Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 167 (16 Oct 2019)
Sequence version 1 (01 Aug 1998)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Fibroblast growth factor 17

Gene

FGF17

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays an important role in the regulation of embryonic development and as signaling molecule in the induction and patterning of the embryonic brain. Required for normal brain development.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, Growth factor

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-109704 PI3K Cascade [O60258-1]
R-HSA-1257604 PIP3 activates AKT signaling [O60258-1]
R-HSA-1839122 Signaling by activated point mutants of FGFR1 [O60258-1]
R-HSA-1839130 Signaling by activated point mutants of FGFR3 [O60258-1]
R-HSA-190322 FGFR4 ligand binding and activation [O60258-1]
R-HSA-190371 FGFR3b ligand binding and activation [O60258-1]
R-HSA-190372 FGFR3c ligand binding and activation [O60258-1]
R-HSA-190373 FGFR1c ligand binding and activation [O60258-1]
R-HSA-190375 FGFR2c ligand binding and activation [O60258-1]
R-HSA-2033514 FGFR3 mutant receptor activation [O60258-1]
R-HSA-2033519 Activated point mutants of FGFR2 [O60258-1]
R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer [O60258-1]
R-HSA-5654219 Phospholipase C-mediated cascade: FGFR1 [O60258-1]
R-HSA-5654221 Phospholipase C-mediated cascade, FGFR2 [O60258-1]
R-HSA-5654227 Phospholipase C-mediated cascade, FGFR3 [O60258-1]
R-HSA-5654228 Phospholipase C-mediated cascade, FGFR4 [O60258-1]
R-HSA-5654687 Downstream signaling of activated FGFR1 [O60258-1]
R-HSA-5654688 SHC-mediated cascade:FGFR1 [O60258-1]
R-HSA-5654689 PI-3K cascade:FGFR1 [O60258-1]
R-HSA-5654693 FRS-mediated FGFR1 signaling [O60258-1]
R-HSA-5654695 PI-3K cascade:FGFR2 [O60258-1]
R-HSA-5654699 SHC-mediated cascade:FGFR2 [O60258-1]
R-HSA-5654700 FRS-mediated FGFR2 signaling [O60258-1]
R-HSA-5654704 SHC-mediated cascade:FGFR3 [O60258-1]
R-HSA-5654706 FRS-mediated FGFR3 signaling [O60258-1]
R-HSA-5654710 PI-3K cascade:FGFR3 [O60258-1]
R-HSA-5654712 FRS-mediated FGFR4 signaling [O60258-1]
R-HSA-5654719 SHC-mediated cascade:FGFR4 [O60258-1]
R-HSA-5654720 PI-3K cascade:FGFR4 [O60258-1]
R-HSA-5654726 Negative regulation of FGFR1 signaling [O60258-1]
R-HSA-5654727 Negative regulation of FGFR2 signaling [O60258-1]
R-HSA-5654732 Negative regulation of FGFR3 signaling [O60258-1]
R-HSA-5654733 Negative regulation of FGFR4 signaling [O60258-1]
R-HSA-5655253 Signaling by FGFR2 in disease [O60258-1]
R-HSA-5655302 Signaling by FGFR1 in disease [O60258-1]
R-HSA-5658623 FGFRL1 modulation of FGFR1 signaling [O60258-1]
R-HSA-5673001 RAF/MAP kinase cascade [O60258-1]
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling [O60258-1]
R-HSA-8853338 Signaling by FGFR3 point mutants in cancer [O60258-1]

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
O60258

SIGNOR Signaling Network Open Resource

More...
SIGNORi
O60258

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Fibroblast growth factor 17
Short name:
FGF-17
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FGF17
ORF Names:UNQ161/PRO187
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:3673 FGF17

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
603725 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O60258

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Hypogonadotropic hypogonadism 20 with or without anosmia (HH20)1 Publication
The disease is caused by mutations affecting distinct genetic loci, including the gene represented in this entry. Some patients carrying mutations in FGF17 also have a mutation in another HH-associated gene including FGFR1, HS6ST1 and FLRT3 (PubMed:23643382).1 Publication
Disease descriptionA disorder characterized by absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. In some cases, it is associated with non-reproductive phenotypes, such as anosmia, cleft palate, and sensorineural hearing loss. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin-releasing hormone-synthesizing neurons. In the presence of anosmia, idiopathic hypogonadotropic hypogonadism is referred to as Kallmann syndrome, whereas in the presence of a normal sense of smell, it has been termed normosmic idiopathic hypogonadotropic hypogonadism (nIHH).
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_069947108I → T in HH20; rare variant associated with susceptibility to disease; some patients have a second mutation in another HH-associated gene including FGFR1, HS6ST1 and FLRT3; the mutant has reduced ability to activate FGFR1. 1 PublicationCorresponds to variant dbSNP:rs398123024EnsemblClinVar.1
Natural variantiVAR_069948177R → H in HH20; the mutant has reduced ability to activate FGFR1. 1 PublicationCorresponds to variant dbSNP:rs398123025EnsemblClinVar.1
Natural variantiVAR_069949187N → S in HH20. 1 PublicationCorresponds to variant dbSNP:rs398123026EnsemblClinVar.1

Keywords - Diseasei

Disease mutation, Hypogonadotropic hypogonadism, Kallmann syndrome

Organism-specific databases

DisGeNET

More...
DisGeNETi
8822

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
FGF17

MalaCards human disease database

More...
MalaCardsi
FGF17
MIMi615270 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000158815

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
478 Kallmann syndrome
432 Normosmic congenital hypogonadotropic hypogonadism

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA28112

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
O60258

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
FGF17

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 22Sequence analysisAdd BLAST22
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000898523 – 216Fibroblast growth factor 17Add BLAST194

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi137N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O60258

PeptideAtlas

More...
PeptideAtlasi
O60258

PRoteomics IDEntifications database

More...
PRIDEi
O60258

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
49284 [O60258-1]
49285 [O60258-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O60258

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O60258

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Preferentially expressed in the embryonic brain.

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Detected in embryos at E14.5, but not at E10.5 and E19.5. Preferentially expressed in the neuroepithelia of the isthmus and septum of the embryonic brain at E14.5.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000158815 Expressed in 86 organ(s), highest expression level in right hemisphere of cerebellum

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O60258 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA052600

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with FGFR3 and FGFR4.

1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
114349, 44 interactors

Protein interaction database and analysis system

More...
IntActi
O60258, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000352414

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O60258

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3885 Eukaryota
ENOG4111IPH LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161965

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000115986

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O60258

KEGG Orthology (KO)

More...
KOi
K04358

Identification of Orthologs from Complete Genome Data

More...
OMAi
LCCQTQV

Database of Orthologous Groups

More...
OrthoDBi
388324at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O60258

TreeFam database of animal gene trees

More...
TreeFami
TF331233

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00058 FGF, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR028287 FGF17
IPR002209 Fibroblast_GF_fam
IPR008996 IL1/FGF

The PANTHER Classification System

More...
PANTHERi
PTHR11486 PTHR11486, 1 hit
PTHR11486:SF71 PTHR11486:SF71, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00167 FGF, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00442 FGF, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50353 SSF50353, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00247 HBGF_FGF, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: O60258-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGAARLLPNL TLCLQLLILC CQTQGENHPS PNFNQYVRDQ GAMTDQLSRR
60 70 80 90 100
QIREYQLYSR TSGKHVQVTG RRISATAEDG NKFAKLIVET DTFGSRVRIK
110 120 130 140 150
GAESEKYICM NKRGKLIGKP SGKSKDCVFT EIVLENNYTA FQNARHEGWF
160 170 180 190 200
MAFTRQGRPR QASRSRQNQR EAHFIKRLYQ GQLPFPNHAE KQKQFEFVGS
210
APTRRTKRTR RPQPLT
Length:216
Mass (Da):24,891
Last modified:August 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2EE0288675220F4C
GO
Isoform 2 (identifier: O60258-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     25-35: Missing.

Note: No experimental confirmation available.
Show »
Length:205
Mass (Da):23,669
Checksum:i7DCA34B12D3602A7
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_069947108I → T in HH20; rare variant associated with susceptibility to disease; some patients have a second mutation in another HH-associated gene including FGFR1, HS6ST1 and FLRT3; the mutant has reduced ability to activate FGFR1. 1 PublicationCorresponds to variant dbSNP:rs398123024EnsemblClinVar.1
Natural variantiVAR_069948177R → H in HH20; the mutant has reduced ability to activate FGFR1. 1 PublicationCorresponds to variant dbSNP:rs398123025EnsemblClinVar.1
Natural variantiVAR_069949187N → S in HH20. 1 PublicationCorresponds to variant dbSNP:rs398123026EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_00871525 – 35Missing in isoform 2. 2 PublicationsAdd BLAST11

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB009249 mRNA Translation: BAA25429.1
AY358869 mRNA Translation: AAQ89228.1
AF497475 Genomic DNA Translation: AAM09570.1
CH471080 Genomic DNA Translation: EAW63729.1
BC069475 mRNA Translation: AAH69475.1
BC105131 mRNA Translation: AAI05132.1
BC113489 mRNA Translation: AAI13490.1
BC143789 mRNA Translation: AAI43790.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS6019.1 [O60258-1]
CCDS78310.1 [O60258-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001291407.1, NM_001304478.1 [O60258-2]
NP_003858.1, NM_003867.3 [O60258-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000359441; ENSP00000352414; ENSG00000158815 [O60258-1]
ENST00000518533; ENSP00000431041; ENSG00000158815 [O60258-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
8822

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:8822

UCSC genome browser

More...
UCSCi
uc003xag.4 human [O60258-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB009249 mRNA Translation: BAA25429.1
AY358869 mRNA Translation: AAQ89228.1
AF497475 Genomic DNA Translation: AAM09570.1
CH471080 Genomic DNA Translation: EAW63729.1
BC069475 mRNA Translation: AAH69475.1
BC105131 mRNA Translation: AAI05132.1
BC113489 mRNA Translation: AAI13490.1
BC143789 mRNA Translation: AAI43790.1
CCDSiCCDS6019.1 [O60258-1]
CCDS78310.1 [O60258-2]
RefSeqiNP_001291407.1, NM_001304478.1 [O60258-2]
NP_003858.1, NM_003867.3 [O60258-1]

3D structure databases

SMRiO60258
ModBaseiSearch...

Protein-protein interaction databases

BioGridi114349, 44 interactors
IntActiO60258, 2 interactors
STRINGi9606.ENSP00000352414

PTM databases

iPTMnetiO60258
PhosphoSitePlusiO60258

Polymorphism and mutation databases

BioMutaiFGF17

Proteomic databases

PaxDbiO60258
PeptideAtlasiO60258
PRIDEiO60258
ProteomicsDBi49284 [O60258-1]
49285 [O60258-2]

Genome annotation databases

EnsembliENST00000359441; ENSP00000352414; ENSG00000158815 [O60258-1]
ENST00000518533; ENSP00000431041; ENSG00000158815 [O60258-2]
GeneIDi8822
KEGGihsa:8822
UCSCiuc003xag.4 human [O60258-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8822
DisGeNETi8822

GeneCards: human genes, protein and diseases

More...
GeneCardsi
FGF17
GeneReviewsiFGF17
HGNCiHGNC:3673 FGF17
HPAiHPA052600
MalaCardsiFGF17
MIMi603725 gene
615270 phenotype
neXtProtiNX_O60258
OpenTargetsiENSG00000158815
Orphaneti478 Kallmann syndrome
432 Normosmic congenital hypogonadotropic hypogonadism
PharmGKBiPA28112

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3885 Eukaryota
ENOG4111IPH LUCA
GeneTreeiENSGT00940000161965
HOGENOMiHOG000115986
InParanoidiO60258
KOiK04358
OMAiLCCQTQV
OrthoDBi388324at2759
PhylomeDBiO60258
TreeFamiTF331233

Enzyme and pathway databases

ReactomeiR-HSA-109704 PI3K Cascade [O60258-1]
R-HSA-1257604 PIP3 activates AKT signaling [O60258-1]
R-HSA-1839122 Signaling by activated point mutants of FGFR1 [O60258-1]
R-HSA-1839130 Signaling by activated point mutants of FGFR3 [O60258-1]
R-HSA-190322 FGFR4 ligand binding and activation [O60258-1]
R-HSA-190371 FGFR3b ligand binding and activation [O60258-1]
R-HSA-190372 FGFR3c ligand binding and activation [O60258-1]
R-HSA-190373 FGFR1c ligand binding and activation [O60258-1]
R-HSA-190375 FGFR2c ligand binding and activation [O60258-1]
R-HSA-2033514 FGFR3 mutant receptor activation [O60258-1]
R-HSA-2033519 Activated point mutants of FGFR2 [O60258-1]
R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer [O60258-1]
R-HSA-5654219 Phospholipase C-mediated cascade: FGFR1 [O60258-1]
R-HSA-5654221 Phospholipase C-mediated cascade, FGFR2 [O60258-1]
R-HSA-5654227 Phospholipase C-mediated cascade, FGFR3 [O60258-1]
R-HSA-5654228 Phospholipase C-mediated cascade, FGFR4 [O60258-1]
R-HSA-5654687 Downstream signaling of activated FGFR1 [O60258-1]
R-HSA-5654688 SHC-mediated cascade:FGFR1 [O60258-1]
R-HSA-5654689 PI-3K cascade:FGFR1 [O60258-1]
R-HSA-5654693 FRS-mediated FGFR1 signaling [O60258-1]
R-HSA-5654695 PI-3K cascade:FGFR2 [O60258-1]
R-HSA-5654699 SHC-mediated cascade:FGFR2 [O60258-1]
R-HSA-5654700 FRS-mediated FGFR2 signaling [O60258-1]
R-HSA-5654704 SHC-mediated cascade:FGFR3 [O60258-1]
R-HSA-5654706 FRS-mediated FGFR3 signaling [O60258-1]
R-HSA-5654710 PI-3K cascade:FGFR3 [O60258-1]
R-HSA-5654712 FRS-mediated FGFR4 signaling [O60258-1]
R-HSA-5654719 SHC-mediated cascade:FGFR4 [O60258-1]
R-HSA-5654720 PI-3K cascade:FGFR4 [O60258-1]
R-HSA-5654726 Negative regulation of FGFR1 signaling [O60258-1]
R-HSA-5654727 Negative regulation of FGFR2 signaling [O60258-1]
R-HSA-5654732 Negative regulation of FGFR3 signaling [O60258-1]
R-HSA-5654733 Negative regulation of FGFR4 signaling [O60258-1]
R-HSA-5655253 Signaling by FGFR2 in disease [O60258-1]
R-HSA-5655302 Signaling by FGFR1 in disease [O60258-1]
R-HSA-5658623 FGFRL1 modulation of FGFR1 signaling [O60258-1]
R-HSA-5673001 RAF/MAP kinase cascade [O60258-1]
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling [O60258-1]
R-HSA-8853338 Signaling by FGFR3 point mutants in cancer [O60258-1]
SignaLinkiO60258
SIGNORiO60258

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
FGF17

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
8822
PharosiO60258

Protein Ontology

More...
PROi
PR:O60258

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000158815 Expressed in 86 organ(s), highest expression level in right hemisphere of cerebellum
GenevisibleiO60258 HS

Family and domain databases

CDDicd00058 FGF, 1 hit
InterProiView protein in InterPro
IPR028287 FGF17
IPR002209 Fibroblast_GF_fam
IPR008996 IL1/FGF
PANTHERiPTHR11486 PTHR11486, 1 hit
PTHR11486:SF71 PTHR11486:SF71, 1 hit
PfamiView protein in Pfam
PF00167 FGF, 1 hit
SMARTiView protein in SMART
SM00442 FGF, 1 hit
SUPFAMiSSF50353 SSF50353, 1 hit
PROSITEiView protein in PROSITE
PS00247 HBGF_FGF, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFGF17_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O60258
Secondary accession number(s): B7ZLG4, Q2M2W1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: August 1, 1998
Last modified: October 16, 2019
This is version 167 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again