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Entry version 170 (18 Sep 2019)
Sequence version 2 (28 Jul 2009)
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Protein

Protocadherin-7

Gene

PCDH7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion
LigandCalcium

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-114608 Platelet degranulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protocadherin-7
Alternative name(s):
Brain-heart protocadherin
Short name:
BH-Pcdh
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PCDH7
Synonyms:BHPCDH
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:8659 PCDH7

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
602988 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O60245

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini29 – 879ExtracellularSequence analysisAdd BLAST851
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei880 – 900HelicalSequence analysisAdd BLAST21
Topological domaini901 – 1069CytoplasmicSequence analysisAdd BLAST169

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
5099

Open Targets

More...
OpenTargetsi
ENSG00000169851

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA33006

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
O60245

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PCDH7

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 28Sequence analysisAdd BLAST28
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000399229 – 1069Protocadherin-7Add BLAST1041

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi79N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi689N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi747N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi780N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi822N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi840N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi845N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei989PhosphoserineCombined sources1
Modified residuei1011PhosphoserineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O60245

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O60245

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
O60245

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O60245

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O60245

PeptideAtlas

More...
PeptideAtlasi
O60245

PRoteomics IDEntifications database

More...
PRIDEi
O60245

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
49279 [O60245-1]
49280 [O60245-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O60245

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O60245

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
O60245

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed predominantly in brain and heart and at lower levels in various other tissues.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000169851 Expressed in 204 organ(s), highest expression level in primary visual cortex

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O60245 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O60245 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA011866
HPA046521

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
111132, 48 interactors

Protein interaction database and analysis system

More...
IntActi
O60245, 30 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000441802

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11069
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O60245

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
O60245

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini29 – 143Cadherin 1PROSITE-ProRule annotationAdd BLAST115
Domaini144 – 308Cadherin 2PROSITE-ProRule annotationAdd BLAST165
Domaini309 – 415Cadherin 3PROSITE-ProRule annotationAdd BLAST107
Domaini424 – 535Cadherin 4PROSITE-ProRule annotationAdd BLAST112
Domaini536 – 639Cadherin 5PROSITE-ProRule annotationAdd BLAST104
Domaini640 – 742Cadherin 6PROSITE-ProRule annotationAdd BLAST103
Domaini745 – 862Cadherin 7PROSITE-ProRule annotationAdd BLAST118

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410II7Q Eukaryota
ENOG410XPHP LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157221

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000234535

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O60245

KEGG Orthology (KO)

More...
KOi
K16498

Identification of Orthologs from Complete Genome Data

More...
OMAi
LHPYITV

Database of Orthologous Groups

More...
OrthoDBi
97260at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O60245

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
IPR013164 Cadherin_N
IPR013585 Protocadherin

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00028 Cadherin, 6 hits
PF08266 Cadherin_2, 1 hit
PF08374 Protocadherin, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00205 CADHERIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00112 CA, 7 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49313 SSF49313, 7 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00232 CADHERIN_1, 6 hits
PS50268 CADHERIN_2, 7 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform A (identifier: O60245-1) [UniParc]FASTAAdd to basket
Also known as: BH-Pcdh-a

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLRMRTAGWA RGWCLGCCLL LPLSLSLAAA KQLLRYRLAE EGPADVRIGN
60 70 80 90 100
VASDLGIVTG SGEVTFSLES GSEYLKIDNL TGELSTSERR IDREKLPQCQ
110 120 130 140 150
MIFDENECFL DFEVSVIGPS QSWVDLFEGQ VIVLDINDNT PTFPSPVLTL
160 170 180 190 200
TVEENRPVGT LYLLPTATDR DFGRNGIERY ELLQEPGGGG SGGESRRAGA
210 220 230 240 250
ADSAPYPGGG GNGASGGGSG GSKRRLDASE GGGGTNPGGR SSVFELQVAD
260 270 280 290 300
TPDGEKQPQL IVKGALDREQ RDSYELTLRV RDGGDPPRSS QAILRVLITD
310 320 330 340 350
VNDNSPRFEK SVYEADLAEN SAPGTPILQL RAADLDVGVN GQIEYVFGAA
360 370 380 390 400
TESVRRLLRL DETSGWLSVL HRIDREEVNQ LRFTVMARDR GQPPKTDKAT
410 420 430 440 450
VVLNIKDEND NVPSIEIRKI GRIPLKDGVA NVAEDVLVDT PIALVQVSDR
460 470 480 490 500
DQGENGVVTC TVVGDVPFQL KPASDTEGDQ NKKKYFLHTS TPLDYEATRE
510 520 530 540 550
FNVVIVAVDS GSPSLSSNNS LIVKVGDTND NPPMFGQSVV EVYFPENNIP
560 570 580 590 600
GERVATVLAT DADSGKNAEI AYSLDSSVMG IFAIDPDSGD ILVNTVLDRE
610 620 630 640 650
QTDRYEFKVN AKDKGIPVLQ GSTTVIVQVA DKNDNDPKFM QDVFTFYVKE
660 670 680 690 700
NLQPNSPVGM VTVMDADKGR NAEMSLYIEE NNNIFSIEND TGTIYSTMSF
710 720 730 740 750
DREHQTTYTF RVKAVDGGDP PRSATATVSL FVMDENDNAP TVTLPKNISY
760 770 780 790 800
TLLPPSSNVR TVVATVLATD SDDGINADLN YSIVGGNPFK LFEIDPTSGV
810 820 830 840 850
VSLVGKLTQK HYGLHRLVVQ VNDSGQPSQS TTTLVHVFVN ESVSNATAID
860 870 880 890 900
SQIARSLHIP LTQDIAGDPS YEISKQRLSI VIGVVAGIMT VILIILIVVM
910 920 930 940 950
ARYCRSKNKN GYEAGKKDHE DFFTPQQHDK SKKPKKDKKN KKSKQPLYSS
960 970 980 990 1000
IVTVEASKPN GQRYDSVNEK LSDSPSMGRY RSVNGGPGSP DLARHYKSSS
1010 1020 1030 1040 1050
PLPTVQLHPQ SPTAGKKHQA VQDLPPANTF VGAGDNISIG SDHCSEYSCQ
1060
TNNKYSKQMR LHPYITVFG
Length:1,069
Mass (Da):116,071
Last modified:July 28, 2009 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6150CAF0599D5DAF
GO
Isoform B (identifier: O60245-2) [UniParc]FASTAAdd to basket
Also known as: BH-Pcdh-b

The sequence of this isoform differs from the canonical sequence as follows:
     1059-1069: MRLHPYITVFG → VRCIPNIFKYPREG

Show »
Length:1,072
Mass (Da):116,429
Checksum:iB37D12C7A156AF39
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YAH0H0YAH0_HUMAN
Protocadherin-7
PCDH7
937Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087X2C4A0A087X2C4_HUMAN
Protocadherin-7
PCDH7
584Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087X0C9A0A087X0C9_HUMAN
Protocadherin-7
PCDH7
125Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA25196 differs from that shown. Aberrant splicing.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti25L → F in BAA25194 (PubMed:9615233).Curated1
Sequence conflicti25L → F in BAA25195 (PubMed:9615233).Curated1
Sequence conflicti25L → F in BAA25196 (PubMed:9615233).Curated1
Sequence conflicti518N → K in BAA25194 (PubMed:9615233).Curated1
Sequence conflicti518N → K in BAA25195 (PubMed:9615233).Curated1
Sequence conflicti518N → K in BAA25196 (PubMed:9615233).Curated1
Sequence conflicti834L → V in BAA25194 (PubMed:9615233).Curated1
Sequence conflicti834L → V in BAA25195 (PubMed:9615233).Curated1
Sequence conflicti834L → V in BAA25196 (PubMed:9615233).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0007041059 – 1069MRLHPYITVFG → VRCIPNIFKYPREG in isoform B. 1 PublicationAdd BLAST11

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB006755 mRNA Translation: BAA25194.1
AB006756 mRNA Translation: BAA25195.1
AB006757 mRNA Translation: BAA25196.1 Sequence problems.
AC097716 Genomic DNA No translation available.
AC098595 Genomic DNA No translation available.
AC107394 Genomic DNA No translation available.
AC110766 Genomic DNA Translation: AAY40944.1
AC112239 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS33971.1 [O60245-1]
CCDS75116.1 [O60245-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
T00041
T00042

NCBI Reference Sequences

More...
RefSeqi
NP_002580.2, NM_002589.2 [O60245-1]
NP_115832.1, NM_032456.2 [O60245-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000361762; ENSP00000355243; ENSG00000169851 [O60245-1]
ENST00000543491; ENSP00000441802; ENSG00000169851 [O60245-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
5099

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:5099

UCSC genome browser

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UCSCi
uc003gsk.2 human [O60245-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB006755 mRNA Translation: BAA25194.1
AB006756 mRNA Translation: BAA25195.1
AB006757 mRNA Translation: BAA25196.1 Sequence problems.
AC097716 Genomic DNA No translation available.
AC098595 Genomic DNA No translation available.
AC107394 Genomic DNA No translation available.
AC110766 Genomic DNA Translation: AAY40944.1
AC112239 Genomic DNA No translation available.
CCDSiCCDS33971.1 [O60245-1]
CCDS75116.1 [O60245-2]
PIRiT00041
T00042
RefSeqiNP_002580.2, NM_002589.2 [O60245-1]
NP_115832.1, NM_032456.2 [O60245-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2YSTNMR-A302-413[»]
SMRiO60245
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi111132, 48 interactors
IntActiO60245, 30 interactors
STRINGi9606.ENSP00000441802

PTM databases

iPTMnetiO60245
PhosphoSitePlusiO60245
SwissPalmiO60245

Polymorphism and mutation databases

BioMutaiPCDH7

Proteomic databases

EPDiO60245
jPOSTiO60245
MassIVEiO60245
MaxQBiO60245
PaxDbiO60245
PeptideAtlasiO60245
PRIDEiO60245
ProteomicsDBi49279 [O60245-1]
49280 [O60245-2]

Genome annotation databases

EnsembliENST00000361762; ENSP00000355243; ENSG00000169851 [O60245-1]
ENST00000543491; ENSP00000441802; ENSG00000169851 [O60245-2]
GeneIDi5099
KEGGihsa:5099
UCSCiuc003gsk.2 human [O60245-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
5099
DisGeNETi5099

GeneCards: human genes, protein and diseases

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GeneCardsi
PCDH7
HGNCiHGNC:8659 PCDH7
HPAiHPA011866
HPA046521
MIMi602988 gene
neXtProtiNX_O60245
OpenTargetsiENSG00000169851
PharmGKBiPA33006

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410II7Q Eukaryota
ENOG410XPHP LUCA
GeneTreeiENSGT00940000157221
HOGENOMiHOG000234535
InParanoidiO60245
KOiK16498
OMAiLHPYITV
OrthoDBi97260at2759
PhylomeDBiO60245

Enzyme and pathway databases

ReactomeiR-HSA-114608 Platelet degranulation

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
PCDH7 human
EvolutionaryTraceiO60245

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
PCDH7

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
5099
PharosiO60245

Protein Ontology

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PROi
PR:O60245

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000169851 Expressed in 204 organ(s), highest expression level in primary visual cortex
ExpressionAtlasiO60245 baseline and differential
GenevisibleiO60245 HS

Family and domain databases

InterProiView protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
IPR013164 Cadherin_N
IPR013585 Protocadherin
PfamiView protein in Pfam
PF00028 Cadherin, 6 hits
PF08266 Cadherin_2, 1 hit
PF08374 Protocadherin, 1 hit
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 7 hits
SUPFAMiSSF49313 SSF49313, 7 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 6 hits
PS50268 CADHERIN_2, 7 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPCDH7_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O60245
Secondary accession number(s): O60246, O60247, Q4W5C4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 5, 2001
Last sequence update: July 28, 2009
Last modified: September 18, 2019
This is version 170 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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