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Protein

BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like

Gene

BNIP3L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. Inhibits apoptosis induced by BNIP3. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. May function as a tumor suppressor.2 Publications

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • lamin binding Source: UniProtKB
  • protein heterodimerization activity Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB

GO - Biological processi

Keywordsi

Biological processApoptosis, Host-virus interaction

Enzyme and pathway databases

ReactomeiR-HSA-6803204 TP53 Regulates Transcription of Genes Involved in Cytochrome C Release

Protein family/group databases

TCDBi1.A.20.1.2 the bcl2/adenovirus e1b-interacting protein 3 (bnip3) family

Names & Taxonomyi

Protein namesi
Recommended name:
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like
Alternative name(s):
Adenovirus E1B19K-binding protein B5
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3A
NIP3-like protein X
Short name:
NIP3L
Gene namesi
Name:BNIP3L
Synonyms:BNIP3A, BNIP3H, NIX
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000104765.14
HGNCiHGNC:1085 BNIP3L
MIMi605368 gene
neXtProtiNX_O60238

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei188 – 208HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Mitochondrion, Mitochondrion outer membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi665
OpenTargetsiENSG00000104765
PharmGKBiPA25395

Polymorphism and mutation databases

BioMutaiBNIP3L

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000649571 – 219BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-likeAdd BLAST219

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei62PhosphoserineCombined sources1
Modified residuei117PhosphoserineBy similarity1
Modified residuei118PhosphoserineCombined sources1
Modified residuei120PhosphoserineCombined sources1
Modified residuei166PhosphoserineCombined sources1

Post-translational modificationi

Undergoes progressive proteolysis to an 11 kDa C-terminal fragment, which is blocked by the proteasome inhibitor lactacystin.

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO60238
PaxDbiO60238
PeptideAtlasiO60238
PRIDEiO60238
ProteomicsDBi49267

PTM databases

iPTMnetiO60238
PhosphoSitePlusiO60238

Expressioni

Gene expression databases

BgeeiENSG00000104765 Expressed in 241 organ(s), highest expression level in blood
CleanExiHS_BNIP3L
ExpressionAtlasiO60238 baseline and differential
GenevisibleiO60238 HS

Organism-specific databases

HPAiCAB025371
HPA015652

Interactioni

Subunit structurei

Self-associates. Interacts with BNIP3 and STEAP3. Interacts (via BH3 domain) with SPATA18 (via coiled-coil domains).3 Publications
(Microbial infection) Interacts with human adenovirus-2 E1B 19 kDa protein.1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi107133, 34 interactors
DIPiDIP-35187N
IntActiO60238, 40 interactors
MINTiO60238
STRINGi9606.ENSP00000370003

Structurei

3D structure databases

ProteinModelPortaliO60238
SMRiO60238
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi126 – 148BH3Add BLAST23

Sequence similaritiesi

Belongs to the NIP3 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IK24 Eukaryota
ENOG4111HIM LUCA
GeneTreeiENSGT00390000013415
HOGENOMiHOG000232139
HOVERGENiHBG050707
InParanoidiO60238
KOiK15465
OMAiPQDDGQI
PhylomeDBiO60238
TreeFamiTF315424

Family and domain databases

InterProiView protein in InterPro
IPR010548 BNIP3
PANTHERiPTHR15186 PTHR15186, 1 hit
PfamiView protein in Pfam
PF06553 BNIP3, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O60238-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSSHLVEPPP PLHNNNNNCE ENEQSLPPPA GLNSSWVELP MNSSNGNDNG
60 70 80 90 100
NGKNGGLEHV PSSSSIHNGD MEKILLDAQH ESGQSSSRGS SHCDSPSPQE
110 120 130 140 150
DGQIMFDVEM HTSRDHSSQS EEEVVEGEKE VEALKKSADW VSDWSSRPEN
160 170 180 190 200
IPPKEFHFRH PKRSVSLSMR KSGAMKKGGI FSAEFLKVFI PSLFLSHVLA
210
LGLGIYIGKR LSTPSASTY
Length:219
Mass (Da):23,930
Last modified:August 1, 1998 - v1
Checksum:i19372E897BC63609
GO
Isoform 2 (identifier: O60238-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-40: Missing.

Note: No experimental confirmation available.
Show »
Length:179
Mass (Da):19,559
Checksum:i3C5A4AA97F65D467
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YBC7H0YBC7_HUMAN
BCL2/adenovirus E1B 19 kDa protein-...
BNIP3L
185Annotation score:
E5RFE9E5RFE9_HUMAN
BCL2/adenovirus E1B 19 kDa protein-...
BNIP3L
60Annotation score:

Sequence cautioni

The sequence CAI46217 differs from that shown. Reason: Erroneous termination at position 122. Translated as Glu.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti107D → E in AAN04051 (PubMed:10381623).Curated1
Sequence conflicti150N → S in CAI46217 (PubMed:17974005).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0562481 – 40Missing in isoform 2. 1 PublicationAdd BLAST40

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB004788 mRNA Translation: BAA28692.1
AF079221 mRNA Translation: AAC27723.1
AF067396 mRNA Translation: AAD03589.1
AF536326 mRNA Translation: AAN04051.1
AF452712 mRNA Translation: AAL50978.1
AF255051 Genomic DNA Translation: AAF70290.1
AK315870 mRNA Translation: BAF98761.1
AK316315 mRNA Translation: BAH14686.1
BT019501 mRNA Translation: AAV38308.1
AL132665 mRNA Translation: CAI46217.1 Sequence problems.
AC011726 Genomic DNA No translation available.
AC015743 Genomic DNA No translation available.
AC022911 Genomic DNA No translation available.
BC001559 mRNA Translation: AAH01559.1
BC009603 mRNA Translation: AAH09603.1
CCDSiCCDS6050.1 [O60238-1]
CCDS83267.1 [O60238-2]
PIRiT34523
RefSeqiNP_001317420.1, NM_001330491.1 [O60238-2]
NP_004322.1, NM_004331.2 [O60238-1]
UniGeneiHs.131226

Genome annotation databases

EnsembliENST00000380629; ENSP00000370003; ENSG00000104765 [O60238-1]
ENST00000518611; ENSP00000429851; ENSG00000104765 [O60238-2]
ENST00000520409; ENSP00000428597; ENSG00000104765 [O60238-2]
ENST00000523515; ENSP00000429698; ENSG00000104765 [O60238-2]
GeneIDi665
KEGGihsa:665
UCSCiuc003xey.3 human [O60238-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB004788 mRNA Translation: BAA28692.1
AF079221 mRNA Translation: AAC27723.1
AF067396 mRNA Translation: AAD03589.1
AF536326 mRNA Translation: AAN04051.1
AF452712 mRNA Translation: AAL50978.1
AF255051 Genomic DNA Translation: AAF70290.1
AK315870 mRNA Translation: BAF98761.1
AK316315 mRNA Translation: BAH14686.1
BT019501 mRNA Translation: AAV38308.1
AL132665 mRNA Translation: CAI46217.1 Sequence problems.
AC011726 Genomic DNA No translation available.
AC015743 Genomic DNA No translation available.
AC022911 Genomic DNA No translation available.
BC001559 mRNA Translation: AAH01559.1
BC009603 mRNA Translation: AAH09603.1
CCDSiCCDS6050.1 [O60238-1]
CCDS83267.1 [O60238-2]
PIRiT34523
RefSeqiNP_001317420.1, NM_001330491.1 [O60238-2]
NP_004322.1, NM_004331.2 [O60238-1]
UniGeneiHs.131226

3D structure databases

ProteinModelPortaliO60238
SMRiO60238
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107133, 34 interactors
DIPiDIP-35187N
IntActiO60238, 40 interactors
MINTiO60238
STRINGi9606.ENSP00000370003

Protein family/group databases

TCDBi1.A.20.1.2 the bcl2/adenovirus e1b-interacting protein 3 (bnip3) family

PTM databases

iPTMnetiO60238
PhosphoSitePlusiO60238

Polymorphism and mutation databases

BioMutaiBNIP3L

Proteomic databases

EPDiO60238
PaxDbiO60238
PeptideAtlasiO60238
PRIDEiO60238
ProteomicsDBi49267

Protocols and materials databases

DNASUi665
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000380629; ENSP00000370003; ENSG00000104765 [O60238-1]
ENST00000518611; ENSP00000429851; ENSG00000104765 [O60238-2]
ENST00000520409; ENSP00000428597; ENSG00000104765 [O60238-2]
ENST00000523515; ENSP00000429698; ENSG00000104765 [O60238-2]
GeneIDi665
KEGGihsa:665
UCSCiuc003xey.3 human [O60238-1]

Organism-specific databases

CTDi665
DisGeNETi665
EuPathDBiHostDB:ENSG00000104765.14
GeneCardsiBNIP3L
HGNCiHGNC:1085 BNIP3L
HPAiCAB025371
HPA015652
MIMi605368 gene
neXtProtiNX_O60238
OpenTargetsiENSG00000104765
PharmGKBiPA25395
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IK24 Eukaryota
ENOG4111HIM LUCA
GeneTreeiENSGT00390000013415
HOGENOMiHOG000232139
HOVERGENiHBG050707
InParanoidiO60238
KOiK15465
OMAiPQDDGQI
PhylomeDBiO60238
TreeFamiTF315424

Enzyme and pathway databases

ReactomeiR-HSA-6803204 TP53 Regulates Transcription of Genes Involved in Cytochrome C Release

Miscellaneous databases

ChiTaRSiBNIP3L human
GeneWikiiBNIP3L
GenomeRNAii665
PROiPR:O60238
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000104765 Expressed in 241 organ(s), highest expression level in blood
CleanExiHS_BNIP3L
ExpressionAtlasiO60238 baseline and differential
GenevisibleiO60238 HS

Family and domain databases

InterProiView protein in InterPro
IPR010548 BNIP3
PANTHERiPTHR15186 PTHR15186, 1 hit
PfamiView protein in Pfam
PF06553 BNIP3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiBNI3L_HUMAN
AccessioniPrimary (citable) accession number: O60238
Secondary accession number(s): B0AZS9, Q5JW63, Q8NF87
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: August 1, 1998
Last modified: October 10, 2018
This is version 172 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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