Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Phosphoribosyl pyrophosphate synthase-associated protein 2

Gene

PRPSAP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Seems to play a negative regulatory role in 5-phosphoribose 1-diphosphate synthesis.

GO - Molecular functioni

  • enzyme inhibitor activity Source: ProtInc
  • enzyme regulator activity Source: GO_Central
  • magnesium ion binding Source: InterPro
  • ribose phosphate diphosphokinase activity Source: InterPro

GO - Biological processi

Keywordsi

Biological processNucleotide biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosyl pyrophosphate synthase-associated protein 2
Short name:
PRPP synthase-associated protein 2
Alternative name(s):
41 kDa phosphoribosypyrophosphate synthetase-associated protein
Short name:
PAP41
Gene namesi
Name:PRPSAP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000141127.14
HGNCiHGNC:9467 PRPSAP2
MIMi603762 gene
neXtProtiNX_O60256

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

DisGeNETi5636
OpenTargetsiENSG00000141127
PharmGKBiPA33822

Chemistry databases

ChEMBLiCHEMBL2646

Polymorphism and mutation databases

BioMutaiPRPSAP2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001410821 – 369Phosphoribosyl pyrophosphate synthase-associated protein 2Add BLAST369

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei5PhosphothreonineCombined sources1
Modified residuei219PhosphoserineCombined sources1
Modified residuei227PhosphoserineCombined sources1 Publication1
Modified residuei233PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO60256
MaxQBiO60256
PaxDbiO60256
PeptideAtlasiO60256
PRIDEiO60256
ProteomicsDBi49283

PTM databases

iPTMnetiO60256
PhosphoSitePlusiO60256

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSG00000141127 Expressed in 223 organ(s), highest expression level in testis
CleanExiHS_PRPSAP2
ExpressionAtlasiO60256 baseline and differential
GenevisibleiO60256 HS

Organism-specific databases

HPAiHPA021881

Interactioni

Subunit structurei

Binds to PRPS1 and PRPS2.

Binary interactionsi

Protein-protein interaction databases

BioGridi111619, 34 interactors
IntActiO60256, 13 interactors
MINTiO60256
STRINGi9606.ENSP00000268835

Chemistry databases

BindingDBiO60256

Structurei

Secondary structure

1369
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO60256
SMRiO60256
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO60256

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1503 Eukaryota
COG0462 LUCA
GeneTreeiENSGT00550000074583
HOGENOMiHOG000210451
HOVERGENiHBG001520
InParanoidiO60256
OMAiHYAYARS
OrthoDBiEOG091G0ZG8
PhylomeDBiO60256
TreeFamiTF106367

Family and domain databases

CDDicd06223 PRTases_typeI, 1 hit
InterProiView protein in InterPro
IPR029099 Pribosyltran_N
IPR000836 PRibTrfase_dom
IPR029057 PRTase-like
IPR005946 Rib-P_diPkinase
PANTHERiPTHR10210 PTHR10210, 1 hit
PfamiView protein in Pfam
PF14572 Pribosyl_synth, 1 hit
PF13793 Pribosyltran_N, 1 hit
SUPFAMiSSF53271 SSF53271, 2 hits
TIGRFAMsiTIGR01251 ribP_PPkin, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 14 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O60256-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MFCVTPPELE TKMNITKGGL VLFSANSNSS CMELSKKIAE RLGVEMGKVQ
60 70 80 90 100
VYQEPNRETR VQIQESVRGK DVFIIQTVSK DVNTTIMELL IMVYACKTSC
110 120 130 140 150
AKSIIGVIPY FPYSKQCKMR KRGSIVSKLL ASMMCKAGLT HLITMDLHQK
160 170 180 190 200
EIQGFFNIPV DNLRASPFLL QYIQEEIPDY RNAVIVAKSP ASAKRAQSFA
210 220 230 240 250
ERLRLGIAVI HGEAQDAESD LVDGRHSPPM VRSVAAIHPS LEIPMLIPKE
260 270 280 290 300
KPPITVVGDV GGRIAIIVDD IIDDVDSFLA AAETLKERGA YKIFVMATHG
310 320 330 340 350
LLSSDAPRRI EESAIDEVVV TNTIPHEVQK LQCPKIKTVD ISMILSEAIR
360
RIHNGESMSY LFRNIGLDD
Length:369
Mass (Da):40,926
Last modified:August 1, 1998 - v1
Checksum:i12A0E46BD4AC55BF
GO
Isoform 2 (identifier: O60256-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     41-80: Missing.

Note: No experimental confirmation available.
Show »
Length:329
Mass (Da):36,297
Checksum:i8920D91D0C8535EF
GO
Isoform 3 (identifier: O60256-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     269-317: Missing.

Note: No experimental confirmation available.
Show »
Length:320
Mass (Da):35,548
Checksum:i4844D7A06BBE45FC
GO
Isoform 4 (identifier: O60256-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-86: Missing.

Note: No experimental confirmation available.
Show »
Length:283
Mass (Da):31,322
Checksum:i25A38F2CDBFC3429
GO

Computationally mapped potential isoform sequencesi

There are 14 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
I3L0S1I3L0S1_HUMAN
Phosphoribosyl pyrophosphate syntha...
PRPSAP2
260Annotation score:
C9K0K7C9K0K7_HUMAN
Phosphoribosyl pyrophosphate syntha...
PRPSAP2
244Annotation score:
C9JJS3C9JJS3_HUMAN
Phosphoribosyl pyrophosphate syntha...
PRPSAP2
194Annotation score:
C9JDU5C9JDU5_HUMAN
Phosphoribosyl pyrophosphate syntha...
PRPSAP2
176Annotation score:
C9JDH0C9JDH0_HUMAN
Phosphoribosyl pyrophosphate syntha...
PRPSAP2
140Annotation score:
I3L331I3L331_HUMAN
Phosphoribosyl pyrophosphate syntha...
PRPSAP2
93Annotation score:
E7EW35E7EW35_HUMAN
Phosphoribosyl pyrophosphate syntha...
PRPSAP2
161Annotation score:
I3L164I3L164_HUMAN
Phosphoribosyl pyrophosphate syntha...
PRPSAP2
104Annotation score:
E7EPA1E7EPA1_HUMAN
Phosphoribosyl pyrophosphate syntha...
PRPSAP2
268Annotation score:
I3L4G9I3L4G9_HUMAN
Phosphoribosyl pyrophosphate syntha...
PRPSAP2
143Annotation score:
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti121K → R in BAG64840 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0547651 – 86Missing in isoform 4. 1 PublicationAdd BLAST86
Alternative sequenceiVSP_04473141 – 80Missing in isoform 2. 1 PublicationAdd BLAST40
Alternative sequenceiVSP_046462269 – 317Missing in isoform 3. 1 PublicationAdd BLAST49

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007851 mRNA Translation: BAA25435.1
AK303911 mRNA Translation: BAG64840.1
AK304544 mRNA Translation: BAG65341.1
CR457082 mRNA Translation: CAG33363.1
AC090286 Genomic DNA No translation available.
AC107982 Genomic DNA No translation available.
BC106050 mRNA Translation: AAI06051.1
BC101670 mRNA Translation: AAI01671.1
BC101672 mRNA Translation: AAI01673.1
BC143475 mRNA Translation: AAI43476.1
CCDSiCCDS11200.1 [O60256-1]
CCDS58525.1 [O60256-3]
CCDS58526.1 [O60256-2]
CCDS58527.1 [O60256-4]
RefSeqiNP_001230865.1, NM_001243936.1 [O60256-2]
NP_001230869.1, NM_001243940.1 [O60256-3]
NP_001230870.1, NM_001243941.1 [O60256-4]
NP_001230871.1, NM_001243942.1 [O60256-4]
NP_002758.1, NM_002767.3 [O60256-1]
XP_005256782.1, XM_005256725.2
XP_005256783.1, XM_005256726.1
XP_005256786.1, XM_005256729.4
XP_016880354.1, XM_017024865.1 [O60256-1]
XP_016880355.1, XM_017024866.1 [O60256-1]
XP_016880356.1, XM_017024867.1
XP_016880360.1, XM_017024871.1 [O60256-4]
XP_016880361.1, XM_017024872.1
XP_016880362.1, XM_017024873.1 [O60256-4]
XP_016880363.1, XM_017024874.1 [O60256-4]
XP_016880364.1, XM_017024875.1 [O60256-4]
XP_016880365.1, XM_017024876.1
UniGeneiHs.632236

Genome annotation databases

EnsembliENST00000268835; ENSP00000268835; ENSG00000141127 [O60256-1]
ENST00000419071; ENSP00000392536; ENSG00000141127 [O60256-2]
ENST00000536323; ENSP00000443967; ENSG00000141127 [O60256-4]
ENST00000542013; ENSP00000439129; ENSG00000141127 [O60256-3]
ENST00000610773; ENSP00000481322; ENSG00000141127 [O60256-4]
GeneIDi5636
KEGGihsa:5636
UCSCiuc002guo.3 human [O60256-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007851 mRNA Translation: BAA25435.1
AK303911 mRNA Translation: BAG64840.1
AK304544 mRNA Translation: BAG65341.1
CR457082 mRNA Translation: CAG33363.1
AC090286 Genomic DNA No translation available.
AC107982 Genomic DNA No translation available.
BC106050 mRNA Translation: AAI06051.1
BC101670 mRNA Translation: AAI01671.1
BC101672 mRNA Translation: AAI01673.1
BC143475 mRNA Translation: AAI43476.1
CCDSiCCDS11200.1 [O60256-1]
CCDS58525.1 [O60256-3]
CCDS58526.1 [O60256-2]
CCDS58527.1 [O60256-4]
RefSeqiNP_001230865.1, NM_001243936.1 [O60256-2]
NP_001230869.1, NM_001243940.1 [O60256-3]
NP_001230870.1, NM_001243941.1 [O60256-4]
NP_001230871.1, NM_001243942.1 [O60256-4]
NP_002758.1, NM_002767.3 [O60256-1]
XP_005256782.1, XM_005256725.2
XP_005256783.1, XM_005256726.1
XP_005256786.1, XM_005256729.4
XP_016880354.1, XM_017024865.1 [O60256-1]
XP_016880355.1, XM_017024866.1 [O60256-1]
XP_016880356.1, XM_017024867.1
XP_016880360.1, XM_017024871.1 [O60256-4]
XP_016880361.1, XM_017024872.1
XP_016880362.1, XM_017024873.1 [O60256-4]
XP_016880363.1, XM_017024874.1 [O60256-4]
XP_016880364.1, XM_017024875.1 [O60256-4]
XP_016880365.1, XM_017024876.1
UniGeneiHs.632236

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2JI4X-ray2.55A13-369[»]
ProteinModelPortaliO60256
SMRiO60256
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111619, 34 interactors
IntActiO60256, 13 interactors
MINTiO60256
STRINGi9606.ENSP00000268835

Chemistry databases

BindingDBiO60256
ChEMBLiCHEMBL2646

PTM databases

iPTMnetiO60256
PhosphoSitePlusiO60256

Polymorphism and mutation databases

BioMutaiPRPSAP2

Proteomic databases

EPDiO60256
MaxQBiO60256
PaxDbiO60256
PeptideAtlasiO60256
PRIDEiO60256
ProteomicsDBi49283

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000268835; ENSP00000268835; ENSG00000141127 [O60256-1]
ENST00000419071; ENSP00000392536; ENSG00000141127 [O60256-2]
ENST00000536323; ENSP00000443967; ENSG00000141127 [O60256-4]
ENST00000542013; ENSP00000439129; ENSG00000141127 [O60256-3]
ENST00000610773; ENSP00000481322; ENSG00000141127 [O60256-4]
GeneIDi5636
KEGGihsa:5636
UCSCiuc002guo.3 human [O60256-1]

Organism-specific databases

CTDi5636
DisGeNETi5636
EuPathDBiHostDB:ENSG00000141127.14
GeneCardsiPRPSAP2
HGNCiHGNC:9467 PRPSAP2
HPAiHPA021881
MIMi603762 gene
neXtProtiNX_O60256
OpenTargetsiENSG00000141127
PharmGKBiPA33822
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1503 Eukaryota
COG0462 LUCA
GeneTreeiENSGT00550000074583
HOGENOMiHOG000210451
HOVERGENiHBG001520
InParanoidiO60256
OMAiHYAYARS
OrthoDBiEOG091G0ZG8
PhylomeDBiO60256
TreeFamiTF106367

Miscellaneous databases

ChiTaRSiPRPSAP2 human
EvolutionaryTraceiO60256
GeneWikiiPRPSAP2
GenomeRNAii5636
PROiPR:O60256
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000141127 Expressed in 223 organ(s), highest expression level in testis
CleanExiHS_PRPSAP2
ExpressionAtlasiO60256 baseline and differential
GenevisibleiO60256 HS

Family and domain databases

CDDicd06223 PRTases_typeI, 1 hit
InterProiView protein in InterPro
IPR029099 Pribosyltran_N
IPR000836 PRibTrfase_dom
IPR029057 PRTase-like
IPR005946 Rib-P_diPkinase
PANTHERiPTHR10210 PTHR10210, 1 hit
PfamiView protein in Pfam
PF14572 Pribosyl_synth, 1 hit
PF13793 Pribosyltran_N, 1 hit
SUPFAMiSSF53271 SSF53271, 2 hits
TIGRFAMsiTIGR01251 ribP_PPkin, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiKPRB_HUMAN
AccessioniPrimary (citable) accession number: O60256
Secondary accession number(s): B4E1M8
, B4E329, B7ZKZ1, E7EMY2, Q6IAS2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: August 1, 1998
Last modified: November 7, 2018
This is version 148 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again