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Protein

Protein SOX-15

Gene

SOX15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds to the 5'-AACAAT-3' sequence.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi49 – 117HMG boxPROSITE-ProRule annotationAdd BLAST69

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein SOX-15
Alternative name(s):
Protein SOX-12
Protein SOX-20
Gene namesi
Name:SOX15
Synonyms:SOX12, SOX20, SOX26, SOX27
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000129194.7
HGNCiHGNC:11196 SOX15
MIMi601297 gene
neXtProtiNX_O60248

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi6665
OpenTargetsiENSG00000129194
PharmGKBiPA36033

Polymorphism and mutation databases

BioMutaiSOX15

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000487621 – 233Protein SOX-15Add BLAST233

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei37PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO60248
MaxQBiO60248
PaxDbiO60248
PeptideAtlasiO60248
PRIDEiO60248
ProteomicsDBi49282

PTM databases

iPTMnetiO60248
PhosphoSitePlusiO60248

Expressioni

Tissue specificityi

Widely expressed in fetal and adult tissues examined, highest level found in fetal spinal cord and adult brain and testis.2 Publications

Gene expression databases

BgeeiENSG00000129194 Expressed in 173 organ(s), highest expression level in lower esophagus mucosa
CleanExiHS_SOX12
HS_SOX15
GenevisibleiO60248 HS

Organism-specific databases

HPAiHPA067196
HPA074049

Interactioni

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi112548, 3 interactors
IntActiO60248, 2 interactors
STRINGi9606.ENSP00000355354

Structurei

3D structure databases

ProteinModelPortaliO60248
SMRiO60248
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiKOG0527 Eukaryota
ENOG410XT0K LUCA
GeneTreeiENSGT00760000118988
HOGENOMiHOG000231647
HOVERGENiHBG055512
InParanoidiO60248
KOiK09271
OMAiYGSSHCK
OrthoDBiEOG091G0M3O
PhylomeDBiO60248
TreeFamiTF351735

Family and domain databases

Gene3Di1.10.30.10, 1 hit
InterProiView protein in InterPro
IPR009071 HMG_box_dom
IPR036910 HMG_box_dom_sf
IPR031269 SOX15
PANTHERiPTHR10270:SF45 PTHR10270:SF45, 1 hit
PfamiView protein in Pfam
PF00505 HMG_box, 1 hit
SMARTiView protein in SMART
SM00398 HMG, 1 hit
SUPFAMiSSF47095 SSF47095, 1 hit
PROSITEiView protein in PROSITE
PS50118 HMG_BOX_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: O60248-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MALPGSSQDQ AWSLEPPAAT AAASSSSGPQ EREGAGSPAA PGTLPLEKVK
60 70 80 90 100
RPMNAFMVWS SAQRRQMAQQ NPKMHNSEIS KRLGAQWKLL DEDEKRPFVE
110 120 130 140 150
EAKRLRARHL RDYPDYKYRP RRKAKSSGAG PSRCGQGRGN LASGGPLWGP
160 170 180 190 200
GYATTQPSRG FGYRPPSYST AYLPGSYGSS HCKLEAPSPC SLPQSDPRLQ
210 220 230
GELLPTYTHY LPPGSPTPYN PPLAGAPMPL THL
Length:233
Mass (Da):25,251
Last modified:August 1, 1998 - v1
Checksum:i6B52AE455C7C8CCE
GO
Isoform 2 (identifier: O60248-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     179-233: Missing.

Note: No experimental confirmation available.
Show »
Length:178
Mass (Da):19,393
Checksum:i82400844712B1E2D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti25 – 27SSS → AAA (PubMed:8978787).Curated3
Sequence conflicti69 – 70QQ → HE in CAA51520 (PubMed:8332506).Curated2
Sequence conflicti191S → F in BAA78784 (Ref. 9) Curated1
Sequence conflicti216 – 218PTP → STS in BAA78784 (Ref. 9) Curated3
Sequence conflicti225 – 226GA → VP in BAA78784 (Ref. 9) Curated2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_056668179 – 233Missing in isoform 2. 1 PublicationAdd BLAST55

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB006867 mRNA Translation: BAA25663.1
AK301687 mRNA Translation: BAG63159.1
AC016876 Genomic DNA No translation available.
CH471108 Genomic DNA Translation: EAW90156.1
CH471108 Genomic DNA Translation: EAW90157.1
BC000985 mRNA Translation: AAH00985.1
BC072003 mRNA Translation: AAH72003.1
X73039 Genomic DNA Translation: CAA51520.1
AJ006222 mRNA Translation: CAA06920.1
AB025355 Genomic DNA Translation: BAA78784.1
CCDSiCCDS32549.1 [O60248-1]
PIRiS34119
RefSeqiNP_008873.1, NM_006942.1 [O60248-1]
UniGeneiHs.95582

Genome annotation databases

EnsembliENST00000250055; ENSP00000355354; ENSG00000129194 [O60248-1]
ENST00000538513; ENSP00000439311; ENSG00000129194 [O60248-1]
ENST00000570788; ENSP00000458286; ENSG00000129194 [O60248-2]
GeneIDi6665
KEGGihsa:6665
UCSCiuc002ghy.2 human [O60248-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB006867 mRNA Translation: BAA25663.1
AK301687 mRNA Translation: BAG63159.1
AC016876 Genomic DNA No translation available.
CH471108 Genomic DNA Translation: EAW90156.1
CH471108 Genomic DNA Translation: EAW90157.1
BC000985 mRNA Translation: AAH00985.1
BC072003 mRNA Translation: AAH72003.1
X73039 Genomic DNA Translation: CAA51520.1
AJ006222 mRNA Translation: CAA06920.1
AB025355 Genomic DNA Translation: BAA78784.1
CCDSiCCDS32549.1 [O60248-1]
PIRiS34119
RefSeqiNP_008873.1, NM_006942.1 [O60248-1]
UniGeneiHs.95582

3D structure databases

ProteinModelPortaliO60248
SMRiO60248
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112548, 3 interactors
IntActiO60248, 2 interactors
STRINGi9606.ENSP00000355354

PTM databases

iPTMnetiO60248
PhosphoSitePlusiO60248

Polymorphism and mutation databases

BioMutaiSOX15

Proteomic databases

EPDiO60248
MaxQBiO60248
PaxDbiO60248
PeptideAtlasiO60248
PRIDEiO60248
ProteomicsDBi49282

Protocols and materials databases

DNASUi6665
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000250055; ENSP00000355354; ENSG00000129194 [O60248-1]
ENST00000538513; ENSP00000439311; ENSG00000129194 [O60248-1]
ENST00000570788; ENSP00000458286; ENSG00000129194 [O60248-2]
GeneIDi6665
KEGGihsa:6665
UCSCiuc002ghy.2 human [O60248-1]

Organism-specific databases

CTDi6665
DisGeNETi6665
EuPathDBiHostDB:ENSG00000129194.7
GeneCardsiSOX15
HGNCiHGNC:11196 SOX15
HPAiHPA067196
HPA074049
MIMi601297 gene
neXtProtiNX_O60248
OpenTargetsiENSG00000129194
PharmGKBiPA36033
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0527 Eukaryota
ENOG410XT0K LUCA
GeneTreeiENSGT00760000118988
HOGENOMiHOG000231647
HOVERGENiHBG055512
InParanoidiO60248
KOiK09271
OMAiYGSSHCK
OrthoDBiEOG091G0M3O
PhylomeDBiO60248
TreeFamiTF351735

Miscellaneous databases

GeneWikiiSOX15
GenomeRNAii6665
PROiPR:O60248
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000129194 Expressed in 173 organ(s), highest expression level in lower esophagus mucosa
CleanExiHS_SOX12
HS_SOX15
GenevisibleiO60248 HS

Family and domain databases

Gene3Di1.10.30.10, 1 hit
InterProiView protein in InterPro
IPR009071 HMG_box_dom
IPR036910 HMG_box_dom_sf
IPR031269 SOX15
PANTHERiPTHR10270:SF45 PTHR10270:SF45, 1 hit
PfamiView protein in Pfam
PF00505 HMG_box, 1 hit
SMARTiView protein in SMART
SM00398 HMG, 1 hit
SUPFAMiSSF47095 SSF47095, 1 hit
PROSITEiView protein in PROSITE
PS50118 HMG_BOX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSOX15_HUMAN
AccessioniPrimary (citable) accession number: O60248
Secondary accession number(s): B4DWU7
, D3DTQ0, P35717, Q9Y6W7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: August 1, 1998
Last modified: November 7, 2018
This is version 163 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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