UniProtKB - O60239 (3BP5_HUMAN)

BLAST

>sp|O60239|3BP5_HUMAN SH3 domain-binding protein 5 OS=Homo sapiens OX=9606 GN=SH3BP5 PE=1 SV=2
MDAALKRSRSEEPAEILPPARDEEEEEEEGMEQGLEEEEEVDPRIQGELEKLNQSTDDIN
RRETELEDARQKFRSVLVEATVKLDELVKKIGKAVEDSKPYWEARRVARQAQLEAQKATQ
DFQRATEVLRAAKETISLAEQRLLEDDKRQFDSAWQEMLNHATQRVMEAEQTKTRSELVH
KETAARYNAAMGRMRQLEKKLKRAINKSKPYFELKAKYYVQLEQLKKTVDDLQAKLTLAK
GEYKMALKNLEMISDEIHERRRSSAMGPRGCGVGAEGSSTSVEDLPGSKPEPDAISVASE
AFEDDSCSNFVSEDDSETQSVSSFSSGPTSPSEMPDQFPAVVRPGSLDLPSPVSLSEFGM
MFPVLGPRSECSGASSPECEVERGDRAEGAENKTSDKANNNRGLSSSSGSGGSSKSQSST
SPEGQALENRMKQLSLQCSKGRDGIIADIKMVQIG

Align

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History
Entry version 153 (07 Nov 2018)
Sequence version 2 (23 Jan 2007)
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Protein

SH3 domain-binding protein 5

Gene

SH3BP5

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Inhibits the auto- and transphosphorylation activity of BTK. Plays a negative regulatory role in BTK-related cytoplasmic signaling in B-cells. May be involved in BCR-induced apoptotic cell death.2 Publications

GO - Molecular functionⁱ

protein kinase inhibitor activity
Source: MGI
Inferred from direct assayⁱ
- 10339589
SH3 domain binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

intracellular signal transduction
Source: MGI
Inferred from direct assayⁱ
- 10339589
negative regulation of protein tyrosine kinase activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
signal transduction
Source: ProtInc
Traceable author statementⁱ
- 9571151

View the complete GO annotation on QuickGO ...

Enzyme and pathway databases

SignaLinkⁱ	O60239
SIGNORⁱ	O60239

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: SH3 domain-binding protein 5 Short name: SH3BP-5 Alternative name(s): SH3 domain-binding protein that preferentially associates with BTK
Gene namesⁱ	Name:SH3BP5 Synonyms:SAB
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 3

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000131370.15
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:10827 SH3BP5
MIMⁱ	605612 gene
neXtProtⁱ	NX_O60239

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Mitochondrion

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	347	L → A: Loss of phosphorylation and binding by phospho-JNK; when associated with A-349. 1 Publication	1
Mutagenesisⁱ	349	L → A: Loss of phosphorylation and binding by phospho-JNK; when associated with A-347. 1 Publication	1
Mutagenesisⁱ	434	L → A: No change of phosphorylation or binding by phospho-JNK; when associated with A-436. 1 Publication	1
Mutagenesisⁱ	436	L → A: No change of phosphorylation or binding by phospho-JNK; when associated with A-434. 1 Publication	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	9467
Open Targets More...OpenTargetsⁱ	ENSG00000131370
PharmGKBⁱ	PA35735

Polymorphism and mutation databases

BioMutaⁱ	SH3BP5

BioMutaⁱ

SH3BP5

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000064368	1 – 455	SH3 domain-binding protein 5Add BLAST		455

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	351	Phosphoserine; by MAPK12 and MAPK9By similarity	1
Modified residueⁱ	375	PhosphoserineBy similarity	1
Modified residueⁱ	376	PhosphoserineBy similarity	1
Modified residueⁱ	418	PhosphoserineBy similarity	1
Modified residueⁱ	421	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	O60239
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O60239
PaxDbⁱ	O60239
PeptideAtlas More...PeptideAtlasⁱ	O60239
PRIDEⁱ	O60239
ProteomicsDBⁱ	49268 49269 [O60239-2]
TopDownProteomicsⁱ	O60239-1 [O60239-1]

PTM databases

iPTMnetⁱ	O60239
PhosphoSitePlusⁱ	O60239

Expressionⁱ

Tissue specificityⁱ

Highly expressed in testis and ovaries. It is also expressed in a variety of tissues including spleen, lymph node, thymus, bone marrow, fetal liver, colon, small intestine and prostate.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000131370 Expressed in 238 organ(s), highest expression level in metanephros
CleanExⁱ	HS_SH3BP5
ExpressionAtlasⁱ	O60239 baseline and differential
Genevisibleⁱ	O60239 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA036445 HPA057988

HPAⁱ

HPA036445
HPA057988

Interactionⁱ

Subunit structureⁱ

Interacts with BTK (PubMed:9571151, PubMed:10339589). Interacts with all isoforms of MAPK8, MAPK9, MAPK10 and MAPK12 (PubMed:12167088). Interacts with GDP-bound and nucleotide-free forms of RAB11A (PubMed:26506309).4 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
BTK	Q06187	4	EBI-624860,EBI-624835

With

Entry

#Exp.

IntAct

Notes

BTK

Q06187

EBI-624860,EBI-624835

GO - Molecular functionⁱ

SH3 domain binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	114853, 21 interactors
ELMⁱ	O60239
IntActⁱ	O60239, 12 interactors
STRINGⁱ	9606.ENSP00000373301

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O60239
SMRⁱ	O60239
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Compositional bias

Feature key	Position(s)	DescriptionActions	Length
Compositional biasⁱ	11 – 67	Glu-richAdd BLAST	57
Compositional biasⁱ	36 – 40	Poly-Glu	5
Compositional biasⁱ	278 – 421	Ser-richAdd BLAST	144
Compositional biasⁱ	405 – 410	Poly-Ser	6

Sequence similaritiesⁱ

Belongs to the SH3BP5 family.Curated

Keywords - Domainⁱ

SH3-binding

Phylogenomic databases

eggNOGⁱ	KOG2008 Eukaryota ENOG410ZK48 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000018500
HOGENOMⁱ	HOG000212681
HOVERGENⁱ	HBG018168
InParanoidⁱ	O60239
OMAⁱ	PECDLER
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G08YD
PhylomeDBⁱ	O60239
TreeFamⁱ	TF105573

Family and domain databases

InterProⁱ	View protein in InterPro IPR007940 SH3BP5
PANTHERⁱ	PTHR19423 PTHR19423, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF05276 SH3BP5, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: O60239-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDAALKRSRS EEPAEILPPA RDEEEEEEEG MEQGLEEEEE VDPRIQGELE 
        60         70         80         90        100
KLNQSTDDIN RRETELEDAR QKFRSVLVEA TVKLDELVKK IGKAVEDSKP 
       110        120        130        140        150
YWEARRVARQ AQLEAQKATQ DFQRATEVLR AAKETISLAE QRLLEDDKRQ 
       160        170        180        190        200
FDSAWQEMLN HATQRVMEAE QTKTRSELVH KETAARYNAA MGRMRQLEKK 
       210        220        230        240        250
LKRAINKSKP YFELKAKYYV QLEQLKKTVD DLQAKLTLAK GEYKMALKNL 
       260        270        280        290        300
EMISDEIHER RRSSAMGPRG CGVGAEGSST SVEDLPGSKP EPDAISVASE 
       310        320        330        340        350
AFEDDSCSNF VSEDDSETQS VSSFSSGPTS PSEMPDQFPA VVRPGSLDLP 
       360        370        380        390        400
SPVSLSEFGM MFPVLGPRSE CSGASSPECE VERGDRAEGA ENKTSDKANN 
       410        420        430        440        450
NRGLSSSSGS GGSSKSQSST SPEGQALENR MKQLSLQCSK GRDGIIADIK 

MVQIG

Length:455

Mass (Da):50,425

Last modified:January 23, 2007 - v2

Checksum:ⁱ5C8CA4861D66346B

Isoform 2 (identifier: O60239-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-157: Missing.

« Hide

        10         20         30         40         50
MLNHATQRVM EAEQTKTRSE LVHKETAARY NAAMGRMRQL EKKLKRAINK 
        60         70         80         90        100
SKPYFELKAK YYVQLEQLKK TVDDLQAKLT LAKGEYKMAL KNLEMISDEI 
       110        120        130        140        150
HERRRSSAMG PRGCGVGAEG SSTSVEDLPG SKPEPDAISV ASEAFEDDSC 
       160        170        180        190        200
SNFVSEDDSE TQSVSSFSSG PTSPSEMPDQ FPAVVRPGSL DLPSPVSLSE 
       210        220        230        240        250
FGMMFPVLGP RSECSGASSP ECEVERGDRA EGAENKTSDK ANNNRGLSSS 
       260        270        280        290 
SGSGGSSKSQ SSTSPEGQAL ENRMKQLSLQ CSKGRDGIIA DIKMVQIG

Note: No experimental confirmation available.

Show »

Length:298

Mass (Da):32,202

Checksum:ⁱ4326AF41042E6F58

Computationally mapped potential isoform sequencesⁱ

There are 4 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

F8WDU8	F8WDU8_HUMAN	SH3 domain-binding protein 5 SH3 domain-binding protein 5	SH3BP5	69	Annotation score:
C9JK30	C9JK30_HUMAN	SH3 domain-binding protein 5 SH3 domain-binding protein 5	SH3BP5	128	Annotation score:
C9JNW0	C9JNW0_HUMAN	SH3 domain-binding protein 5 SH3 domain-binding protein 5	SH3BP5	51	Annotation score:
C9J140	C9J140_HUMAN	SH3 domain-binding protein 5 SH3 domain-binding protein 5	SH3BP5	57	Annotation score:

Sequence cautionⁱ

The sequence BAA25922 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_042854	1 – 157	Missing in isoform 2. 1 PublicationAdd BLAST		157

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK090524 mRNA Translation: BAG52178.1 AC087590 Genomic DNA No translation available. AL117422 mRNA Translation: CAI46220.1 CH471055 Genomic DNA Translation: EAW64225.1 BC010123 mRNA Translation: AAH10123.2 AB005047 mRNA Translation: BAA25922.1 Different initiation.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS2625.2 [O60239-1] CCDS43055.1 [O60239-2]
PIRⁱ	JE0086
NCBI Reference Sequences More...RefSeqⁱ	NP_001018009.2, NM_001018009.3 [O60239-2] NP_004835.2, NM_004844.4 [O60239-1] XP_016863011.1, XM_017007522.1 [O60239-2] XP_016863012.1, XM_017007523.1 [O60239-2] XP_016863013.1, XM_017007524.1 [O60239-2] XP_016863014.1, XM_017007525.1 [O60239-2]
UniGeneⁱ	Hs.257761

Genome annotation databases

Ensemblⁱ	ENST00000383791; ENSP00000373301; ENSG00000131370 [O60239-1] ENST00000408919; ENSP00000386231; ENSG00000131370 [O60239-2] ENST00000426925; ENSP00000388553; ENSG00000131370 [O60239-2]
GeneIDⁱ	9467
KEGGⁱ	hsa:9467
UCSC genome browser More...UCSCⁱ	uc003bzp.3 human [O60239-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Protein	Similar proteins		Species	Score	Length	Source
O60239	SH3-domain binding protein 5 (BTK-associated), isoform CRA_b		HUMAN		455	UniRef100_O60239
SH3 domain binding protein 5		PANTR		455
cDNA, FLJ93663, Homo sapiens SH3-domain binding protein 5 (BTK-associated)(SH3BP5), mRNA		HUMAN		425
Uncharacterized protein DKFZp686F05233		HUMAN		122
SH3BP5 isoform 8		PANTR		166
+3

Protein	Similar proteins		Species	Score	Length	Source
O60239	SH3-domain binding protein 5 (BTK-associated), isoform CRA_b		HUMAN		455	UniRef90_O60239
SH3 domain binding protein 5		PANTR		455
SH3 domain-binding protein 5		ERIEU		464
Uncharacterized protein		AOTNA		458
Uncharacterized protein		Cebus capucinus imitator		458
+59

Protein	Similar proteins		Species	Score	Length	Source
O60239	SH3 domain-binding protein 5		MOUSE		463	UniRef50_O60239
SH3 domain-binding protein 5		RAT		457
SH3-domain binding protein 5 (BTK-associated), isoform CRA_b		HUMAN		455
SH3 domain binding protein 5		PANTR		455
SH3 domain-binding protein 5		ERIEU		464
+309

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK090524 mRNA Translation: BAG52178.1 AC087590 Genomic DNA No translation available. AL117422 mRNA Translation: CAI46220.1 CH471055 Genomic DNA Translation: EAW64225.1 BC010123 mRNA Translation: AAH10123.2 AB005047 mRNA Translation: BAA25922.1 Different initiation.
CCDSⁱ	CCDS2625.2 [O60239-1] CCDS43055.1 [O60239-2]
PIRⁱ	JE0086
RefSeqⁱ	NP_001018009.2, NM_001018009.3 [O60239-2] NP_004835.2, NM_004844.4 [O60239-1] XP_016863011.1, XM_017007522.1 [O60239-2] XP_016863012.1, XM_017007523.1 [O60239-2] XP_016863013.1, XM_017007524.1 [O60239-2] XP_016863014.1, XM_017007525.1 [O60239-2]
UniGeneⁱ	Hs.257761

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	4H3B	X-ray	2.08	B/D	341-350	[»]
	6DJL	X-ray	3.10	B/C/D/E	1-265	[»]
ProteinModelPortalⁱ	O60239
SMRⁱ	O60239
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	114853, 21 interactors
ELMⁱ	O60239
IntActⁱ	O60239, 12 interactors
STRINGⁱ	9606.ENSP00000373301

PTM databases

iPTMnetⁱ	O60239
PhosphoSitePlusⁱ	O60239

Polymorphism and mutation databases

BioMutaⁱ	SH3BP5

BioMutaⁱ

SH3BP5

Proteomic databases

EPDⁱ	O60239
MaxQBⁱ	O60239
PaxDbⁱ	O60239
PeptideAtlasⁱ	O60239
PRIDEⁱ	O60239
ProteomicsDBⁱ	49268 49269 [O60239-2]
TopDownProteomicsⁱ	O60239-1 [O60239-1]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	9467
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000383791; ENSP00000373301; ENSG00000131370 [O60239-1] ENST00000408919; ENSP00000386231; ENSG00000131370 [O60239-2] ENST00000426925; ENSP00000388553; ENSG00000131370 [O60239-2]
GeneIDⁱ	9467
KEGGⁱ	hsa:9467
UCSCⁱ	uc003bzp.3 human [O60239-1]

Organism-specific databases

CTDⁱ	9467
DisGeNETⁱ	9467
EuPathDBⁱ	HostDB:ENSG00000131370.15
GeneCardsⁱ	SH3BP5
H-InvDBⁱ	HIX0003099
HGNCⁱ	HGNC:10827 SH3BP5
HPAⁱ	HPA036445 HPA057988
MIMⁱ	605612 gene
neXtProtⁱ	NX_O60239
OpenTargetsⁱ	ENSG00000131370
PharmGKBⁱ	PA35735
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2008 Eukaryota ENOG410ZK48 LUCA
GeneTreeⁱ	ENSGT00390000018500
HOGENOMⁱ	HOG000212681
HOVERGENⁱ	HBG018168
InParanoidⁱ	O60239
OMAⁱ	PECDLER
OrthoDBⁱ	EOG091G08YD
PhylomeDBⁱ	O60239
TreeFamⁱ	TF105573

Enzyme and pathway databases

SignaLinkⁱ	O60239
SIGNORⁱ	O60239

Miscellaneous databases

ChiTaRSⁱ	SH3BP5 human
GeneWikiⁱ	SH3BP5
GenomeRNAiⁱ	9467
Protein Ontology More...PROⁱ	PR:O60239
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000131370 Expressed in 238 organ(s), highest expression level in metanephros
CleanExⁱ	HS_SH3BP5
ExpressionAtlasⁱ	O60239 baseline and differential
Genevisibleⁱ	O60239 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR007940 SH3BP5
PANTHERⁱ	PTHR19423 PTHR19423, 1 hit
Pfamⁱ	View protein in Pfam PF05276 SH3BP5, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	3BP5_HUMAN
Accessionⁱ	O60239Primary (citable) accession number: O60239 Secondary accession number(s): B3KQW6, Q5JWV9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 23, 2002
	Last sequence update:	January 23, 2007
	Last modified:	November 7, 2018
	This is version 153 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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UniRef

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Annotation systems

Supporting data

UniProtKB - O60239 (3BP5_HUMAN)

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SH3 domain-binding protein 5

SH3BP5

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Mitochondrion

Mitochondrion

Nucleus

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ