UniProtKB - O60241 (AGRB2_HUMAN)
Adhesion G protein-coupled receptor B2
ADGRB2
Functioni
Orphan G-protein coupled receptor involved in cell adhesion and probably in cell-cell interactions. Activates NFAT-signaling pathway, a transcription factor, via the G-protein GNAZ (PubMed:20367554, PubMed:28891236).
Involved in angiogenesis inhibition (By similarity).
By similarity2 PublicationsActivity regulationi
GO - Molecular functioni
- G protein-coupled receptor activity Source: UniProtKB
GO - Biological processi
- adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: GO_Central
- calcineurin-NFAT signaling cascade Source: UniProtKB
- cell surface receptor signaling pathway Source: InterPro
- G protein-coupled receptor signaling pathway Source: UniProtKB
- negative regulation of angiogenesis Source: InterPro
- peripheral nervous system development Source: GO_Central
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
PathwayCommonsi | O60241 |
SignaLinki | O60241 |
Protein family/group databases
MEROPSi | P02.029 |
TCDBi | 9.A.14.6.6, the g-protein-coupled receptor (gpcr) family |
Names & Taxonomyi
Protein namesi | Recommended name: Adhesion G protein-coupled receptor B21 PublicationAlternative name(s): Brain-specific angiogenesis inhibitor 2 |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:944, ADGRB2 |
MIMi | 602683, gene |
neXtProti | NX_O60241 |
VEuPathDBi | HostDB:ENSG00000121753 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Multi-pass membrane protein Sequence analysis
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
- plasma membrane Source: UniProtKB
Other locations
- integral component of membrane Source: GDB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 33 – 936 | ExtracellularCuratedAdd BLAST | 904 | |
Transmembranei | 937 – 957 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 958 – 965 | CytoplasmicCurated | 8 | |
Transmembranei | 966 – 986 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 987 – 994 | ExtracellularCurated | 8 | |
Transmembranei | 995 – 1015 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 1016 – 1036 | CytoplasmicCuratedAdd BLAST | 21 | |
Transmembranei | 1037 – 1057 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 1058 – 1078 | ExtracellularCuratedAdd BLAST | 21 | |
Transmembranei | 1079 – 1099 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 1100 – 1121 | CytoplasmicCuratedAdd BLAST | 22 | |
Transmembranei | 1122 – 1142 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 1143 – 1153 | ExtracellularCuratedAdd BLAST | 11 | |
Transmembranei | 1154 – 1174 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 1175 – 1585 | CytoplasmicCuratedAdd BLAST | 411 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 889 | W → S: Inhibits autoproteolytic cleavage. 1 Publication | 1 | |
Mutagenesisi | 908 | C → W: Inhibits autoproteolytic cleavage. 1 Publication | 1 | |
Mutagenesisi | 912 | S → P: Inhibits autoproteolytic cleavage. 1 Publication | 1 |
Keywords - Diseasei
Disease variantOrganism-specific databases
DisGeNETi | 576 |
OpenTargetsi | ENSG00000121753 |
PharmGKBi | PA25248 |
Miscellaneous databases
Pharosi | O60241, Tbio |
Genetic variation databases
BioMutai | ADGRB2 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 32 | Sequence analysisAdd BLAST | 32 | |
ChainiPRO_0000012864 | 33 – 1585 | Adhesion G protein-coupled receptor B2Add BLAST | 1553 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 106 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 191 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 192 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 321 ↔ 355 | PROSITE-ProRule annotation | ||
Disulfide bondi | 325 ↔ 361 | PROSITE-ProRule annotation | ||
Disulfide bondi | 336 ↔ 345 | PROSITE-ProRule annotation | ||
Glycosylationi | 356 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 376 ↔ 411 | PROSITE-ProRule annotation | ||
Disulfide bondi | 380 ↔ 416 | PROSITE-ProRule annotation | ||
Disulfide bondi | 391 ↔ 401 | PROSITE-ProRule annotation | ||
Disulfide bondi | 431 ↔ 466 | PROSITE-ProRule annotation | ||
Disulfide bondi | 435 ↔ 471 | PROSITE-ProRule annotation | ||
Glycosylationi | 437 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 446 ↔ 456 | PROSITE-ProRule annotation | ||
Disulfide bondi | 487 ↔ 522 | PROSITE-ProRule annotation | ||
Disulfide bondi | 491 ↔ 527 | PROSITE-ProRule annotation | ||
Disulfide bondi | 502 ↔ 512 | PROSITE-ProRule annotation | ||
Disulfide bondi | 534 ↔ 569 | PROSITE-ProRule annotation | ||
Disulfide bondi | 557 ↔ 587 | PROSITE-ProRule annotation | ||
Glycosylationi | 560 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 645 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 867 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 874 ↔ 906 | PROSITE-ProRule annotation | ||
Disulfide bondi | 894 ↔ 908 | PROSITE-ProRule annotation | ||
Modified residuei | 1351 | PhosphotyrosineBy similarity | 1 |
Post-translational modificationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 296 – 297 | Cleavage; by furin1 Publication | 2 |
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
jPOSTi | O60241 |
MassIVEi | O60241 |
PaxDbi | O60241 |
PeptideAtlasi | O60241 |
PRIDEi | O60241 |
ProteomicsDBi | 49271 [O60241-1] 49272 [O60241-2] 49273 [O60241-3] 49274 [O60241-4] |
PTM databases
CarbonylDBi | O60241 |
GlyGeni | O60241, 8 sites |
iPTMneti | O60241 |
PhosphoSitePlusi | O60241 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000121753, Expressed in right frontal lobe and 167 other tissues |
ExpressionAtlasi | O60241, baseline and differential |
Genevisiblei | O60241, HS |
Organism-specific databases
HPAi | ENSG00000121753, Tissue enriched (brain) |
Interactioni
Subunit structurei
Heterodimer of 2 chains generated by proteolytic processing; the large extracellular N-terminal fragment and the membrane-bound C-terminal fragment predominantly remain associated and non-covalently linked.
Interacts with GABPB2 (By similarity).
Interacts (via carboxy-terminus) with TAX1BP3 (PubMed:21787750).
Interacts with GNAZ (PubMed:28891236).
Interacts with SH3GL2 (PubMed:28891236).
By similarity2 PublicationsProtein-protein interaction databases
BioGRIDi | 107052, 9 interactors |
IntActi | O60241, 9 interactors |
MINTi | O60241 |
STRINGi | 9606.ENSP00000362759 |
Miscellaneous databases
RNActi | O60241, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 309 – 362 | TSP type-1 1PROSITE-ProRule annotationAdd BLAST | 54 | |
Domaini | 364 – 417 | TSP type-1 2PROSITE-ProRule annotationAdd BLAST | 54 | |
Domaini | 419 – 472 | TSP type-1 3PROSITE-ProRule annotationAdd BLAST | 54 | |
Domaini | 475 – 528 | TSP type-1 4PROSITE-ProRule annotationAdd BLAST | 54 | |
Domaini | 871 – 923 | GPSPROSITE-ProRule annotationAdd BLAST | 53 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 229 – 271 | DisorderedSequence analysisAdd BLAST | 43 | |
Regioni | 767 – 806 | DisorderedSequence analysisAdd BLAST | 40 | |
Regioni | 1359 – 1385 | DisorderedSequence analysisAdd BLAST | 27 | |
Regioni | 1423 – 1454 | DisorderedSequence analysisAdd BLAST | 32 | |
Regioni | 1498 – 1585 | DisorderedSequence analysisAdd BLAST | 88 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 229 – 244 | Polar residuesSequence analysisAdd BLAST | 16 |
Sequence similaritiesi
Keywords - Domaini
Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QRKJ, Eukaryota |
GeneTreei | ENSGT00940000160103 |
InParanoidi | O60241 |
OMAi | NILMPMA |
OrthoDBi | 27621at2759 |
PhylomeDBi | O60241 |
TreeFami | TF331634 |
Family and domain databases
Gene3Di | 2.20.100.10, 4 hits 4.10.1240.10, 1 hit |
InterProi | View protein in InterPro IPR043838, AGRB_N IPR032471, GAIN_dom_N IPR017981, GPCR_2-like IPR008077, GPCR_2_brain_angio_inhib IPR036445, GPCR_2_extracell_dom_sf IPR001879, GPCR_2_extracellular_dom IPR000832, GPCR_2_secretin-like IPR000203, GPS IPR000884, TSP1_rpt IPR036383, TSP1_rpt_sf |
Pfami | View protein in Pfam PF00002, 7tm_2, 1 hit PF19188, AGRB_N, 1 hit PF16489, GAIN, 1 hit PF01825, GPS, 1 hit PF00090, TSP_1, 4 hits |
PRINTSi | PR01694, BAIPRECURSOR PR00249, GPCRSECRETIN |
SMARTi | View protein in SMART SM00303, GPS, 1 hit SM00008, HormR, 1 hit SM00209, TSP1, 4 hits |
SUPFAMi | SSF82895, SSF82895, 4 hits |
PROSITEi | View protein in PROSITE PS50227, G_PROTEIN_RECEP_F2_3, 1 hit PS50261, G_PROTEIN_RECEP_F2_4, 1 hit PS50221, GPS, 1 hit PS50092, TSP1, 4 hits |
s (4+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MENTGWMGKG HRMTPACPLL LSVILSLRLA TAFDPAPSAC SALASGVLYG
60 70 80 90 100
AFSLQDLFPT IASGCSWTLE NPDPTKYSLY LRFNRQEQVC AHFAPRLLPL
110 120 130 140 150
DHYLVNFTCL RPSPEEAVAQ AESEVGRPEE EEAEAAAGLE LCSGSGPFTF
160 170 180 190 200
LHFDKNFVQL CLSAEPSEAP RLLAPAALAF RFVEVLLINN NNSSQFTCGV
210 220 230 240 250
LCRWSEECGR AAGRACGFAQ PGCSCPGEAG AGSTTTTSPG PPAAHTLSNA
260 270 280 290 300
LVPGGPAPPA EADLHSGSSN DLFTTEMRYG EEPEEEPKVK TQWPRSADEP
310 320 330 340 350
GLYMAQTGDP AAEEWSPWSV CSLTCGQGLQ VRTRSCVSSP YGTLCSGPLR
360 370 380 390 400
ETRPCNNSAT CPVHGVWEEW GSWSLCSRSC GRGSRSRMRT CVPPQHGGKA
410 420 430 440 450
CEGPELQTKL CSMAACPVEG QWLEWGPWGP CSTSCANGTQ QRSRKCSVAG
460 470 480 490 500
PAWATCTGAL TDTRECSNLE CPATDSKWGP WNAWSLCSKT CDTGWQRRFR
510 520 530 540 550
MCQATGTQGY PCEGTGEEVK PCSEKRCPAF HEMCRDEYVM LMTWKKAAAG
560 570 580 590 600
EIIYNKCPPN ASGSASRRCL LSAQGVAYWG LPSFARCISH EYRYLYLSLR
610 620 630 640 650
EHLAKGQRML AGEGMSQVVR SLQELLARRT YYSGDLLFSV DILRNVTDTF
660 670 680 690 700
KRATYVPSAD DVQRFFQVVS FMVDAENKEK WDDAQQVSPG SVHLLRVVED
710 720 730 740 750
FIHLVGDALK AFQSSLIVTD NLVISIQREP VSAVSSDITF PMRGRRGMKD
760 770 780 790 800
WVRHSEDRLF LPKEVLSLSS PGKPATSGAA GSPGRGRGPG TVPPGPGHSH
810 820 830 840 850
QRLLPADPDE SSYFVIGAVL YRTLGLILPP PRPPLAVTSR VMTVTVRPPT
860 870 880 890 900
QPPAEPLITV ELSYIINGTT DPHCASWDYS RADASSGDWD TENCQTLETQ
910 920 930 940 950
AAHTRCQCQH LSTFAVLAQP PKDLTLELAG SPSVPLVIGC AVSCMALLTL
960 970 980 990 1000
LAIYAAFWRF IKSERSIILL NFCLSILASN ILILVGQSRV LSKGVCTMTA
1010 1020 1030 1040 1050
AFLHFFFLSS FCWVLTEAWQ SYLAVIGRMR TRLVRKRFLC LGWGLPALVV
1060 1070 1080 1090 1100
AVSVGFTRTK GYGTSSYCWL SLEGGLLYAF VGPAAVIVLV NMLIGIIVFN
1110 1120 1130 1140 1150
KLMARDGISD KSKKQRAGSE RCPWASLLLP CSACGAVPSP LLSSASARNA
1160 1170 1180 1190 1200
MASLWSSCVV LPLLALTWMS AVLAMTDRRS VLFQALFAVF NSAQGFVITA
1210 1220 1230 1240 1250
VHCFLRREVQ DVVKCQMGVC RADESEDSPD SCKNGQLQIL SDFEKDVDLA
1260 1270 1280 1290 1300
CQTVLFKEVN TCNPSTITGT LSRLSLDEDE EPKSCLVGPE GSLSFSPLPG
1310 1320 1330 1340 1350
NILVPMAASP GLGEPPPPQE ANPVYMCGEG GLRQLDLTWL RPTEPGSEGD
1360 1370 1380 1390 1400
YMVLPRRTLS LQPGGGGGGG EDAPRARPEG TPRRAAKTVA HTEGYPSFLS
1410 1420 1430 1440 1450
VDHSGLGLGP AYGSLQNPYG MTFQPPPPTP SARQVPEPGE RSRTMPRTVP
1460 1470 1480 1490 1500
GSTMKMGSLE RKKLRYSDLD FEKVMHTRKR HSELYHELNQ KFHTFDRYRS
1510 1520 1530 1540 1550
QSTAKREKRW SVSSGGAAER SVCTDKPSPG ERPSLSQHRR HQSWSTFKSM
1560 1570 1580
TLGSLPPKPR ERLTLHRAAA WEPTEPPDGD FQTEV
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA2A3C1 | A2A3C1_HUMAN | Adhesion G protein-coupled receptor... | ADGRB2 | 1,466 | Annotation score: | ||
A2A3C2 | A2A3C2_HUMAN | Adhesion G protein-coupled receptor... | ADGRB2 | 1,554 | Annotation score: | ||
A2A3C3 | A2A3C3_HUMAN | Adhesion G protein-coupled receptor... | ADGRB2 | 1,499 | Annotation score: | ||
A2A3C6 | A2A3C6_HUMAN | Adhesion G protein-coupled receptor... | ADGRB2 | 1,500 | Annotation score: | ||
A2A3C4 | A2A3C4_HUMAN | Adhesion G protein-coupled receptor... | ADGRB2 | 847 | Annotation score: | ||
E9PND1 | E9PND1_HUMAN | Adhesion G protein-coupled receptor... | ADGRB2 | 507 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 325 | C → R in AAI36534 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_079840 | 1465 | R → W Probable disease-associated variant found in a patient with progressive spastic paraparesis and other neurological symptoms; enhances receptor surface expression; increases the constitutive signaling activity; does not affect interaction with GNAZ; promotes enhanced interaction with GNAI1; decreases interaction with SH3GL2. 1 PublicationCorresponds to variant dbSNP:rs778361520EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_037045 | 1 – 12 | Missing in isoform 3. CuratedAdd BLAST | 12 | |
Alternative sequenceiVSP_037046 | 1119 – 1151 | Missing in isoform 4. 1 PublicationAdd BLAST | 33 | |
Alternative sequenceiVSP_037047 | 1473 | Missing in isoform 2 and isoform 4. 2 Publications | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB005298 mRNA Translation: BAA25362.1 Different initiation. AB065648 Genomic DNA Translation: BAC05874.1 AC114488 Genomic DNA No translation available. AL354919 Genomic DNA No translation available. BC009035 mRNA Translation: AAH09035.1 BC136533 mRNA Translation: AAI36534.1 |
CCDSi | CCDS72746.1 [O60241-4] CCDS72747.1 [O60241-2] |
PIRi | T00027 |
RefSeqi | NP_001281264.1, NM_001294335.1 [O60241-2] NP_001281265.1, NM_001294336.1 [O60241-4] XP_011540150.1, XM_011541848.2 [O60241-1] XP_011540151.1, XM_011541849.2 [O60241-3] XP_016857388.1, XM_017001899.1 [O60241-1] XP_016857389.1, XM_017001900.1 [O60241-2] XP_016857394.1, XM_017001905.1 [O60241-4] |
Genome annotation databases
Ensembli | ENST00000373655; ENSP00000362759; ENSG00000121753 [O60241-2] ENST00000373658; ENSP00000362762; ENSG00000121753 ENST00000527361; ENSP00000435397; ENSG00000121753 [O60241-4] |
GeneIDi | 576 |
KEGGi | hsa:576 |
MANE-Selecti | ENST00000373658.8; ENSP00000362762.3; NM_001364857.2; NP_001351786.1 |
UCSCi | uc001btn.4, human [O60241-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB005298 mRNA Translation: BAA25362.1 Different initiation. AB065648 Genomic DNA Translation: BAC05874.1 AC114488 Genomic DNA No translation available. AL354919 Genomic DNA No translation available. BC009035 mRNA Translation: AAH09035.1 BC136533 mRNA Translation: AAI36534.1 |
CCDSi | CCDS72746.1 [O60241-4] CCDS72747.1 [O60241-2] |
PIRi | T00027 |
RefSeqi | NP_001281264.1, NM_001294335.1 [O60241-2] NP_001281265.1, NM_001294336.1 [O60241-4] XP_011540150.1, XM_011541848.2 [O60241-1] XP_011540151.1, XM_011541849.2 [O60241-3] XP_016857388.1, XM_017001899.1 [O60241-1] XP_016857389.1, XM_017001900.1 [O60241-2] XP_016857394.1, XM_017001905.1 [O60241-4] |
3D structure databases
SMRi | O60241 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 107052, 9 interactors |
IntActi | O60241, 9 interactors |
MINTi | O60241 |
STRINGi | 9606.ENSP00000362759 |
Protein family/group databases
MEROPSi | P02.029 |
TCDBi | 9.A.14.6.6, the g-protein-coupled receptor (gpcr) family |
GPCRDBi | Search... |
PTM databases
CarbonylDBi | O60241 |
GlyGeni | O60241, 8 sites |
iPTMneti | O60241 |
PhosphoSitePlusi | O60241 |
Genetic variation databases
BioMutai | ADGRB2 |
Proteomic databases
jPOSTi | O60241 |
MassIVEi | O60241 |
PaxDbi | O60241 |
PeptideAtlasi | O60241 |
PRIDEi | O60241 |
ProteomicsDBi | 49271 [O60241-1] 49272 [O60241-2] 49273 [O60241-3] 49274 [O60241-4] |
Protocols and materials databases
Antibodypediai | 16794, 289 antibodies from 32 providers |
DNASUi | 576 |
Genome annotation databases
Ensembli | ENST00000373655; ENSP00000362759; ENSG00000121753 [O60241-2] ENST00000373658; ENSP00000362762; ENSG00000121753 ENST00000527361; ENSP00000435397; ENSG00000121753 [O60241-4] |
GeneIDi | 576 |
KEGGi | hsa:576 |
MANE-Selecti | ENST00000373658.8; ENSP00000362762.3; NM_001364857.2; NP_001351786.1 |
UCSCi | uc001btn.4, human [O60241-1] |
Organism-specific databases
CTDi | 576 |
DisGeNETi | 576 |
GeneCardsi | ADGRB2 |
HGNCi | HGNC:944, ADGRB2 |
HPAi | ENSG00000121753, Tissue enriched (brain) |
MIMi | 602683, gene |
neXtProti | NX_O60241 |
OpenTargetsi | ENSG00000121753 |
PharmGKBi | PA25248 |
VEuPathDBi | HostDB:ENSG00000121753 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QRKJ, Eukaryota |
GeneTreei | ENSGT00940000160103 |
InParanoidi | O60241 |
OMAi | NILMPMA |
OrthoDBi | 27621at2759 |
PhylomeDBi | O60241 |
TreeFami | TF331634 |
Enzyme and pathway databases
PathwayCommonsi | O60241 |
SignaLinki | O60241 |
Miscellaneous databases
BioGRID-ORCSi | 576, 16 hits in 666 CRISPR screens |
ChiTaRSi | ADGRB2, human |
GeneWikii | Brain-specific_angiogenesis_inhibitor_2 |
GenomeRNAii | 576 |
Pharosi | O60241, Tbio |
PROi | PR:O60241 |
RNActi | O60241, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000121753, Expressed in right frontal lobe and 167 other tissues |
ExpressionAtlasi | O60241, baseline and differential |
Genevisiblei | O60241, HS |
Family and domain databases
Gene3Di | 2.20.100.10, 4 hits 4.10.1240.10, 1 hit |
InterProi | View protein in InterPro IPR043838, AGRB_N IPR032471, GAIN_dom_N IPR017981, GPCR_2-like IPR008077, GPCR_2_brain_angio_inhib IPR036445, GPCR_2_extracell_dom_sf IPR001879, GPCR_2_extracellular_dom IPR000832, GPCR_2_secretin-like IPR000203, GPS IPR000884, TSP1_rpt IPR036383, TSP1_rpt_sf |
Pfami | View protein in Pfam PF00002, 7tm_2, 1 hit PF19188, AGRB_N, 1 hit PF16489, GAIN, 1 hit PF01825, GPS, 1 hit PF00090, TSP_1, 4 hits |
PRINTSi | PR01694, BAIPRECURSOR PR00249, GPCRSECRETIN |
SMARTi | View protein in SMART SM00303, GPS, 1 hit SM00008, HormR, 1 hit SM00209, TSP1, 4 hits |
SUPFAMi | SSF82895, SSF82895, 4 hits |
PROSITEi | View protein in PROSITE PS50227, G_PROTEIN_RECEP_F2_3, 1 hit PS50261, G_PROTEIN_RECEP_F2_4, 1 hit PS50221, GPS, 1 hit PS50092, TSP1, 4 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | AGRB2_HUMAN | |
Accessioni | O60241Primary (citable) accession number: O60241 Secondary accession number(s): B9EGK9 Q96GZ9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 2000 |
Last sequence update: | May 5, 2009 | |
Last modified: | February 23, 2022 | |
This is version 194 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families