595.1
BC014466 mRNA Translation: AAH14466.1
BC053630 mRNA Translation: AAH53630.1
CCDSiCCDS12091.1
PIRiJW0050
RefSeqiNP_443079.1, NM_052847.2
XP_016882095.1, XM_017026606.1
UniGeneiHs.515544
Hs.735237

Genome annotation databases

EnsembliENST00000382159; ENSP00000371594; ENSG00000176533
GeneIDi2788
KEGGihsa:2788
UCSCiuc002lwd.3 human

Similar proteinsi

Entry informationi

Entry nameiGBG7_HUMAN
AccessioniPrimary (citable) accession number: O60262
Secondary accession number(s): B2R496
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: August 1, 1998
Last modified: June 20, 2018
This is version 157 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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