Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
The new UniProt website is here! Take me to UniProt BETA

UniProtKB - O60229 (KALRN_HUMAN)

Entry version 210 (25 May 2022)
Sequence version 3 (31 Jul 2019)
Previous versions | rss
Add a publicationFeedback
Protein

Kalirin

Gene

KALRN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity.

1 Publication

Miscellaneous

Called DUO because the encoded protein is closely related to but shorter than TRIO.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei2713ATP1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei2803Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi2690 – 2698ATPPROSITE-ProRule annotation9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGuanine-nucleotide releasing factor, Kinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		O60229

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-193648, NRAGE signals death through JNK
R-HSA-3928662, EPHB-mediated forward signaling
R-HSA-416476, G alpha (q) signalling events
R-HSA-416482, G alpha (12/13) signalling events
R-HSA-5687128, MAPK6/MAPK4 signaling
R-HSA-8980692, RHOA GTPase cycle
R-HSA-9013149, RAC1 GTPase cycle
R-HSA-9013408, RHOG GTPase cycle

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		O60229

SIGNOR Signaling Network Open Resource

More...SIGNORi		O60229

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
KalirinBy similarity (EC:2.7.11.1)
Alternative name(s):
Huntingtin-associated protein-interacting protein
Protein Duo
Serine/threonine-protein kinase with Dbl- and pleckstrin homology domain
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KALRNImported
Synonyms:DUET, DUO, HAPIP, TRAD
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:4814, KALRN

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		604605, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O60229

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000160145

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi2713K → A: Loss of autophosphorylation. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		8997

MalaCards human disease database

More...MalaCardsi		KALRN

Open Targets

More...OpenTargetsi		ENSG00000160145

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA29189

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O60229, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		KALRN

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000809551 – 2986KalirinAdd BLAST2986

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1750PhosphoserineCombined sources1
Modified residuei1753PhosphoserineCombined sources1
Modified residuei1799PhosphoserineCombined sources1
Modified residuei1812PhosphothreonineBy similarity1
Modified residuei1817PhosphoserineCombined sources1
Modified residuei1913PhosphothreonineBy similarity1
Modified residuei2262PhosphoserineCombined sources1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi2492 ↔ 2548PROSITE-ProRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Autophosphorylated.

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		O60229

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O60229

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O60229

MaxQB - The MaxQuant DataBase

More...MaxQBi		O60229

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O60229

PeptideAtlas

More...PeptideAtlasi		O60229

PRoteomics IDEntifications database

More...PRIDEi		O60229

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		11196
49252 [O60229-1]
49253 [O60229-2]
49255 [O60229-4]
49256 [O60229-5]
49257 [O60229-6]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O60229

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O60229

SwissPalm database of S-palmitoylation events

More...SwissPalmi		O60229

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 2 is brain specific. Highly expressed in cerebral cortex, putamen, amygdala, hippocampus and caudate nucleus. Weakly expressed in brain stem and cerebellum. Isoform 4 is expressed in skeletal muscle.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000160145, Expressed in secondary oocyte and 209 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O60229, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O60229, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000160145, Tissue enhanced (brain)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with the C-terminal of peptidylglycine alpha-amidating monooxygenase (PAM) and with the huntingtin-associated protein 1 (HAP1) (By similarity).

Interacts with FASLG.

By similarity1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		114478, 26 interactors

Protein interaction database and analysis system

More...IntActi		O60229, 19 interactors

Molecular INTeraction database

More...MINTi		O60229

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000240874

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O60229, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

12986
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O60229

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini35 – 180CRAL-TRIOPROSITE-ProRule annotationAdd BLAST146
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati167 – 308Spectrin 1Sequence analysisAdd BLAST142
Repeati310 – 417Spectrin 2Sequence analysisAdd BLAST108
Repeati418 – 535Spectrin 3Sequence analysisAdd BLAST118
Repeati536 – 639Spectrin 4Sequence analysisAdd BLAST104
Repeati640 – 770Spectrin 5Sequence analysisAdd BLAST131
Repeati771 – 888Spectrin 6Sequence analysisAdd BLAST118
Repeati889 – 1004Spectrin 7Sequence analysisAdd BLAST116
Repeati1005 – 1128Spectrin 8Sequence analysisAdd BLAST124
Repeati1129 – 1234Spectrin 9Sequence analysisAdd BLAST106
Domaini1281 – 1456DH 1PROSITE-ProRule annotationAdd BLAST176
Domaini1468 – 1580PH 1PROSITE-ProRule annotationAdd BLAST113
Domaini1646 – 1711SH3 1PROSITE-ProRule annotationAdd BLAST66
Domaini1929 – 2104DH 2PROSITE-ProRule annotationAdd BLAST176
Domaini2116 – 2226PH 2PROSITE-ProRule annotationAdd BLAST111
Domaini2321 – 2386SH3 2PROSITE-ProRule annotationAdd BLAST66
Domaini2471 – 2564Ig-like C2-typeAdd BLAST94
Domaini2571 – 2665Fibronectin type-IIIPROSITE-ProRule annotationAdd BLAST95
Domaini2684 – 2938Protein kinasePROSITE-ProRule annotationAdd BLAST255

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni710 – 735DisorderedSequence analysisAdd BLAST26
Regioni1594 – 1642DisorderedSequence analysisAdd BLAST49
Regioni1750 – 1857DisorderedSequence analysisAdd BLAST108
Regioni2244 – 2310DisorderedSequence analysisAdd BLAST67
Regioni2412 – 2454DisorderedSequence analysisAdd BLAST43

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi721 – 735Polar residuesSequence analysisAdd BLAST15
Compositional biasi1617 – 1642Polar residuesSequence analysisAdd BLAST26
Compositional biasi1750 – 1773Polar residuesSequence analysisAdd BLAST24
Compositional biasi1782 – 1804Basic and acidic residuesSequence analysisAdd BLAST23
Compositional biasi1813 – 1837Basic and acidic residuesSequence analysisAdd BLAST25
Compositional biasi2286 – 2300Polar residuesSequence analysisAdd BLAST15
Compositional biasi2412 – 2434Basic and acidic residuesSequence analysisAdd BLAST23

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The two GEF domains catalyze nucleotide exchange for RAC1 and RhoA which are bound by DH1 and DH2 respectively. The two GEF domains appear to play differing roles in neuronal development and axonal outgrowth. SH3 1 binds to the first GEF domain inhibiting GEF activity only when in the presence of a PXXP peptide, suggesting that the SH3 domain/peptide interaction mediates binding to GEF1. CRK1 SH3 domain binds to and inhibits GEF1 activity (By similarity).By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, SH3 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4240, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155248

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000373_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O60229

Identification of Orthologs from Complete Genome Data

More...OMAi		AKXFIMA

Database of Orthologous Groups

More...OrthoDBi		5761at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O60229

TreeFam database of animal gene trees

More...TreeFami		TF318080

Family and domain databases

Conserved Domains Database

More...CDDi		cd00063, FN3, 1 hit
cd00160, RhoGEF, 2 hits
cd00170, SEC14, 1 hit
cd00176, SPEC, 4 hits

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.900.10, 2 hits
2.30.29.30, 2 hits
2.60.40.10, 2 hits
3.40.525.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001251, CRAL-TRIO_dom
IPR036865, CRAL-TRIO_dom_sf
IPR035899, DBL_dom_sf
IPR000219, DH-domain
IPR003961, FN3_dom
IPR036116, FN3_sf
IPR007110, Ig-like_dom
IPR013783, Ig-like_fold
IPR013098, Ig_I-set
IPR003599, Ig_sub
IPR003598, Ig_sub2
IPR028570, Kalirin/TRIO
IPR011009, Kinase-like_dom_sf
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR008271, Ser/Thr_kinase_AS
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
IPR018159, Spectrin/alpha-actinin
IPR002017, Spectrin_repeat

The PANTHER Classification System

More...PANTHERi		PTHR22826:SF104, PTHR22826:SF104, 2 hits

Pfam protein domain database

More...Pfami		View protein in Pfam
PF13716, CRAL_TRIO_2, 1 hit
PF00041, fn3, 1 hit
PF07679, I-set, 1 hit
PF00169, PH, 1 hit
PF00069, Pkinase, 1 hit
PF00621, RhoGEF, 2 hits
PF00435, Spectrin, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00060, FN3, 1 hit
SM00409, IG, 1 hit
SM00408, IGc2, 1 hit
SM00233, PH, 2 hits
SM00325, RhoGEF, 2 hits
SM00220, S_TKc, 1 hit
SM00516, SEC14, 1 hit
SM00326, SH3, 2 hits
SM00150, SPEC, 7 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48065, SSF48065, 2 hits
SSF49265, SSF49265, 1 hit
SSF50044, SSF50044, 2 hits
SSF52087, SSF52087, 1 hit
SSF56112, SSF56112, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50191, CRAL_TRIO, 1 hit
PS50010, DH_2, 2 hits
PS50853, FN3, 1 hit
PS50835, IG_LIKE, 1 hit
PS50003, PH_DOMAIN, 2 hits
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit
PS50002, SH3, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 25 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O60229-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTDRFWDQWY LWYLRLLRLL DRGSFRNDGL KASDVLPILK EKVAFVSGGR 
        60         70         80         90        100
DKRGGPILTF PARSNHDRIR QEDLRKLVTY LASVPSEDVC KRGFTVIIDM 
       110        120        130        140        150
RGSKWDLIKP LLKTLQEAFP AEIHVALIIK PDNFWQKQKT NFGSSKFIFE 
       160        170        180        190        200
TSMVSVEGLT KLVDPSQLTE EFDGSLDYNH EEWIELRLSL EEFFNSAVHL 
       210        220        230        240        250
LSRLEDLQEM LARKEFPVDV EGSRRLIDEH TQLKKKVLKA PVEELDREGQ 
       260        270        280        290        300
RLLQCIRCSD GFSGRNCIPG SADFQSLVPK ITSLLDKLHS TRQHLHQMWH 
       310        320        330        340        350
VRKLKLDQCF QLRLFEQDAE KMFDWISHNK ELFLQSHTEI GVSYQYALDL 
       360        370        380        390        400
QTQHNHFAMN SMNAYVNINR IMSVASRLSE AGHYASQQIK QISTQLDQEW 
       410        420        430        440        450
KSFAAALDER STILAMSAVF HQKAEQFLSG VDAWCKMCSE GGLPSEMQDL 
       460        470        480        490        500
ELAIHHHQTL YEQVTQAYTE VSQDGKALLD VLQRPLSPGN SESLTATANY 
       510        520        530        540        550
SKAVHQVLDV VHEVLHHQRR LESIWQHRKV RLHQRLQLCV FQQDVQQVLD 
       560        570        580        590        600
WIENHGEAFL SKHTGVGKSL HRARALQKRH DDFEEVAQNT YTNADKLLEA 
       610        620        630        640        650
AEQLAQTGEC DPEEIYKAAR HLEVRIQDFV RRVEQRKLLL DMSVSFHTHT 
       660        670        680        690        700
KELWTWMEDL QKEMLEDVCA DSVDAVQELI KQFQQQQTAT LDATLNVIKE 
       710        720        730        740        750
GEDLIQQLRS APPSLGEPSE ARDSAVSNNK TPHSSSISHI ESVLQQLDDA 
       760        770        780        790        800
QVQMEELFHE RKIKLDIFLQ LRIFEQYTIE VTAELDAWNE DLLRQMNDFN 
       810        820        830        840        850
TEDLTLAEQR LQRHTERKLA MNNMTFEVIQ QGQDLHQYIT EVQASGIELI 
       860        870        880        890        900
CEKDIDLAAQ VQELLEFLHE KQHELELNAE QTHKRLEQCL QLRHLQAEVK 
       910        920        930        940        950
QVLGWIRNGE SMLNASLVNA SSLSEAEQLQ REHEQFQLAI ESLFHATSLQ 
       960        970        980        990       1000
KTHQSALQVQ QKAEVLLQAG HYDADAIREC AEKVALHWQQ LMLKMEDRLK 
      1010       1020       1030       1040       1050
LVNASVAFYK TSEQVCSVLE SLEQEYRRDE DWCGGRDKLG PAAEIDHVIP 
      1060       1070       1080       1090       1100
LISKHLEQKE AFLKACTLAR RNAEVFLKYI HRNNVSMPSV ASHTRGPEQQ 
      1110       1120       1130       1140       1150
VKAILSELLQ RENRVLHFWT LKKRRLDQCQ QYVVFERSAK QALDWIQETG 
      1160       1170       1180       1190       1200
EFYLSTHTST GETTEETQEL LKEYGEFRVP AKQTKEKVKL LIQLADSFVE 
      1210       1220       1230       1240       1250
KGHIHATEIR KWVTTVDKHY RDFSLRMGKY RYSLEKALGV NTEDNKDLEL 
      1260       1270       1280       1290       1300
DIIPASLSDR EVKLRDANHE VNEEKRKSAR KKEFIMAELL QTEKAYVRDL 
      1310       1320       1330       1340       1350
HECLETYLWE MTSGVEEIPP GILNKEHIIF GNIQEIYDFH NNIFLKELEK 
      1360       1370       1380       1390       1400
YEQLPEDVGH CFVTWADKFQ MYVTYCKNKP DSNQLILEHA GTFFDEIQQR 
      1410       1420       1430       1440       1450
HGLANSISSY LIKPVQRITK YQLLLKELLT CCEEGKGELK DGLEVMLSVP 
      1460       1470       1480       1490       1500
KKANDAMHVS MLEGFDENLD VQGELILQDA FQVWDPKSLI RKGRERHLFL 
      1510       1520       1530       1540       1550
FEISLVFSKE IKDSSGHTKY VYKNKLLTSE LGVTEHVEGD PCKFALWSGR 
      1560       1570       1580       1590       1600
TPSSDNKTVL KASNIETKQE WIKNIREVIQ ERIIHLKGAL KEPLQLPKTP 
      1610       1620       1630       1640       1650
AKQRNNSKRD GVEDIDSQGD GSSQPDTISI ASRTSQNTVD SDKLSGGCEL 
      1660       1670       1680       1690       1700
TVVLQDFSAG HSSELTIQVG QTVELLERPS ERPGWCLVRT TERSPPLEGL 
      1710       1720       1730       1740       1750
VPSSALCISH SRSSVEMDCF FPLVKDAYSH SSSENGGKSE SVANLQAQPS 
      1760       1770       1780       1790       1800
LNSIHSSPGP KRSTNTLKKW LTSPVRRLNS GKADGNIKKQ KKVRDGRKSF 
      1810       1820       1830       1840       1850
DLGSPKPGDE TTPQGDSADE KSKKGWGEDE PDEESHTPLP PPMKIFDNDP 
      1860       1870       1880       1890       1900
TQDEMSSSLL AARQASTEVP TAADLVNAIE KLVKNKLSLE GSSYRGSLKD 
      1910       1920       1930       1940       1950
PAGCLNEGMA PPTPPKNPEE EQKAKALRGR MFVLNELVQT EKDYVKDLGI 
      1960       1970       1980       1990       2000
VVEGFMKRIE EKGVPEDMRG KDKIVFGNIH QIYDWHKDFF LAELEKCIQE 
      2010       2020       2030       2040       2050
QDRLAQLFIK HERKLHIYVW YCQNKPRSEY IVAEYDAYFE EVKQEINQRL 
      2060       2070       2080       2090       2100
TLSDFLIKPI QRITKYQLLL KDFLRYSEKA GLECSDIEKA VELMCLVPKR 
      2110       2120       2130       2140       2150
CNDMMNLGRL QGFEGTLTAQ GKLLQQDTFY VIELDAGMQS RTKERRVFLF 
      2160       2170       2180       2190       2200
EQIVIFSELL RKGSLTPGYM FKRSIKMNYL VLEENVDNDP CKFALMNRET 
      2210       2220       2230       2240       2250
SERVVLQAAN ADIQQAWVQD INQVLETQRD FLNALQSPIE YQRKERSTAV 
      2260       2270       2280       2290       2300
MRSQPARLPQ ASPRPYSSVP AGSEKPPKGS SYNPPLPPLK ISTSNGSPGF 
      2310       2320       2330       2340       2350
EYHQPGDKFE ASKQNDLGGC NGTSSMAVIK DYYALKENEI CVSQGEVVQV 
      2360       2370       2380       2390       2400
LAVNQQNMCL VYQPASDHSP AAEGWVPGSI LAPLTKATAA ESSDGSIKKS 
      2410       2420       2430       2440       2450
CSWHTLRMRK RAEVENTGKN EATGPRKPKD ILGNKVSVKE TNSSEESECD 
      2460       2470       2480       2490       2500
DLDPNTSMEI LNPNFIQEVA PEFLVPLVDV TCLLGDTVIL QCKVCGRPKP 
      2510       2520       2530       2540       2550
TITWKGPDQN ILDTDNSSAT YTVSSCDSGE ITLKICNLMP QDSGIYTCIA 
      2560       2570       2580       2590       2600
TNDHGTTSTS ATVKVQGVPA APNRPIAQER SCTSVILRWL PPSSTGNCTI 
      2610       2620       2630       2640       2650
SGYTVEYREE GSQIWQQSVA STLDTYLVIE DLSPGCPYQF RVSASNPWGI 
      2660       2670       2680       2690       2700
SLPSEPSEFV RLPEYDAAAD GATISWKENF DSAYTELNEI GRGRFSIVKK 
      2710       2720       2730       2740       2750
CIHKATRKDV AVKFVSKKMK KKEQAAHEAA LLQHLQHPQY ITLHDTYESP 
      2760       2770       2780       2790       2800
TSYILILELM DDGRLLDYLM NHDELMEEKV AFYIRDIMEA LQYLHNCRVA 
      2810       2820       2830       2840       2850
HLDIKPENLL IDLRIPVPRV KLIDLEDAVQ ISGHFHIHHL LGNPEFAAPE 
      2860       2870       2880       2890       2900
VIQGIPVSLG TDIWSIGVLT YVMLSGVSPF LDESKEETCI NVCRVDFSFP 
      2910       2920       2930       2940       2950
HEYFCGVSNA ARDFINVILQ EDFRRRPTAA TCLQHPWLQP HNGSYSKIPL 
      2960       2970       2980 
DTSRLACFIE RRKHQNDVRP IPNVKSYIVN RVNQGT
Length:2,986
Mass (Da):340,261
Last modified:July 31, 2019 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEA7B559A9E4AFFA0
GO
Isoform 2 (identifier: O60229-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1644-1663: LSGGCELTVVLQDFSAGHSS → DGNLVPRWHLGPGDPFSTYV
     1664-2986: Missing.

Show »
Length:1,663
Mass (Da):192,229
Checksum:iFAE683734C83417C
GO
Isoform 4 (identifier: O60229-4) [UniParc]FASTAAdd to basket
Also known as: DUET, TRAD

The sequence of this isoform differs from the canonical sequence as follows:
     1-1697: Missing.
     1698-1725: EGLVPSSALCISHSRSSVEMDCFFPLVK → MKGGDRAYTRGPSLGWLFAKCCCCFPCR

Show »
Length:1,289
Mass (Da):144,485
Checksum:iC0C2F3DBC8C2B34A
GO
Isoform 5 (identifier: O60229-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1627: Missing.
     1628-1643: ISIASRTSQNTVDSDK → MLKWISWRQSKANKAQ
     1857-1888: Missing.
     2314-2314: Missing.
     2399-2986: Missing.

Show »
Length:738
Mass (Da):82,806
Checksum:i1C9AC959DC07903E
GO
Isoform 6 (identifier: O60229-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1697: Missing.
     1698-1725: EGLVPSSALCISHSRSSVEMDCFFPLVK → MKGGDRAYTRGPSLGWLFAKCCCCFPCR
     1857-1888: Missing.

Show »
Length:1,257
Mass (Da):141,164
Checksum:iA45112D100678192
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 25 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7BXZ5H7BXZ5_HUMAN
Non-specific serine/threonine prote...
KALRN
2,955Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A804HLI0A0A804HLI0_HUMAN
Non-specific serine/threonine prote...
KALRN
2,986Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9IZQ6C9IZQ6_HUMAN
HCG2022551, isoform CRA_j
KALRN hCG_2022551
1,654Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A804HKT9A0A804HKT9_HUMAN
Kalirin
KALRN
1,613Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A804HI91A0A804HI91_HUMAN
Kalirin
KALRN
1,022Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A804HII1A0A804HII1_HUMAN
Kalirin
KALRN
1,198Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A804HIK8A0A804HIK8_HUMAN
Kalirin
KALRN
939Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A804HIN3A0A804HIN3_HUMAN
Kalirin
KALRN
1,000Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A804HJC5A0A804HJC5_HUMAN
Kalirin
KALRN
1,008Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A804HLF3A0A804HLF3_HUMAN
Kalirin
KALRN
1,059Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH58015 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence BAD18530 differs from that shown. Probable cloning artifact.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti2459E → G in BAA76314 (PubMed:10023074).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_041898196S → L1 Publication1
Natural variantiVAR_035976213R → W in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs1187034389Ensembl.1
Natural variantiVAR_0201921326E → D. Corresponds to variant dbSNP:rs2289838Ensembl.1
Natural variantiVAR_0356251897S → C in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_0571901930R → M. Corresponds to variant dbSNP:rs35298864Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0289031 – 1697Missing in isoform 4 and isoform 6. 1 PublicationAdd BLAST1697
Alternative sequenceiVSP_0289041 – 1627Missing in isoform 5. 3 PublicationsAdd BLAST1627
Alternative sequenceiVSP_0289091628 – 1643ISIAS…VDSDK → MLKWISWRQSKANKAQ in isoform 5. 3 PublicationsAdd BLAST16
Alternative sequenceiVSP_0289101644 – 1663LSGGC…AGHSS → DGNLVPRWHLGPGDPFSTYV in isoform 2. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_0289111664 – 2986Missing in isoform 2. 1 PublicationAdd BLAST1323
Alternative sequenceiVSP_0289121698 – 1725EGLVP…FPLVK → MKGGDRAYTRGPSLGWLFAK CCCCFPCR in isoform 4 and isoform 6. 1 PublicationAdd BLAST28
Alternative sequenceiVSP_0289131857 – 1888Missing in isoform 5 and isoform 6. 3 PublicationsAdd BLAST32
Alternative sequenceiVSP_0289142314Missing in isoform 5. 3 Publications1
Alternative sequenceiVSP_0289152399 – 2986Missing in isoform 5. 3 PublicationsAdd BLAST588

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U94190 mRNA Translation: AAC15791.1
AB011422 mRNA Translation: BAA76314.1
AK125979 mRNA Translation: BAC86373.1
AK131379 mRNA Translation: BAD18530.1 Sequence problems.
AC022336 Genomic DNA No translation available.
AC069233 Genomic DNA No translation available.
AC080008 Genomic DNA No translation available.
AC112129 Genomic DNA No translation available.
AC117401 Genomic DNA No translation available.
KF457679 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW79410.1
BC026865 mRNA Translation: AAH26865.1
BC058015 mRNA Translation: AAH58015.1 Sequence problems.
AL137629 mRNA Translation: CAB70850.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS3027.1 [O60229-2]
CCDS3028.1 [O60229-4]

Protein sequence database of the Protein Information Resource

More...PIRi		T46482

NCBI Reference Sequences

More...RefSeqi		NP_001019831.2, NM_001024660.4 [O60229-1]
NP_001309917.1, NM_001322988.1
NP_001309918.1, NM_001322989.1
NP_001309923.1, NM_001322994.1
NP_001309924.1, NM_001322995.1
NP_001309925.1, NM_001322996.1
NP_001309926.1, NM_001322997.1
NP_001309927.1, NM_001322998.1
NP_001309928.1, NM_001322999.1
NP_001309929.1, NM_001323000.1
NP_001309930.1, NM_001323001.1
NP_003938.1, NM_003947.5 [O60229-2]
NP_008995.2, NM_007064.4 [O60229-4]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000240874.7; ENSP00000240874.3; ENSG00000160145.16 [O60229-2]
ENST00000291478.9; ENSP00000291478.4; ENSG00000160145.16 [O60229-4]
ENST00000360013.7; ENSP00000353109.3; ENSG00000160145.16

Database of genes from NCBI RefSeq genomes

More...GeneIDi		8997

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:8997

UCSC genome browser

More...UCSCi		uc003ehf.2, human [O60229-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U94190 mRNA Translation: AAC15791.1
AB011422 mRNA Translation: BAA76314.1
AK125979 mRNA Translation: BAC86373.1
AK131379 mRNA Translation: BAD18530.1 Sequence problems.
AC022336 Genomic DNA No translation available.
AC069233 Genomic DNA No translation available.
AC080008 Genomic DNA No translation available.
AC112129 Genomic DNA No translation available.
AC117401 Genomic DNA No translation available.
KF457679 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW79410.1
BC026865 mRNA Translation: AAH26865.1
BC058015 mRNA Translation: AAH58015.1 Sequence problems.
AL137629 mRNA Translation: CAB70850.1
CCDSiCCDS3027.1 [O60229-2]
CCDS3028.1 [O60229-4]
PIRiT46482
RefSeqiNP_001019831.2, NM_001024660.4 [O60229-1]
NP_001309917.1, NM_001322988.1
NP_001309918.1, NM_001322989.1
NP_001309923.1, NM_001322994.1
NP_001309924.1, NM_001322995.1
NP_001309925.1, NM_001322996.1
NP_001309926.1, NM_001322997.1
NP_001309927.1, NM_001322998.1
NP_001309928.1, NM_001322999.1
NP_001309929.1, NM_001323000.1
NP_001309930.1, NM_001323001.1
NP_003938.1, NM_003947.5 [O60229-2]
NP_008995.2, NM_007064.4 [O60229-4]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5QQDX-ray1.91B1280-1459[»]
5QQEX-ray1.95B1280-1459[»]
5QQFX-ray2.26B1280-1459[»]
5QQGX-ray2.23B1280-1459[»]
5QQHX-ray2.09B1280-1459[»]
5QQIX-ray2.08B1280-1459[»]
5QQJX-ray1.90B1280-1459[»]
5QQKX-ray2.24B1280-1459[»]
5QQLX-ray2.25B1280-1459[»]
5QQMX-ray2.02B1280-1459[»]
5QQNX-ray2.26B1280-1459[»]
5QU9X-ray2.00B1280-1459[»]
SMRiO60229
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi114478, 26 interactors
IntActiO60229, 19 interactors
MINTiO60229
STRINGi9606.ENSP00000240874

PTM databases

iPTMnetiO60229
PhosphoSitePlusiO60229
SwissPalmiO60229

Genetic variation databases

BioMutaiKALRN

Proteomic databases

EPDiO60229
jPOSTiO60229
MassIVEiO60229
MaxQBiO60229
PaxDbiO60229
PeptideAtlasiO60229
PRIDEiO60229
ProteomicsDBi11196
49252 [O60229-1]
49253 [O60229-2]
49255 [O60229-4]
49256 [O60229-5]
49257 [O60229-6]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		2142, 178 antibodies from 34 providers

The DNASU plasmid repository

More...DNASUi		8997

Genome annotation databases

EnsembliENST00000240874.7; ENSP00000240874.3; ENSG00000160145.16 [O60229-2]
ENST00000291478.9; ENSP00000291478.4; ENSG00000160145.16 [O60229-4]
ENST00000360013.7; ENSP00000353109.3; ENSG00000160145.16
GeneIDi8997
KEGGihsa:8997
UCSCiuc003ehf.2, human [O60229-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		8997
DisGeNETi8997

GeneCards: human genes, protein and diseases

More...GeneCardsi		KALRN
HGNCiHGNC:4814, KALRN
HPAiENSG00000160145, Tissue enhanced (brain)
MalaCardsiKALRN
MIMi604605, gene
neXtProtiNX_O60229
OpenTargetsiENSG00000160145
PharmGKBiPA29189
VEuPathDBiHostDB:ENSG00000160145

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4240, Eukaryota
GeneTreeiENSGT00940000155248
HOGENOMiCLU_000373_0_1_1
InParanoidiO60229
OMAiAKXFIMA
OrthoDBi5761at2759
PhylomeDBiO60229
TreeFamiTF318080

Enzyme and pathway databases

PathwayCommonsiO60229
ReactomeiR-HSA-193648, NRAGE signals death through JNK
R-HSA-3928662, EPHB-mediated forward signaling
R-HSA-416476, G alpha (q) signalling events
R-HSA-416482, G alpha (12/13) signalling events
R-HSA-5687128, MAPK6/MAPK4 signaling
R-HSA-8980692, RHOA GTPase cycle
R-HSA-9013149, RAC1 GTPase cycle
R-HSA-9013408, RHOG GTPase cycle
SignaLinkiO60229
SIGNORiO60229

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		8997, 10 hits in 1108 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		KALRN, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Kalirin

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		8997
PharosiO60229, Tbio

Protein Ontology

More...PROi		PR:O60229
RNActiO60229, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000160145, Expressed in secondary oocyte and 209 other tissues
ExpressionAtlasiO60229, baseline and differential
GenevisibleiO60229, HS

Family and domain databases

CDDicd00063, FN3, 1 hit
cd00160, RhoGEF, 2 hits
cd00170, SEC14, 1 hit
cd00176, SPEC, 4 hits
Gene3Di1.20.900.10, 2 hits
2.30.29.30, 2 hits
2.60.40.10, 2 hits
3.40.525.10, 1 hit
InterProiView protein in InterPro
IPR001251, CRAL-TRIO_dom
IPR036865, CRAL-TRIO_dom_sf
IPR035899, DBL_dom_sf
IPR000219, DH-domain
IPR003961, FN3_dom
IPR036116, FN3_sf
IPR007110, Ig-like_dom
IPR013783, Ig-like_fold
IPR013098, Ig_I-set
IPR003599, Ig_sub
IPR003598, Ig_sub2
IPR028570, Kalirin/TRIO
IPR011009, Kinase-like_dom_sf
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR008271, Ser/Thr_kinase_AS
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
IPR018159, Spectrin/alpha-actinin
IPR002017, Spectrin_repeat
PANTHERiPTHR22826:SF104, PTHR22826:SF104, 2 hits
PfamiView protein in Pfam
PF13716, CRAL_TRIO_2, 1 hit
PF00041, fn3, 1 hit
PF07679, I-set, 1 hit
PF00169, PH, 1 hit
PF00069, Pkinase, 1 hit
PF00621, RhoGEF, 2 hits
PF00435, Spectrin, 4 hits
SMARTiView protein in SMART
SM00060, FN3, 1 hit
SM00409, IG, 1 hit
SM00408, IGc2, 1 hit
SM00233, PH, 2 hits
SM00325, RhoGEF, 2 hits
SM00220, S_TKc, 1 hit
SM00516, SEC14, 1 hit
SM00326, SH3, 2 hits
SM00150, SPEC, 7 hits
SUPFAMiSSF48065, SSF48065, 2 hits
SSF49265, SSF49265, 1 hit
SSF50044, SSF50044, 2 hits
SSF52087, SSF52087, 1 hit
SSF56112, SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50191, CRAL_TRIO, 1 hit
PS50010, DH_2, 2 hits
PS50853, FN3, 1 hit
PS50835, IG_LIKE, 1 hit
PS50003, PH_DOMAIN, 2 hits
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit
PS50002, SH3, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKALRN_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O60229
Secondary accession number(s): A8MSI4
, C9JQ37, J3QSW6, Q6ZN45, Q8TBQ5, Q9NSZ4, Q9Y2A5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: July 31, 2019
Last modified: May 25, 2022
This is version 210 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with genetic variants
    List of human entries with genetic variants
  4. Human variants curated from literature reports
    Index of human variants curated from literature reports
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again