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Protein

Glia maturation factor gamma

Gene

GMFG

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGrowth factor

Enzyme and pathway databases

ReactomeiR-HSA-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Glia maturation factor gamma
Short name:
GMF-gamma
Gene namesi
Name:GMFG
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000130755.12
HGNCiHGNC:4374 GMFG
MIMi604104 gene
neXtProtiNX_O60234

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi9535
OpenTargetsiENSG00000130755
PharmGKBiPA28759

Polymorphism and mutation databases

BioMutaiGMFG

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002149472 – 142Glia maturation factor gammaAdd BLAST141

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiO60234
PaxDbiO60234
PeptideAtlasiO60234
PRIDEiO60234
ProteomicsDBi49260
TopDownProteomicsiO60234

2D gel databases

OGPiO60234

PTM databases

iPTMnetiO60234
PhosphoSitePlusiO60234

Expressioni

Tissue specificityi

Expressed predominantly in lung, heart and placenta.

Gene expression databases

BgeeiENSG00000130755 Expressed in 190 organ(s), highest expression level in bone marrow
CleanExiHS_GMFG
ExpressionAtlasiO60234 baseline and differential
GenevisibleiO60234 HS

Organism-specific databases

HPAiHPA002954

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi114911, 8 interactors
IntActiO60234, 4 interactors
STRINGi9606.ENSP00000472249

Structurei

Secondary structure

1142
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO60234
SMRiO60234
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO60234

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 139ADF-HPROSITE-ProRule annotationAdd BLAST136

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1736 Eukaryota
ENOG4111RK6 LUCA
GeneTreeiENSGT00390000008920
HOGENOMiHOG000175654
HOVERGENiHBG003045
InParanoidiO60234
OMAiNAAILMK
OrthoDBiEOG091G0YYO
PhylomeDBiO60234
TreeFamiTF315147

Family and domain databases

CDDicd11283 ADF_GMF-beta_like, 1 hit
Gene3Di3.40.20.10, 1 hit
InterProiView protein in InterPro
IPR002108 ADF-H
IPR029006 ADF-H/Gelsolin-like_dom_sf
IPR011171 GMF
IPR030076 GMFG
PANTHERiPTHR11249 PTHR11249, 1 hit
PTHR11249:SF4 PTHR11249:SF4, 1 hit
PfamiView protein in Pfam
PF00241 Cofilin_ADF, 1 hit
PIRSFiPIRSF001788 GMF-beta, 1 hit
SMARTiView protein in SMART
SM00102 ADF, 1 hit
PROSITEiView protein in PROSITE
PS51263 ADF_H, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 9 potential isoforms that are computationally mapped.Show allAlign All

O60234-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSDSLVVCEV DPELTEKLRK FRFRKETDNA AIIMKVDKDR QMVVLEEEFQ
60 70 80 90 100
NISPEELKME LPERQPRFVV YSYKYVHDDG RVSYPLCFIF SSPVGCKPEQ
110 120 130 140
QMMYAGSKNR LVQTAELTKV FEIRTTDDLT EAWLQEKLSF FR
Length:142
Mass (Da):16,801
Last modified:August 1, 1998 - v1
Checksum:iDB64BD8DE4F88170
GO

Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0R1D2M0R1D2_HUMAN
Glia maturation factor gamma
GMFG
101Annotation score:
M0QYG8M0QYG8_HUMAN
Glia maturation factor gamma
GMFG
93Annotation score:
M0R0C1M0R0C1_HUMAN
Glia maturation factor gamma
GMFG
109Annotation score:
M0QYJ8M0QYJ8_HUMAN
Glia maturation factor gamma
GMFG
138Annotation score:
M0QXC2M0QXC2_HUMAN
Glia maturation factor gamma
GMFG
79Annotation score:
M0QX47M0QX47_HUMAN
Glia maturation factor gamma
GMFG
73Annotation score:
M0R2P2M0R2P2_HUMAN
Glia maturation factor gamma
GMFG
60Annotation score:
M0QXZ6M0QXZ6_HUMAN
Glia maturation factor gamma
GMFG
59Annotation score:
M0QYD5M0QYD5_HUMAN
Glia maturation factor gamma
GMFG
11Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_048196122E → K. Corresponds to variant dbSNP:rs36110047Ensembl.1
Natural variantiVAR_048197136E → K. Corresponds to variant dbSNP:rs34035414Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB001993 mRNA Translation: BAA25572.1
AF108027
, AF108022, AF108023, AF108024, AF108025, AF108026 Genomic DNA Translation: AAD27807.1
AF038956 mRNA Translation: AAC39870.1
CR456967 mRNA Translation: CAG33248.1
CR542114 mRNA Translation: CAG46911.1
CH471126 Genomic DNA Translation: EAW56874.1
BC032819 mRNA Translation: AAH32819.2
BC080180 mRNA Translation: AAH80180.1
BC093799 mRNA Translation: AAH93799.1
BC101818 mRNA Translation: AAI01819.1
BC143543 mRNA Translation: AAI43544.1
BC143546 mRNA Translation: AAI43547.1
BC143548 mRNA Translation: AAI43549.1
CCDSiCCDS12532.1
RefSeqiNP_001287937.1, NM_001301008.1
NP_004868.1, NM_004877.3
UniGeneiHs.5210

Genome annotation databases

EnsembliENST00000597595; ENSP00000472249; ENSG00000130755
GeneIDi9535
KEGGihsa:9535
UCSCiuc002okz.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB001993 mRNA Translation: BAA25572.1
AF108027
, AF108022, AF108023, AF108024, AF108025, AF108026 Genomic DNA Translation: AAD27807.1
AF038956 mRNA Translation: AAC39870.1
CR456967 mRNA Translation: CAG33248.1
CR542114 mRNA Translation: CAG46911.1
CH471126 Genomic DNA Translation: EAW56874.1
BC032819 mRNA Translation: AAH32819.2
BC080180 mRNA Translation: AAH80180.1
BC093799 mRNA Translation: AAH93799.1
BC101818 mRNA Translation: AAI01819.1
BC143543 mRNA Translation: AAI43544.1
BC143546 mRNA Translation: AAI43547.1
BC143548 mRNA Translation: AAI43549.1
CCDSiCCDS12532.1
RefSeqiNP_001287937.1, NM_001301008.1
NP_004868.1, NM_004877.3
UniGeneiHs.5210

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3L50X-ray1.90A/B7-140[»]
ProteinModelPortaliO60234
SMRiO60234
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114911, 8 interactors
IntActiO60234, 4 interactors
STRINGi9606.ENSP00000472249

PTM databases

iPTMnetiO60234
PhosphoSitePlusiO60234

Polymorphism and mutation databases

BioMutaiGMFG

2D gel databases

OGPiO60234

Proteomic databases

EPDiO60234
PaxDbiO60234
PeptideAtlasiO60234
PRIDEiO60234
ProteomicsDBi49260
TopDownProteomicsiO60234

Protocols and materials databases

DNASUi9535
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000597595; ENSP00000472249; ENSG00000130755
GeneIDi9535
KEGGihsa:9535
UCSCiuc002okz.5 human

Organism-specific databases

CTDi9535
DisGeNETi9535
EuPathDBiHostDB:ENSG00000130755.12
GeneCardsiGMFG
HGNCiHGNC:4374 GMFG
HPAiHPA002954
MIMi604104 gene
neXtProtiNX_O60234
OpenTargetsiENSG00000130755
PharmGKBiPA28759
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1736 Eukaryota
ENOG4111RK6 LUCA
GeneTreeiENSGT00390000008920
HOGENOMiHOG000175654
HOVERGENiHBG003045
InParanoidiO60234
OMAiNAAILMK
OrthoDBiEOG091G0YYO
PhylomeDBiO60234
TreeFamiTF315147

Enzyme and pathway databases

ReactomeiR-HSA-6798695 Neutrophil degranulation

Miscellaneous databases

ChiTaRSiGMFG human
EvolutionaryTraceiO60234
GenomeRNAii9535
PROiPR:O60234
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000130755 Expressed in 190 organ(s), highest expression level in bone marrow
CleanExiHS_GMFG
ExpressionAtlasiO60234 baseline and differential
GenevisibleiO60234 HS

Family and domain databases

CDDicd11283 ADF_GMF-beta_like, 1 hit
Gene3Di3.40.20.10, 1 hit
InterProiView protein in InterPro
IPR002108 ADF-H
IPR029006 ADF-H/Gelsolin-like_dom_sf
IPR011171 GMF
IPR030076 GMFG
PANTHERiPTHR11249 PTHR11249, 1 hit
PTHR11249:SF4 PTHR11249:SF4, 1 hit
PfamiView protein in Pfam
PF00241 Cofilin_ADF, 1 hit
PIRSFiPIRSF001788 GMF-beta, 1 hit
SMARTiView protein in SMART
SM00102 ADF, 1 hit
PROSITEiView protein in PROSITE
PS51263 ADF_H, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGMFG_HUMAN
AccessioniPrimary (citable) accession number: O60234
Secondary accession number(s): Q6IB37
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: September 12, 2018
This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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