SOX15

Functionⁱ

Binds to the 5'-AACAAT-3' sequence.

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
DNA bindingⁱ	49 – 117	HMG boxPROSITE-ProRule annotationAdd BLAST		69

GO - Molecular functionⁱ

chromatin binding Source: Ensembl
DNA binding
Source: UniProtKB
Non-traceable author statementⁱ
- 8332506
DNA-binding transcription factor activity
Source: UniProtKB
Non-traceable author statementⁱ
- 8332506
DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
protein heterodimerization activity Source: Ensembl
proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell differentiation
Source: BHF-UCL
Inferred from sequence or structural similarityⁱ
- 16759287
chromatin organization
Source: UniProtKB
Non-traceable author statementⁱ
- 8332506
male gonad development
Source: ProtInc
Traceable author statementⁱ
- 9540826
myoblast development
Source: BHF-UCL
Inferred from sequence or structural similarityⁱ
- 15367664
negative regulation of striated muscle tissue development
Source: BHF-UCL
Inferred from sequence or structural similarityⁱ
- 10821863
negative regulation of transcription by RNA polymerase II
Source: BHF-UCL
Inferred from sequence or structural similarityⁱ
- 17363903
positive regulation of G0 to G1 transition
Source: BHF-UCL
Inferred from sequence or structural similarityⁱ
- 17363903
positive regulation of myoblast proliferation
Source: BHF-UCL
Inferred from sequence or structural similarityⁱ
- 17363903
positive regulation of satellite cell activation involved in skeletal muscle regeneration
Source: BHF-UCL
Inferred from sequence or structural similarityⁱ
- 17363903
positive regulation of transcription by RNA polymerase II
Source: BHF-UCL
Inferred from sequence or structural similarityⁱ
- 17363903
regulation of transcription, DNA-templated
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
regulation of transcription by RNA polymerase II
Source: ProtInc
Traceable author statementⁱ
- 9540826
skeletal muscle tissue regeneration Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding

Molecular function

DNA-binding

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Protein SOX-15 Alternative name(s): Protein SOX-12 Protein SOX-20
Gene namesⁱ	Name:SOX15 Synonyms:SOX12, SOX20, SOX26, SOX27
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 17

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000129194.7
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:11196 SOX15
MIMⁱ	601297 gene
neXtProtⁱ	NX_O60248

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	6665
Open Targets More...OpenTargetsⁱ	ENSG00000129194
PharmGKBⁱ	PA36033

Polymorphism and mutation databases

BioMutaⁱ	SOX15

BioMutaⁱ

SOX15

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000048762	1 – 233	Protein SOX-15Add BLAST		233

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	37	PhosphoserineCombined sources		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	O60248
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O60248
PaxDbⁱ	O60248
PeptideAtlas More...PeptideAtlasⁱ	O60248
PRIDEⁱ	O60248
ProteomicsDBⁱ	49282

PTM databases

iPTMnetⁱ	O60248
PhosphoSitePlusⁱ	O60248

Expressionⁱ

Tissue specificityⁱ

Widely expressed in fetal and adult tissues examined, highest level found in fetal spinal cord and adult brain and testis.2 Publications

Gene expression databases

Bgeeⁱ	ENSG00000129194 Expressed in 173 organ(s), highest expression level in lower esophagus mucosa
CleanExⁱ	HS_SOX12 HS_SOX15
Genevisibleⁱ	O60248 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA067196 HPA074049

HPAⁱ

HPA067196
HPA074049

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
BHLHE40	O14503	3	EBI-5452954,EBI-711810
HSFY2	Q96LI6	3	EBI-5452954,EBI-3957665

GO - Molecular functionⁱ

protein heterodimerization activity Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	112548, 3 interactors
IntActⁱ	O60248, 2 interactors
STRINGⁱ	9606.ENSP00000355354

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O60248
SMRⁱ	O60248
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Phylogenomic databases

eggNOGⁱ	KOG0527 Eukaryota ENOG410XT0K LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118988
HOGENOMⁱ	HOG000231647
HOVERGENⁱ	HBG055512
InParanoidⁱ	O60248
KEGG Orthology (KO) More...KOⁱ	K09271
OMAⁱ	YGSSHCK
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0M3O
PhylomeDBⁱ	O60248
TreeFamⁱ	TF351735

Family and domain databases

Gene3Dⁱ	1.10.30.10, 1 hit
InterProⁱ	View protein in InterPro IPR009071 HMG_box_dom IPR036910 HMG_box_dom_sf IPR031269 SOX15
PANTHERⁱ	PTHR10270:SF45 PTHR10270:SF45, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00505 HMG_box, 1 hit
SMARTⁱ	View protein in SMART SM00398 HMG, 1 hit
SUPFAMⁱ	SSF47095 SSF47095, 1 hit
PROSITEⁱ	View protein in PROSITE PS50118 HMG_BOX_2, 1 hit

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: O60248-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALPGSSQDQ AWSLEPPAAT AAASSSSGPQ EREGAGSPAA PGTLPLEKVK 
        60         70         80         90        100
RPMNAFMVWS SAQRRQMAQQ NPKMHNSEIS KRLGAQWKLL DEDEKRPFVE 
       110        120        130        140        150
EAKRLRARHL RDYPDYKYRP RRKAKSSGAG PSRCGQGRGN LASGGPLWGP 
       160        170        180        190        200
GYATTQPSRG FGYRPPSYST AYLPGSYGSS HCKLEAPSPC SLPQSDPRLQ 
       210        220        230 
GELLPTYTHY LPPGSPTPYN PPLAGAPMPL THL

Length:233

Mass (Da):25,251

Last modified:August 1, 1998 - v1

Checksum:ⁱ6B52AE455C7C8CCE

GO

Isoform 2 (identifier: O60248-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
179-233: Missing.

« Hide

        10         20         30         40         50
MALPGSSQDQ AWSLEPPAAT AAASSSSGPQ EREGAGSPAA PGTLPLEKVK 
        60         70         80         90        100
RPMNAFMVWS SAQRRQMAQQ NPKMHNSEIS KRLGAQWKLL DEDEKRPFVE 
       110        120        130        140        150
EAKRLRARHL RDYPDYKYRP RRKAKSSGAG PSRCGQGRGN LASGGPLWGP 
       160        170 
GYATTQPSRG FGYRPPSYST AYLPGSYG

Note: No experimental confirmation available.

Show »

Length:178

Mass (Da):19,393

Checksum:ⁱ82400844712B1E2D

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	25 – 27	SSS → AAA (PubMed:8978787).Curated	3
Sequence conflictⁱ	69 – 70	QQ → HE in CAA51520 (PubMed:8332506).Curated	2
Sequence conflictⁱ	191	S → F in BAA78784 (Ref. 9) Curated	1
Sequence conflictⁱ	216 – 218	PTP → STS in BAA78784 (Ref. 9) Curated	3
Sequence conflictⁱ	225 – 226	GA → VP in BAA78784 (Ref. 9) Curated	2

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_056668	179 – 233	Missing in isoform 2. 1 PublicationAdd BLAST		55

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB006867 mRNA Translation: BAA25663.1 AK301687 mRNA Translation: BAG63159.1 AC016876 Genomic DNA No translation available. CH471108 Genomic DNA Translation: EAW90156.1 CH471108 Genomic DNA Translation: EAW90157.1 BC000985 mRNA Translation: AAH00985.1 BC072003 mRNA Translation: AAH72003.1 X73039 Genomic DNA Translation: CAA51520.1 AJ006222 mRNA Translation: CAA06920.1 AB025355 Genomic DNA Translation: BAA78784.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS32549.1 [O60248-1]
PIRⁱ	S34119
NCBI Reference Sequences More...RefSeqⁱ	NP_008873.1, NM_006942.1 [O60248-1]
UniGeneⁱ	Hs.95582

Genome annotation databases

Ensemblⁱ	ENST00000250055; ENSP00000355354; ENSG00000129194 [O60248-1] ENST00000538513; ENSP00000439311; ENSG00000129194 [O60248-1] ENST00000570788; ENSP00000458286; ENSG00000129194 [O60248-2]
GeneIDⁱ	6665
KEGGⁱ	hsa:6665
UCSC genome browser More...UCSCⁱ	uc002ghy.2 human [O60248-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O60248	SOX15 isoform 2		PANTR		178	UniRef100_O60248
Isoform 2 of Protein SOX-15		HUMAN		178

Protein	Similar proteins		Species	Score	Length	Source
O60248	SOX15 isoform 2		PANTR		178	UniRef90_O60248
Isoform 2 of Protein SOX-15		HUMAN		178
Protein SOX-15		CALJA		233
SOX15 isoform 1		PONAB		233
SRY-box 15		SAIBB		233
+22

Protein	Similar proteins		Species	Score	Length	Source
O60248	Protein SOX-15		MOUSE		231	UniRef50_P43267
HMG-box transcription factor (Fragment)		MUSSI		224
Protein SOX-15		MYOBR		232
Uncharacterized protein		CAVPO		216
protein SOX-15		DIPOR		226
+117

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB006867 mRNA Translation: BAA25663.1 AK301687 mRNA Translation: BAG63159.1 AC016876 Genomic DNA No translation available. CH471108 Genomic DNA Translation: EAW90156.1 CH471108 Genomic DNA Translation: EAW90157.1 BC000985 mRNA Translation: AAH00985.1 BC072003 mRNA Translation: AAH72003.1 X73039 Genomic DNA Translation: CAA51520.1 AJ006222 mRNA Translation: CAA06920.1 AB025355 Genomic DNA Translation: BAA78784.1
CCDSⁱ	CCDS32549.1 [O60248-1]
PIRⁱ	S34119
RefSeqⁱ	NP_008873.1, NM_006942.1 [O60248-1]
UniGeneⁱ	Hs.95582

3D structure databases

ProteinModelPortalⁱ	O60248
SMRⁱ	O60248
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	112548, 3 interactors
IntActⁱ	O60248, 2 interactors
STRINGⁱ	9606.ENSP00000355354

PTM databases

iPTMnetⁱ	O60248
PhosphoSitePlusⁱ	O60248

Polymorphism and mutation databases

BioMutaⁱ	SOX15

BioMutaⁱ

SOX15

Proteomic databases

EPDⁱ	O60248
MaxQBⁱ	O60248
PaxDbⁱ	O60248
PeptideAtlasⁱ	O60248
PRIDEⁱ	O60248
ProteomicsDBⁱ	49282

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	6665
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000250055; ENSP00000355354; ENSG00000129194 [O60248-1] ENST00000538513; ENSP00000439311; ENSG00000129194 [O60248-1] ENST00000570788; ENSP00000458286; ENSG00000129194 [O60248-2]
GeneIDⁱ	6665
KEGGⁱ	hsa:6665
UCSCⁱ	uc002ghy.2 human [O60248-1]

Organism-specific databases

CTDⁱ	6665
DisGeNETⁱ	6665
EuPathDBⁱ	HostDB:ENSG00000129194.7
GeneCardsⁱ	SOX15
HGNCⁱ	HGNC:11196 SOX15
HPAⁱ	HPA067196 HPA074049
MIMⁱ	601297 gene
neXtProtⁱ	NX_O60248
OpenTargetsⁱ	ENSG00000129194
PharmGKBⁱ	PA36033
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0527 Eukaryota ENOG410XT0K LUCA
GeneTreeⁱ	ENSGT00760000118988
HOGENOMⁱ	HOG000231647
HOVERGENⁱ	HBG055512
InParanoidⁱ	O60248
KOⁱ	K09271
OMAⁱ	YGSSHCK
OrthoDBⁱ	EOG091G0M3O
PhylomeDBⁱ	O60248
TreeFamⁱ	TF351735

Miscellaneous databases

GeneWikiⁱ	SOX15
GenomeRNAiⁱ	6665
Protein Ontology More...PROⁱ	PR:O60248
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000129194 Expressed in 173 organ(s), highest expression level in lower esophagus mucosa
CleanExⁱ	HS_SOX12 HS_SOX15
Genevisibleⁱ	O60248 HS

Family and domain databases

Gene3Dⁱ	1.10.30.10, 1 hit
InterProⁱ	View protein in InterPro IPR009071 HMG_box_dom IPR036910 HMG_box_dom_sf IPR031269 SOX15
PANTHERⁱ	PTHR10270:SF45 PTHR10270:SF45, 1 hit
Pfamⁱ	View protein in Pfam PF00505 HMG_box, 1 hit
SMARTⁱ	View protein in SMART SM00398 HMG, 1 hit
SUPFAMⁱ	SSF47095 SSF47095, 1 hit
PROSITEⁱ	View protein in PROSITE PS50118 HMG_BOX_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SOX15_HUMAN
Accessionⁱ	O60248Primary (citable) accession number: O60248 Secondary accession number(s): B4DWU7 , D3DTQ0, P35717, Q9Y6W7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
	Last sequence update:	August 1, 1998
	Last modified:	November 7, 2018
	This is version 163 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - O60248 (SOX15_HUMAN)

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Protein SOX-15

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ