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UniProtKB - O60239 (3BP5_HUMAN)

Entry version 176 (25 May 2022)
Sequence version 2 (23 Jan 2007)
Previous versions | rss
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Protein

SH3 domain-binding protein 5

Gene

SH3BP5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Functions as guanine nucleotide exchange factor (GEF) with specificity for RAB11A and RAB25 (PubMed:26506309, PubMed:30217979).

Inhibits the auto- and transphosphorylation activity of BTK. Plays a negative regulatory role in BTK-related cytoplasmic signaling in B-cells. May be involved in BCR-induced apoptotic cell death.

4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGuanine-nucleotide releasing factor

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		O60239

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		O60239

SIGNOR Signaling Network Open Resource

More...SIGNORi		O60239

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
SH3 domain-binding protein 5
Short name:
SH3BP-5
Alternative name(s):
SH3 domain-binding protein that preferentially associates with BTK
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SH3BP5
Synonyms:SAB
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:10827, SH3BP5

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		605612, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O60239

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000131370

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasmic vesicle, Membrane, Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi52 – 54LNQ → AAA: Loss of guanine nucleotide exchange factor activity. 1 Publication3
Mutagenesisi250 – 251LE → AK: Loss of guanine nucleotide exchange factor activity. 1 Publication2
Mutagenesisi347L → A: Loss of phosphorylation and binding by phospho-JNK; when associated with A-349. 1 Publication1
Mutagenesisi349L → A: Loss of phosphorylation and binding by phospho-JNK; when associated with A-347. 1 Publication1
Mutagenesisi434L → A: No change of phosphorylation or binding by phospho-JNK; when associated with A-436. 1 Publication1
Mutagenesisi436L → A: No change of phosphorylation or binding by phospho-JNK; when associated with A-434. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		9467

Open Targets

More...OpenTargetsi		ENSG00000131370

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA35735

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O60239, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SH3BP5

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000643681 – 455SH3 domain-binding protein 5Add BLAST455

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei351Phosphoserine; by MAPK12 and MAPK9By similarity1
Modified residuei375PhosphoserineBy similarity1
Modified residuei376PhosphoserineBy similarity1
Modified residuei418PhosphoserineBy similarity1
Modified residuei421PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		O60239

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O60239

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O60239

MaxQB - The MaxQuant DataBase

More...MaxQBi		O60239

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O60239

PeptideAtlas

More...PeptideAtlasi		O60239

PRoteomics IDEntifications database

More...PRIDEi		O60239

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		49268 [O60239-1]
49269 [O60239-2]

Consortium for Top Down Proteomics

More...TopDownProteomicsi		O60239-1 [O60239-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O60239

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O60239

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in testis and ovaries. It is also expressed in a variety of tissues including spleen, lymph node, thymus, bone marrow, fetal liver, colon, small intestine and prostate.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000131370, Expressed in metanephros and 250 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O60239, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O60239, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000131370, Tissue enhanced (adrenal)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with BTK (PubMed:9571151, PubMed:10339589).

Interacts with all isoforms of MAPK8, MAPK9, MAPK10 and MAPK12 (PubMed:12167088).

Interacts with GDP-bound and nucleotide-free forms of RAB11A (PubMed:26506309, PubMed:30217979).

5 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		114853, 23 interactors

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...ELMi		O60239

Protein interaction database and analysis system

More...IntActi		O60239, 22 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000373301

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O60239, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1455
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		O60239

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O60239

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 63DisorderedSequence analysisAdd BLAST63
Regioni31 – 265Sufficient for interaction with RAB11A and for guanine nucleotide exchange activity1 PublicationAdd BLAST235
Regioni259 – 293DisorderedSequence analysisAdd BLAST35
Regioni306 – 345DisorderedSequence analysisAdd BLAST40
Regioni369 – 435DisorderedSequence analysisAdd BLAST67

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili44 – 901 PublicationAdd BLAST47
Coiled coili97 – 1451 PublicationAdd BLAST49
Coiled coili154 – 2001 PublicationAdd BLAST47
Coiled coili211 – 2551 PublicationAdd BLAST45

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 17Basic and acidic residuesSequence analysisAdd BLAST17
Compositional biasi18 – 43Acidic residuesSequence analysisAdd BLAST26
Compositional biasi306 – 333Polar residuesSequence analysisAdd BLAST28
Compositional biasi379 – 395Basic and acidic residuesSequence analysisAdd BLAST17
Compositional biasi396 – 435Polar residuesSequence analysisAdd BLAST40

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The N-terminal half of the protein mediates interaction with RAB11A and functions as guanine nucleotide exchange factor. Four long alpha-helices (interrupted by a central kink) assemble into coiled coils, giving rise to a 'V' shape.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SH3BP5 family.Curated

Keywords - Domaini

Coiled coil, SH3-binding

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2008, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000018500

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_048895_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O60239

Identification of Orthologs from Complete Genome Data

More...OMAi		QFPPATR

Database for complete collections of gene phylogenies

More...PhylomeDBi		O60239

TreeFam database of animal gene trees

More...TreeFami		TF105573

Family and domain databases

Database of protein disorder

More...DisProti		DP02850

Intrinsically Disordered proteins with Extensive Annotations and Literature

More...IDEALi		IID00507

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR007940, SH3BP5

The PANTHER Classification System

More...PANTHERi		PTHR19423, PTHR19423, 2 hits

Pfam protein domain database

More...Pfami		View protein in Pfam
PF05276, SH3BP5, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O60239-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDAALKRSRS EEPAEILPPA RDEEEEEEEG MEQGLEEEEE VDPRIQGELE 
        60         70         80         90        100
KLNQSTDDIN RRETELEDAR QKFRSVLVEA TVKLDELVKK IGKAVEDSKP 
       110        120        130        140        150
YWEARRVARQ AQLEAQKATQ DFQRATEVLR AAKETISLAE QRLLEDDKRQ 
       160        170        180        190        200
FDSAWQEMLN HATQRVMEAE QTKTRSELVH KETAARYNAA MGRMRQLEKK 
       210        220        230        240        250
LKRAINKSKP YFELKAKYYV QLEQLKKTVD DLQAKLTLAK GEYKMALKNL 
       260        270        280        290        300
EMISDEIHER RRSSAMGPRG CGVGAEGSST SVEDLPGSKP EPDAISVASE 
       310        320        330        340        350
AFEDDSCSNF VSEDDSETQS VSSFSSGPTS PSEMPDQFPA VVRPGSLDLP 
       360        370        380        390        400
SPVSLSEFGM MFPVLGPRSE CSGASSPECE VERGDRAEGA ENKTSDKANN 
       410        420        430        440        450
NRGLSSSSGS GGSSKSQSST SPEGQALENR MKQLSLQCSK GRDGIIADIK 

MVQIG
Length:455
Mass (Da):50,425
Last modified:January 23, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5C8CA4861D66346B
GO
Isoform 2 (identifier: O60239-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-157: Missing.

Show »
Length:298
Mass (Da):32,202
Checksum:i4326AF41042E6F58
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JK30C9JK30_HUMAN
SH3 domain-binding protein 5
SH3BP5
128Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WDU8F8WDU8_HUMAN
SH3 domain-binding protein 5
SH3BP5
69Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JNW0C9JNW0_HUMAN
SH3 domain-binding protein 5
SH3BP5
51Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J140C9J140_HUMAN
SH3 domain-binding protein 5
SH3BP5
57Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA25922 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0428541 – 157Missing in isoform 2. 1 PublicationAdd BLAST157

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK090524 mRNA Translation: BAG52178.1
AC087590 Genomic DNA No translation available.
AL117422 mRNA Translation: CAI46220.1
CH471055 Genomic DNA Translation: EAW64225.1
BC010123 mRNA Translation: AAH10123.2
AB005047 mRNA Translation: BAA25922.1 Different initiation.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS2625.2 [O60239-1]
CCDS43055.1 [O60239-2]

Protein sequence database of the Protein Information Resource

More...PIRi		JE0086

NCBI Reference Sequences

More...RefSeqi		NP_001018009.2, NM_001018009.3 [O60239-2]
NP_004835.2, NM_004844.4 [O60239-1]
XP_016863011.1, XM_017007522.1 [O60239-2]
XP_016863012.1, XM_017007523.1 [O60239-2]
XP_016863013.1, XM_017007524.1 [O60239-2]
XP_016863014.1, XM_017007525.1 [O60239-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000383791.8; ENSP00000373301.3; ENSG00000131370.16
ENST00000408919.7; ENSP00000386231.3; ENSG00000131370.16 [O60239-2]
ENST00000426925.5; ENSP00000388553.1; ENSG00000131370.16 [O60239-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		9467

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:9467

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000383791.8; ENSP00000373301.3; NM_004844.5; NP_004835.2

UCSC genome browser

More...UCSCi		uc003bzp.3, human [O60239-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK090524 mRNA Translation: BAG52178.1
AC087590 Genomic DNA No translation available.
AL117422 mRNA Translation: CAI46220.1
CH471055 Genomic DNA Translation: EAW64225.1
BC010123 mRNA Translation: AAH10123.2
AB005047 mRNA Translation: BAA25922.1 Different initiation.
CCDSiCCDS2625.2 [O60239-1]
CCDS43055.1 [O60239-2]
PIRiJE0086
RefSeqiNP_001018009.2, NM_001018009.3 [O60239-2]
NP_004835.2, NM_004844.4 [O60239-1]
XP_016863011.1, XM_017007522.1 [O60239-2]
XP_016863012.1, XM_017007523.1 [O60239-2]
XP_016863013.1, XM_017007524.1 [O60239-2]
XP_016863014.1, XM_017007525.1 [O60239-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4H3BX-ray2.08B/D341-350[»]
6DJLX-ray3.10B/C/D/E1-265[»]
6IXEX-ray3.35A41-266[»]
6IXFX-ray3.60A/B41-266[»]
6IXGX-ray3.80A/B41-266[»]
6IXVX-ray3.80A/B/C/D10-276[»]
AlphaFoldDBiO60239
SMRiO60239
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi114853, 23 interactors
ELMiO60239
IntActiO60239, 22 interactors
STRINGi9606.ENSP00000373301

PTM databases

iPTMnetiO60239
PhosphoSitePlusiO60239

Genetic variation databases

BioMutaiSH3BP5

Proteomic databases

EPDiO60239
jPOSTiO60239
MassIVEiO60239
MaxQBiO60239
PaxDbiO60239
PeptideAtlasiO60239
PRIDEiO60239
ProteomicsDBi49268 [O60239-1]
49269 [O60239-2]
TopDownProteomicsiO60239-1 [O60239-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		26718, 165 antibodies from 27 providers

The DNASU plasmid repository

More...DNASUi		9467

Genome annotation databases

EnsembliENST00000383791.8; ENSP00000373301.3; ENSG00000131370.16
ENST00000408919.7; ENSP00000386231.3; ENSG00000131370.16 [O60239-2]
ENST00000426925.5; ENSP00000388553.1; ENSG00000131370.16 [O60239-2]
GeneIDi9467
KEGGihsa:9467
MANE-SelectiENST00000383791.8; ENSP00000373301.3; NM_004844.5; NP_004835.2
UCSCiuc003bzp.3, human [O60239-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		9467
DisGeNETi9467

GeneCards: human genes, protein and diseases

More...GeneCardsi		SH3BP5
HGNCiHGNC:10827, SH3BP5
HPAiENSG00000131370, Tissue enhanced (adrenal)
MIMi605612, gene
neXtProtiNX_O60239
OpenTargetsiENSG00000131370
PharmGKBiPA35735
VEuPathDBiHostDB:ENSG00000131370

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2008, Eukaryota
GeneTreeiENSGT00390000018500
HOGENOMiCLU_048895_1_0_1
InParanoidiO60239
OMAiQFPPATR
PhylomeDBiO60239
TreeFamiTF105573

Enzyme and pathway databases

PathwayCommonsiO60239
SignaLinkiO60239
SIGNORiO60239

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		9467, 16 hits in 1081 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		SH3BP5, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		SH3BP5

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		9467
PharosiO60239, Tbio

Protein Ontology

More...PROi		PR:O60239
RNActiO60239, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000131370, Expressed in metanephros and 250 other tissues
ExpressionAtlasiO60239, baseline and differential
GenevisibleiO60239, HS

Family and domain databases

DisProtiDP02850
IDEALiIID00507
InterProiView protein in InterPro
IPR007940, SH3BP5
PANTHERiPTHR19423, PTHR19423, 2 hits
PfamiView protein in Pfam
PF05276, SH3BP5, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry namei3BP5_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O60239
Secondary accession number(s): B3KQW6, Q5JWV9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: January 23, 2007
Last modified: May 25, 2022
This is version 176 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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