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UniProtKB - O60231 (DHX16_HUMAN)

Entry version 212 (23 Feb 2022)
Sequence version 2 (28 Nov 2002)
Previous versions | rss
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Protein

Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16

Gene

DHX16

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for pre-mRNA splicing as component of the spliceosome (PubMed:20423332, PubMed:20841358, PubMed:25296192, PubMed:29360106).

Contributes to pre-mRNA splicing after spliceosome formation and prior to the first transesterification reaction.

4 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi422 – 429ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHelicase, Hydrolase
Biological processmRNA processing, mRNA splicing
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		3.6.4.13, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		O60231

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-72163, mRNA Splicing - Major Pathway

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		O60231

SIGNOR Signaling Network Open Resource

More...SIGNORi		O60231

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 (EC:3.6.4.13)
Alternative name(s):
ATP-dependent RNA helicase #3
DEAH-box protein 16
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DHX16
Synonyms:DBP2, DDX16, KIAA0577, PRP22 Publications
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:2739, DHX16

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		603405, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O60231

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000204560

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus, Spliceosome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Neuromuscular oculoauditory syndrome (NMOAS)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionAn autosomal dominant neuromuscular disorder characterized by variable features including myopathy, neuropathy, hypotonia, joint contractures, growth delay, chorioretinal lacunae, sensorineuronal deafness, agenesis of the corpus callosum, and seizures.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_083621427G → E in NMOAS. 1 Publication1
Natural variantiVAR_083622582F → I in NMOAS; unknown pathological significance. 1 Publication1
Natural variantiVAR_083623674T → M in NMOAS; unknown pathological significance. 1 Publication1
Natural variantiVAR_083624697Q → H in NMOAS; unknown pathological significance. 1 Publication1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi428K → A: Impairs pre-mRNA splicing activity. 1 Publication1
Mutagenesisi520D → A: Impairs pre-mRNA splicing activity. 1 Publication1
Mutagenesisi523H → A: No loss of pre-mRNA splicing activity. 1 Publication1
Mutagenesisi552S → L: Dominant-negative mutant. Impairs pre-mRNA splicing activity. 2 Publications1
Mutagenesisi724G → N: Dominant-negative mutant. Impairs pre-mRNA splicing activity. 3 Publications1

Keywords - Diseasei

Disease variant, Neuropathy

Organism-specific databases

DisGeNET

More...DisGeNETi		8449

MalaCards human disease database

More...MalaCardsi		DHX16
MIMi618733, phenotype

Open Targets

More...OpenTargetsi		ENSG00000204560

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA27205

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O60231, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		DHX16

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000551511 – 1041Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16Add BLAST1041

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei103PhosphoserineCombined sources1
Modified residuei106PhosphoserineCombined sources1
Modified residuei107PhosphoserineCombined sources1
Modified residuei160PhosphoserineCombined sources1
Modified residuei712PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		O60231

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O60231

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O60231

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O60231

PeptideAtlas

More...PeptideAtlasi		O60231

PRoteomics IDEntifications database

More...PRIDEi		O60231

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		49258

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		O60231, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O60231

MetOSite database of methionine sulfoxide sites

More...MetOSitei		O60231

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O60231

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the spleen, thyroid and testis. Also expressed in the brain and cerebellum.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000204560, Expressed in left lobe of thyroid gland and 235 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O60231, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O60231, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000204560, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of pre-catalytic spliceosome complexes (PubMed:20423332, PubMed:20841358, PubMed:25296192, PubMed:29360106).

Interacts with GPKOW.

4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		114027, 132 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		O60231

Protein interaction database and analysis system

More...IntActi		O60231, 34 interactors

Molecular INTeraction database

More...MINTi		O60231

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000365625

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O60231, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O60231

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini409 – 573Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST165
Domaini598 – 771Helicase C-terminalPROSITE-ProRule annotationAdd BLAST174

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni101 – 207DisorderedSequence analysisAdd BLAST107
Regioni371 – 391DisorderedSequence analysisAdd BLAST21

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi520 – 523DEAH box4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi130 – 207Basic and acidic residuesSequence analysisAdd BLAST78
Compositional biasi375 – 391Polar residuesSequence analysisAdd BLAST17

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DEAD box helicase family. DEAH subfamily. DDX16/PRP8 sub-subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0923, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000158480

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_001832_7_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O60231

Identification of Orthologs from Complete Genome Data

More...OMAi		NVWNQWV

Database of Orthologous Groups

More...OrthoDBi		354219at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O60231

TreeFam database of animal gene trees

More...TreeFami		TF313473

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.50.300, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011545, DEAD/DEAH_box_helicase_dom
IPR002464, DNA/RNA_helicase_DEAH_CS
IPR011709, DUF1605
IPR007502, Helicase-assoc_dom
IPR014001, Helicase_ATP-bd
IPR001650, Helicase_C
IPR027417, P-loop_NTPase

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00270, DEAD, 1 hit
PF04408, HA2, 1 hit
PF00271, Helicase_C, 1 hit
PF07717, OB_NTP_bind, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00487, DEXDc, 1 hit
SM00847, HA2, 1 hit
SM00490, HELICc, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF52540, SSF52540, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00690, DEAH_ATP_HELICASE, 1 hit
PS51192, HELICASE_ATP_BIND_1, 1 hit
PS51194, HELICASE_CTER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

O60231-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATPAGLERW VQDELHSVLG LSERHVAQFL IGTAQRCTSA EEFVQRLRDT 
        60         70         80         90        100
DTLDLSGPAR DFALRLWNKV PRKAVVEKPA RAAEREARAL LEKNRSYRLL 
       110        120        130        140        150
EDSEESSEET VSRAGSSLQK KRKKRKHLRK KREEEEEEEA SEKGKKKTGG 
       160        170        180        190        200
SKQQTEKPES EDEWERTERE RLQDLEERDA FAERVRQRDK DRTRNVLERS 
       210        220        230        240        250
DKKAYEEAQK RLKMAEEDRK AMVPELRKKS RREYLAKRER EKLEDLEAEL 
       260        270        280        290        300
ADEEFLFGDV ELSRHERQEL KYKRRVRDLA REYRAAGEQE KLEATNRYHM 
       310        320        330        340        350
PKETRGQPAR AVDLVEEESG APGEEQRRWE EARLGAASLK FGARDAASQE 
       360        370        380        390        400
PKYQLVLEEE ETIEFVRATQ LQGDEEPSAP PTSTQAQQKE SIQAVRRSLP 
       410        420        430        440        450
VFPFREELLA AIANHQVLII EGETGSGKTT QIPQYLFEEG YTNKGMKIAC 
       460        470        480        490        500
TQPRRVAAMS VAARVAREMG VKLGNEVGYS IRFEDCTSER TVLRYMTDGM 
       510        520        530        540        550
LLREFLSEPD LASYSVVMVD EAHERTLHTD ILFGLIKDVA RFRPELKVLV 
       560        570        580        590        600
ASATMDTARF STFFDDAPVF RIPGRRFPVD IFYTKAPEAD YLEACVVSVL 
       610        620        630        640        650
QIHVTQPPGD ILVFLTGQEE IEAACEMLQD RCRRLGSKIR ELLVLPIYAN 
       660        670        680        690        700
LPSDMQARIF QPTPPGARKV VVATNIAETS LTIEGIIYVL DPGFCKQKSY 
       710        720        730        740        750
NPRTGMESLT VTPCSKASAN QRAGRAGRVA AGKCFRLYTA WAYQHELEET 
       760        770        780        790        800
TVPEIQRTSL GNVVLLLKSL GIHDLMHFDF LDPPPYETLL LALEQLYALG 
       810        820        830        840        850
ALNHLGELTT SGRKMAELPV DPMLSKMILA SEKYSCSEEI LTVAAMLSVN 
       860        870        880        890        900
NSIFYRPKDK VVHADNARVN FFLPGGDHLV LLNVYTQWAE SGYSSQWCYE 
       910        920        930        940        950
NFVQFRSMRR ARDVREQLEG LLERVEVGLS SCQGDYIRVR KAITAGYFYH 
       960        970        980        990       1000
TARLTRSGYR TVKQQQTVFI HPNSSLFEQQ PRWLLYHELV LTTKEFMRQV 
      1010       1020       1030       1040 
LEIESSWLLE VAPHYYKAKE LEDPHAKKMP KKIGKTREEL G
Length:1,041
Mass (Da):119,264
Last modified:November 28, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5CAC4DBEF21A4E6D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5SQH5Q5SQH5_HUMAN
RNA helicase
DHX16 hCG_26008
560Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A140T8Y5A0A140T8Y5_HUMAN
RNA helicase
DHX16
560Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A140T947A0A140T947_HUMAN
Pre-mRNA-splicing factor ATP-depend...
DHX16
669Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2AB15A2AB15_HUMAN
Pre-mRNA-splicing factor ATP-depend...
DHX16
295Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A140T9T4A0A140T9T4_HUMAN
Pre-mRNA-splicing factor ATP-depend...
DHX16
188Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA25503 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti223V → I in BAA25908 (PubMed:9547260).Curated1
Sequence conflicti631R → P in BAA25908 (PubMed:9547260).Curated1
Sequence conflicti681L → P in BAA25908 (PubMed:9547260).Curated1
Sequence conflicti792A → T in BAA25908 (PubMed:9547260).Curated1
Sequence conflicti899Y → C in BAA25908 (PubMed:9547260).Curated1
Sequence conflicti1032K → KK in AAH08825 (PubMed:15489334).Curated1
Sequence conflicti1032K → KK in AAH09392 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_057236352K → E. Corresponds to variant dbSNP:rs17189239EnsemblClinVar.1
Natural variantiVAR_083621427G → E in NMOAS. 1 Publication1
Natural variantiVAR_057237502L → F. Corresponds to variant dbSNP:rs17189232Ensembl.1
Natural variantiVAR_057238566D → G1 PublicationCorresponds to variant dbSNP:rs9262138Ensembl.1
Natural variantiVAR_083622582F → I in NMOAS; unknown pathological significance. 1 Publication1
Natural variantiVAR_083623674T → M in NMOAS; unknown pathological significance. 1 Publication1
Natural variantiVAR_083624697Q → H in NMOAS; unknown pathological significance. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB001601 mRNA Translation: BAA25908.1
BA000025 Genomic DNA Translation: BAB63323.1
AB011149 mRNA Translation: BAA25503.2 Different initiation.
AL845353 Genomic DNA No translation available.
BC008825 mRNA Translation: AAH08825.1
BC009392 mRNA Translation: AAH09392.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS4685.1

NCBI Reference Sequences

More...RefSeqi		NP_001157711.1, NM_001164239.1
NP_003578.2, NM_003587.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000376442; ENSP00000365625; ENSG00000204560
ENST00000383577; ENSP00000373071; ENSG00000206486
ENST00000417308; ENSP00000390938; ENSG00000233561
ENST00000421095; ENSP00000396193; ENSG00000226171
ENST00000424672; ENSP00000389862; ENSG00000233418
ENST00000451456; ENSP00000408956; ENSG00000233049
ENST00000458094; ENSP00000393958; ENSG00000231377

Database of genes from NCBI RefSeq genomes

More...GeneIDi		8449

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:8449

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000376442.8; ENSP00000365625.3; NM_003587.5; NP_003578.2

UCSC genome browser

More...UCSCi		uc011ijv.3, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB001601 mRNA Translation: BAA25908.1
BA000025 Genomic DNA Translation: BAB63323.1
AB011149 mRNA Translation: BAA25503.2 Different initiation.
AL845353 Genomic DNA No translation available.
BC008825 mRNA Translation: AAH08825.1
BC009392 mRNA Translation: AAH09392.1
CCDSiCCDS4685.1
RefSeqiNP_001157711.1, NM_001164239.1
NP_003578.2, NM_003587.4

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5Z56electron microscopy5.10x1-1041[»]
5Z57electron microscopy6.50x1-1041[»]
5Z58electron microscopy4.90x1-1041[»]
6FF7electron microscopy4.50q1-1041[»]
7DVQelectron microscopy2.89x1-1041[»]
SMRiO60231
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi114027, 132 interactors
CORUMiO60231
IntActiO60231, 34 interactors
MINTiO60231
STRINGi9606.ENSP00000365625

PTM databases

GlyGeniO60231, 1 site, 1 O-linked glycan (1 site)
iPTMnetiO60231
MetOSiteiO60231
PhosphoSitePlusiO60231

Genetic variation databases

BioMutaiDHX16

Proteomic databases

EPDiO60231
jPOSTiO60231
MassIVEiO60231
PaxDbiO60231
PeptideAtlasiO60231
PRIDEiO60231
ProteomicsDBi49258

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		26473, 99 antibodies from 24 providers

The DNASU plasmid repository

More...DNASUi		8449

Genome annotation databases

EnsembliENST00000376442; ENSP00000365625; ENSG00000204560
ENST00000383577; ENSP00000373071; ENSG00000206486
ENST00000417308; ENSP00000390938; ENSG00000233561
ENST00000421095; ENSP00000396193; ENSG00000226171
ENST00000424672; ENSP00000389862; ENSG00000233418
ENST00000451456; ENSP00000408956; ENSG00000233049
ENST00000458094; ENSP00000393958; ENSG00000231377
GeneIDi8449
KEGGihsa:8449
MANE-SelectiENST00000376442.8; ENSP00000365625.3; NM_003587.5; NP_003578.2
UCSCiuc011ijv.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		8449
DisGeNETi8449

GeneCards: human genes, protein and diseases

More...GeneCardsi		DHX16
HGNCiHGNC:2739, DHX16
HPAiENSG00000204560, Low tissue specificity
MalaCardsiDHX16
MIMi603405, gene
618733, phenotype
neXtProtiNX_O60231
OpenTargetsiENSG00000204560
PharmGKBiPA27205
VEuPathDBiHostDB:ENSG00000204560

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0923, Eukaryota
GeneTreeiENSGT00940000158480
HOGENOMiCLU_001832_7_1_1
InParanoidiO60231
OMAiNVWNQWV
OrthoDBi354219at2759
PhylomeDBiO60231
TreeFamiTF313473

Enzyme and pathway databases

BRENDAi3.6.4.13, 2681
PathwayCommonsiO60231
ReactomeiR-HSA-72163, mRNA Splicing - Major Pathway
SignaLinkiO60231
SIGNORiO60231

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		8449, 722 hits in 1058 CRISPR screens

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		DHX16

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		8449
PharosiO60231, Tbio

Protein Ontology

More...PROi		PR:O60231
RNActiO60231, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000204560, Expressed in left lobe of thyroid gland and 235 other tissues
ExpressionAtlasiO60231, baseline and differential
GenevisibleiO60231, HS

Family and domain databases

Gene3Di3.40.50.300, 2 hits
InterProiView protein in InterPro
IPR011545, DEAD/DEAH_box_helicase_dom
IPR002464, DNA/RNA_helicase_DEAH_CS
IPR011709, DUF1605
IPR007502, Helicase-assoc_dom
IPR014001, Helicase_ATP-bd
IPR001650, Helicase_C
IPR027417, P-loop_NTPase
PfamiView protein in Pfam
PF00270, DEAD, 1 hit
PF04408, HA2, 1 hit
PF00271, Helicase_C, 1 hit
PF07717, OB_NTP_bind, 1 hit
SMARTiView protein in SMART
SM00487, DEXDc, 1 hit
SM00847, HA2, 1 hit
SM00490, HELICc, 1 hit
SUPFAMiSSF52540, SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00690, DEAH_ATP_HELICASE, 1 hit
PS51192, HELICASE_ATP_BIND_1, 1 hit
PS51194, HELICASE_CTER, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDHX16_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O60231
Secondary accession number(s): O60322
, Q5JP45, Q969X7, Q96QC1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 28, 2002
Last modified: February 23, 2022
This is version 212 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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