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Protein

Phosphoribosyl pyrophosphate synthase-associated protein 2

Gene

PRPSAP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Seems to play a negative regulatory role in 5-phosphoribose 1-diphosphate synthesis.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • enzyme inhibitor activity Source: ProtInc
  • magnesium ion binding Source: InterPro
  • ribose phosphate diphosphokinase activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processNucleotide biosynthesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Phosphoribosyl pyrophosphate synthase-associated protein 2
Short name:
PRPP synthase-associated protein 2
Alternative name(s):
41 kDa phosphoribosypyrophosphate synthetase-associated protein
Short name:
PAP41
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PRPSAP2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000141127.14

Human Gene Nomenclature Database

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HGNCi
HGNC:9467 PRPSAP2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
603762 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O60256

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
5636

Open Targets

More...
OpenTargetsi
ENSG00000141127

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA33822

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2646

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PRPSAP2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001410821 – 369Phosphoribosyl pyrophosphate synthase-associated protein 2Add BLAST369

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
Modified residuei5PhosphothreonineCombined sources1
Modified residuei219PhosphoserineCombined sources1
Modified residuei227PhosphoserineCombined sources1 Publication1
Modified residuei233PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
O60256

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
O60256

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O60256

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
O60256

PeptideAtlas

More...
PeptideAtlasi
O60256

PRoteomics IDEntifications database

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PRIDEi
O60256

ProteomicsDB human proteome resource

More...
ProteomicsDBi
49283

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
O60256

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
O60256

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000141127 Expressed in 223 organ(s), highest expression level in testis

CleanEx database of gene expression profiles

More...
CleanExi
HS_PRPSAP2

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
O60256 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O60256 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA021881

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds to PRPS1 and PRPS2.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
111619, 33 interactors

Protein interaction database and analysis system

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IntActi
O60256, 13 interactors

Molecular INTeraction database

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MINTi
O60256

STRING: functional protein association networks

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STRINGi
9606.ENSP00000268835

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
O60256

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1369
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2JI4X-ray2.55A13-369[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
O60256

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O60256

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
O60256

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1503 Eukaryota
COG0462 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000153482

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000210451

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG001520

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
O60256

Identification of Orthologs from Complete Genome Data

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OMAi
HYAYARS

Database of Orthologous Groups

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OrthoDBi
1043963at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
O60256

TreeFam database of animal gene trees

More...
TreeFami
TF106367

Family and domain databases

Conserved Domains Database

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CDDi
cd06223 PRTases_typeI, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR029099 Pribosyltran_N
IPR000836 PRibTrfase_dom
IPR029057 PRTase-like
IPR005946 Rib-P_diPkinase

The PANTHER Classification System

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PANTHERi
PTHR10210 PTHR10210, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14572 Pribosyl_synth, 1 hit
PF13793 Pribosyltran_N, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53271 SSF53271, 2 hits

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01251 ribP_PPkin, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 14 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O60256-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MFCVTPPELE TKMNITKGGL VLFSANSNSS CMELSKKIAE RLGVEMGKVQ
60 70 80 90 100
VYQEPNRETR VQIQESVRGK DVFIIQTVSK DVNTTIMELL IMVYACKTSC
110 120 130 140 150
AKSIIGVIPY FPYSKQCKMR KRGSIVSKLL ASMMCKAGLT HLITMDLHQK
160 170 180 190 200
EIQGFFNIPV DNLRASPFLL QYIQEEIPDY RNAVIVAKSP ASAKRAQSFA
210 220 230 240 250
ERLRLGIAVI HGEAQDAESD LVDGRHSPPM VRSVAAIHPS LEIPMLIPKE
260 270 280 290 300
KPPITVVGDV GGRIAIIVDD IIDDVDSFLA AAETLKERGA YKIFVMATHG
310 320 330 340 350
LLSSDAPRRI EESAIDEVVV TNTIPHEVQK LQCPKIKTVD ISMILSEAIR
360
RIHNGESMSY LFRNIGLDD
Length:369
Mass (Da):40,926
Last modified:August 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i12A0E46BD4AC55BF
GO
Isoform 2 (identifier: O60256-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     41-80: Missing.

Note: No experimental confirmation available.
Show »
Length:329
Mass (Da):36,297
Checksum:i8920D91D0C8535EF
GO
Isoform 3 (identifier: O60256-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     269-317: Missing.

Note: No experimental confirmation available.
Show »
Length:320
Mass (Da):35,548
Checksum:i4844D7A06BBE45FC
GO
Isoform 4 (identifier: O60256-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-86: Missing.

Note: No experimental confirmation available.
Show »
Length:283
Mass (Da):31,322
Checksum:i25A38F2CDBFC3429
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 14 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
I3L0S1I3L0S1_HUMAN
Phosphoribosyl pyrophosphate syntha...
PRPSAP2
260Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9K0K7C9K0K7_HUMAN
Phosphoribosyl pyrophosphate syntha...
PRPSAP2
244Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JJS3C9JJS3_HUMAN
Phosphoribosyl pyrophosphate syntha...
PRPSAP2
194Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JDU5C9JDU5_HUMAN
Phosphoribosyl pyrophosphate syntha...
PRPSAP2
176Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JDH0C9JDH0_HUMAN
Phosphoribosyl pyrophosphate syntha...
PRPSAP2
140Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EPA1E7EPA1_HUMAN
Phosphoribosyl pyrophosphate syntha...
PRPSAP2
268Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L331I3L331_HUMAN
Phosphoribosyl pyrophosphate syntha...
PRPSAP2
93Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EW35E7EW35_HUMAN
Phosphoribosyl pyrophosphate syntha...
PRPSAP2
161Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L164I3L164_HUMAN
Phosphoribosyl pyrophosphate syntha...
PRPSAP2
104Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L4G9I3L4G9_HUMAN
Phosphoribosyl pyrophosphate syntha...
PRPSAP2
143Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti121K → R in BAG64840 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0547651 – 86Missing in isoform 4. 1 PublicationAdd BLAST86
Alternative sequenceiVSP_04473141 – 80Missing in isoform 2. 1 PublicationAdd BLAST40
Alternative sequenceiVSP_046462269 – 317Missing in isoform 3. 1 PublicationAdd BLAST49

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB007851 mRNA Translation: BAA25435.1
AK303911 mRNA Translation: BAG64840.1
AK304544 mRNA Translation: BAG65341.1
CR457082 mRNA Translation: CAG33363.1
AC090286 Genomic DNA No translation available.
AC107982 Genomic DNA No translation available.
BC106050 mRNA Translation: AAI06051.1
BC101670 mRNA Translation: AAI01671.1
BC101672 mRNA Translation: AAI01673.1
BC143475 mRNA Translation: AAI43476.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS11200.1 [O60256-1]
CCDS58525.1 [O60256-3]
CCDS58526.1 [O60256-2]
CCDS58527.1 [O60256-4]

NCBI Reference Sequences

More...
RefSeqi
NP_001230865.1, NM_001243936.1 [O60256-2]
NP_001230869.1, NM_001243940.1 [O60256-3]
NP_001230870.1, NM_001243941.1 [O60256-4]
NP_001230871.1, NM_001243942.1 [O60256-4]
NP_002758.1, NM_002767.3 [O60256-1]
XP_005256782.1, XM_005256725.2
XP_005256783.1, XM_005256726.1
XP_005256786.1, XM_005256729.4
XP_016880354.1, XM_017024865.1 [O60256-1]
XP_016880355.1, XM_017024866.1 [O60256-1]
XP_016880356.1, XM_017024867.1
XP_016880360.1, XM_017024871.1 [O60256-4]
XP_016880361.1, XM_017024872.1
XP_016880362.1, XM_017024873.1 [O60256-4]
XP_016880363.1, XM_017024874.1 [O60256-4]
XP_016880364.1, XM_017024875.1 [O60256-4]
XP_016880365.1, XM_017024876.1

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.632236

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000268835; ENSP00000268835; ENSG00000141127 [O60256-1]
ENST00000419071; ENSP00000392536; ENSG00000141127 [O60256-2]
ENST00000536323; ENSP00000443967; ENSG00000141127 [O60256-4]
ENST00000542013; ENSP00000439129; ENSG00000141127 [O60256-3]
ENST00000610773; ENSP00000481322; ENSG00000141127 [O60256-4]

Database of genes from NCBI RefSeq genomes

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GeneIDi
5636

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:5636

UCSC genome browser

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UCSCi
uc002guo.3 human [O60256-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007851 mRNA Translation: BAA25435.1
AK303911 mRNA Translation: BAG64840.1
AK304544 mRNA Translation: BAG65341.1
CR457082 mRNA Translation: CAG33363.1
AC090286 Genomic DNA No translation available.
AC107982 Genomic DNA No translation available.
BC106050 mRNA Translation: AAI06051.1
BC101670 mRNA Translation: AAI01671.1
BC101672 mRNA Translation: AAI01673.1
BC143475 mRNA Translation: AAI43476.1
CCDSiCCDS11200.1 [O60256-1]
CCDS58525.1 [O60256-3]
CCDS58526.1 [O60256-2]
CCDS58527.1 [O60256-4]
RefSeqiNP_001230865.1, NM_001243936.1 [O60256-2]
NP_001230869.1, NM_001243940.1 [O60256-3]
NP_001230870.1, NM_001243941.1 [O60256-4]
NP_001230871.1, NM_001243942.1 [O60256-4]
NP_002758.1, NM_002767.3 [O60256-1]
XP_005256782.1, XM_005256725.2
XP_005256783.1, XM_005256726.1
XP_005256786.1, XM_005256729.4
XP_016880354.1, XM_017024865.1 [O60256-1]
XP_016880355.1, XM_017024866.1 [O60256-1]
XP_016880356.1, XM_017024867.1
XP_016880360.1, XM_017024871.1 [O60256-4]
XP_016880361.1, XM_017024872.1
XP_016880362.1, XM_017024873.1 [O60256-4]
XP_016880363.1, XM_017024874.1 [O60256-4]
XP_016880364.1, XM_017024875.1 [O60256-4]
XP_016880365.1, XM_017024876.1
UniGeneiHs.632236

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2JI4X-ray2.55A13-369[»]
ProteinModelPortaliO60256
SMRiO60256
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111619, 33 interactors
IntActiO60256, 13 interactors
MINTiO60256
STRINGi9606.ENSP00000268835

Chemistry databases

BindingDBiO60256
ChEMBLiCHEMBL2646

PTM databases

iPTMnetiO60256
PhosphoSitePlusiO60256

Polymorphism and mutation databases

BioMutaiPRPSAP2

Proteomic databases

EPDiO60256
jPOSTiO60256
MaxQBiO60256
PaxDbiO60256
PeptideAtlasiO60256
PRIDEiO60256
ProteomicsDBi49283

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000268835; ENSP00000268835; ENSG00000141127 [O60256-1]
ENST00000419071; ENSP00000392536; ENSG00000141127 [O60256-2]
ENST00000536323; ENSP00000443967; ENSG00000141127 [O60256-4]
ENST00000542013; ENSP00000439129; ENSG00000141127 [O60256-3]
ENST00000610773; ENSP00000481322; ENSG00000141127 [O60256-4]
GeneIDi5636
KEGGihsa:5636
UCSCiuc002guo.3 human [O60256-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
5636
DisGeNETi5636
EuPathDBiHostDB:ENSG00000141127.14

GeneCards: human genes, protein and diseases

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GeneCardsi
PRPSAP2
HGNCiHGNC:9467 PRPSAP2
HPAiHPA021881
MIMi603762 gene
neXtProtiNX_O60256
OpenTargetsiENSG00000141127
PharmGKBiPA33822

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1503 Eukaryota
COG0462 LUCA
GeneTreeiENSGT00940000153482
HOGENOMiHOG000210451
HOVERGENiHBG001520
InParanoidiO60256
OMAiHYAYARS
OrthoDBi1043963at2759
PhylomeDBiO60256
TreeFamiTF106367

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
PRPSAP2 human
EvolutionaryTraceiO60256

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
PRPSAP2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
5636

Protein Ontology

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PROi
PR:O60256

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000141127 Expressed in 223 organ(s), highest expression level in testis
CleanExiHS_PRPSAP2
ExpressionAtlasiO60256 baseline and differential
GenevisibleiO60256 HS

Family and domain databases

CDDicd06223 PRTases_typeI, 1 hit
InterProiView protein in InterPro
IPR029099 Pribosyltran_N
IPR000836 PRibTrfase_dom
IPR029057 PRTase-like
IPR005946 Rib-P_diPkinase
PANTHERiPTHR10210 PTHR10210, 1 hit
PfamiView protein in Pfam
PF14572 Pribosyl_synth, 1 hit
PF13793 Pribosyltran_N, 1 hit
SUPFAMiSSF53271 SSF53271, 2 hits
TIGRFAMsiTIGR01251 ribP_PPkin, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKPRB_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O60256
Secondary accession number(s): B4E1M8
, B4E329, B7ZKZ1, E7EMY2, Q6IAS2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: August 1, 1998
Last modified: January 16, 2019
This is version 150 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
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