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Protein

Perilipin-1

Gene

PLIN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Modulator of adipocyte lipid metabolism. Coats lipid storage droplets to protect them from breakdown by hormone-sensitive lipase (HSL). Its absence may result in leanness. Plays a role in unilocular lipid droplet formation by activating CIDEC. Their interaction promotes lipid droplet enlargement and directional net neutral lipid transfer. May modulate lipolysis and triglyceride levels.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • lipid binding Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processLipid metabolism

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-163560 Triglyceride catabolism
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation

SIGNOR Signaling Network Open Resource

More...
SIGNORi
O60240

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Perilipin-1
Alternative name(s):
Lipid droplet-associated protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PLIN1
Synonyms:PERI, PLIN
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000166819.11

Human Gene Nomenclature Database

More...
HGNCi
HGNC:9076 PLIN1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
170290 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O60240

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Lipid droplet

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Lipodystrophy, familial partial, 4 (FPLD4)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of lipodystrophy characterized by loss of subcutaneous adipose tissue primarily affecting the lower limbs, insulin-resistant diabetes mellitus, hypertriglyceridemia, and hypertension.
See also OMIM:613877

Organism-specific databases

DisGeNET

More...
DisGeNETi
5346

MalaCards human disease database

More...
MalaCardsi
PLIN1
MIMi613877 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000166819

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
280356 PLIN1-related familial partial lipodystrophy

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA33409

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL1741164

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PLIN1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000998841 – 522Perilipin-1Add BLAST522

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei81PhosphoserineCombined sources1
Modified residuei85PhosphothreonineBy similarity1
Modified residuei126PhosphoserineBy similarity1
Modified residuei130PhosphoserineCombined sources1
Modified residuei132PhosphoserineBy similarity1
Modified residuei137PhosphoserineBy similarity1
Modified residuei174PhosphoserineCombined sources1
Modified residuei299PhosphothreonineBy similarity1
Modified residuei301PhosphothreonineBy similarity1
Modified residuei382PhosphoserineCombined sources1
Modified residuei384PhosphoserineBy similarity1
Modified residuei408PhosphoserineBy similarity1
Modified residuei436PhosphoserineCombined sources1
Modified residuei497PhosphoserineCombined sources1
Modified residuei499PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Major cAMP-dependent protein kinase-substrate in adipocytes, also dephosphorylated by PP1. When phosphorylated, may be maximally sensitive to HSL and when unphosphorylated, may play a role in the inhibition of lipolysis, by acting as a barrier in lipid droplet (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O60240

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O60240

PeptideAtlas

More...
PeptideAtlasi
O60240

PRoteomics IDEntifications database

More...
PRIDEi
O60240

ProteomicsDB human proteome resource

More...
ProteomicsDBi
49270

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O60240

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O60240

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Adipocytes.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000166819 Expressed in 123 organ(s), highest expression level in adipose tissue

CleanEx database of gene expression profiles

More...
CleanExi
HS_PLIN

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O60240 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O60240 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB033821
CAB037333
HPA024299

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with ABHD5 (By similarity). Interacts with CIDEC.By similarity1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
111361, 5 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000300055

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
O60240

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
O60240

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni291 – 319Required for interaction with CIDECBy similarityAdd BLAST29

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi307 – 316Poly-Glu10

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the perilipin family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IGIT Eukaryota
ENOG4111TBF LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153161

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000261608

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O60240

KEGG Orthology (KO)

More...
KOi
K08768

Identification of Orthologs from Complete Genome Data

More...
OMAi
EDQTDTE

Database of Orthologous Groups

More...
OrthoDBi
1437332at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O60240

TreeFam database of animal gene trees

More...
TreeFami
TF325901

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR004279 Perilipin

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03036 Perilipin, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF036881 PAT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O60240-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAVNKGLTLL DGDLPEQENV LQRVLQLPVV SGTCECFQKT YTSTKEAHPL
60 70 80 90 100
VASVCNAYEK GVQSASSLAA WSMEPVVRRL STQFTAANEL ACRGLDHLEE
110 120 130 140 150
KIPALQYPPE KIASELKDTI STRLRSARNS ISVPIASTSD KVLGAALAGC
160 170 180 190 200
ELAWGVARDT AEFAANTRAG RLASGGADLA LGSIEKVVEY LLPPDKEESA
210 220 230 240 250
PAPGHQQAQK SPKAKPSLLS RVGALTNTLS RYTVQTMARA LEQGHTVAMW
260 270 280 290 300
IPGVVPLSSL AQWGASVAMQ AVSRRRSEVR VPWLHSLAAA QEEDHEDQTD
310 320 330 340 350
TEGEDTEEEE ELETEENKFS EVAALPGPRG LLGGVAHTLQ KTLQTTISAV
360 370 380 390 400
TWAPAAVLGM AGRVLHLTPA PAVSSTKGRA MSLSDALKGV TDNVVDTVVH
410 420 430 440 450
YVPLPRLSLM EPESEFRDID NPPAEVERRE AERRASGAPS AGPEPAPRLA
460 470 480 490 500
QPRRSLRSAQ SPGAPPGPGL EDEVATPAAP RPGFPAVPRE KPKRRVSDSF
510 520
FRPSVMEPIL GRTHYSQLRK KS
Length:522
Mass (Da):55,990
Last modified:May 5, 2009 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i394FC14388EB5DCC
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YM16H0YM16_HUMAN
Perilipin-1
PLIN1
73Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti510L → V in BAA25420 (PubMed:9521880).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_055046194P → A2 PublicationsCorresponds to variant dbSNP:rs6496589EnsemblClinVar.1
Natural variantiVAR_055047210K → E1 PublicationCorresponds to variant dbSNP:rs17852910Ensembl.1
Natural variantiVAR_061505271A → V. Corresponds to variant dbSNP:rs58361219EnsemblClinVar.1
Natural variantiVAR_055048348S → L. Corresponds to variant dbSNP:rs8179071EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB005293 mRNA Translation: BAA25420.1
AC013787 Genomic DNA No translation available.
BC031084 mRNA Translation: AAH31084.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS10353.1

NCBI Reference Sequences

More...
RefSeqi
NP_001138783.1, NM_001145311.1
NP_002657.3, NM_002666.4
XP_005254991.1, XM_005254934.4

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.103253

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000300055; ENSP00000300055; ENSG00000166819
ENST00000430628; ENSP00000402167; ENSG00000166819

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
5346

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:5346

UCSC genome browser

More...
UCSCi
uc002boh.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Protein Spotlight

Fat, wonderful fat - Issue 10 of May 2001

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB005293 mRNA Translation: BAA25420.1
AC013787 Genomic DNA No translation available.
BC031084 mRNA Translation: AAH31084.1
CCDSiCCDS10353.1
RefSeqiNP_001138783.1, NM_001145311.1
NP_002657.3, NM_002666.4
XP_005254991.1, XM_005254934.4
UniGeneiHs.103253

3D structure databases

ProteinModelPortaliO60240
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111361, 5 interactors
STRINGi9606.ENSP00000300055

Chemistry databases

BindingDBiO60240
ChEMBLiCHEMBL1741164

PTM databases

iPTMnetiO60240
PhosphoSitePlusiO60240

Polymorphism and mutation databases

BioMutaiPLIN1

Proteomic databases

jPOSTiO60240
PaxDbiO60240
PeptideAtlasiO60240
PRIDEiO60240
ProteomicsDBi49270

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000300055; ENSP00000300055; ENSG00000166819
ENST00000430628; ENSP00000402167; ENSG00000166819
GeneIDi5346
KEGGihsa:5346
UCSCiuc002boh.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5346
DisGeNETi5346
EuPathDBiHostDB:ENSG00000166819.11

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PLIN1

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0202172
HGNCiHGNC:9076 PLIN1
HPAiCAB033821
CAB037333
HPA024299
MalaCardsiPLIN1
MIMi170290 gene
613877 phenotype
neXtProtiNX_O60240
OpenTargetsiENSG00000166819
Orphaneti280356 PLIN1-related familial partial lipodystrophy
PharmGKBiPA33409

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IGIT Eukaryota
ENOG4111TBF LUCA
GeneTreeiENSGT00940000153161
HOGENOMiHOG000261608
InParanoidiO60240
KOiK08768
OMAiEDQTDTE
OrthoDBi1437332at2759
PhylomeDBiO60240
TreeFamiTF325901

Enzyme and pathway databases

ReactomeiR-HSA-163560 Triglyceride catabolism
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation
SIGNORiO60240

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Perilipin

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
5346

Protein Ontology

More...
PROi
PR:O60240

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000166819 Expressed in 123 organ(s), highest expression level in adipose tissue
CleanExiHS_PLIN
ExpressionAtlasiO60240 baseline and differential
GenevisibleiO60240 HS

Family and domain databases

InterProiView protein in InterPro
IPR004279 Perilipin
PfamiView protein in Pfam
PF03036 Perilipin, 1 hit
PIRSFiPIRSF036881 PAT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPLIN1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O60240
Secondary accession number(s): Q8N5Y6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 5, 2009
Last modified: January 16, 2019
This is version 151 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  6. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
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