UniProtKB - O60242 (AGRB3_HUMAN)

BLAST

>sp|O60242|AGRB3_HUMAN Adhesion G protein-coupled receptor B3 OS=Homo sapiens OX=9606 GN=ADGRB3 PE=1 SV=2
MKAVRNLLIYIFSTYLLVMFGFNAAQDFWCSTLVKGVIYGSYSVSEMFPKNFTNCTWTLE
NPDPTKYSIYLKFSKKDLSCSNFSLLAYQFDHFSHEKIKDLLRKNHSIMQLCNSKNAFVF
LQYDKNFIQIRRVFPTNFPGLQKKGEEDQKSFFEFLVLNKVSPSQFGCHVLCTWLESCLK
SENGRTESCGIMYTKCTCPQHLGEWGIDDQSLILLNNVVLPLNEQTEGCLTQELQTTQVC
NLTREAKRPPKEEFGMMGDHTIKSQRPRSVHEKRVPQEQADAAKFMAQTGESGVEEWSQW
STCSVTCGQGSQVRTRTCVSPYGTHCSGPLRESRVCNNTALCPVHGVWEEWSPWSLCSFT
CGRGQRTRTRSCTPPQYGGRPCEGPETHHKPCNIALCPVDGQWQEWSSWSQCSVTCSNGT
QQRSRQCTAAAHGGSECRGPWAESRECYNPECTANGQWNQWGHWSGCSKSCDGGWERRIR
TCQGAVITGQQCEGTGEEVRRCNEQRCPAPYEICPEDYLMSMVWKRTPAGDLAFNQCPLN
ATGTTSRRCSLSLHGVAFWEQPSFARCISNEYRHLQHSIKEHLAKGQRMLAGDGMSQVTK
TLLDLTQRKNFYAGDLLMSVEILRNVTDTFKRASYIPASDGVQNFFQIVSNLLDEENKEK
WEDAQQIYPGSIELMQVIEDFIHIVGMGMMDFQNSYLMTGNVVASIQKLPAASVLTDINF
PMKGRKGMVDWARNSEDRVVIPKSIFTPVSSKELDESSVFVLGAVLYKNLDLILPTLRNY
TVINSKIIVVTIRPEPKTTDSFLEIELAHLANGTLNPYCVLWDDSKTNESLGTWSTQGCK
TVLTDASHTKCLCDRLSTFAILAQQPREIIMESSGTPSVTLIVGSGLSCLALITLAVVYA
ALWRYIRSERSIILINFCLSIISSNILILVGQTQTHNKSICTTTTAFLHFFFLASFCWVL
TEAWQSYMAVTGKIRTRLIRKRFLCLGWGLPALVVATSVGFTRTKGYGTDHYCWLSLEGG
LLYAFVGPAAAVVLVNMVIGILVFNKLVSRDGILDKKLKHRAGQMSEPHSGLTLKCAKCG
VVSTTALSATTASNAMASLWSSCVVLPLLALTWMSAVLAMTDKRSILFQILFAVFDSLQG
FVIVMVHCILRREVQDAFRCRLRNCQDPINADSSSSFPNGHAQIMTDFEKDVDIACRSVL
HKDIGPCRAATITGTLSRISLNDDEEEKGTNPEGLSYSTLPGNVISKVIIQQPTGLHMPM
SMNELSNPCLKKENSELRRTVYLCTDDNLRGADMDIVHPQERMMESDYIVMPRSSVNNQP
SMKEESKMNIGMETLPHERLLHYKVNPEFNMNPPVMDQFNMNLEQHLAPQEHMQNLPFEP
RTAVKNFMASELDDNAGLSRSETGSTISMSSLERRKSRYSDLDFEKVMHTRKRHMELFQE
LNQKFQTLDRFRDIPNTSSMENPAPNKNPWDTFKNPSEYPHYTTINVLDTEAKDALELRP
AEWEKCLNLPLDVQEGDFQTEV

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Format
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History
Entry version 166 (07 Nov 2018)
Sequence version 2 (02 Nov 2010)
Previous versions | rss
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Protein

Adhesion G protein-coupled receptor B3

Gene

ADGRB3

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Receptor that plays a role in the regulation of synaptogenesis and dendritic spine formation at least partly via interaction with ELMO1 and RAC1 activity (By similarity). Promotes myoblast fusion through ELMO/DOCK1 (PubMed:24567399).By similarity1 Publication

Miscellaneous

GO - Molecular functionⁱ

G protein-coupled receptor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
GTPase activator activity Source: UniProtKB

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

adenylate cyclase-activating G protein-coupled receptor signaling pathway
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
cell surface receptor signaling pathway Source: InterPro
G protein-coupled receptor signaling pathway
Source: GDB
Traceable author statementⁱ
- 15203201
maintenance of synapse structure Source: Ensembl
motor learning Source: Ensembl
myoblast fusion
Source: UniProtKB
Inferred from direct assayⁱ
- 24567399
negative regulation of angiogenesis Source: InterPro
neuron remodeling
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of synapse assembly Source: Ensembl
regulation of dendrite morphogenesis Source: UniProtKB

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	G-protein coupled receptor, Receptor, Transducer

Molecular function

G-protein coupled receptor, Receptor, Transducer

Protein family/group databases

MEROPS protease database More...MEROPSⁱ	P02.027

MEROPSⁱ

P02.027

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Adhesion G protein-coupled receptor B31 Publication Alternative name(s): Brain-specific angiogenesis inhibitor 3
Gene namesⁱ	Name:ADGRB3Imported Synonyms:BAI3, KIAA0550
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 6

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000135298.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:945 ADGRB3
MIMⁱ	602684 gene
neXtProtⁱ	NX_O60242

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	25 – 880	ExtracellularCuratedAdd BLAST	856
Transmembraneⁱ	881 – 901	Helical; Name=1Sequence analysisAdd BLAST	21
Topological domainⁱ	902 – 910	CytoplasmicCurated	9
Transmembraneⁱ	911 – 931	Helical; Name=2Sequence analysisAdd BLAST	21
Topological domainⁱ	932 – 939	ExtracellularCurated	8
Transmembraneⁱ	940 – 960	Helical; Name=3Sequence analysisAdd BLAST	21
Topological domainⁱ	961 – 981	CytoplasmicCuratedAdd BLAST	21
Transmembraneⁱ	982 – 1002	Helical; Name=4Sequence analysisAdd BLAST	21
Topological domainⁱ	1003 – 1023	ExtracellularCuratedAdd BLAST	21
Transmembraneⁱ	1024 – 1044	Helical; Name=5Sequence analysisAdd BLAST	21
Topological domainⁱ	1045 – 1098	CytoplasmicCuratedAdd BLAST	54
Transmembraneⁱ	1099 – 1119	Helical; Name=6Sequence analysisAdd BLAST	21
Topological domainⁱ	1120 – 1125	ExtracellularCurated	6
Transmembraneⁱ	1126 – 1146	Helical; Name=7Sequence analysisAdd BLAST	21
Topological domainⁱ	1147 – 1522	CytoplasmicCuratedAdd BLAST	376

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	577
Open Targets More...OpenTargetsⁱ	ENSG00000135298
PharmGKBⁱ	PA25249

Polymorphism and mutation databases

BioMutaⁱ	BAI3

BioMutaⁱ

BAI3

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 24	Sequence analysisAdd BLAST		24
ChainⁱPRO_0000012865	25 – 1522	Adhesion G protein-coupled receptor B3Add BLAST		1498

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	30 ↔ 55	PROSITE-ProRule annotation
Glycosylationⁱ	51	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	54	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	82	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	105	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	241	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	303 ↔ 336	PROSITE-ProRule annotation
Disulfide bondⁱ	307 ↔ 342	PROSITE-ProRule annotation
Disulfide bondⁱ	318 ↔ 326	PROSITE-ProRule annotation
Glycosylationⁱ	337	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	357 ↔ 392	PROSITE-ProRule annotation
Disulfide bondⁱ	361 ↔ 397	PROSITE-ProRule annotation
Disulfide bondⁱ	372 ↔ 382	PROSITE-ProRule annotation
Disulfide bondⁱ	412 ↔ 447	PROSITE-ProRule annotation
Disulfide bondⁱ	416 ↔ 452	PROSITE-ProRule annotation
Glycosylationⁱ	418	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	427 ↔ 437	PROSITE-ProRule annotation
Disulfide bondⁱ	467 ↔ 502	PROSITE-ProRule annotation
Disulfide bondⁱ	471 ↔ 507	PROSITE-ProRule annotation
Disulfide bondⁱ	482 ↔ 492	PROSITE-ProRule annotation
Disulfide bondⁱ	514 ↔ 549	1 Publication
Disulfide bondⁱ	537 ↔ 567	1 Publication
Glycosylationⁱ	540	N-linked (GlcNAc...) asparagine1 Publication	1
Modified residueⁱ	619	PhosphoserineCombined sources	1
Glycosylationⁱ	625	N-linked (GlcNAc...) asparagine1 Publication	1
Glycosylationⁱ	779	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	812	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	819 ↔ 851	1 Publication
Glycosylationⁱ	828	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	839 ↔ 853	1 Publication
Glycosylationⁱ	937	N-linked (GlcNAc...) asparagineSequence analysis	1
Modified residueⁱ	1220	PhosphoserineBy similarity	1
Modified residueⁱ	1411	PhosphoserineBy similarity	1

Post-translational modificationⁱ

The endogenous protein is proteolytically cleaved into 2 subunits, an extracellular subunit and a seven-transmembrane subunit.1 Publication

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbⁱ	O60242
PeptideAtlas More...PeptideAtlasⁱ	O60242
PRIDEⁱ	O60242
ProteomicsDBⁱ	49275

PTM databases

iPTMnetⁱ	O60242
PhosphoSitePlusⁱ	O60242

Expressionⁱ

Tissue specificityⁱ

Strongly expressed in brain. Also detected in heart. Reduced expression in some glioblastoma cell lines.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000135298 Expressed in 137 organ(s), highest expression level in middle temporal gyrus
CleanExⁱ	HS_BAI3
ExpressionAtlasⁱ	O60242 baseline and differential
Genevisibleⁱ	O60242 HS

Interactionⁱ

Subunit structureⁱ

Forms a heterodimer, consisting of a large extracellular region non-covalently linked to a seven-transmembrane moiety. Interacts (via TSP N-terminal domains) with C1QL1, C1QL2, C1QL3 and C1QL4 (PubMed:21262840). Interacts with ELMO1, ELMO2 AND ELMO3 (PubMed:24567399).2 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
C1ql3	Q9ESN4	4	EBI-2682765,EBI-15907894	From Mus musculus.
GPATCH11	Q8N954	3	EBI-2682765,EBI-2555378

Protein-protein interaction databases

BioGridⁱ	107053, 3 interactors
Database of interacting proteins More...DIPⁱ	DIP-56121N
IntActⁱ	O60242, 8 interactors
STRINGⁱ	9606.ENSP00000359630

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Turnⁱ	502 – 504	Combined sources	3
Turnⁱ	519 – 521	Combined sources	3
Beta strandⁱ	532 – 535	Combined sources	4
Beta strandⁱ	541 – 551	Combined sources	11
Beta strandⁱ	557 – 559	Combined sources	3
Beta strandⁱ	563 – 569	Combined sources	7
Helixⁱ	570 – 583	Combined sources	14
Helixⁱ	589 – 608	Combined sources	20
Helixⁱ	613 – 632	Combined sources	20
Helixⁱ	639 – 652	Combined sources	14
Helixⁱ	655 – 657	Combined sources	3
Helixⁱ	658 – 664	Combined sources	7
Turnⁱ	665 – 667	Combined sources	3
Helixⁱ	670 – 687	Combined sources	18
Beta strandⁱ	694 – 698	Combined sources	5
Beta strandⁱ	700 – 710	Combined sources	11
Beta strandⁱ	718 – 721	Combined sources	4
Helixⁱ	730 – 734	Combined sources	5
Beta strandⁱ	738 – 741	Combined sources	4
Helixⁱ	743 – 746	Combined sources	4
Beta strandⁱ	759 – 769	Combined sources	11
Helixⁱ	770 – 772	Combined sources	3
Beta strandⁱ	781 – 783	Combined sources	3
Beta strandⁱ	787 – 794	Combined sources	8
Beta strandⁱ	803 – 808	Combined sources	6
Beta strandⁱ	815 – 823	Combined sources	9
Beta strandⁱ	833 – 835	Combined sources	3
Beta strandⁱ	839 – 845	Combined sources	7
Beta strandⁱ	848 – 855	Combined sources	8
Beta strandⁱ	857 – 864	Combined sources	8

Show more details

3D structure databases

ProteinModelPortalⁱ	O60242
SMRⁱ	O60242
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	30 – 159	CUBPROSITE-ProRule annotationAdd BLAST	130
Domainⁱ	291 – 343	TSP type-1 1PROSITE-ProRule annotationAdd BLAST	53
Domainⁱ	345 – 398	TSP type-1 2PROSITE-ProRule annotationAdd BLAST	54
Domainⁱ	400 – 453	TSP type-1 3PROSITE-ProRule annotationAdd BLAST	54
Domainⁱ	455 – 508	TSP type-1 4PROSITE-ProRule annotationAdd BLAST	54
Domainⁱ	816 – 868	GPSPROSITE-ProRule annotationAdd BLAST	53

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	942 – 945	Poly-Thr		4
Compositional biasⁱ	1173 – 1176	Poly-Ser		4

Sequence similaritiesⁱ

Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.Curated

Keywords - Domainⁱ

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IEA0 Eukaryota ENOG4111FBM LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00930000150838
HOGENOMⁱ	HOG000230916
HOVERGENⁱ	HBG004813
InParanoidⁱ	O60242
KEGG Orthology (KO) More...KOⁱ	K04598
OMAⁱ	WERRIRT
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G00C7
PhylomeDBⁱ	O60242
TreeFamⁱ	TF331634

Family and domain databases

Gene3Dⁱ	2.20.100.10, 4 hits 4.10.1240.10, 1 hit
InterProⁱ	View protein in InterPro IPR000859 CUB_dom IPR032471 GAIN_dom_N IPR017981 GPCR_2-like IPR008077 GPCR_2_brain_angio_inhib IPR036445 GPCR_2_extracell_dom_sf IPR001879 GPCR_2_extracellular_dom IPR000832 GPCR_2_secretin-like IPR017983 GPCR_2_secretin-like_CS IPR000203 GPS IPR000884 TSP1_rpt IPR036383 TSP1_rpt_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00002 7tm_2, 1 hit PF16489 GAIN, 1 hit PF01825 GPS, 1 hit PF02793 HRM, 1 hit PF00090 TSP_1, 4 hits
PRINTSⁱ	PR01694 BAIPRECURSOR PR00249 GPCRSECRETIN
SMARTⁱ	View protein in SMART SM00303 GPS, 1 hit SM00008 HormR, 1 hit SM00209 TSP1, 4 hits
SUPFAMⁱ	SSF82895 SSF82895, 4 hits
PROSITEⁱ	View protein in PROSITE PS01180 CUB, 1 hit PS00650 G_PROTEIN_RECEP_F2_2, 1 hit PS50227 G_PROTEIN_RECEP_F2_3, 1 hit PS50261 G_PROTEIN_RECEP_F2_4, 1 hit PS50221 GPS, 1 hit PS50092 TSP1, 4 hits

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: O60242-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKAVRNLLIY IFSTYLLVMF GFNAAQDFWC STLVKGVIYG SYSVSEMFPK 
        60         70         80         90        100
NFTNCTWTLE NPDPTKYSIY LKFSKKDLSC SNFSLLAYQF DHFSHEKIKD 
       110        120        130        140        150
LLRKNHSIMQ LCNSKNAFVF LQYDKNFIQI RRVFPTNFPG LQKKGEEDQK 
       160        170        180        190        200
SFFEFLVLNK VSPSQFGCHV LCTWLESCLK SENGRTESCG IMYTKCTCPQ 
       210        220        230        240        250
HLGEWGIDDQ SLILLNNVVL PLNEQTEGCL TQELQTTQVC NLTREAKRPP 
       260        270        280        290        300
KEEFGMMGDH TIKSQRPRSV HEKRVPQEQA DAAKFMAQTG ESGVEEWSQW 
       310        320        330        340        350
STCSVTCGQG SQVRTRTCVS PYGTHCSGPL RESRVCNNTA LCPVHGVWEE 
       360        370        380        390        400
WSPWSLCSFT CGRGQRTRTR SCTPPQYGGR PCEGPETHHK PCNIALCPVD 
       410        420        430        440        450
GQWQEWSSWS QCSVTCSNGT QQRSRQCTAA AHGGSECRGP WAESRECYNP 
       460        470        480        490        500
ECTANGQWNQ WGHWSGCSKS CDGGWERRIR TCQGAVITGQ QCEGTGEEVR 
       510        520        530        540        550
RCNEQRCPAP YEICPEDYLM SMVWKRTPAG DLAFNQCPLN ATGTTSRRCS 
       560        570        580        590        600
LSLHGVAFWE QPSFARCISN EYRHLQHSIK EHLAKGQRML AGDGMSQVTK 
       610        620        630        640        650
TLLDLTQRKN FYAGDLLMSV EILRNVTDTF KRASYIPASD GVQNFFQIVS 
       660        670        680        690        700
NLLDEENKEK WEDAQQIYPG SIELMQVIED FIHIVGMGMM DFQNSYLMTG 
       710        720        730        740        750
NVVASIQKLP AASVLTDINF PMKGRKGMVD WARNSEDRVV IPKSIFTPVS 
       760        770        780        790        800
SKELDESSVF VLGAVLYKNL DLILPTLRNY TVINSKIIVV TIRPEPKTTD 
       810        820        830        840        850
SFLEIELAHL ANGTLNPYCV LWDDSKTNES LGTWSTQGCK TVLTDASHTK 
       860        870        880        890        900
CLCDRLSTFA ILAQQPREII MESSGTPSVT LIVGSGLSCL ALITLAVVYA 
       910        920        930        940        950
ALWRYIRSER SIILINFCLS IISSNILILV GQTQTHNKSI CTTTTAFLHF 
       960        970        980        990       1000
FFLASFCWVL TEAWQSYMAV TGKIRTRLIR KRFLCLGWGL PALVVATSVG 
      1010       1020       1030       1040       1050
FTRTKGYGTD HYCWLSLEGG LLYAFVGPAA AVVLVNMVIG ILVFNKLVSR 
      1060       1070       1080       1090       1100
DGILDKKLKH RAGQMSEPHS GLTLKCAKCG VVSTTALSAT TASNAMASLW 
      1110       1120       1130       1140       1150
SSCVVLPLLA LTWMSAVLAM TDKRSILFQI LFAVFDSLQG FVIVMVHCIL 
      1160       1170       1180       1190       1200
RREVQDAFRC RLRNCQDPIN ADSSSSFPNG HAQIMTDFEK DVDIACRSVL 
      1210       1220       1230       1240       1250
HKDIGPCRAA TITGTLSRIS LNDDEEEKGT NPEGLSYSTL PGNVISKVII 
      1260       1270       1280       1290       1300
QQPTGLHMPM SMNELSNPCL KKENSELRRT VYLCTDDNLR GADMDIVHPQ 
      1310       1320       1330       1340       1350
ERMMESDYIV MPRSSVNNQP SMKEESKMNI GMETLPHERL LHYKVNPEFN 
      1360       1370       1380       1390       1400
MNPPVMDQFN MNLEQHLAPQ EHMQNLPFEP RTAVKNFMAS ELDDNAGLSR 
      1410       1420       1430       1440       1450
SETGSTISMS SLERRKSRYS DLDFEKVMHT RKRHMELFQE LNQKFQTLDR 
      1460       1470       1480       1490       1500
FRDIPNTSSM ENPAPNKNPW DTFKNPSEYP HYTTINVLDT EAKDALELRP 
      1510       1520 
AEWEKCLNLP LDVQEGDFQT EV

Length:1,522

Mass (Da):171,518

Last modified:November 2, 2010 - v2

Checksum:ⁱD22D0A5CF59E811F

Isoform 2 (identifier: O60242-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-1036: Missing.

« Hide

        10         20         30         40         50
MVIGILVFNK LVSRDGILDK KLKHRAGQMS EPHSGLTLKC AKCGVVSTTA 
        60         70         80         90        100
LSATTASNAM ASLWSSCVVL PLLALTWMSA VLAMTDKRSI LFQILFAVFD 
       110        120        130        140        150
SLQGFVIVMV HCILRREVQD AFRCRLRNCQ DPINADSSSS FPNGHAQIMT 
       160        170        180        190        200
DFEKDVDIAC RSVLHKDIGP CRAATITGTL SRISLNDDEE EKGTNPEGLS 
       210        220        230        240        250
YSTLPGNVIS KVIIQQPTGL HMPMSMNELS NPCLKKENSE LRRTVYLCTD 
       260        270        280        290        300
DNLRGADMDI VHPQERMMES DYIVMPRSSV NNQPSMKEES KMNIGMETLP 
       310        320        330        340        350
HERLLHYKVN PEFNMNPPVM DQFNMNLEQH LAPQEHMQNL PFEPRTAVKN 
       360        370        380        390        400
FMASELDDNA GLSRSETGST ISMSSLERRK SRYSDLDFEK VMHTRKRHME 
       410        420        430        440        450
LFQELNQKFQ TLDRFRDIPN TSSMENPAPN KNPWDTFKNP SEYPHYTTIN 
       460        470        480 
VLDTEAKDAL ELRPAEWEKC LNLPLDVQEG DFQTEV

Note: No experimental confirmation available.

Show »

Length:486

Mass (Da):55,035

Checksum:ⁱ361BC76A2B85A843

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

J3KMY8	J3KMY8_HUMAN	Adhesion G protein-coupled receptor... Adhesion G protein-coupled receptor B3	ADGRB3	728	Annotation score:
S4R307	S4R307_HUMAN	Adhesion G protein-coupled receptor... Adhesion G protein-coupled receptor B3	ADGRB3	145	Annotation score:
S4R3D0	S4R3D0_HUMAN	Adhesion G protein-coupled receptor... Adhesion G protein-coupled receptor B3	ADGRB3	68	Annotation score:

Sequence cautionⁱ

The sequence BAA25476 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_046525	503	N → S3 PublicationsCorresponds to variant dbSNP:rs1932618Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_056939	1 – 1036	Missing in isoform 2. 1 PublicationAdd BLAST		1036

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB005299 mRNA Translation: BAA25363.1 AB011122 mRNA Translation: BAA25476.2 Different initiation. AK293560 mRNA Translation: BAH11536.1 AL035469 Genomic DNA No translation available. AL078598 Genomic DNA No translation available. AL589875 Genomic DNA No translation available. AL133378 Genomic DNA No translation available. AL158051 Genomic DNA No translation available. AL160401 Genomic DNA No translation available. AL356117 Genomic DNA No translation available. AL359714 Genomic DNA No translation available. AL391807 Genomic DNA No translation available. CH471051 Genomic DNA Translation: EAW48837.1 BC111720 mRNA Translation: AAI11721.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS4968.1 [O60242-1]
PIRⁱ	T00028 T00326
NCBI Reference Sequences More...RefSeqⁱ	NP_001695.1, NM_001704.2 XP_005248809.1, XM_005248752.2 [O60242-1]
UniGeneⁱ	Hs.13261

Genome annotation databases

Ensemblⁱ	ENST00000370598; ENSP00000359630; ENSG00000135298 [O60242-1] ENST00000546190; ENSP00000441821; ENSG00000135298 [O60242-1]
GeneIDⁱ	577
KEGGⁱ	hsa:577
UCSC genome browser More...UCSCⁱ	uc003pev.5 human [O60242-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O60242	Isoform 2 of Adhesion G protein-coupled receptor B3		HUMAN		486	UniRef100_O60242
Uncharacterized protein		CERAT		652
Uncharacterized protein		PAPAN		652
UPI0005D01F6A		HUMAN		1267
UPI000D0C8187		HUMAN		1003
+2

Protein	Similar proteins		Species	Score	Length	Source
O60242	Isoform 2 of Adhesion G protein-coupled receptor B3		HUMAN		486	UniRef90_O60242
Uncharacterized protein		CERAT		652
Uncharacterized protein		PAPAN		652
Uncharacterized protein		FICAL		1526
Brain-specific angiogenesis inhibitor 3		CALJA		1522
+178

Protein	Similar proteins		Species	Score	Length	Source
O60242	Adhesion G protein-coupled receptor B3		MOUSE		1522	UniRef50_O60242
Isoform 2 of Adhesion G protein-coupled receptor B3		HUMAN		486
Uncharacterized protein		CERAT		652
Uncharacterized protein		PAPAN		652
Uncharacterized protein		FICAL		1526
+404

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB005299 mRNA Translation: BAA25363.1 AB011122 mRNA Translation: BAA25476.2 Different initiation. AK293560 mRNA Translation: BAH11536.1 AL035469 Genomic DNA No translation available. AL078598 Genomic DNA No translation available. AL589875 Genomic DNA No translation available. AL133378 Genomic DNA No translation available. AL158051 Genomic DNA No translation available. AL160401 Genomic DNA No translation available. AL356117 Genomic DNA No translation available. AL359714 Genomic DNA No translation available. AL391807 Genomic DNA No translation available. CH471051 Genomic DNA Translation: EAW48837.1 BC111720 mRNA Translation: AAI11721.1
CCDSⁱ	CCDS4968.1 [O60242-1]
PIRⁱ	T00028 T00326
RefSeqⁱ	NP_001695.1, NM_001704.2 XP_005248809.1, XM_005248752.2 [O60242-1]
UniGeneⁱ	Hs.13261

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	4DLO	X-ray	2.30	A/B	498-868	[»]
ProteinModelPortalⁱ	O60242
SMRⁱ	O60242
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	107053, 3 interactors
DIPⁱ	DIP-56121N
IntActⁱ	O60242, 8 interactors
STRINGⁱ	9606.ENSP00000359630

Protein family/group databases

MEROPSⁱ	P02.027
GPCRDBⁱ	Search...

PTM databases

iPTMnetⁱ	O60242
PhosphoSitePlusⁱ	O60242

Polymorphism and mutation databases

BioMutaⁱ	BAI3

BioMutaⁱ

BAI3

Proteomic databases

PaxDbⁱ	O60242
PeptideAtlasⁱ	O60242
PRIDEⁱ	O60242
ProteomicsDBⁱ	49275

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000370598; ENSP00000359630; ENSG00000135298 [O60242-1] ENST00000546190; ENSP00000441821; ENSG00000135298 [O60242-1]
GeneIDⁱ	577
KEGGⁱ	hsa:577
UCSCⁱ	uc003pev.5 human [O60242-1]

Organism-specific databases

CTDⁱ	577
DisGeNETⁱ	577
EuPathDBⁱ	HostDB:ENSG00000135298.13
GeneCardsⁱ	ADGRB3
HGNCⁱ	HGNC:945 ADGRB3
MIMⁱ	602684 gene
neXtProtⁱ	NX_O60242
OpenTargetsⁱ	ENSG00000135298
PharmGKBⁱ	PA25249
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IEA0 Eukaryota ENOG4111FBM LUCA
GeneTreeⁱ	ENSGT00930000150838
HOGENOMⁱ	HOG000230916
HOVERGENⁱ	HBG004813
InParanoidⁱ	O60242
KOⁱ	K04598
OMAⁱ	WERRIRT
OrthoDBⁱ	EOG091G00C7
PhylomeDBⁱ	O60242
TreeFamⁱ	TF331634

Miscellaneous databases

ChiTaRSⁱ	ADGRB3 human
GeneWikiⁱ	Brain-specific_angiogenesis_inhibitor_3
GenomeRNAiⁱ	577
Protein Ontology More...PROⁱ	PR:O60242
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000135298 Expressed in 137 organ(s), highest expression level in middle temporal gyrus
CleanExⁱ	HS_BAI3
ExpressionAtlasⁱ	O60242 baseline and differential
Genevisibleⁱ	O60242 HS

Family and domain databases

Gene3Dⁱ	2.20.100.10, 4 hits 4.10.1240.10, 1 hit
InterProⁱ	View protein in InterPro IPR000859 CUB_dom IPR032471 GAIN_dom_N IPR017981 GPCR_2-like IPR008077 GPCR_2_brain_angio_inhib IPR036445 GPCR_2_extracell_dom_sf IPR001879 GPCR_2_extracellular_dom IPR000832 GPCR_2_secretin-like IPR017983 GPCR_2_secretin-like_CS IPR000203 GPS IPR000884 TSP1_rpt IPR036383 TSP1_rpt_sf
Pfamⁱ	View protein in Pfam PF00002 7tm_2, 1 hit PF16489 GAIN, 1 hit PF01825 GPS, 1 hit PF02793 HRM, 1 hit PF00090 TSP_1, 4 hits
PRINTSⁱ	PR01694 BAIPRECURSOR PR00249 GPCRSECRETIN
SMARTⁱ	View protein in SMART SM00303 GPS, 1 hit SM00008 HormR, 1 hit SM00209 TSP1, 4 hits
SUPFAMⁱ	SSF82895 SSF82895, 4 hits
PROSITEⁱ	View protein in PROSITE PS01180 CUB, 1 hit PS00650 G_PROTEIN_RECEP_F2_2, 1 hit PS50227 G_PROTEIN_RECEP_F2_3, 1 hit PS50261 G_PROTEIN_RECEP_F2_4, 1 hit PS50221 GPS, 1 hit PS50092 TSP1, 4 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	AGRB3_HUMAN
Accessionⁱ	O60242Primary (citable) accession number: O60242 Secondary accession number(s): B7Z1K0 , O60297, Q2NKN6, Q5VY37, Q9BX54
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
	Last sequence update:	November 2, 2010
	Last modified:	November 7, 2018
	This is version 166 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM
7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries

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UniProtKB - O60242 (AGRB3_HUMAN)

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Adhesion G protein-coupled receptor B3

ADGRB3

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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GO - Molecular functionⁱ

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Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

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Keywords - PTMⁱ

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Keywords - Domainⁱ

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Keywords - Coding sequence diversityⁱ

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Keywords - Technical termⁱ