UniProtKB - O60231 (DHX16_HUMAN)

BLAST

>sp|O60231|DHX16_HUMAN Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 OS=Homo sapiens OX=9606 GN=DHX16 PE=1 SV=2
MATPAGLERWVQDELHSVLGLSERHVAQFLIGTAQRCTSAEEFVQRLRDTDTLDLSGPAR
DFALRLWNKVPRKAVVEKPARAAEREARALLEKNRSYRLLEDSEESSEETVSRAGSSLQK
KRKKRKHLRKKREEEEEEEASEKGKKKTGGSKQQTEKPESEDEWERTERERLQDLEERDA
FAERVRQRDKDRTRNVLERSDKKAYEEAQKRLKMAEEDRKAMVPELRKKSRREYLAKRER
EKLEDLEAELADEEFLFGDVELSRHERQELKYKRRVRDLAREYRAAGEQEKLEATNRYHM
PKETRGQPARAVDLVEEESGAPGEEQRRWEEARLGAASLKFGARDAASQEPKYQLVLEEE
ETIEFVRATQLQGDEEPSAPPTSTQAQQKESIQAVRRSLPVFPFREELLAAIANHQVLII
EGETGSGKTTQIPQYLFEEGYTNKGMKIACTQPRRVAAMSVAARVAREMGVKLGNEVGYS
IRFEDCTSERTVLRYMTDGMLLREFLSEPDLASYSVVMVDEAHERTLHTDILFGLIKDVA
RFRPELKVLVASATMDTARFSTFFDDAPVFRIPGRRFPVDIFYTKAPEADYLEACVVSVL
QIHVTQPPGDILVFLTGQEEIEAACEMLQDRCRRLGSKIRELLVLPIYANLPSDMQARIF
QPTPPGARKVVVATNIAETSLTIEGIIYVLDPGFCKQKSYNPRTGMESLTVTPCSKASAN
QRAGRAGRVAAGKCFRLYTAWAYQHELEETTVPEIQRTSLGNVVLLLKSLGIHDLMHFDF
LDPPPYETLLLALEQLYALGALNHLGELTTSGRKMAELPVDPMLSKMILASEKYSCSEEI
LTVAAMLSVNNSIFYRPKDKVVHADNARVNFFLPGGDHLVLLNVYTQWAESGYSSQWCYE
NFVQFRSMRRARDVREQLEGLLERVEVGLSSCQGDYIRVRKAITAGYFYHTARLTRSGYR
TVKQQQTVFIHPNSSLFEQQPRWLLYHELVLTTKEFMRQVLEIESSWLLEVAPHYYKAKE
LEDPHAKKMPKKIGKTREELG

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History
Entry version 190 (12 Sep 2018)
Sequence version 2 (28 Nov 2002)
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Protein

Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16

Gene

DHX16

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Involved in pre-mRNA splicing. Contributes to pre-mRNA splicing after spliceosome formation and prior to the first transesterification reaction.3 Publications

Catalytic activityⁱ

ATP + H₂O = ADP + phosphate.

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	422 – 429	ATPPROSITE-ProRule annotation		8

GO - Molecular functionⁱ

ATPase activity
Source: Reactome
Inferred from experimentⁱ
- 20423332
ATP binding Source: UniProtKB-KW
ATP-dependent RNA helicase activity Source: GO_Central
RNA binding
Source: UniProtKB
Inferred from high throughput direct assayⁱ
- 22658674
- 22681889
RNA helicase activity
Source: ProtInc
Traceable author statementⁱ
- 9547260

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

mRNA splicing, via spliceosome
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20423332
- 25296192
RNA splicing
Source: ProtInc
Traceable author statementⁱ
- 9547260

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Helicase, Hydrolase
Biological process	mRNA processing, mRNA splicing
Ligand	ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAⁱ	3.6.4.13 2681
Reactomeⁱ	R-HSA-72163 mRNA Splicing - Major Pathway

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 (EC:3.6.4.13) Alternative name(s): ATP-dependent RNA helicase #3 DEAH-box protein 16
Gene namesⁱ	Name:DHX16 Synonyms:DBP2, DDX16, KIAA0577, PRP22 Publications
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 6

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000204560.9
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:2739 DHX16
MIMⁱ	603405 gene
neXtProtⁱ	NX_O60231

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	428	K → A: Impairs pre-mRNA splicing activity. 1 Publication	1
Mutagenesisⁱ	520	D → A: Impairs pre-mRNA splicing activity. 1 Publication	1
Mutagenesisⁱ	523	H → A: No loss of pre-mRNA splicing activity. 1 Publication	1
Mutagenesisⁱ	552	S → L: Dominant-negative mutant. Impairs pre-mRNA splicing activity. 2 Publications	1
Mutagenesisⁱ	724	G → N: Dominant-negative mutant. Impairs pre-mRNA splicing activity. 3 Publications	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	8449
Open Targets More...OpenTargetsⁱ	ENSG00000204560
PharmGKBⁱ	PA27205

Polymorphism and mutation databases

BioMutaⁱ	DHX16

BioMutaⁱ

DHX16

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000055151	1 – 1041	Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16Add BLAST		1041

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	103	PhosphoserineCombined sources	1
Modified residueⁱ	106	PhosphoserineCombined sources	1
Modified residueⁱ	107	PhosphoserineCombined sources	1
Modified residueⁱ	160	PhosphoserineCombined sources	1
Modified residueⁱ	712	PhosphothreonineCombined sources	1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	O60231
PaxDbⁱ	O60231
PeptideAtlas More...PeptideAtlasⁱ	O60231
PRIDEⁱ	O60231
ProteomicsDBⁱ	49258

PTM databases

iPTMnetⁱ	O60231
PhosphoSitePlusⁱ	O60231

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000204560 Expressed in 223 organ(s), highest expression level in left lobe of thyroid gland
CleanExⁱ	HS_DHX16
ExpressionAtlasⁱ	O60231 baseline and differential
Genevisibleⁱ	O60231 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA051455

HPAⁱ

HPA051455

Interactionⁱ

Subunit structureⁱ

Interacts with GPKOW.1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
DHX38	Q92620	2	EBI-311446,EBI-1043041
GPKOW	Q92917	2	EBI-311446,EBI-746309
SF3B2	Q13435	2	EBI-311446,EBI-749111
XAB2	Q9HCS7	2	EBI-311446,EBI-295232

Protein-protein interaction databases

BioGridⁱ	114027, 62 interactors
CORUMⁱ	O60231
IntActⁱ	O60231, 22 interactors
Molecular INTeraction database More...MINTⁱ	O60231
STRINGⁱ	9606.ENSP00000365625

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O60231
SMRⁱ	O60231
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	409 – 573	Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST		165
Domainⁱ	598 – 771	Helicase C-terminalPROSITE-ProRule annotationAdd BLAST		174

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	520 – 523	DEAH box		4

Sequence similaritiesⁱ

Belongs to the DEAD box helicase family. DEAH subfamily. DDX16/PRP8 sub-subfamily.Curated

Phylogenomic databases

eggNOGⁱ	KOG0925 Eukaryota COG1643 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00910000144017
HOGENOMⁱ	HOG000175261
HOVERGENⁱ	HBG039428
InParanoidⁱ	O60231
KEGG Orthology (KO) More...KOⁱ	K12813
OMAⁱ	VYNQWVE
Database of Orthologous Groups More...OrthoDBⁱ	EOG0937063J
PhylomeDBⁱ	O60231
TreeFamⁱ	TF313473

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00079 HELICc, 1 hit
InterProⁱ	View protein in InterPro IPR011545 DEAD/DEAH_box_helicase_dom IPR002464 DNA/RNA_helicase_DEAH_CS IPR011709 DUF1605 IPR007502 Helicase-assoc_dom IPR014001 Helicase_ATP-bd IPR001650 Helicase_C IPR027417 P-loop_NTPase
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00270 DEAD, 1 hit PF04408 HA2, 1 hit PF00271 Helicase_C, 1 hit PF07717 OB_NTP_bind, 1 hit
SMARTⁱ	View protein in SMART SM00487 DEXDc, 1 hit SM00847 HA2, 1 hit SM00490 HELICc, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 1 hit
PROSITEⁱ	View protein in PROSITE PS00690 DEAH_ATP_HELICASE, 1 hit PS51192 HELICASE_ATP_BIND_1, 1 hit PS51194 HELICASE_CTER, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show all Align All

O60231-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MATPAGLERW VQDELHSVLG LSERHVAQFL IGTAQRCTSA EEFVQRLRDT 
        60         70         80         90        100
DTLDLSGPAR DFALRLWNKV PRKAVVEKPA RAAEREARAL LEKNRSYRLL 
       110        120        130        140        150
EDSEESSEET VSRAGSSLQK KRKKRKHLRK KREEEEEEEA SEKGKKKTGG 
       160        170        180        190        200
SKQQTEKPES EDEWERTERE RLQDLEERDA FAERVRQRDK DRTRNVLERS 
       210        220        230        240        250
DKKAYEEAQK RLKMAEEDRK AMVPELRKKS RREYLAKRER EKLEDLEAEL 
       260        270        280        290        300
ADEEFLFGDV ELSRHERQEL KYKRRVRDLA REYRAAGEQE KLEATNRYHM 
       310        320        330        340        350
PKETRGQPAR AVDLVEEESG APGEEQRRWE EARLGAASLK FGARDAASQE 
       360        370        380        390        400
PKYQLVLEEE ETIEFVRATQ LQGDEEPSAP PTSTQAQQKE SIQAVRRSLP 
       410        420        430        440        450
VFPFREELLA AIANHQVLII EGETGSGKTT QIPQYLFEEG YTNKGMKIAC 
       460        470        480        490        500
TQPRRVAAMS VAARVAREMG VKLGNEVGYS IRFEDCTSER TVLRYMTDGM 
       510        520        530        540        550
LLREFLSEPD LASYSVVMVD EAHERTLHTD ILFGLIKDVA RFRPELKVLV 
       560        570        580        590        600
ASATMDTARF STFFDDAPVF RIPGRRFPVD IFYTKAPEAD YLEACVVSVL 
       610        620        630        640        650
QIHVTQPPGD ILVFLTGQEE IEAACEMLQD RCRRLGSKIR ELLVLPIYAN 
       660        670        680        690        700
LPSDMQARIF QPTPPGARKV VVATNIAETS LTIEGIIYVL DPGFCKQKSY 
       710        720        730        740        750
NPRTGMESLT VTPCSKASAN QRAGRAGRVA AGKCFRLYTA WAYQHELEET 
       760        770        780        790        800
TVPEIQRTSL GNVVLLLKSL GIHDLMHFDF LDPPPYETLL LALEQLYALG 
       810        820        830        840        850
ALNHLGELTT SGRKMAELPV DPMLSKMILA SEKYSCSEEI LTVAAMLSVN 
       860        870        880        890        900
NSIFYRPKDK VVHADNARVN FFLPGGDHLV LLNVYTQWAE SGYSSQWCYE 
       910        920        930        940        950
NFVQFRSMRR ARDVREQLEG LLERVEVGLS SCQGDYIRVR KAITAGYFYH 
       960        970        980        990       1000
TARLTRSGYR TVKQQQTVFI HPNSSLFEQQ PRWLLYHELV LTTKEFMRQV 
      1010       1020       1030       1040 
LEIESSWLLE VAPHYYKAKE LEDPHAKKMP KKIGKTREEL G

Length:1,041

Mass (Da):119,264

Last modified:November 28, 2002 - v2

Checksum:ⁱ5CAC4DBEF21A4E6D

Computationally mapped potential isoform sequencesⁱ

There are 5 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A140T947	A0A140T947_HUMAN	Pre-mRNA-splicing factor ATP-depend... Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16	DHX16	669	Annotation score:
Q5SQH5	Q5SQH5_HUMAN	DEAH (Asp-Glu-Ala-His) box polypept... DEAH (Asp-Glu-Ala-His) box polypeptide 16, isoform CRA_a (Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16)	DHX16 hCG_26008	560	Annotation score:
A0A140T8Y5	A0A140T8Y5_HUMAN	Pre-mRNA-splicing factor ATP-depend... Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16	DHX16	560	Annotation score:
A2AB15	A2AB15_HUMAN	Pre-mRNA-splicing factor ATP-depend... Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16	DHX16	295	Annotation score:
A0A140T9T4	A0A140T9T4_HUMAN	Pre-mRNA-splicing factor ATP-depend... Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16	DHX16	188	Annotation score:

Sequence cautionⁱ

The sequence BAA25503 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	223	V → I in BAA25908 (PubMed:9547260).Curated	1
Sequence conflictⁱ	631	R → P in BAA25908 (PubMed:9547260).Curated	1
Sequence conflictⁱ	681	L → P in BAA25908 (PubMed:9547260).Curated	1
Sequence conflictⁱ	792	A → T in BAA25908 (PubMed:9547260).Curated	1
Sequence conflictⁱ	899	Y → C in BAA25908 (PubMed:9547260).Curated	1
Sequence conflictⁱ	1032	K → KK in AAH08825 (PubMed:15489334).Curated	1
Sequence conflictⁱ	1032	K → KK in AAH09392 (PubMed:15489334).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_057236	352	K → E. Corresponds to variant dbSNP:rs17189239Ensembl.	1
Natural variantⁱVAR_057237	502	L → F. Corresponds to variant dbSNP:rs17189232Ensembl.	1
Natural variantⁱVAR_057238	566	D → G1 PublicationCorresponds to variant dbSNP:rs9262138Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB001601 mRNA Translation: BAA25908.1 BA000025 Genomic DNA Translation: BAB63323.1 AB011149 mRNA Translation: BAA25503.2 Different initiation. AL845353 Genomic DNA No translation available. BC008825 mRNA Translation: AAH08825.1 BC009392 mRNA Translation: AAH09392.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS4685.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001157711.1, NM_001164239.1 NP_003578.2, NM_003587.4
UniGeneⁱ	Hs.485060

Genome annotation databases

Ensemblⁱ	ENST00000376442; ENSP00000365625; ENSG00000204560 ENST00000383577; ENSP00000373071; ENSG00000206486 ENST00000417308; ENSP00000390938; ENSG00000233561 ENST00000421095; ENSP00000396193; ENSG00000226171 ENST00000424672; ENSP00000389862; ENSG00000233418 ENST00000451456; ENSP00000408956; ENSG00000233049 ENST00000458094; ENSP00000393958; ENSG00000231377
GeneIDⁱ	8449
KEGGⁱ	hsa:8449
UCSC genome browser More...UCSCⁱ	uc011ijv.3 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O60231	DBP2 protein		HUMAN		1041	UniRef100_O60231
Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 (Fragment)		HUMAN		669

Protein	Similar proteins		Species	Score	Length	Source
O60231	Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16		PIG		1045	UniRef90_O60231
Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16		PANTR		1044
DBP2 protein		HUMAN		1041
Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16		FUKDA		1193
Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16		MACFA		1059
+123

Protein	Similar proteins		Species	Score	Length	Source
O60231	Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16		PIG		1045	UniRef50_O60231
Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16		PANTR		1044
Pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH1		ARATH		1044
DBP2 protein		HUMAN		1041
Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16		FUKDA		1193
+271

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB001601 mRNA Translation: BAA25908.1 BA000025 Genomic DNA Translation: BAB63323.1 AB011149 mRNA Translation: BAA25503.2 Different initiation. AL845353 Genomic DNA No translation available. BC008825 mRNA Translation: AAH08825.1 BC009392 mRNA Translation: AAH09392.1
CCDSⁱ	CCDS4685.1
RefSeqⁱ	NP_001157711.1, NM_001164239.1 NP_003578.2, NM_003587.4
UniGeneⁱ	Hs.485060

3D structure databases

ProteinModelPortalⁱ	O60231
SMRⁱ	O60231
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	114027, 62 interactors
CORUMⁱ	O60231
IntActⁱ	O60231, 22 interactors
MINTⁱ	O60231
STRINGⁱ	9606.ENSP00000365625

PTM databases

iPTMnetⁱ	O60231
PhosphoSitePlusⁱ	O60231

Polymorphism and mutation databases

BioMutaⁱ	DHX16

BioMutaⁱ

DHX16

Proteomic databases

EPDⁱ	O60231
PaxDbⁱ	O60231
PeptideAtlasⁱ	O60231
PRIDEⁱ	O60231
ProteomicsDBⁱ	49258

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	8449
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000376442; ENSP00000365625; ENSG00000204560 ENST00000383577; ENSP00000373071; ENSG00000206486 ENST00000417308; ENSP00000390938; ENSG00000233561 ENST00000421095; ENSP00000396193; ENSG00000226171 ENST00000424672; ENSP00000389862; ENSG00000233418 ENST00000451456; ENSP00000408956; ENSG00000233049 ENST00000458094; ENSP00000393958; ENSG00000231377
GeneIDⁱ	8449
KEGGⁱ	hsa:8449
UCSCⁱ	uc011ijv.3 human

Organism-specific databases

CTDⁱ	8449
DisGeNETⁱ	8449
EuPathDBⁱ	HostDB:ENSG00000204560.9
GeneCardsⁱ	DHX16
HGNCⁱ	HGNC:2739 DHX16
HPAⁱ	HPA051455
MIMⁱ	603405 gene
neXtProtⁱ	NX_O60231
OpenTargetsⁱ	ENSG00000204560
PharmGKBⁱ	PA27205
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0925 Eukaryota COG1643 LUCA
GeneTreeⁱ	ENSGT00910000144017
HOGENOMⁱ	HOG000175261
HOVERGENⁱ	HBG039428
InParanoidⁱ	O60231
KOⁱ	K12813
OMAⁱ	VYNQWVE
OrthoDBⁱ	EOG0937063J
PhylomeDBⁱ	O60231
TreeFamⁱ	TF313473

Enzyme and pathway databases

BRENDAⁱ	3.6.4.13 2681
Reactomeⁱ	R-HSA-72163 mRNA Splicing - Major Pathway

Miscellaneous databases

GeneWikiⁱ	DHX16
GenomeRNAiⁱ	8449
Protein Ontology More...PROⁱ	PR:O60231
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000204560 Expressed in 223 organ(s), highest expression level in left lobe of thyroid gland
CleanExⁱ	HS_DHX16
ExpressionAtlasⁱ	O60231 baseline and differential
Genevisibleⁱ	O60231 HS

Family and domain databases

CDDⁱ	cd00079 HELICc, 1 hit
InterProⁱ	View protein in InterPro IPR011545 DEAD/DEAH_box_helicase_dom IPR002464 DNA/RNA_helicase_DEAH_CS IPR011709 DUF1605 IPR007502 Helicase-assoc_dom IPR014001 Helicase_ATP-bd IPR001650 Helicase_C IPR027417 P-loop_NTPase
Pfamⁱ	View protein in Pfam PF00270 DEAD, 1 hit PF04408 HA2, 1 hit PF00271 Helicase_C, 1 hit PF07717 OB_NTP_bind, 1 hit
SMARTⁱ	View protein in SMART SM00487 DEXDc, 1 hit SM00847 HA2, 1 hit SM00490 HELICc, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 1 hit
PROSITEⁱ	View protein in PROSITE PS00690 DEAH_ATP_HELICASE, 1 hit PS51192 HELICASE_ATP_BIND_1, 1 hit PS51194 HELICASE_CTER, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	DHX16_HUMAN
Accessionⁱ	O60231Primary (citable) accession number: O60231 Secondary accession number(s): O60322 , Q5JP45, Q969X7, Q96QC1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
	Last sequence update:	November 28, 2002
	Last modified:	September 12, 2018
	This is version 190 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
SIMILARITY comments
Index of protein domains and families
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - O60231 (DHX16_HUMAN)

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Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16

DHX16

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ