Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Adhesion G protein-coupled receptor B2

Gene

ADGRB2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Orphan G-protein coupled receptor involved in cell adhesion and probably in cell-cell interactions. Activates NFAT-signaling pathway, a transcription factor, via the G-protein GNAZ (PubMed:20367554, PubMed:28891236). Involved in angiogenesis inhibition (By similarity).By similarity2 Publications

Activity regulationi

Receptor activity is regulated by proteolytic processing. The long N-terminal has a an inhibitory effect on the constitutive signaling activity. Removal of the N-terminal region induces an increase of the receptor activity.2 Publications

GO - Molecular functioni

  • G protein-coupled receptor activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Protein family/group databases

MEROPSiP02.029
TCDBi9.A.14.6.6 the g-protein-coupled receptor (gpcr) family

Names & Taxonomyi

Protein namesi
Recommended name:
Adhesion G protein-coupled receptor B21 Publication
Alternative name(s):
Brain-specific angiogenesis inhibitor 2
Gene namesi
Name:ADGRB2Imported
Synonyms:BAI2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000121753.12
HGNCiHGNC:944 ADGRB2
MIMi602683 gene
neXtProtiNX_O60241

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini33 – 936ExtracellularCuratedAdd BLAST904
Transmembranei937 – 957Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini958 – 965CytoplasmicCurated8
Transmembranei966 – 986Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini987 – 994ExtracellularCurated8
Transmembranei995 – 1015Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini1016 – 1036CytoplasmicCuratedAdd BLAST21
Transmembranei1037 – 1057Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini1058 – 1078ExtracellularCuratedAdd BLAST21
Transmembranei1079 – 1099Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini1100 – 1121CytoplasmicCuratedAdd BLAST22
Transmembranei1122 – 1142Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini1143 – 1153ExtracellularCuratedAdd BLAST11
Transmembranei1154 – 1174Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini1175 – 1585CytoplasmicCuratedAdd BLAST411

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi889W → S: Inhibits autoproteolytic cleavage. 1 Publication1
Mutagenesisi908C → W: Inhibits autoproteolytic cleavage. 1 Publication1
Mutagenesisi912S → P: Inhibits autoproteolytic cleavage. 1 Publication1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi576
OpenTargetsiENSG00000121753
PharmGKBiPA25248

Polymorphism and mutation databases

BioMutaiBAI2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 32Sequence analysisAdd BLAST32
ChainiPRO_000001286433 – 1585Adhesion G protein-coupled receptor B2Add BLAST1553

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi106N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi191N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi192N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi321 ↔ 355PROSITE-ProRule annotation
Disulfide bondi325 ↔ 361PROSITE-ProRule annotation
Disulfide bondi336 ↔ 345PROSITE-ProRule annotation
Glycosylationi356N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi376 ↔ 411PROSITE-ProRule annotation
Disulfide bondi380 ↔ 416PROSITE-ProRule annotation
Disulfide bondi391 ↔ 401PROSITE-ProRule annotation
Disulfide bondi431 ↔ 466PROSITE-ProRule annotation
Disulfide bondi435 ↔ 471PROSITE-ProRule annotation
Glycosylationi437N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi446 ↔ 456PROSITE-ProRule annotation
Disulfide bondi487 ↔ 522PROSITE-ProRule annotation
Disulfide bondi491 ↔ 527PROSITE-ProRule annotation
Disulfide bondi502 ↔ 512PROSITE-ProRule annotation
Disulfide bondi534 ↔ 569PROSITE-ProRule annotation
Disulfide bondi557 ↔ 587PROSITE-ProRule annotation
Glycosylationi560N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi645N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi867N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi874 ↔ 906PROSITE-ProRule annotation
Disulfide bondi894 ↔ 908PROSITE-ProRule annotation
Modified residuei1351PhosphotyrosineBy similarity1

Post-translational modificationi

Autoproteolytic processes at the GPS domain; this cleavage modulates receptor activity. Additionally, furin is involved in the cleavage at another site, in the middle of the extracellular domain, generating a soluble fragment.1 Publication
Glycosylated.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei296 – 297Cleavage; by furin1 Publication2

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiO60241
PaxDbiO60241
PeptideAtlasiO60241
PRIDEiO60241
ProteomicsDBi49271
49272 [O60241-2]
49273 [O60241-3]
49274 [O60241-4]

PTM databases

CarbonylDBiO60241
iPTMnetiO60241
PhosphoSitePlusiO60241

Expressioni

Tissue specificityi

Strongly expressed in brain. Also detected in heart, thymus, skeletal muscle, and different cell lines.

Gene expression databases

BgeeiENSG00000121753 Expressed in 145 organ(s), highest expression level in right frontal lobe
CleanExiHS_BAI2
ExpressionAtlasiO60241 baseline and differential
GenevisibleiO60241 HS

Organism-specific databases

HPAiHPA052612
HPA054617

Interactioni

Subunit structurei

Heterodimer of 2 chains generated by proteolytic processing; the large extracellular N-terminal fragment and the membrane-bound C-terminal fragment predominantly remain associated and non-covalently linked. Interacts with GABPB2 (By similarity). Interacts (via carboxy-terminus) with TAX1BP3 (PubMed:21787750). Interacts with GNAZ (PubMed:28891236). Interacts with SH3GL2 (PubMed:28891236).By similarity2 Publications

Protein-protein interaction databases

BioGridi107052, 3 interactors
IntActiO60241, 4 interactors
MINTiO60241
STRINGi9606.ENSP00000362762

Structurei

3D structure databases

ProteinModelPortaliO60241
SMRiO60241
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini309 – 362TSP type-1 1PROSITE-ProRule annotationAdd BLAST54
Domaini364 – 417TSP type-1 2PROSITE-ProRule annotationAdd BLAST54
Domaini419 – 472TSP type-1 3PROSITE-ProRule annotationAdd BLAST54
Domaini475 – 528TSP type-1 4PROSITE-ProRule annotationAdd BLAST54
Domaini871 – 923GPSPROSITE-ProRule annotationAdd BLAST53

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi129 – 134Poly-Glu6
Compositional biasi189 – 192Poly-Asn4
Compositional biasi234 – 237Poly-Thr4
Compositional biasi1315 – 1318Poly-Pro4
Compositional biasi1364 – 1370Poly-Gly7
Compositional biasi1425 – 1430Poly-Pro6

Sequence similaritiesi

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEA0 Eukaryota
ENOG4111FBM LUCA
GeneTreeiENSGT00930000150838
HOGENOMiHOG000230916
HOVERGENiHBG004813
InParanoidiO60241
KOiK04597
OMAiCNNTATC
OrthoDBiEOG091G00C7
PhylomeDBiO60241
TreeFamiTF331634

Family and domain databases

Gene3Di2.20.100.10, 4 hits
4.10.1240.10, 1 hit
InterProiView protein in InterPro
IPR032471 GAIN_dom_N
IPR017981 GPCR_2-like
IPR008077 GPCR_2_brain_angio_inhib
IPR036445 GPCR_2_extracell_dom_sf
IPR001879 GPCR_2_extracellular_dom
IPR000832 GPCR_2_secretin-like
IPR000203 GPS
IPR000884 TSP1_rpt
IPR036383 TSP1_rpt_sf
PfamiView protein in Pfam
PF00002 7tm_2, 1 hit
PF16489 GAIN, 1 hit
PF01825 GPS, 1 hit
PF00090 TSP_1, 4 hits
PRINTSiPR01694 BAIPRECURSOR
PR00249 GPCRSECRETIN
SMARTiView protein in SMART
SM00303 GPS, 1 hit
SM00008 HormR, 1 hit
SM00209 TSP1, 4 hits
SUPFAMiSSF82895 SSF82895, 4 hits
PROSITEiView protein in PROSITE
PS50227 G_PROTEIN_RECEP_F2_3, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit
PS50221 GPS, 1 hit
PS50092 TSP1, 4 hits

Sequences (4+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O60241-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MENTGWMGKG HRMTPACPLL LSVILSLRLA TAFDPAPSAC SALASGVLYG
60 70 80 90 100
AFSLQDLFPT IASGCSWTLE NPDPTKYSLY LRFNRQEQVC AHFAPRLLPL
110 120 130 140 150
DHYLVNFTCL RPSPEEAVAQ AESEVGRPEE EEAEAAAGLE LCSGSGPFTF
160 170 180 190 200
LHFDKNFVQL CLSAEPSEAP RLLAPAALAF RFVEVLLINN NNSSQFTCGV
210 220 230 240 250
LCRWSEECGR AAGRACGFAQ PGCSCPGEAG AGSTTTTSPG PPAAHTLSNA
260 270 280 290 300
LVPGGPAPPA EADLHSGSSN DLFTTEMRYG EEPEEEPKVK TQWPRSADEP
310 320 330 340 350
GLYMAQTGDP AAEEWSPWSV CSLTCGQGLQ VRTRSCVSSP YGTLCSGPLR
360 370 380 390 400
ETRPCNNSAT CPVHGVWEEW GSWSLCSRSC GRGSRSRMRT CVPPQHGGKA
410 420 430 440 450
CEGPELQTKL CSMAACPVEG QWLEWGPWGP CSTSCANGTQ QRSRKCSVAG
460 470 480 490 500
PAWATCTGAL TDTRECSNLE CPATDSKWGP WNAWSLCSKT CDTGWQRRFR
510 520 530 540 550
MCQATGTQGY PCEGTGEEVK PCSEKRCPAF HEMCRDEYVM LMTWKKAAAG
560 570 580 590 600
EIIYNKCPPN ASGSASRRCL LSAQGVAYWG LPSFARCISH EYRYLYLSLR
610 620 630 640 650
EHLAKGQRML AGEGMSQVVR SLQELLARRT YYSGDLLFSV DILRNVTDTF
660 670 680 690 700
KRATYVPSAD DVQRFFQVVS FMVDAENKEK WDDAQQVSPG SVHLLRVVED
710 720 730 740 750
FIHLVGDALK AFQSSLIVTD NLVISIQREP VSAVSSDITF PMRGRRGMKD
760 770 780 790 800
WVRHSEDRLF LPKEVLSLSS PGKPATSGAA GSPGRGRGPG TVPPGPGHSH
810 820 830 840 850
QRLLPADPDE SSYFVIGAVL YRTLGLILPP PRPPLAVTSR VMTVTVRPPT
860 870 880 890 900
QPPAEPLITV ELSYIINGTT DPHCASWDYS RADASSGDWD TENCQTLETQ
910 920 930 940 950
AAHTRCQCQH LSTFAVLAQP PKDLTLELAG SPSVPLVIGC AVSCMALLTL
960 970 980 990 1000
LAIYAAFWRF IKSERSIILL NFCLSILASN ILILVGQSRV LSKGVCTMTA
1010 1020 1030 1040 1050
AFLHFFFLSS FCWVLTEAWQ SYLAVIGRMR TRLVRKRFLC LGWGLPALVV
1060 1070 1080 1090 1100
AVSVGFTRTK GYGTSSYCWL SLEGGLLYAF VGPAAVIVLV NMLIGIIVFN
1110 1120 1130 1140 1150
KLMARDGISD KSKKQRAGSE RCPWASLLLP CSACGAVPSP LLSSASARNA
1160 1170 1180 1190 1200
MASLWSSCVV LPLLALTWMS AVLAMTDRRS VLFQALFAVF NSAQGFVITA
1210 1220 1230 1240 1250
VHCFLRREVQ DVVKCQMGVC RADESEDSPD SCKNGQLQIL SDFEKDVDLA
1260 1270 1280 1290 1300
CQTVLFKEVN TCNPSTITGT LSRLSLDEDE EPKSCLVGPE GSLSFSPLPG
1310 1320 1330 1340 1350
NILVPMAASP GLGEPPPPQE ANPVYMCGEG GLRQLDLTWL RPTEPGSEGD
1360 1370 1380 1390 1400
YMVLPRRTLS LQPGGGGGGG EDAPRARPEG TPRRAAKTVA HTEGYPSFLS
1410 1420 1430 1440 1450
VDHSGLGLGP AYGSLQNPYG MTFQPPPPTP SARQVPEPGE RSRTMPRTVP
1460 1470 1480 1490 1500
GSTMKMGSLE RKKLRYSDLD FEKVMHTRKR HSELYHELNQ KFHTFDRYRS
1510 1520 1530 1540 1550
QSTAKREKRW SVSSGGAAER SVCTDKPSPG ERPSLSQHRR HQSWSTFKSM
1560 1570 1580
TLGSLPPKPR ERLTLHRAAA WEPTEPPDGD FQTEV
Length:1,585
Mass (Da):172,656
Last modified:May 5, 2009 - v2
Checksum:i56D253AE0AB1552D
GO
Isoform 2 (identifier: O60241-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1473-1473: Missing.

Show »
Length:1,584
Mass (Da):172,528
Checksum:iA22E0B77267D56B4
GO
Isoform 3 (identifier: O60241-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-12: Missing.

Show »
Length:1,573
Mass (Da):171,270
Checksum:i7A690AF3382053B9
GO
Isoform 4 (identifier: O60241-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1119-1151: Missing.
     1473-1473: Missing.

Show »
Length:1,551
Mass (Da):169,199
Checksum:iEA1685A0E11C2592
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2A3C2A2A3C2_HUMAN
Adhesion G protein-coupled receptor...
ADGRB2
1,554Annotation score:
A2A3C1A2A3C1_HUMAN
Adhesion G protein-coupled receptor...
ADGRB2
1,466Annotation score:
A2A3C6A2A3C6_HUMAN
Adhesion G protein-coupled receptor...
ADGRB2
1,500Annotation score:
A2A3C3A2A3C3_HUMAN
Adhesion G protein-coupled receptor...
ADGRB2
1,499Annotation score:
A2A3C4A2A3C4_HUMAN
Adhesion G protein-coupled receptor...
ADGRB2
847Annotation score:
E9PND1E9PND1_HUMAN
Adhesion G protein-coupled receptor...
ADGRB2
507Annotation score:

Sequence cautioni

The sequence BAA25362 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti325C → R in AAI36534 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0798401465R → W Probable disease-associated mutation found in a patient with progressive spastic paraparesis and other neurological symptoms; enhances receptor surface expression; increases the constitutive signaling activity; does not affect interaction with GNAZ; promotes enhanced interaction with GNAI1; decreases interaction with SH3GL2. 1 PublicationCorresponds to variant dbSNP:rs778361520EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0370451 – 12Missing in isoform 3. CuratedAdd BLAST12
Alternative sequenceiVSP_0370461119 – 1151Missing in isoform 4. 1 PublicationAdd BLAST33
Alternative sequenceiVSP_0370471473Missing in isoform 2 and isoform 4. 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB005298 mRNA Translation: BAA25362.1 Different initiation.
AB065648 Genomic DNA Translation: BAC05874.1
AC114488 Genomic DNA No translation available.
AL354919 Genomic DNA No translation available.
BC009035 mRNA Translation: AAH09035.1
BC136533 mRNA Translation: AAI36534.1
CCDSiCCDS72746.1 [O60241-4]
CCDS72747.1 [O60241-2]
PIRiT00027
RefSeqiNP_001281264.1, NM_001294335.1 [O60241-2]
NP_001281265.1, NM_001294336.1 [O60241-4]
XP_011540150.1, XM_011541848.2 [O60241-1]
XP_011540151.1, XM_011541849.2 [O60241-3]
XP_016857388.1, XM_017001899.1 [O60241-1]
XP_016857389.1, XM_017001900.1 [O60241-2]
XP_016857394.1, XM_017001905.1 [O60241-4]
UniGeneiHs.524138

Genome annotation databases

EnsembliENST00000373655; ENSP00000362759; ENSG00000121753 [O60241-2]
ENST00000373658; ENSP00000362762; ENSG00000121753 [O60241-1]
ENST00000527361; ENSP00000435397; ENSG00000121753 [O60241-4]
GeneIDi576
KEGGihsa:576
UCSCiuc001btn.4 human [O60241-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB005298 mRNA Translation: BAA25362.1 Different initiation.
AB065648 Genomic DNA Translation: BAC05874.1
AC114488 Genomic DNA No translation available.
AL354919 Genomic DNA No translation available.
BC009035 mRNA Translation: AAH09035.1
BC136533 mRNA Translation: AAI36534.1
CCDSiCCDS72746.1 [O60241-4]
CCDS72747.1 [O60241-2]
PIRiT00027
RefSeqiNP_001281264.1, NM_001294335.1 [O60241-2]
NP_001281265.1, NM_001294336.1 [O60241-4]
XP_011540150.1, XM_011541848.2 [O60241-1]
XP_011540151.1, XM_011541849.2 [O60241-3]
XP_016857388.1, XM_017001899.1 [O60241-1]
XP_016857389.1, XM_017001900.1 [O60241-2]
XP_016857394.1, XM_017001905.1 [O60241-4]
UniGeneiHs.524138

3D structure databases

ProteinModelPortaliO60241
SMRiO60241
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107052, 3 interactors
IntActiO60241, 4 interactors
MINTiO60241
STRINGi9606.ENSP00000362762

Protein family/group databases

MEROPSiP02.029
TCDBi9.A.14.6.6 the g-protein-coupled receptor (gpcr) family
GPCRDBiSearch...

PTM databases

CarbonylDBiO60241
iPTMnetiO60241
PhosphoSitePlusiO60241

Polymorphism and mutation databases

BioMutaiBAI2

Proteomic databases

EPDiO60241
PaxDbiO60241
PeptideAtlasiO60241
PRIDEiO60241
ProteomicsDBi49271
49272 [O60241-2]
49273 [O60241-3]
49274 [O60241-4]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373655; ENSP00000362759; ENSG00000121753 [O60241-2]
ENST00000373658; ENSP00000362762; ENSG00000121753 [O60241-1]
ENST00000527361; ENSP00000435397; ENSG00000121753 [O60241-4]
GeneIDi576
KEGGihsa:576
UCSCiuc001btn.4 human [O60241-1]

Organism-specific databases

CTDi576
DisGeNETi576
EuPathDBiHostDB:ENSG00000121753.12
GeneCardsiADGRB2
H-InvDBiHIX0023509
HGNCiHGNC:944 ADGRB2
HPAiHPA052612
HPA054617
MIMi602683 gene
neXtProtiNX_O60241
OpenTargetsiENSG00000121753
PharmGKBiPA25248
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEA0 Eukaryota
ENOG4111FBM LUCA
GeneTreeiENSGT00930000150838
HOGENOMiHOG000230916
HOVERGENiHBG004813
InParanoidiO60241
KOiK04597
OMAiCNNTATC
OrthoDBiEOG091G00C7
PhylomeDBiO60241
TreeFamiTF331634

Miscellaneous databases

ChiTaRSiADGRB2 human
GeneWikiiBrain-specific_angiogenesis_inhibitor_2
GenomeRNAii576
PROiPR:O60241
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000121753 Expressed in 145 organ(s), highest expression level in right frontal lobe
CleanExiHS_BAI2
ExpressionAtlasiO60241 baseline and differential
GenevisibleiO60241 HS

Family and domain databases

Gene3Di2.20.100.10, 4 hits
4.10.1240.10, 1 hit
InterProiView protein in InterPro
IPR032471 GAIN_dom_N
IPR017981 GPCR_2-like
IPR008077 GPCR_2_brain_angio_inhib
IPR036445 GPCR_2_extracell_dom_sf
IPR001879 GPCR_2_extracellular_dom
IPR000832 GPCR_2_secretin-like
IPR000203 GPS
IPR000884 TSP1_rpt
IPR036383 TSP1_rpt_sf
PfamiView protein in Pfam
PF00002 7tm_2, 1 hit
PF16489 GAIN, 1 hit
PF01825 GPS, 1 hit
PF00090 TSP_1, 4 hits
PRINTSiPR01694 BAIPRECURSOR
PR00249 GPCRSECRETIN
SMARTiView protein in SMART
SM00303 GPS, 1 hit
SM00008 HormR, 1 hit
SM00209 TSP1, 4 hits
SUPFAMiSSF82895 SSF82895, 4 hits
PROSITEiView protein in PROSITE
PS50227 G_PROTEIN_RECEP_F2_3, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit
PS50221 GPS, 1 hit
PS50092 TSP1, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiAGRB2_HUMAN
AccessioniPrimary (citable) accession number: O60241
Secondary accession number(s): B9EGK9
, Q5T6K0, Q8NGW8, Q96GZ9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 5, 2009
Last modified: November 7, 2018
This is version 174 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again