Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - O60239 (3BP5_HUMAN)

(max 400 entries)x

Your basket is currently empty. i

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

SH3 domain-binding protein 5

Gene

SH3BP5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibits the auto- and transphosphorylation activity of BTK. Plays a negative regulatory role in BTK-related cytoplasmic signaling in B-cells. May be involved in BCR-induced apoptotic cell death.2 Publications

GO - Molecular functioni

  • protein kinase inhibitor activity Source: MGI
  • SH3 domain binding Source: GO_Central
View the complete GO annotation on QuickGO ...

GO - Biological processi

  • intracellular signal transduction Source: MGI
  • negative regulation of protein tyrosine kinase activity Source: GO_Central
  • signal transduction Source: ProtInc
View the complete GO annotation on QuickGO ...

Enzyme and pathway databases

SignaLinkiO60239
SIGNORiO60239

Names & Taxonomyi

Protein namesi
Recommended name:
SH3 domain-binding protein 5
Short name:
SH3BP-5
Alternative name(s):
SH3 domain-binding protein that preferentially associates with BTK
Gene namesi
Name:SH3BP5
Synonyms:SAB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000131370.15
HGNCiHGNC:10827 SH3BP5
MIMi605612 gene
neXtProtiNX_O60239

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi347L → A: Loss of phosphorylation and binding by phospho-JNK; when associated with A-349. 1 Publication1
Mutagenesisi349L → A: Loss of phosphorylation and binding by phospho-JNK; when associated with A-347. 1 Publication1
Mutagenesisi434L → A: No change of phosphorylation or binding by phospho-JNK; when associated with A-436. 1 Publication1
Mutagenesisi436L → A: No change of phosphorylation or binding by phospho-JNK; when associated with A-434. 1 Publication1

Organism-specific databases

DisGeNETi9467
OpenTargetsiENSG00000131370
PharmGKBiPA35735

Polymorphism and mutation databases

BioMutaiSH3BP5

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000643681 – 455SH3 domain-binding protein 5Add BLAST455

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei351Phosphoserine; by MAPK12 and MAPK9By similarity1
Modified residuei375PhosphoserineBy similarity1
Modified residuei376PhosphoserineBy similarity1
Modified residuei418PhosphoserineBy similarity1
Modified residuei421PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO60239
MaxQBiO60239
PaxDbiO60239
PeptideAtlasiO60239
PRIDEiO60239
ProteomicsDBi49268
49269 [O60239-2]
TopDownProteomicsiO60239-1 [O60239-1]

PTM databases

iPTMnetiO60239
PhosphoSitePlusiO60239

Expressioni

Tissue specificityi

Highly expressed in testis and ovaries. It is also expressed in a variety of tissues including spleen, lymph node, thymus, bone marrow, fetal liver, colon, small intestine and prostate.1 Publication

Gene expression databases

BgeeiENSG00000131370
CleanExiHS_SH3BP5
ExpressionAtlasiO60239 baseline and differential
GenevisibleiO60239 HS

Organism-specific databases

HPAiHPA036445
HPA057988

Interactioni

Subunit structurei

Interacts with BTK (PubMed:9571151, PubMed:10339589). Interacts with all isoforms of MAPK8, MAPK9, MAPK10 and MAPK12 (PubMed:12167088). Interacts with GDP-bound and nucleotide-free forms of RAB11A (PubMed:26506309).4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
BTKQ061874EBI-624860,EBI-624835

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi114853, 21 interactors
ELMiO60239
IntActiO60239, 11 interactors
STRINGi9606.ENSP00000373301

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4H3BX-ray2.08B/D341-350[»]
ProteinModelPortaliO60239
SMRiO60239
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi11 – 67Glu-richAdd BLAST57
Compositional biasi36 – 40Poly-Glu5
Compositional biasi278 – 421Ser-richAdd BLAST144
Compositional biasi405 – 410Poly-Ser6

Sequence similaritiesi

Belongs to the SH3BP5 family.Curated

Keywords - Domaini

SH3-binding

Phylogenomic databases

eggNOGiKOG2008 Eukaryota
ENOG410ZK48 LUCA
GeneTreeiENSGT00390000018500
HOGENOMiHOG000212681
HOVERGENiHBG018168
InParanoidiO60239
OMAiRATQDFQ
OrthoDBiEOG091G08YD
PhylomeDBiO60239
TreeFamiTF105573

Family and domain databases

InterProiView protein in InterPro
IPR007940 SH3BP5
PANTHERiPTHR19423 PTHR19423, 1 hit
PfamiView protein in Pfam
PF05276 SH3BP5, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O60239-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDAALKRSRS EEPAEILPPA RDEEEEEEEG MEQGLEEEEE VDPRIQGELE 
        60         70         80         90        100
KLNQSTDDIN RRETELEDAR QKFRSVLVEA TVKLDELVKK IGKAVEDSKP 
       110        120        130        140        150
YWEARRVARQ AQLEAQKATQ DFQRATEVLR AAKETISLAE QRLLEDDKRQ 
       160        170        180        190        200
FDSAWQEMLN HATQRVMEAE QTKTRSELVH KETAARYNAA MGRMRQLEKK 
       210        220        230        240        250
LKRAINKSKP YFELKAKYYV QLEQLKKTVD DLQAKLTLAK GEYKMALKNL 
       260        270        280        290        300
EMISDEIHER RRSSAMGPRG CGVGAEGSST SVEDLPGSKP EPDAISVASE 
       310        320        330        340        350
AFEDDSCSNF VSEDDSETQS VSSFSSGPTS PSEMPDQFPA VVRPGSLDLP 
       360        370        380        390        400
SPVSLSEFGM MFPVLGPRSE CSGASSPECE VERGDRAEGA ENKTSDKANN 
       410        420        430        440        450
NRGLSSSSGS GGSSKSQSST SPEGQALENR MKQLSLQCSK GRDGIIADIK 

MVQIG
Length:455
Mass (Da):50,425
Last modified:January 23, 2007 - v2
Checksum:i5C8CA4861D66346B
GO
Isoform 2 (identifier: O60239-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-157: Missing.

Note: No experimental confirmation available.
Show »
Length:298
Mass (Da):32,202
Checksum:i4326AF41042E6F58
GO

Sequence cautioni

The sequence BAA25922 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0428541 – 157Missing in isoform 2. 1 PublicationAdd BLAST157

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK090524 mRNA Translation: BAG52178.1
AC087590 Genomic DNA No translation available.
AL117422 mRNA Translation: CAI46220.1
CH471055 Genomic DNA Translation: EAW64225.1
BC010123 mRNA Translation: AAH10123.2
AB005047 mRNA Translation: BAA25922.1 Different initiation.
CCDSiCCDS2625.2 [O60239-1]
CCDS43055.1 [O60239-2]
PIRiJE0086
RefSeqiNP_001018009.2, NM_001018009.3 [O60239-2]
NP_004835.2, NM_004844.4 [O60239-1]
XP_016863011.1, XM_017007522.1 [O60239-2]
XP_016863012.1, XM_017007523.1 [O60239-2]
XP_016863013.1, XM_017007524.1 [O60239-2]
XP_016863014.1, XM_017007525.1 [O60239-2]
UniGeneiHs.257761

Genome annotation databases

EnsembliENST00000383791; ENSP00000373301; ENSG00000131370 [O60239-1]
ENST00000408919; ENSP00000386231; ENSG00000131370 [O60239-2]
ENST00000426925; ENSP00000388553; ENSG00000131370 [O60239-2]
GeneIDi9467
KEGGihsa:9467
UCSCiuc003bzp.3 human [O60239-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry namei3BP5_HUMAN
AccessioniPrimary (citable) accession number: O60239
Secondary accession number(s): B3KQW6, Q5JWV9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: January 23, 2007
Last modified: June 20, 2018
This is version 150 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health