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Protein

SH3 domain-binding protein 5

Gene

SH3BP5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibits the auto- and transphosphorylation activity of BTK. Plays a negative regulatory role in BTK-related cytoplasmic signaling in B-cells. May be involved in BCR-induced apoptotic cell death.2 Publications

GO - Molecular functioni

  • protein kinase inhibitor activity Source: MGI
  • SH3 domain binding Source: UniProtKB-KW

GO - Biological processi

  • intracellular signal transduction Source: MGI
  • negative regulation of protein tyrosine kinase activity Source: GO_Central
  • signal transduction Source: ProtInc

Enzyme and pathway databases

SignaLinkiO60239
SIGNORiO60239

Names & Taxonomyi

Protein namesi
Recommended name:
SH3 domain-binding protein 5
Short name:
SH3BP-5
Alternative name(s):
SH3 domain-binding protein that preferentially associates with BTK
Gene namesi
Name:SH3BP5
Synonyms:SAB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000131370.15
HGNCiHGNC:10827 SH3BP5
MIMi605612 gene
neXtProtiNX_O60239

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi347L → A: Loss of phosphorylation and binding by phospho-JNK; when associated with A-349. 1 Publication1
Mutagenesisi349L → A: Loss of phosphorylation and binding by phospho-JNK; when associated with A-347. 1 Publication1
Mutagenesisi434L → A: No change of phosphorylation or binding by phospho-JNK; when associated with A-436. 1 Publication1
Mutagenesisi436L → A: No change of phosphorylation or binding by phospho-JNK; when associated with A-434. 1 Publication1

Organism-specific databases

DisGeNETi9467
OpenTargetsiENSG00000131370
PharmGKBiPA35735

Polymorphism and mutation databases

BioMutaiSH3BP5

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000643681 – 455SH3 domain-binding protein 5Add BLAST455

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei351Phosphoserine; by MAPK12 and MAPK9By similarity1
Modified residuei375PhosphoserineBy similarity1
Modified residuei376PhosphoserineBy similarity1
Modified residuei418PhosphoserineBy similarity1
Modified residuei421PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO60239
MaxQBiO60239
PaxDbiO60239
PeptideAtlasiO60239
PRIDEiO60239
ProteomicsDBi49268
49269 [O60239-2]
TopDownProteomicsiO60239-1 [O60239-1]

PTM databases

iPTMnetiO60239
PhosphoSitePlusiO60239

Expressioni

Tissue specificityi

Highly expressed in testis and ovaries. It is also expressed in a variety of tissues including spleen, lymph node, thymus, bone marrow, fetal liver, colon, small intestine and prostate.1 Publication

Gene expression databases

BgeeiENSG00000131370 Expressed in 238 organ(s), highest expression level in metanephros
CleanExiHS_SH3BP5
ExpressionAtlasiO60239 baseline and differential
GenevisibleiO60239 HS

Organism-specific databases

HPAiHPA036445
HPA057988

Interactioni

Subunit structurei

Interacts with BTK (PubMed:9571151, PubMed:10339589). Interacts with all isoforms of MAPK8, MAPK9, MAPK10 and MAPK12 (PubMed:12167088). Interacts with GDP-bound and nucleotide-free forms of RAB11A (PubMed:26506309).4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
BTKQ061874EBI-624860,EBI-624835

GO - Molecular functioni

Protein-protein interaction databases

BioGridi114853, 21 interactors
ELMiO60239
IntActiO60239, 12 interactors
STRINGi9606.ENSP00000373301

Structurei

3D structure databases

ProteinModelPortaliO60239
SMRiO60239
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi11 – 67Glu-richAdd BLAST57
Compositional biasi36 – 40Poly-Glu5
Compositional biasi278 – 421Ser-richAdd BLAST144
Compositional biasi405 – 410Poly-Ser6

Sequence similaritiesi

Belongs to the SH3BP5 family.Curated

Keywords - Domaini

SH3-binding

Phylogenomic databases

eggNOGiKOG2008 Eukaryota
ENOG410ZK48 LUCA
GeneTreeiENSGT00390000018500
HOGENOMiHOG000212681
HOVERGENiHBG018168
InParanoidiO60239
OMAiPECDLER
OrthoDBiEOG091G08YD
PhylomeDBiO60239
TreeFamiTF105573

Family and domain databases

InterProiView protein in InterPro
IPR007940 SH3BP5
PANTHERiPTHR19423 PTHR19423, 1 hit
PfamiView protein in Pfam
PF05276 SH3BP5, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O60239-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDAALKRSRS EEPAEILPPA RDEEEEEEEG MEQGLEEEEE VDPRIQGELE
60 70 80 90 100
KLNQSTDDIN RRETELEDAR QKFRSVLVEA TVKLDELVKK IGKAVEDSKP
110 120 130 140 150
YWEARRVARQ AQLEAQKATQ DFQRATEVLR AAKETISLAE QRLLEDDKRQ
160 170 180 190 200
FDSAWQEMLN HATQRVMEAE QTKTRSELVH KETAARYNAA MGRMRQLEKK
210 220 230 240 250
LKRAINKSKP YFELKAKYYV QLEQLKKTVD DLQAKLTLAK GEYKMALKNL
260 270 280 290 300
EMISDEIHER RRSSAMGPRG CGVGAEGSST SVEDLPGSKP EPDAISVASE
310 320 330 340 350
AFEDDSCSNF VSEDDSETQS VSSFSSGPTS PSEMPDQFPA VVRPGSLDLP
360 370 380 390 400
SPVSLSEFGM MFPVLGPRSE CSGASSPECE VERGDRAEGA ENKTSDKANN
410 420 430 440 450
NRGLSSSSGS GGSSKSQSST SPEGQALENR MKQLSLQCSK GRDGIIADIK

MVQIG
Length:455
Mass (Da):50,425
Last modified:January 23, 2007 - v2
Checksum:i5C8CA4861D66346B
GO
Isoform 2 (identifier: O60239-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-157: Missing.

Note: No experimental confirmation available.
Show »
Length:298
Mass (Da):32,202
Checksum:i4326AF41042E6F58
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WDU8F8WDU8_HUMAN
SH3 domain-binding protein 5
SH3BP5
69Annotation score:
C9JK30C9JK30_HUMAN
SH3 domain-binding protein 5
SH3BP5
128Annotation score:
C9JNW0C9JNW0_HUMAN
SH3 domain-binding protein 5
SH3BP5
51Annotation score:
C9J140C9J140_HUMAN
SH3 domain-binding protein 5
SH3BP5
57Annotation score:

Sequence cautioni

The sequence BAA25922 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0428541 – 157Missing in isoform 2. 1 PublicationAdd BLAST157

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK090524 mRNA Translation: BAG52178.1
AC087590 Genomic DNA No translation available.
AL117422 mRNA Translation: CAI46220.1
CH471055 Genomic DNA Translation: EAW64225.1
BC010123 mRNA Translation: AAH10123.2
AB005047 mRNA Translation: BAA25922.1 Different initiation.
CCDSiCCDS2625.2 [O60239-1]
CCDS43055.1 [O60239-2]
PIRiJE0086
RefSeqiNP_001018009.2, NM_001018009.3 [O60239-2]
NP_004835.2, NM_004844.4 [O60239-1]
XP_016863011.1, XM_017007522.1 [O60239-2]
XP_016863012.1, XM_017007523.1 [O60239-2]
XP_016863013.1, XM_017007524.1 [O60239-2]
XP_016863014.1, XM_017007525.1 [O60239-2]
UniGeneiHs.257761

Genome annotation databases

EnsembliENST00000383791; ENSP00000373301; ENSG00000131370 [O60239-1]
ENST00000408919; ENSP00000386231; ENSG00000131370 [O60239-2]
ENST00000426925; ENSP00000388553; ENSG00000131370 [O60239-2]
GeneIDi9467
KEGGihsa:9467
UCSCiuc003bzp.3 human [O60239-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK090524 mRNA Translation: BAG52178.1
AC087590 Genomic DNA No translation available.
AL117422 mRNA Translation: CAI46220.1
CH471055 Genomic DNA Translation: EAW64225.1
BC010123 mRNA Translation: AAH10123.2
AB005047 mRNA Translation: BAA25922.1 Different initiation.
CCDSiCCDS2625.2 [O60239-1]
CCDS43055.1 [O60239-2]
PIRiJE0086
RefSeqiNP_001018009.2, NM_001018009.3 [O60239-2]
NP_004835.2, NM_004844.4 [O60239-1]
XP_016863011.1, XM_017007522.1 [O60239-2]
XP_016863012.1, XM_017007523.1 [O60239-2]
XP_016863013.1, XM_017007524.1 [O60239-2]
XP_016863014.1, XM_017007525.1 [O60239-2]
UniGeneiHs.257761

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4H3BX-ray2.08B/D341-350[»]
6DJLX-ray3.10B/C/D/E1-265[»]
ProteinModelPortaliO60239
SMRiO60239
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114853, 21 interactors
ELMiO60239
IntActiO60239, 12 interactors
STRINGi9606.ENSP00000373301

PTM databases

iPTMnetiO60239
PhosphoSitePlusiO60239

Polymorphism and mutation databases

BioMutaiSH3BP5

Proteomic databases

EPDiO60239
MaxQBiO60239
PaxDbiO60239
PeptideAtlasiO60239
PRIDEiO60239
ProteomicsDBi49268
49269 [O60239-2]
TopDownProteomicsiO60239-1 [O60239-1]

Protocols and materials databases

DNASUi9467
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000383791; ENSP00000373301; ENSG00000131370 [O60239-1]
ENST00000408919; ENSP00000386231; ENSG00000131370 [O60239-2]
ENST00000426925; ENSP00000388553; ENSG00000131370 [O60239-2]
GeneIDi9467
KEGGihsa:9467
UCSCiuc003bzp.3 human [O60239-1]

Organism-specific databases

CTDi9467
DisGeNETi9467
EuPathDBiHostDB:ENSG00000131370.15
GeneCardsiSH3BP5
H-InvDBiHIX0003099
HGNCiHGNC:10827 SH3BP5
HPAiHPA036445
HPA057988
MIMi605612 gene
neXtProtiNX_O60239
OpenTargetsiENSG00000131370
PharmGKBiPA35735
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2008 Eukaryota
ENOG410ZK48 LUCA
GeneTreeiENSGT00390000018500
HOGENOMiHOG000212681
HOVERGENiHBG018168
InParanoidiO60239
OMAiPECDLER
OrthoDBiEOG091G08YD
PhylomeDBiO60239
TreeFamiTF105573

Enzyme and pathway databases

SignaLinkiO60239
SIGNORiO60239

Miscellaneous databases

ChiTaRSiSH3BP5 human
GeneWikiiSH3BP5
GenomeRNAii9467
PROiPR:O60239
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000131370 Expressed in 238 organ(s), highest expression level in metanephros
CleanExiHS_SH3BP5
ExpressionAtlasiO60239 baseline and differential
GenevisibleiO60239 HS

Family and domain databases

InterProiView protein in InterPro
IPR007940 SH3BP5
PANTHERiPTHR19423 PTHR19423, 1 hit
PfamiView protein in Pfam
PF05276 SH3BP5, 1 hit
ProtoNetiSearch...

Entry informationi

Entry namei3BP5_HUMAN
AccessioniPrimary (citable) accession number: O60239
Secondary accession number(s): B3KQW6, Q5JWV9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 153 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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