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UniProtKB - O60241 (AGRB2_HUMAN)

Entry version 194 (23 Feb 2022)
Sequence version 2 (05 May 2009)
Previous versions | rss
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Protein

Adhesion G protein-coupled receptor B2

Gene

ADGRB2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Orphan G-protein coupled receptor involved in cell adhesion and probably in cell-cell interactions. Activates NFAT-signaling pathway, a transcription factor, via the G-protein GNAZ (PubMed:20367554, PubMed:28891236).

Involved in angiogenesis inhibition (By similarity).

By similarity2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Receptor activity is regulated by proteolytic processing. The long N-terminal has a an inhibitory effect on the constitutive signaling activity. Removal of the N-terminal region induces an increase of the receptor activity.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • G protein-coupled receptor activity Source: UniProtKB
Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		O60241

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		O60241

Protein family/group databases

MEROPS protease database

More...MEROPSi		P02.029

Transport Classification Database

More...TCDBi		9.A.14.6.6, the g-protein-coupled receptor (gpcr) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Adhesion G protein-coupled receptor B21 Publication
Alternative name(s):
Brain-specific angiogenesis inhibitor 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ADGRB2Imported
Synonyms:BAI2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:944, ADGRB2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		602683, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O60241

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000121753

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini33 – 936ExtracellularCuratedAdd BLAST904
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei937 – 957Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini958 – 965CytoplasmicCurated8
Transmembranei966 – 986Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini987 – 994ExtracellularCurated8
Transmembranei995 – 1015Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini1016 – 1036CytoplasmicCuratedAdd BLAST21
Transmembranei1037 – 1057Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini1058 – 1078ExtracellularCuratedAdd BLAST21
Transmembranei1079 – 1099Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini1100 – 1121CytoplasmicCuratedAdd BLAST22
Transmembranei1122 – 1142Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini1143 – 1153ExtracellularCuratedAdd BLAST11
Transmembranei1154 – 1174Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini1175 – 1585CytoplasmicCuratedAdd BLAST411

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi889W → S: Inhibits autoproteolytic cleavage. 1 Publication1
Mutagenesisi908C → W: Inhibits autoproteolytic cleavage. 1 Publication1
Mutagenesisi912S → P: Inhibits autoproteolytic cleavage. 1 Publication1

Keywords - Diseasei

Disease variant

Organism-specific databases

DisGeNET

More...DisGeNETi		576

Open Targets

More...OpenTargetsi		ENSG00000121753

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA25248

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O60241, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ADGRB2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 32Sequence analysisAdd BLAST32
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001286433 – 1585Adhesion G protein-coupled receptor B2Add BLAST1553

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi106N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi191N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi192N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi321 ↔ 355PROSITE-ProRule annotation
Disulfide bondi325 ↔ 361PROSITE-ProRule annotation
Disulfide bondi336 ↔ 345PROSITE-ProRule annotation
Glycosylationi356N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi376 ↔ 411PROSITE-ProRule annotation
Disulfide bondi380 ↔ 416PROSITE-ProRule annotation
Disulfide bondi391 ↔ 401PROSITE-ProRule annotation
Disulfide bondi431 ↔ 466PROSITE-ProRule annotation
Disulfide bondi435 ↔ 471PROSITE-ProRule annotation
Glycosylationi437N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi446 ↔ 456PROSITE-ProRule annotation
Disulfide bondi487 ↔ 522PROSITE-ProRule annotation
Disulfide bondi491 ↔ 527PROSITE-ProRule annotation
Disulfide bondi502 ↔ 512PROSITE-ProRule annotation
Disulfide bondi534 ↔ 569PROSITE-ProRule annotation
Disulfide bondi557 ↔ 587PROSITE-ProRule annotation
Glycosylationi560N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi645N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi867N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi874 ↔ 906PROSITE-ProRule annotation
Disulfide bondi894 ↔ 908PROSITE-ProRule annotation
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1351PhosphotyrosineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Autoproteolytic processes at the GPS domain; this cleavage modulates receptor activity. Additionally, furin is involved in the cleavage at another site, in the middle of the extracellular domain, generating a soluble fragment.1 Publication
Glycosylated.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei296 – 297Cleavage; by furin1 Publication2

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O60241

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O60241

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O60241

PeptideAtlas

More...PeptideAtlasi		O60241

PRoteomics IDEntifications database

More...PRIDEi		O60241

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		49271 [O60241-1]
49272 [O60241-2]
49273 [O60241-3]
49274 [O60241-4]

PTM databases

CarbonylDB database of protein carbonylation sites

More...CarbonylDBi		O60241

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		O60241, 8 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O60241

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O60241

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Strongly expressed in brain. Also detected in heart, thymus, skeletal muscle, and different cell lines.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000121753, Expressed in right frontal lobe and 167 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O60241, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O60241, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000121753, Tissue enriched (brain)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer of 2 chains generated by proteolytic processing; the large extracellular N-terminal fragment and the membrane-bound C-terminal fragment predominantly remain associated and non-covalently linked.

Interacts with GABPB2 (By similarity).

Interacts (via carboxy-terminus) with TAX1BP3 (PubMed:21787750).

Interacts with GNAZ (PubMed:28891236).

Interacts with SH3GL2 (PubMed:28891236).

By similarity2 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		107052, 9 interactors

Protein interaction database and analysis system

More...IntActi		O60241, 9 interactors

Molecular INTeraction database

More...MINTi		O60241

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000362759

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O60241, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O60241

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini309 – 362TSP type-1 1PROSITE-ProRule annotationAdd BLAST54
Domaini364 – 417TSP type-1 2PROSITE-ProRule annotationAdd BLAST54
Domaini419 – 472TSP type-1 3PROSITE-ProRule annotationAdd BLAST54
Domaini475 – 528TSP type-1 4PROSITE-ProRule annotationAdd BLAST54
Domaini871 – 923GPSPROSITE-ProRule annotationAdd BLAST53

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni229 – 271DisorderedSequence analysisAdd BLAST43
Regioni767 – 806DisorderedSequence analysisAdd BLAST40
Regioni1359 – 1385DisorderedSequence analysisAdd BLAST27
Regioni1423 – 1454DisorderedSequence analysisAdd BLAST32
Regioni1498 – 1585DisorderedSequence analysisAdd BLAST88

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi229 – 244Polar residuesSequence analysisAdd BLAST16

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QRKJ, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000160103

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O60241

Identification of Orthologs from Complete Genome Data

More...OMAi		NILMPMA

Database of Orthologous Groups

More...OrthoDBi		27621at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O60241

TreeFam database of animal gene trees

More...TreeFami		TF331634

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.20.100.10, 4 hits
4.10.1240.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR043838, AGRB_N
IPR032471, GAIN_dom_N
IPR017981, GPCR_2-like
IPR008077, GPCR_2_brain_angio_inhib
IPR036445, GPCR_2_extracell_dom_sf
IPR001879, GPCR_2_extracellular_dom
IPR000832, GPCR_2_secretin-like
IPR000203, GPS
IPR000884, TSP1_rpt
IPR036383, TSP1_rpt_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00002, 7tm_2, 1 hit
PF19188, AGRB_N, 1 hit
PF16489, GAIN, 1 hit
PF01825, GPS, 1 hit
PF00090, TSP_1, 4 hits

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01694, BAIPRECURSOR
PR00249, GPCRSECRETIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00303, GPS, 1 hit
SM00008, HormR, 1 hit
SM00209, TSP1, 4 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF82895, SSF82895, 4 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50227, G_PROTEIN_RECEP_F2_3, 1 hit
PS50261, G_PROTEIN_RECEP_F2_4, 1 hit
PS50221, GPS, 1 hit
PS50092, TSP1, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O60241-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MENTGWMGKG HRMTPACPLL LSVILSLRLA TAFDPAPSAC SALASGVLYG 
        60         70         80         90        100
AFSLQDLFPT IASGCSWTLE NPDPTKYSLY LRFNRQEQVC AHFAPRLLPL 
       110        120        130        140        150
DHYLVNFTCL RPSPEEAVAQ AESEVGRPEE EEAEAAAGLE LCSGSGPFTF 
       160        170        180        190        200
LHFDKNFVQL CLSAEPSEAP RLLAPAALAF RFVEVLLINN NNSSQFTCGV 
       210        220        230        240        250
LCRWSEECGR AAGRACGFAQ PGCSCPGEAG AGSTTTTSPG PPAAHTLSNA 
       260        270        280        290        300
LVPGGPAPPA EADLHSGSSN DLFTTEMRYG EEPEEEPKVK TQWPRSADEP 
       310        320        330        340        350
GLYMAQTGDP AAEEWSPWSV CSLTCGQGLQ VRTRSCVSSP YGTLCSGPLR 
       360        370        380        390        400
ETRPCNNSAT CPVHGVWEEW GSWSLCSRSC GRGSRSRMRT CVPPQHGGKA 
       410        420        430        440        450
CEGPELQTKL CSMAACPVEG QWLEWGPWGP CSTSCANGTQ QRSRKCSVAG 
       460        470        480        490        500
PAWATCTGAL TDTRECSNLE CPATDSKWGP WNAWSLCSKT CDTGWQRRFR 
       510        520        530        540        550
MCQATGTQGY PCEGTGEEVK PCSEKRCPAF HEMCRDEYVM LMTWKKAAAG 
       560        570        580        590        600
EIIYNKCPPN ASGSASRRCL LSAQGVAYWG LPSFARCISH EYRYLYLSLR 
       610        620        630        640        650
EHLAKGQRML AGEGMSQVVR SLQELLARRT YYSGDLLFSV DILRNVTDTF 
       660        670        680        690        700
KRATYVPSAD DVQRFFQVVS FMVDAENKEK WDDAQQVSPG SVHLLRVVED 
       710        720        730        740        750
FIHLVGDALK AFQSSLIVTD NLVISIQREP VSAVSSDITF PMRGRRGMKD 
       760        770        780        790        800
WVRHSEDRLF LPKEVLSLSS PGKPATSGAA GSPGRGRGPG TVPPGPGHSH 
       810        820        830        840        850
QRLLPADPDE SSYFVIGAVL YRTLGLILPP PRPPLAVTSR VMTVTVRPPT 
       860        870        880        890        900
QPPAEPLITV ELSYIINGTT DPHCASWDYS RADASSGDWD TENCQTLETQ 
       910        920        930        940        950
AAHTRCQCQH LSTFAVLAQP PKDLTLELAG SPSVPLVIGC AVSCMALLTL 
       960        970        980        990       1000
LAIYAAFWRF IKSERSIILL NFCLSILASN ILILVGQSRV LSKGVCTMTA 
      1010       1020       1030       1040       1050
AFLHFFFLSS FCWVLTEAWQ SYLAVIGRMR TRLVRKRFLC LGWGLPALVV 
      1060       1070       1080       1090       1100
AVSVGFTRTK GYGTSSYCWL SLEGGLLYAF VGPAAVIVLV NMLIGIIVFN 
      1110       1120       1130       1140       1150
KLMARDGISD KSKKQRAGSE RCPWASLLLP CSACGAVPSP LLSSASARNA 
      1160       1170       1180       1190       1200
MASLWSSCVV LPLLALTWMS AVLAMTDRRS VLFQALFAVF NSAQGFVITA 
      1210       1220       1230       1240       1250
VHCFLRREVQ DVVKCQMGVC RADESEDSPD SCKNGQLQIL SDFEKDVDLA 
      1260       1270       1280       1290       1300
CQTVLFKEVN TCNPSTITGT LSRLSLDEDE EPKSCLVGPE GSLSFSPLPG 
      1310       1320       1330       1340       1350
NILVPMAASP GLGEPPPPQE ANPVYMCGEG GLRQLDLTWL RPTEPGSEGD 
      1360       1370       1380       1390       1400
YMVLPRRTLS LQPGGGGGGG EDAPRARPEG TPRRAAKTVA HTEGYPSFLS 
      1410       1420       1430       1440       1450
VDHSGLGLGP AYGSLQNPYG MTFQPPPPTP SARQVPEPGE RSRTMPRTVP 
      1460       1470       1480       1490       1500
GSTMKMGSLE RKKLRYSDLD FEKVMHTRKR HSELYHELNQ KFHTFDRYRS 
      1510       1520       1530       1540       1550
QSTAKREKRW SVSSGGAAER SVCTDKPSPG ERPSLSQHRR HQSWSTFKSM 
      1560       1570       1580 
TLGSLPPKPR ERLTLHRAAA WEPTEPPDGD FQTEV
Length:1,585
Mass (Da):172,656
Last modified:May 5, 2009 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i56D253AE0AB1552D
GO
Isoform 2 (identifier: O60241-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1473-1473: Missing.

Show »
Length:1,584
Mass (Da):172,528
Checksum:iA22E0B77267D56B4
GO
Isoform 3 (identifier: O60241-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-12: Missing.

Show »
Length:1,573
Mass (Da):171,270
Checksum:i7A690AF3382053B9
GO
Isoform 4 (identifier: O60241-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1119-1151: Missing.
     1473-1473: Missing.

Show »
Length:1,551
Mass (Da):169,199
Checksum:iEA1685A0E11C2592
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2A3C1A2A3C1_HUMAN
Adhesion G protein-coupled receptor...
ADGRB2
1,466Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2A3C2A2A3C2_HUMAN
Adhesion G protein-coupled receptor...
ADGRB2
1,554Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2A3C3A2A3C3_HUMAN
Adhesion G protein-coupled receptor...
ADGRB2
1,499Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2A3C6A2A3C6_HUMAN
Adhesion G protein-coupled receptor...
ADGRB2
1,500Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2A3C4A2A3C4_HUMAN
Adhesion G protein-coupled receptor...
ADGRB2
847Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PND1E9PND1_HUMAN
Adhesion G protein-coupled receptor...
ADGRB2
507Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA25362 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti325C → R in AAI36534 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0798401465R → W Probable disease-associated variant found in a patient with progressive spastic paraparesis and other neurological symptoms; enhances receptor surface expression; increases the constitutive signaling activity; does not affect interaction with GNAZ; promotes enhanced interaction with GNAI1; decreases interaction with SH3GL2. 1 PublicationCorresponds to variant dbSNP:rs778361520EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0370451 – 12Missing in isoform 3. CuratedAdd BLAST12
Alternative sequenceiVSP_0370461119 – 1151Missing in isoform 4. 1 PublicationAdd BLAST33
Alternative sequenceiVSP_0370471473Missing in isoform 2 and isoform 4. 2 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB005298 mRNA Translation: BAA25362.1 Different initiation.
AB065648 Genomic DNA Translation: BAC05874.1
AC114488 Genomic DNA No translation available.
AL354919 Genomic DNA No translation available.
BC009035 mRNA Translation: AAH09035.1
BC136533 mRNA Translation: AAI36534.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS72746.1 [O60241-4]
CCDS72747.1 [O60241-2]

Protein sequence database of the Protein Information Resource

More...PIRi		T00027

NCBI Reference Sequences

More...RefSeqi		NP_001281264.1, NM_001294335.1 [O60241-2]
NP_001281265.1, NM_001294336.1 [O60241-4]
XP_011540150.1, XM_011541848.2 [O60241-1]
XP_011540151.1, XM_011541849.2 [O60241-3]
XP_016857388.1, XM_017001899.1 [O60241-1]
XP_016857389.1, XM_017001900.1 [O60241-2]
XP_016857394.1, XM_017001905.1 [O60241-4]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000373655; ENSP00000362759; ENSG00000121753 [O60241-2]
ENST00000373658; ENSP00000362762; ENSG00000121753
ENST00000527361; ENSP00000435397; ENSG00000121753 [O60241-4]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		576

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:576

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000373658.8; ENSP00000362762.3; NM_001364857.2; NP_001351786.1

UCSC genome browser

More...UCSCi		uc001btn.4, human [O60241-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB005298 mRNA Translation: BAA25362.1 Different initiation.
AB065648 Genomic DNA Translation: BAC05874.1
AC114488 Genomic DNA No translation available.
AL354919 Genomic DNA No translation available.
BC009035 mRNA Translation: AAH09035.1
BC136533 mRNA Translation: AAI36534.1
CCDSiCCDS72746.1 [O60241-4]
CCDS72747.1 [O60241-2]
PIRiT00027
RefSeqiNP_001281264.1, NM_001294335.1 [O60241-2]
NP_001281265.1, NM_001294336.1 [O60241-4]
XP_011540150.1, XM_011541848.2 [O60241-1]
XP_011540151.1, XM_011541849.2 [O60241-3]
XP_016857388.1, XM_017001899.1 [O60241-1]
XP_016857389.1, XM_017001900.1 [O60241-2]
XP_016857394.1, XM_017001905.1 [O60241-4]

3D structure databases

SMRiO60241
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi107052, 9 interactors
IntActiO60241, 9 interactors
MINTiO60241
STRINGi9606.ENSP00000362759

Protein family/group databases

MEROPSiP02.029
TCDBi9.A.14.6.6, the g-protein-coupled receptor (gpcr) family

Information system for G protein-coupled receptors (GPCRs)

More...GPCRDBi		Search...

PTM databases

CarbonylDBiO60241
GlyGeniO60241, 8 sites
iPTMnetiO60241
PhosphoSitePlusiO60241

Genetic variation databases

BioMutaiADGRB2

Proteomic databases

jPOSTiO60241
MassIVEiO60241
PaxDbiO60241
PeptideAtlasiO60241
PRIDEiO60241
ProteomicsDBi49271 [O60241-1]
49272 [O60241-2]
49273 [O60241-3]
49274 [O60241-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		16794, 289 antibodies from 32 providers

The DNASU plasmid repository

More...DNASUi		576

Genome annotation databases

EnsembliENST00000373655; ENSP00000362759; ENSG00000121753 [O60241-2]
ENST00000373658; ENSP00000362762; ENSG00000121753
ENST00000527361; ENSP00000435397; ENSG00000121753 [O60241-4]
GeneIDi576
KEGGihsa:576
MANE-SelectiENST00000373658.8; ENSP00000362762.3; NM_001364857.2; NP_001351786.1
UCSCiuc001btn.4, human [O60241-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		576
DisGeNETi576

GeneCards: human genes, protein and diseases

More...GeneCardsi		ADGRB2
HGNCiHGNC:944, ADGRB2
HPAiENSG00000121753, Tissue enriched (brain)
MIMi602683, gene
neXtProtiNX_O60241
OpenTargetsiENSG00000121753
PharmGKBiPA25248
VEuPathDBiHostDB:ENSG00000121753

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QRKJ, Eukaryota
GeneTreeiENSGT00940000160103
InParanoidiO60241
OMAiNILMPMA
OrthoDBi27621at2759
PhylomeDBiO60241
TreeFamiTF331634

Enzyme and pathway databases

PathwayCommonsiO60241
SignaLinkiO60241

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		576, 16 hits in 666 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ADGRB2, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Brain-specific_angiogenesis_inhibitor_2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		576
PharosiO60241, Tbio

Protein Ontology

More...PROi		PR:O60241
RNActiO60241, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000121753, Expressed in right frontal lobe and 167 other tissues
ExpressionAtlasiO60241, baseline and differential
GenevisibleiO60241, HS

Family and domain databases

Gene3Di2.20.100.10, 4 hits
4.10.1240.10, 1 hit
InterProiView protein in InterPro
IPR043838, AGRB_N
IPR032471, GAIN_dom_N
IPR017981, GPCR_2-like
IPR008077, GPCR_2_brain_angio_inhib
IPR036445, GPCR_2_extracell_dom_sf
IPR001879, GPCR_2_extracellular_dom
IPR000832, GPCR_2_secretin-like
IPR000203, GPS
IPR000884, TSP1_rpt
IPR036383, TSP1_rpt_sf
PfamiView protein in Pfam
PF00002, 7tm_2, 1 hit
PF19188, AGRB_N, 1 hit
PF16489, GAIN, 1 hit
PF01825, GPS, 1 hit
PF00090, TSP_1, 4 hits
PRINTSiPR01694, BAIPRECURSOR
PR00249, GPCRSECRETIN
SMARTiView protein in SMART
SM00303, GPS, 1 hit
SM00008, HormR, 1 hit
SM00209, TSP1, 4 hits
SUPFAMiSSF82895, SSF82895, 4 hits
PROSITEiView protein in PROSITE
PS50227, G_PROTEIN_RECEP_F2_3, 1 hit
PS50261, G_PROTEIN_RECEP_F2_4, 1 hit
PS50221, GPS, 1 hit
PS50092, TSP1, 4 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAGRB2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O60241
Secondary accession number(s): B9EGK9
, Q5T6K0, Q8NGW8, Q96GZ9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 5, 2009
Last modified: February 23, 2022
This is version 194 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with genetic variants
    List of human entries with genetic variants
  4. Human variants curated from literature reports
    Index of human variants curated from literature reports
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families
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