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UniProtKB - O60242 (AGRB3_HUMAN)

Entry version 187 (23 Feb 2022)
Sequence version 2 (02 Nov 2010)
Previous versions | rss
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Protein

Adhesion G protein-coupled receptor B3

Gene

ADGRB3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor that plays a role in the regulation of synaptogenesis and dendritic spine formation at least partly via interaction with ELMO1 and RAC1 activity (By similarity).

Promotes myoblast fusion through ELMO/DOCK1 (PubMed:24567399).

By similarity1 Publication

Miscellaneous

Autoproteolysis appears to be cell specific, does not readily undergo proteolytic cleavage in HEK293T cells.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		O60242

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		O60242

Protein family/group databases

MEROPS protease database

More...MEROPSi		P02.027

Transport Classification Database

More...TCDBi		9.A.14.6.7, the g-protein-coupled receptor (gpcr) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Adhesion G protein-coupled receptor B31 Publication
Alternative name(s):
Brain-specific angiogenesis inhibitor 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ADGRB3Imported
Synonyms:BAI3, KIAA0550
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:945, ADGRB3

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		602684, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O60242

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000135298

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini25 – 880ExtracellularCuratedAdd BLAST856
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei881 – 901Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini902 – 910CytoplasmicCurated9
Transmembranei911 – 931Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini932 – 939ExtracellularCurated8
Transmembranei940 – 960Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini961 – 981CytoplasmicCuratedAdd BLAST21
Transmembranei982 – 1002Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini1003 – 1023ExtracellularCuratedAdd BLAST21
Transmembranei1024 – 1044Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini1045 – 1098CytoplasmicCuratedAdd BLAST54
Transmembranei1099 – 1119Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini1120 – 1125ExtracellularCurated6
Transmembranei1126 – 1146Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini1147 – 1522CytoplasmicCuratedAdd BLAST376

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		577

Open Targets

More...OpenTargetsi		ENSG00000135298

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA25249

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O60242, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ADGRB3

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 24Sequence analysisAdd BLAST24
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001286525 – 1522Adhesion G protein-coupled receptor B3Add BLAST1498

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi30 ↔ 55PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi51N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi54N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi82N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi105N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi241N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi303 ↔ 336PROSITE-ProRule annotation
Disulfide bondi307 ↔ 342PROSITE-ProRule annotation
Disulfide bondi318 ↔ 326PROSITE-ProRule annotation
Glycosylationi337N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi357 ↔ 392PROSITE-ProRule annotation
Disulfide bondi361 ↔ 397PROSITE-ProRule annotation
Disulfide bondi372 ↔ 382PROSITE-ProRule annotation
Disulfide bondi412 ↔ 447PROSITE-ProRule annotation
Disulfide bondi416 ↔ 452PROSITE-ProRule annotation
Glycosylationi418N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi427 ↔ 437PROSITE-ProRule annotation
Disulfide bondi467 ↔ 502PROSITE-ProRule annotation
Disulfide bondi471 ↔ 507PROSITE-ProRule annotation
Disulfide bondi482 ↔ 492PROSITE-ProRule annotation
Disulfide bondi514 ↔ 5491 Publication
Disulfide bondi537 ↔ 5671 Publication
Glycosylationi540N-linked (GlcNAc...) asparagine1 Publication1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei619PhosphoserineCombined sources1
Glycosylationi625N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi779N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi812N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi819 ↔ 8511 Publication
Glycosylationi828N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi839 ↔ 8531 Publication
Glycosylationi937N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei1220PhosphoserineBy similarity1
Modified residuei1411PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

The endogenous protein is proteolytically cleaved into 2 subunits, an extracellular subunit and a seven-transmembrane subunit.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O60242

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O60242

PeptideAtlas

More...PeptideAtlasi		O60242

PRoteomics IDEntifications database

More...PRIDEi		O60242

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		49275 [O60242-1]
6341

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		2016, 1 N-Linked glycan (1 site)

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		O60242, 14 sites, 2 N-linked glycans (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O60242

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O60242

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Strongly expressed in brain. Also detected in heart. Reduced expression in some glioblastoma cell lines.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000135298, Expressed in middle temporal gyrus and 156 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O60242, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O60242, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000135298, Group enriched (brain, pituitary gland)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms a heterodimer, consisting of a large extracellular region non-covalently linked to a seven-transmembrane moiety.

Interacts (via TSP N-terminal domains) with C1QL1, C1QL2, C1QL3 and C1QL4 (PubMed:21262840).

Interacts with ELMO1, ELMO2 AND ELMO3 (PubMed:24567399).

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		107053, 11 interactors

Database of interacting proteins

More...DIPi		DIP-56121N

Protein interaction database and analysis system

More...IntActi		O60242, 10 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000359630

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O60242, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11522
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O60242

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini30 – 159CUBPROSITE-ProRule annotationAdd BLAST130
Domaini291 – 343TSP type-1 1PROSITE-ProRule annotationAdd BLAST53
Domaini345 – 398TSP type-1 2PROSITE-ProRule annotationAdd BLAST54
Domaini400 – 453TSP type-1 3PROSITE-ProRule annotationAdd BLAST54
Domaini455 – 508TSP type-1 4PROSITE-ProRule annotationAdd BLAST54
Domaini816 – 868GPSPROSITE-ProRule annotationAdd BLAST53

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QRKJ, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155081

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_003751_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O60242

Identification of Orthologs from Complete Genome Data

More...OMAi		DIACRSX

Database of Orthologous Groups

More...OrthoDBi		27621at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O60242

TreeFam database of animal gene trees

More...TreeFami		TF331634

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.20.100.10, 4 hits
4.10.1240.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR043838, AGRB_N
IPR000859, CUB_dom
IPR032471, GAIN_dom_N
IPR017981, GPCR_2-like
IPR008077, GPCR_2_brain_angio_inhib
IPR036445, GPCR_2_extracell_dom_sf
IPR001879, GPCR_2_extracellular_dom
IPR000832, GPCR_2_secretin-like
IPR017983, GPCR_2_secretin-like_CS
IPR000203, GPS
IPR000884, TSP1_rpt
IPR036383, TSP1_rpt_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00002, 7tm_2, 1 hit
PF19188, AGRB_N, 1 hit
PF16489, GAIN, 1 hit
PF01825, GPS, 1 hit
PF02793, HRM, 1 hit
PF00090, TSP_1, 4 hits

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01694, BAIPRECURSOR
PR00249, GPCRSECRETIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00303, GPS, 1 hit
SM00008, HormR, 1 hit
SM00209, TSP1, 4 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF82895, SSF82895, 4 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS01180, CUB, 1 hit
PS00650, G_PROTEIN_RECEP_F2_2, 1 hit
PS50227, G_PROTEIN_RECEP_F2_3, 1 hit
PS50261, G_PROTEIN_RECEP_F2_4, 1 hit
PS50221, GPS, 1 hit
PS50092, TSP1, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O60242-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKAVRNLLIY IFSTYLLVMF GFNAAQDFWC STLVKGVIYG SYSVSEMFPK 
        60         70         80         90        100
NFTNCTWTLE NPDPTKYSIY LKFSKKDLSC SNFSLLAYQF DHFSHEKIKD 
       110        120        130        140        150
LLRKNHSIMQ LCNSKNAFVF LQYDKNFIQI RRVFPTNFPG LQKKGEEDQK 
       160        170        180        190        200
SFFEFLVLNK VSPSQFGCHV LCTWLESCLK SENGRTESCG IMYTKCTCPQ 
       210        220        230        240        250
HLGEWGIDDQ SLILLNNVVL PLNEQTEGCL TQELQTTQVC NLTREAKRPP 
       260        270        280        290        300
KEEFGMMGDH TIKSQRPRSV HEKRVPQEQA DAAKFMAQTG ESGVEEWSQW 
       310        320        330        340        350
STCSVTCGQG SQVRTRTCVS PYGTHCSGPL RESRVCNNTA LCPVHGVWEE 
       360        370        380        390        400
WSPWSLCSFT CGRGQRTRTR SCTPPQYGGR PCEGPETHHK PCNIALCPVD 
       410        420        430        440        450
GQWQEWSSWS QCSVTCSNGT QQRSRQCTAA AHGGSECRGP WAESRECYNP 
       460        470        480        490        500
ECTANGQWNQ WGHWSGCSKS CDGGWERRIR TCQGAVITGQ QCEGTGEEVR 
       510        520        530        540        550
RCNEQRCPAP YEICPEDYLM SMVWKRTPAG DLAFNQCPLN ATGTTSRRCS 
       560        570        580        590        600
LSLHGVAFWE QPSFARCISN EYRHLQHSIK EHLAKGQRML AGDGMSQVTK 
       610        620        630        640        650
TLLDLTQRKN FYAGDLLMSV EILRNVTDTF KRASYIPASD GVQNFFQIVS 
       660        670        680        690        700
NLLDEENKEK WEDAQQIYPG SIELMQVIED FIHIVGMGMM DFQNSYLMTG 
       710        720        730        740        750
NVVASIQKLP AASVLTDINF PMKGRKGMVD WARNSEDRVV IPKSIFTPVS 
       760        770        780        790        800
SKELDESSVF VLGAVLYKNL DLILPTLRNY TVINSKIIVV TIRPEPKTTD 
       810        820        830        840        850
SFLEIELAHL ANGTLNPYCV LWDDSKTNES LGTWSTQGCK TVLTDASHTK 
       860        870        880        890        900
CLCDRLSTFA ILAQQPREII MESSGTPSVT LIVGSGLSCL ALITLAVVYA 
       910        920        930        940        950
ALWRYIRSER SIILINFCLS IISSNILILV GQTQTHNKSI CTTTTAFLHF 
       960        970        980        990       1000
FFLASFCWVL TEAWQSYMAV TGKIRTRLIR KRFLCLGWGL PALVVATSVG 
      1010       1020       1030       1040       1050
FTRTKGYGTD HYCWLSLEGG LLYAFVGPAA AVVLVNMVIG ILVFNKLVSR 
      1060       1070       1080       1090       1100
DGILDKKLKH RAGQMSEPHS GLTLKCAKCG VVSTTALSAT TASNAMASLW 
      1110       1120       1130       1140       1150
SSCVVLPLLA LTWMSAVLAM TDKRSILFQI LFAVFDSLQG FVIVMVHCIL 
      1160       1170       1180       1190       1200
RREVQDAFRC RLRNCQDPIN ADSSSSFPNG HAQIMTDFEK DVDIACRSVL 
      1210       1220       1230       1240       1250
HKDIGPCRAA TITGTLSRIS LNDDEEEKGT NPEGLSYSTL PGNVISKVII 
      1260       1270       1280       1290       1300
QQPTGLHMPM SMNELSNPCL KKENSELRRT VYLCTDDNLR GADMDIVHPQ 
      1310       1320       1330       1340       1350
ERMMESDYIV MPRSSVNNQP SMKEESKMNI GMETLPHERL LHYKVNPEFN 
      1360       1370       1380       1390       1400
MNPPVMDQFN MNLEQHLAPQ EHMQNLPFEP RTAVKNFMAS ELDDNAGLSR 
      1410       1420       1430       1440       1450
SETGSTISMS SLERRKSRYS DLDFEKVMHT RKRHMELFQE LNQKFQTLDR 
      1460       1470       1480       1490       1500
FRDIPNTSSM ENPAPNKNPW DTFKNPSEYP HYTTINVLDT EAKDALELRP 
      1510       1520 
AEWEKCLNLP LDVQEGDFQT EV
Length:1,522
Mass (Da):171,518
Last modified:November 2, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD22D0A5CF59E811F
GO
Isoform 2 (identifier: O60242-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1036: Missing.

Show »
Length:486
Mass (Da):55,035
Checksum:i361BC76A2B85A843
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KMY8J3KMY8_HUMAN
Adhesion G protein-coupled receptor...
ADGRB3
728Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R307S4R307_HUMAN
Adhesion G protein-coupled receptor...
ADGRB3
145Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R3D0S4R3D0_HUMAN
Adhesion G protein-coupled receptor...
ADGRB3
68Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A804HJR2A0A804HJR2_HUMAN
Adhesion G protein-coupled receptor...
ADGRB3
1,063Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA25476 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_046525503N → S3 PublicationsCorresponds to variant dbSNP:rs1932618Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0569391 – 1036Missing in isoform 2. 1 PublicationAdd BLAST1036

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB005299 mRNA Translation: BAA25363.1
AB011122 mRNA Translation: BAA25476.2 Different initiation.
AK293560 mRNA Translation: BAH11536.1
AL035469 Genomic DNA No translation available.
AL078598 Genomic DNA No translation available.
AL589875 Genomic DNA No translation available.
AL133378 Genomic DNA No translation available.
AL158051 Genomic DNA No translation available.
AL160401 Genomic DNA No translation available.
AL356117 Genomic DNA No translation available.
AL359714 Genomic DNA No translation available.
AL391807 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48837.1
BC111720 mRNA Translation: AAI11721.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS4968.1 [O60242-1]

Protein sequence database of the Protein Information Resource

More...PIRi		T00028
T00326

NCBI Reference Sequences

More...RefSeqi		NP_001695.1, NM_001704.2 [O60242-1]
XP_005248809.1, XM_005248752.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000370598; ENSP00000359630; ENSG00000135298
ENST00000546190; ENSP00000441821; ENSG00000135298

Database of genes from NCBI RefSeq genomes

More...GeneIDi		577

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:577

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000370598.6; ENSP00000359630.1; NM_001704.3; NP_001695.2

UCSC genome browser

More...UCSCi		uc003pev.5, human [O60242-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB005299 mRNA Translation: BAA25363.1
AB011122 mRNA Translation: BAA25476.2 Different initiation.
AK293560 mRNA Translation: BAH11536.1
AL035469 Genomic DNA No translation available.
AL078598 Genomic DNA No translation available.
AL589875 Genomic DNA No translation available.
AL133378 Genomic DNA No translation available.
AL158051 Genomic DNA No translation available.
AL160401 Genomic DNA No translation available.
AL356117 Genomic DNA No translation available.
AL359714 Genomic DNA No translation available.
AL391807 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48837.1
BC111720 mRNA Translation: AAI11721.1
CCDSiCCDS4968.1 [O60242-1]
PIRiT00028
T00326
RefSeqiNP_001695.1, NM_001704.2 [O60242-1]
XP_005248809.1, XM_005248752.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4DLOX-ray2.30A/B498-868[»]
SMRiO60242
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi107053, 11 interactors
DIPiDIP-56121N
IntActiO60242, 10 interactors
STRINGi9606.ENSP00000359630

Protein family/group databases

MEROPSiP02.027
TCDBi9.A.14.6.7, the g-protein-coupled receptor (gpcr) family

Information system for G protein-coupled receptors (GPCRs)

More...GPCRDBi		Search...

PTM databases

GlyConnecti2016, 1 N-Linked glycan (1 site)
GlyGeniO60242, 14 sites, 2 N-linked glycans (1 site)
iPTMnetiO60242
PhosphoSitePlusiO60242

Genetic variation databases

BioMutaiADGRB3

Proteomic databases

MassIVEiO60242
PaxDbiO60242
PeptideAtlasiO60242
PRIDEiO60242
ProteomicsDBi49275 [O60242-1]
6341

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		2938, 239 antibodies from 32 providers

The DNASU plasmid repository

More...DNASUi		577

Genome annotation databases

EnsembliENST00000370598; ENSP00000359630; ENSG00000135298
ENST00000546190; ENSP00000441821; ENSG00000135298
GeneIDi577
KEGGihsa:577
MANE-SelectiENST00000370598.6; ENSP00000359630.1; NM_001704.3; NP_001695.2
UCSCiuc003pev.5, human [O60242-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		577
DisGeNETi577

GeneCards: human genes, protein and diseases

More...GeneCardsi		ADGRB3
HGNCiHGNC:945, ADGRB3
HPAiENSG00000135298, Group enriched (brain, pituitary gland)
MIMi602684, gene
neXtProtiNX_O60242
OpenTargetsiENSG00000135298
PharmGKBiPA25249
VEuPathDBiHostDB:ENSG00000135298

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QRKJ, Eukaryota
GeneTreeiENSGT00940000155081
HOGENOMiCLU_003751_1_0_1
InParanoidiO60242
OMAiDIACRSX
OrthoDBi27621at2759
PhylomeDBiO60242
TreeFamiTF331634

Enzyme and pathway databases

PathwayCommonsiO60242
SignaLinkiO60242

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		577, 7 hits in 1040 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ADGRB3, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Brain-specific_angiogenesis_inhibitor_3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		577
PharosiO60242, Tbio

Protein Ontology

More...PROi		PR:O60242
RNActiO60242, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000135298, Expressed in middle temporal gyrus and 156 other tissues
ExpressionAtlasiO60242, baseline and differential
GenevisibleiO60242, HS

Family and domain databases

Gene3Di2.20.100.10, 4 hits
4.10.1240.10, 1 hit
InterProiView protein in InterPro
IPR043838, AGRB_N
IPR000859, CUB_dom
IPR032471, GAIN_dom_N
IPR017981, GPCR_2-like
IPR008077, GPCR_2_brain_angio_inhib
IPR036445, GPCR_2_extracell_dom_sf
IPR001879, GPCR_2_extracellular_dom
IPR000832, GPCR_2_secretin-like
IPR017983, GPCR_2_secretin-like_CS
IPR000203, GPS
IPR000884, TSP1_rpt
IPR036383, TSP1_rpt_sf
PfamiView protein in Pfam
PF00002, 7tm_2, 1 hit
PF19188, AGRB_N, 1 hit
PF16489, GAIN, 1 hit
PF01825, GPS, 1 hit
PF02793, HRM, 1 hit
PF00090, TSP_1, 4 hits
PRINTSiPR01694, BAIPRECURSOR
PR00249, GPCRSECRETIN
SMARTiView protein in SMART
SM00303, GPS, 1 hit
SM00008, HormR, 1 hit
SM00209, TSP1, 4 hits
SUPFAMiSSF82895, SSF82895, 4 hits
PROSITEiView protein in PROSITE
PS01180, CUB, 1 hit
PS00650, G_PROTEIN_RECEP_F2_2, 1 hit
PS50227, G_PROTEIN_RECEP_F2_3, 1 hit
PS50261, G_PROTEIN_RECEP_F2_4, 1 hit
PS50221, GPS, 1 hit
PS50092, TSP1, 4 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAGRB3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O60242
Secondary accession number(s): B7Z1K0
, O60297, Q2NKN6, Q5VY37, Q9BX54
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 2, 2010
Last modified: February 23, 2022
This is version 187 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  3. Human entries with genetic variants
    List of human entries with genetic variants
  4. Human variants curated from literature reports
    Index of human variants curated from literature reports
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families
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