UniProtKB - O60248 (SOX15_HUMAN)
Protein
Protein SOX-15
Gene
SOX15
Organism
Homo sapiens (Human)
Status
Functioni
Transcription factor that binds to DNA at the 5'-AACAATG-3' consensus sequence (By similarity). Acts as a transcriptional activator and repressor (By similarity). Binds synergistically with POU5F1 (OCT3/4) to gene promoters (By similarity). Binds to the FOXK1 promoter and recruits FHL3, resulting in transcriptional activation of FOXK1 which leads to myoblast proliferation (By similarity). Acts as an inhibitor of myoblast differentiation via transcriptional repression which leads to down-regulation of the muscle-specific genes MYOD and MYOG (By similarity). Involved in trophoblast giant cell differentiation via enhancement of HAND1 transcriptional activity (By similarity). Regulates transcription of HRC via binding to it proximal enhancer region (By similarity). Involved in skeletal muscle regeneration (By similarity). Also plays a role in the development of myogenic precursor cells (By similarity).By similarity
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 49 – 117 | HMG boxPROSITE-ProRule annotationAdd BLAST | 69 |
GO - Molecular functioni
- chromatin binding Source: Ensembl
- DNA binding Source: UniProtKB
- DNA-binding transcription factor activity Source: UniProtKB
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- anatomical structure morphogenesis Source: GO_Central
- cell differentiation Source: BHF-UCL
- chromatin organization Source: UniProtKB
- male gonad development Source: ProtInc
- myoblast development Source: BHF-UCL
- negative regulation of striated muscle tissue development Source: BHF-UCL
- negative regulation of transcription by RNA polymerase II Source: BHF-UCL
- positive regulation of G0 to G1 transition Source: BHF-UCL
- positive regulation of myoblast proliferation Source: BHF-UCL
- positive regulation of satellite cell activation involved in skeletal muscle regeneration Source: BHF-UCL
- positive regulation of transcription by RNA polymerase II Source: BHF-UCL
- regulation of transcription, DNA-templated Source: GO_Central
- regulation of transcription by RNA polymerase II Source: ProtInc
- skeletal muscle tissue regeneration Source: Ensembl
- trophoblast giant cell differentiation Source: UniProtKB
Keywordsi
Molecular function | Activator, DNA-binding, Repressor |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | O60248 |
Names & Taxonomyi
Protein namesi | Recommended name: Protein SOX-15Alternative name(s): Protein SOX-12 Protein SOX-20 |
Gene namesi | Name:SOX15 Synonyms:SOX12, SOX20, SOX26, SOX27 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:11196, SOX15 |
MIMi | 601297, gene |
neXtProti | NX_O60248 |
VEuPathDBi | HostDB:ENSG00000129194.7 |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotation
Nucleus
- nuclear chromatin Source: NTNU_SB
- nucleus Source: UniProtKB
Other locations
- cytoplasm Source: Ensembl
- transcription regulator complex Source: Ensembl
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 6665 |
OpenTargetsi | ENSG00000129194 |
PharmGKBi | PA36033 |
Miscellaneous databases
Pharosi | O60248, Tbio |
Genetic variation databases
BioMutai | SOX15 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000048762 | 1 – 233 | Protein SOX-15Add BLAST | 233 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 37 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | O60248 |
MassIVEi | O60248 |
MaxQBi | O60248 |
PaxDbi | O60248 |
PeptideAtlasi | O60248 |
PRIDEi | O60248 |
ProteomicsDBi | 49282 [O60248-1] 5383 |
PTM databases
iPTMneti | O60248 |
PhosphoSitePlusi | O60248 |
Expressioni
Tissue specificityi
Widely expressed in fetal and adult tissues examined, highest level found in fetal spinal cord and adult brain and testis.2 Publications
Gene expression databases
Bgeei | ENSG00000129194, Expressed in lower esophagus mucosa and 191 other tissues |
Genevisiblei | O60248, HS |
Organism-specific databases
HPAi | ENSG00000129194, Group enriched (esophagus, lymphoid tissue, skin, tongue) |
Interactioni
Subunit structurei
Interacts with HAND1; the interaction enhances HAND1-induced differentiation of trophoblast giant cells (By similarity).
Interacts with POU5F1 (OCT3/4); binds synergistically with POU5F1 to DNA (By similarity).
Interacts with FHL3; the interaction recruits the transcriptional coactivator FHL3 to the FOXK1 promoter (By similarity).
By similarityBinary interactionsi
Hide detailsProtein-protein interaction databases
BioGRIDi | 112548, 3 interactors |
IntActi | O60248, 2 interactors |
STRINGi | 9606.ENSP00000355354 |
Miscellaneous databases
RNActi | O60248, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 47 | Required to promote HAND1 transcriptional activator activityBy similarityAdd BLAST | 47 | |
Regioni | 138 – 183 | Interaction with FHL3By similarityAdd BLAST | 46 |
Phylogenomic databases
eggNOGi | KOG0527, Eukaryota |
GeneTreei | ENSGT00940000162099 |
HOGENOMi | CLU_106341_0_0_1 |
InParanoidi | O60248 |
OMAi | HCKPEAP |
OrthoDBi | 369754at2759 |
PhylomeDBi | O60248 |
TreeFami | TF351735 |
Family and domain databases
Gene3Di | 1.10.30.10, 1 hit |
InterProi | View protein in InterPro IPR009071, HMG_box_dom IPR036910, HMG_box_dom_sf IPR031269, SOX15 |
PANTHERi | PTHR10270:SF45, PTHR10270:SF45, 1 hit |
Pfami | View protein in Pfam PF00505, HMG_box, 1 hit |
SMARTi | View protein in SMART SM00398, HMG, 1 hit |
SUPFAMi | SSF47095, SSF47095, 1 hit |
PROSITEi | View protein in PROSITE PS50118, HMG_BOX_2, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: O60248-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MALPGSSQDQ AWSLEPPAAT AAASSSSGPQ EREGAGSPAA PGTLPLEKVK
60 70 80 90 100
RPMNAFMVWS SAQRRQMAQQ NPKMHNSEIS KRLGAQWKLL DEDEKRPFVE
110 120 130 140 150
EAKRLRARHL RDYPDYKYRP RRKAKSSGAG PSRCGQGRGN LASGGPLWGP
160 170 180 190 200
GYATTQPSRG FGYRPPSYST AYLPGSYGSS HCKLEAPSPC SLPQSDPRLQ
210 220 230
GELLPTYTHY LPPGSPTPYN PPLAGAPMPL THL
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 25 – 27 | SSS → AAA (PubMed:8978787).Curated | 3 | |
Sequence conflicti | 69 – 70 | QQ → HE in CAA51520 (PubMed:8332506).Curated | 2 | |
Sequence conflicti | 191 | S → F in BAA78784 (Ref. 9) Curated | 1 | |
Sequence conflicti | 216 – 218 | PTP → STS in BAA78784 (Ref. 9) Curated | 3 | |
Sequence conflicti | 225 – 226 | GA → VP in BAA78784 (Ref. 9) Curated | 2 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_056668 | 179 – 233 | Missing in isoform 2. 1 PublicationAdd BLAST | 55 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB006867 mRNA Translation: BAA25663.1 AK301687 mRNA Translation: BAG63159.1 AC016876 Genomic DNA No translation available. CH471108 Genomic DNA Translation: EAW90156.1 CH471108 Genomic DNA Translation: EAW90157.1 BC000985 mRNA Translation: AAH00985.1 BC072003 mRNA Translation: AAH72003.1 X73039 Genomic DNA Translation: CAA51520.1 AJ006222 mRNA Translation: CAA06920.1 AB025355 Genomic DNA Translation: BAA78784.1 |
CCDSi | CCDS32549.1 [O60248-1] |
PIRi | S34119 |
RefSeqi | NP_008873.1, NM_006942.1 [O60248-1] |
Genome annotation databases
Ensembli | ENST00000250055; ENSP00000355354; ENSG00000129194 [O60248-1] ENST00000538513; ENSP00000439311; ENSG00000129194 [O60248-1] ENST00000570788; ENSP00000458286; ENSG00000129194 [O60248-2] |
GeneIDi | 6665 |
KEGGi | hsa:6665 |
UCSCi | uc002ghy.2, human [O60248-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB006867 mRNA Translation: BAA25663.1 AK301687 mRNA Translation: BAG63159.1 AC016876 Genomic DNA No translation available. CH471108 Genomic DNA Translation: EAW90156.1 CH471108 Genomic DNA Translation: EAW90157.1 BC000985 mRNA Translation: AAH00985.1 BC072003 mRNA Translation: AAH72003.1 X73039 Genomic DNA Translation: CAA51520.1 AJ006222 mRNA Translation: CAA06920.1 AB025355 Genomic DNA Translation: BAA78784.1 |
CCDSi | CCDS32549.1 [O60248-1] |
PIRi | S34119 |
RefSeqi | NP_008873.1, NM_006942.1 [O60248-1] |
3D structure databases
SMRi | O60248 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 112548, 3 interactors |
IntActi | O60248, 2 interactors |
STRINGi | 9606.ENSP00000355354 |
PTM databases
iPTMneti | O60248 |
PhosphoSitePlusi | O60248 |
Genetic variation databases
BioMutai | SOX15 |
Proteomic databases
EPDi | O60248 |
MassIVEi | O60248 |
MaxQBi | O60248 |
PaxDbi | O60248 |
PeptideAtlasi | O60248 |
PRIDEi | O60248 |
ProteomicsDBi | 49282 [O60248-1] 5383 |
Protocols and materials databases
Antibodypediai | 12118, 194 antibodies |
DNASUi | 6665 |
Genome annotation databases
Ensembli | ENST00000250055; ENSP00000355354; ENSG00000129194 [O60248-1] ENST00000538513; ENSP00000439311; ENSG00000129194 [O60248-1] ENST00000570788; ENSP00000458286; ENSG00000129194 [O60248-2] |
GeneIDi | 6665 |
KEGGi | hsa:6665 |
UCSCi | uc002ghy.2, human [O60248-1] |
Organism-specific databases
CTDi | 6665 |
DisGeNETi | 6665 |
GeneCardsi | SOX15 |
HGNCi | HGNC:11196, SOX15 |
HPAi | ENSG00000129194, Group enriched (esophagus, lymphoid tissue, skin, tongue) |
MIMi | 601297, gene |
neXtProti | NX_O60248 |
OpenTargetsi | ENSG00000129194 |
PharmGKBi | PA36033 |
VEuPathDBi | HostDB:ENSG00000129194.7 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0527, Eukaryota |
GeneTreei | ENSGT00940000162099 |
HOGENOMi | CLU_106341_0_0_1 |
InParanoidi | O60248 |
OMAi | HCKPEAP |
OrthoDBi | 369754at2759 |
PhylomeDBi | O60248 |
TreeFami | TF351735 |
Enzyme and pathway databases
PathwayCommonsi | O60248 |
Miscellaneous databases
BioGRID-ORCSi | 6665, 31 hits in 894 CRISPR screens |
ChiTaRSi | SOX15, human |
GeneWikii | SOX15 |
GenomeRNAii | 6665 |
Pharosi | O60248, Tbio |
PROi | PR:O60248 |
RNActi | O60248, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000129194, Expressed in lower esophagus mucosa and 191 other tissues |
Genevisiblei | O60248, HS |
Family and domain databases
Gene3Di | 1.10.30.10, 1 hit |
InterProi | View protein in InterPro IPR009071, HMG_box_dom IPR036910, HMG_box_dom_sf IPR031269, SOX15 |
PANTHERi | PTHR10270:SF45, PTHR10270:SF45, 1 hit |
Pfami | View protein in Pfam PF00505, HMG_box, 1 hit |
SMARTi | View protein in SMART SM00398, HMG, 1 hit |
SUPFAMi | SSF47095, SSF47095, 1 hit |
PROSITEi | View protein in PROSITE PS50118, HMG_BOX_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SOX15_HUMAN | |
Accessioni | O60248Primary (citable) accession number: O60248 Secondary accession number(s): B4DWU7 Q9Y6W7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 15, 1998 |
Last sequence update: | August 1, 1998 | |
Last modified: | February 10, 2021 | |
This is version 177 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot