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Entry version 191 (13 Feb 2019)
Sequence version 2 (23 Oct 2007)
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Protein

Kalirin

Gene

KALRN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity.1 Publication

Miscellaneous

Called DUO because the encoded protein is closely related to but shorter than TRIO.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei2712ATP1
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei2802Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi2689 – 2697ATPPROSITE-ProRule annotation9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGuanine-nucleotide releasing factor, Kinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-193648 NRAGE signals death through JNK
R-HSA-194840 Rho GTPase cycle
R-HSA-3928662 EPHB-mediated forward signaling
R-HSA-416476 G alpha (q) signalling events
R-HSA-416482 G alpha (12/13) signalling events
R-HSA-5687128 MAPK6/MAPK4 signaling

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
O60229

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
KalirinBy similarity (EC:2.7.11.1)
Alternative name(s):
Huntingtin-associated protein-interacting protein
Protein Duo
Serine/threonine-protein kinase with Dbl- and pleckstrin homology domain
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KALRNImported
Synonyms:DUET, DUO, HAPIP, TRAD
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000160145.15

Human Gene Nomenclature Database

More...
HGNCi
HGNC:4814 KALRN

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
604605 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O60229

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Coronary heart disease 5 (CHDS5)1 Publication
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionA multifactorial disease characterized by an imbalance between myocardial functional requirements and the capacity of the coronary vessels to supply sufficient blood flow. Decreased capacity of the coronary vessels is often associated with thickening and loss of elasticity of the coronary arteries.
See also OMIM:608901

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi2712K → A: Loss of autophosphorylation. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
8997

MalaCards human disease database

More...
MalaCardsi
KALRN
MIMi608901 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000160145

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA29189

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
KALRN

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000809551 – 2985KalirinAdd BLAST2985

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1750PhosphoserineCombined sources1
Modified residuei1753PhosphoserineCombined sources1
Modified residuei1799PhosphoserineCombined sources1
Modified residuei1812PhosphothreonineBy similarity1
Modified residuei1817PhosphoserineCombined sources1
Modified residuei1912PhosphothreonineBy similarity1
Modified residuei2261PhosphoserineCombined sources1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi2491 ↔ 2547PROSITE-ProRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Autophosphorylated.

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
O60229

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
O60229

MaxQB - The MaxQuant DataBase

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MaxQBi
O60229

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
O60229

PeptideAtlas

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PeptideAtlasi
O60229

PRoteomics IDEntifications database

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PRIDEi
O60229

ProteomicsDB human proteome resource

More...
ProteomicsDBi
49252
49253 [O60229-2]
49254 [O60229-3]
49255 [O60229-4]
49256 [O60229-5]
49257 [O60229-6]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O60229

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
O60229

SwissPalm database of S-palmitoylation events

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SwissPalmi
O60229

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 2 is brain specific. Highly expressed in cerebral cortex, putamen, amygdala, hippocampus and caudate nucleus. Weakly expressed in brain stem and cerebellum. Isoform 4 is expressed in skeletal muscle.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000160145 Expressed in 196 organ(s), highest expression level in secondary oocyte

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
O60229 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
O60229 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB026456
HPA011913

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with the C-terminal of peptidylglycine alpha-amidating monooxygenase (PAM) and with the huntingtin-associated protein 1 (HAP1) (By similarity). Interacts with FASLG.By similarity1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
SNCAIPQ9Y6H5-13EBI-9075360,EBI-9075374

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
114478, 16 interactors

Protein interaction database and analysis system

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IntActi
O60229, 12 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000240874

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
O60229

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O60229

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini35 – 180CRAL-TRIOPROSITE-ProRule annotationAdd BLAST146
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati167 – 308Spectrin 1Sequence analysisAdd BLAST142
Repeati310 – 417Spectrin 2Sequence analysisAdd BLAST108
Repeati418 – 535Spectrin 3Sequence analysisAdd BLAST118
Repeati536 – 639Spectrin 4Sequence analysisAdd BLAST104
Repeati640 – 770Spectrin 5Sequence analysisAdd BLAST131
Repeati771 – 888Spectrin 6Sequence analysisAdd BLAST118
Repeati889 – 1004Spectrin 7Sequence analysisAdd BLAST116
Repeati1005 – 1128Spectrin 8Sequence analysisAdd BLAST124
Repeati1129 – 1234Spectrin 9Sequence analysisAdd BLAST106
Domaini1281 – 1456DH 1PROSITE-ProRule annotationAdd BLAST176
Domaini1468 – 1580PH 1PROSITE-ProRule annotationAdd BLAST113
Domaini1646 – 1711SH3 1PROSITE-ProRule annotationAdd BLAST66
Domaini1928 – 2103DH 2PROSITE-ProRule annotationAdd BLAST176
Domaini2115 – 2225PH 2PROSITE-ProRule annotationAdd BLAST111
Domaini2320 – 2385SH3 2PROSITE-ProRule annotationAdd BLAST66
Domaini2470 – 2563Ig-like C2-typeAdd BLAST94
Domaini2570 – 2664Fibronectin type-IIIPROSITE-ProRule annotationAdd BLAST95
Domaini2683 – 2937Protein kinasePROSITE-ProRule annotationAdd BLAST255

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi682 – 687Poly-Gln6

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The two GEF domains catalyze nucleotide exchange for RAC1 and RhoA which are bound by DH1 and DH2 respectively. The two GEF domains appear to play differing roles in neuronal development and axonal outgrowth. SH3 1 binds to the first GEF domain inhibiting GEF activity only when in the presence of a PXXP peptide, suggesting that the SH3 domain/peptide interaction mediates binding to GEF1. CRK1 SH3 domain binds to and inhibits GEF1 activity (By similarity).By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, SH3 domain

Phylogenomic databases

Ensembl GeneTree

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GeneTreei
ENSGT00940000155248

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000044462

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG108598

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
O60229

KEGG Orthology (KO)

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KOi
K15048

Database of Orthologous Groups

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OrthoDBi
5761at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
O60229

TreeFam database of animal gene trees

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TreeFami
TF318080

Family and domain databases

Conserved Domains Database

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CDDi
cd00063 FN3, 1 hit
cd00160 RhoGEF, 2 hits
cd00170 SEC14, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.900.10, 2 hits
2.30.29.30, 2 hits
2.60.40.10, 2 hits
3.40.525.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR001251 CRAL-TRIO_dom
IPR036865 CRAL-TRIO_dom_sf
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR028569 Kalirin
IPR011009 Kinase-like_dom_sf
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR018159 Spectrin/alpha-actinin
IPR002017 Spectrin_repeat

The PANTHER Classification System

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PANTHERi
PTHR22826:SF49 PTHR22826:SF49, 6 hits

Pfam protein domain database

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Pfami
View protein in Pfam
PF00650 CRAL_TRIO, 1 hit
PF00041 fn3, 1 hit
PF07679 I-set, 1 hit
PF00169 PH, 1 hit
PF00069 Pkinase, 1 hit
PF00621 RhoGEF, 2 hits
PF00435 Spectrin, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00060 FN3, 1 hit
SM00409 IG, 1 hit
SM00408 IGc2, 1 hit
SM00233 PH, 2 hits
SM00325 RhoGEF, 2 hits
SM00220 S_TKc, 1 hit
SM00516 SEC14, 1 hit
SM00326 SH3, 2 hits
SM00150 SPEC, 7 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48065 SSF48065, 2 hits
SSF49265 SSF49265, 1 hit
SSF50044 SSF50044, 2 hits
SSF52087 SSF52087, 1 hit
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50191 CRAL_TRIO, 1 hit
PS50010 DH_2, 2 hits
PS50853 FN3, 1 hit
PS50835 IG_LIKE, 1 hit
PS50003 PH_DOMAIN, 2 hits
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
PS50002 SH3, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing and alternative initiation. AlignAdd to basket

This entry has 6 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O60229-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTDRFWDQWY LWYLRLLRLL DRGSFRNDGL KASDVLPILK EKVAFVSGGR
60 70 80 90 100
DKRGGPILTF PARSNHDRIR QEDLRKLVTY LASVPSEDVC KRGFTVIIDM
110 120 130 140 150
RGSKWDLIKP LLKTLQEAFP AEIHVALIIK PDNFWQKQKT NFGSSKFIFE
160 170 180 190 200
TSMVSVEGLT KLVDPSQLTE EFDGSLDYNH EEWIELRLSL EEFFNSAVHL
210 220 230 240 250
LSRLEDLQEM LARKEFPVDV EGSRRLIDEH TQLKKKVLKA PVEELDREGQ
260 270 280 290 300
RLLQCIRCSD GFSGRNCIPG SADFQSLVPK ITSLLDKLHS TRQHLHQMWH
310 320 330 340 350
VRKLKLDQCF QLRLFEQDAE KMFDWISHNK ELFLQSHTEI GVSYQYALDL
360 370 380 390 400
QTQHNHFAMN SMNAYVNINR IMSVASRLSE AGHYASQQIK QISTQLDQEW
410 420 430 440 450
KSFAAALDER STILAMSAVF HQKAEQFLSG VDAWCKMCSE GGLPSEMQDL
460 470 480 490 500
ELAIHHHQTL YEQVTQAYTE VSQDGKALLD VLQRPLSPGN SESLTATANY
510 520 530 540 550
SKAVHQVLDV VHEVLHHQRR LESIWQHRKV RLHQRLQLCV FQQDVQQVLD
560 570 580 590 600
WIENHGEAFL SKHTGVGKSL HRARALQKRH DDFEEVAQNT YTNADKLLEA
610 620 630 640 650
AEQLAQTGEC DPEEIYKAAR HLEVRIQDFV RRVEQRKLLL DMSVSFHTHT
660 670 680 690 700
KELWTWMEDL QKEMLEDVCA DSVDAVQELI KQFQQQQTAT LDATLNVIKE
710 720 730 740 750
GEDLIQQLRS APPSLGEPSE ARDSAVSNNK TPHSSSISHI ESVLQQLDDA
760 770 780 790 800
QVQMEELFHE RKIKLDIFLQ LRIFEQYTIE VTAELDAWNE DLLRQMNDFN
810 820 830 840 850
TEDLTLAEQR LQRHTERKLA MNNMTFEVIQ QGQDLHQYIT EVQASGIELI
860 870 880 890 900
CEKDIDLAAQ VQELLEFLHE KQHELELNAE QTHKRLEQCL QLRHLQAEVK
910 920 930 940 950
QVLGWIRNGE SMLNASLVNA SSLSEAEQLQ REHEQFQLAI ESLFHATSLQ
960 970 980 990 1000
KTHQSALQVQ QKAEVLLQAG HYDADAIREC AEKVALHWQQ LMLKMEDRLK
1010 1020 1030 1040 1050
LVNASVAFYK TSEQVCSVLE SLEQEYRRDE DWCGGRDKLG PAAEIDHVIP
1060 1070 1080 1090 1100
LISKHLEQKE AFLKACTLAR RNAEVFLKYI HRNNVSMPSV ASHTRGPEQQ
1110 1120 1130 1140 1150
VKAILSELLQ RENRVLHFWT LKKRRLDQCQ QYVVFERSAK QALDWIQETG
1160 1170 1180 1190 1200
EFYLSTHTST GETTEETQEL LKEYGEFRVP AKQTKEKVKL LIQLADSFVE
1210 1220 1230 1240 1250
KGHIHATEIR KWVTTVDKHY RDFSLRMGKY RYSLEKALGV NTEDNKDLEL
1260 1270 1280 1290 1300
DIIPASLSDR EVKLRDANHE VNEEKRKSAR KKEFIMAELL QTEKAYVRDL
1310 1320 1330 1340 1350
HECLETYLWE MTSGVEEIPP GILNKEHIIF GNIQEIYDFH NNIFLKELEK
1360 1370 1380 1390 1400
YEQLPEDVGH CFVTWADKFQ MYVTYCKNKP DSNQLILEHA GTFFDEIQQR
1410 1420 1430 1440 1450
HGLANSISSY LIKPVQRITK YQLLLKELLT CCEEGKGELK DGLEVMLSVP
1460 1470 1480 1490 1500
KKANDAMHVS MLEGFDENLD VQGELILQDA FQVWDPKSLI RKGRERHLFL
1510 1520 1530 1540 1550
FEISLVFSKE IKDSSGHTKY VYKNKLLTSE LGVTEHVEGD PCKFALWSGR
1560 1570 1580 1590 1600
TPSSDNKTVL KASNIETKQE WIKNIREVIQ ERIIHLKGAL KEPLQLPKTP
1610 1620 1630 1640 1650
AKQRNNSKRD GVEDIDSQGD GSSQPDTISI ASRTSQNTVD SDKLSGGCEL
1660 1670 1680 1690 1700
TVVLQDFSAG HSSELTIQVG QTVELLERPS ERPGWCLVRT TERSPPLEGL
1710 1720 1730 1740 1750
VPSSALCISH SRSSVEMDCF FPLVKDAYSH SSSENGGKSE SVANLQAQPS
1760 1770 1780 1790 1800
LNSIHSSPGP KRSTNTLKKW LTSPVRRLNS GKADGNIKKQ KKVRDGRKSF
1810 1820 1830 1840 1850
DLGSPKPGDE TTPQGDSADE KSKKGWGEDE PDEESHTPLP PPMKIFDNDP
1860 1870 1880 1890 1900
TQDEMSSLLA ARQASTEVPT AADLVNAIEK LVKNKLSLEG SSYRGSLKDP
1910 1920 1930 1940 1950
AGCLNEGMAP PTPPKNPEEE QKAKALRGRM FVLNELVQTE KDYVKDLGIV
1960 1970 1980 1990 2000
VEGFMKRIEE KGVPEDMRGK DKIVFGNIHQ IYDWHKDFFL AELEKCIQEQ
2010 2020 2030 2040 2050
DRLAQLFIKH ERKLHIYVWY CQNKPRSEYI VAEYDAYFEE VKQEINQRLT
2060 2070 2080 2090 2100
LSDFLIKPIQ RITKYQLLLK DFLRYSEKAG LECSDIEKAV ELMCLVPKRC
2110 2120 2130 2140 2150
NDMMNLGRLQ GFEGTLTAQG KLLQQDTFYV IELDAGMQSR TKERRVFLFE
2160 2170 2180 2190 2200
QIVIFSELLR KGSLTPGYMF KRSIKMNYLV LEENVDNDPC KFALMNRETS
2210 2220 2230 2240 2250
ERVVLQAANA DIQQAWVQDI NQVLETQRDF LNALQSPIEY QRKERSTAVM
2260 2270 2280 2290 2300
RSQPARLPQA SPRPYSSVPA GSEKPPKGSS YNPPLPPLKI STSNGSPGFE
2310 2320 2330 2340 2350
YHQPGDKFEA SKQNDLGGCN GTSSMAVIKD YYALKENEIC VSQGEVVQVL
2360 2370 2380 2390 2400
AVNQQNMCLV YQPASDHSPA AEGWVPGSIL APLTKATAAE SSDGSIKKSC
2410 2420 2430 2440 2450
SWHTLRMRKR AEVENTGKNE ATGPRKPKDI LGNKVSVKET NSSEESECDD
2460 2470 2480 2490 2500
LDPNTSMEIL NPNFIQEVAP EFLVPLVDVT CLLGDTVILQ CKVCGRPKPT
2510 2520 2530 2540 2550
ITWKGPDQNI LDTDNSSATY TVSSCDSGEI TLKICNLMPQ DSGIYTCIAT
2560 2570 2580 2590 2600
NDHGTTSTSA TVKVQGVPAA PNRPIAQERS CTSVILRWLP PSSTGNCTIS
2610 2620 2630 2640 2650
GYTVEYREEG SQIWQQSVAS TLDTYLVIED LSPGCPYQFR VSASNPWGIS
2660 2670 2680 2690 2700
LPSEPSEFVR LPEYDAAADG ATISWKENFD SAYTELNEIG RGRFSIVKKC
2710 2720 2730 2740 2750
IHKATRKDVA VKFVSKKMKK KEQAAHEAAL LQHLQHPQYI TLHDTYESPT
2760 2770 2780 2790 2800
SYILILELMD DGRLLDYLMN HDELMEEKVA FYIRDIMEAL QYLHNCRVAH
2810 2820 2830 2840 2850
LDIKPENLLI DLRIPVPRVK LIDLEDAVQI SGHFHIHHLL GNPEFAAPEV
2860 2870 2880 2890 2900
IQGIPVSLGT DIWSIGVLTY VMLSGVSPFL DESKEETCIN VCRVDFSFPH
2910 2920 2930 2940 2950
EYFCGVSNAA RDFINVILQE DFRRRPTAAT CLQHPWLQPH NGSYSKIPLD
2960 2970 2980
TSRLACFIER RKHQNDVRPI PNVKSYIVNR VNQGT
Note: Produced by alternative splicing.
Length:2,985
Mass (Da):340,174
Last modified:October 23, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF4C01D0F2422A92F
GO
Isoform 2 (identifier: O60229-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1644-1663: LSGGCELTVVLQDFSAGHSS → DGNLVPRWHLGPGDPFSTYV
     1664-2985: Missing.

Note: Produced by alternative splicing. No experimental confirmation available.
Show »
Length:1,663
Mass (Da):192,229
Checksum:iFAE683734C83417C
GO
Isoform 3 (identifier: O60229-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-641: Missing.
     709-721: Missing.
     1465-1505: FDENLDVQGE...RHLFLFEISL → SCPPSTGEAS...ARLEERRNDK
     1506-2985: Missing.

Note: Produced by alternative initiation at Met-624 of isoform 1. Inferred by similarity.
Show »
Length:851
Mass (Da):98,659
Checksum:i3F611F4EF00D376C
GO
Isoform 4 (identifier: O60229-4) [UniParc]FASTAAdd to basket
Also known as: DUET, TRAD

The sequence of this isoform differs from the canonical sequence as follows:
     1-1697: Missing.
     1698-1725: EGLVPSSALCISHSRSSVEMDCFFPLVK → MKGGDRAYTRGPSLGWLFAKCCCCFPCR
     1857-1857: S → SS

Note: Produced by alternative splicing.
Show »
Length:1,289
Mass (Da):144,485
Checksum:iC0C2F3DBC8C2B34A
GO
Isoform 5 (identifier: O60229-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1627: Missing.
     1628-1643: ISIASRTSQNTVDSDK → MLKWISWRQSKANKAQ
     1857-1887: Missing.
     2313-2313: Missing.
     2398-2985: Missing.

Note: Produced by alternative splicing.
Show »
Length:738
Mass (Da):82,806
Checksum:i1C9AC959DC07903E
GO
Isoform 6 (identifier: O60229-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1697: Missing.
     1698-1725: EGLVPSSALCISHSRSSVEMDCFFPLVK → MKGGDRAYTRGPSLGWLFAKCCCCFPCR
     1857-1887: Missing.

Note: Produced by alternative splicing. No experimental confirmation available.
Show »
Length:1,257
Mass (Da):141,164
Checksum:iA45112D100678192
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3QSW6J3QSW6_HUMAN
Kalirin
KALRN
2,986Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BXZ5H7BXZ5_HUMAN
Kalirin
KALRN
2,955Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9IZQ6C9IZQ6_HUMAN
HCG2022551, isoform CRA_j
KALRN hCG_2022551
1,654Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C0I9H7C0I9_HUMAN
Kalirin
KALRN
268Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J1B4C9J1B4_HUMAN
Kalirin
KALRN
194Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C1X7H7C1X7_HUMAN
Kalirin
KALRN
215Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0D9SGH1A0A0D9SGH1_HUMAN
HCG2022551, isoform CRA_f
KALRN hCG_2022551
53Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH58015 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti2458E → G in BAA76314 (PubMed:10023074).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_041898196S → L1 Publication1
Natural variantiVAR_035976213R → W in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_0201921326E → D. Corresponds to variant dbSNP:rs2289838Ensembl.1
Natural variantiVAR_0356251896S → C in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_0571901929R → M. Corresponds to variant dbSNP:rs35298864Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0289031 – 1697Missing in isoform 4 and isoform 6. 1 PublicationAdd BLAST1697
Alternative sequenceiVSP_0289041 – 1627Missing in isoform 5. 3 PublicationsAdd BLAST1627
Alternative sequenceiVSP_0289051 – 641Missing in isoform 3. 2 PublicationsAdd BLAST641
Alternative sequenceiVSP_028906709 – 721Missing in isoform 3. 2 PublicationsAdd BLAST13
Alternative sequenceiVSP_0289071465 – 1505FDENL…FEISL → SCPPSTGEASSLPRHGGACI MGGKWHEVRQGARLEERRND K in isoform 3. 2 PublicationsAdd BLAST41
Alternative sequenceiVSP_0289081506 – 2985Missing in isoform 3. 2 PublicationsAdd BLAST1480
Alternative sequenceiVSP_0289091628 – 1643ISIAS…VDSDK → MLKWISWRQSKANKAQ in isoform 5. 3 PublicationsAdd BLAST16
Alternative sequenceiVSP_0289101644 – 1663LSGGC…AGHSS → DGNLVPRWHLGPGDPFSTYV in isoform 2. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_0289111664 – 2985Missing in isoform 2. 1 PublicationAdd BLAST1322
Alternative sequenceiVSP_0289121698 – 1725EGLVP…FPLVK → MKGGDRAYTRGPSLGWLFAK CCCCFPCR in isoform 4 and isoform 6. 1 PublicationAdd BLAST28
Alternative sequenceiVSP_0289131857 – 1887Missing in isoform 5 and isoform 6. 3 PublicationsAdd BLAST31
Alternative sequenceiVSP_0473531857S → SS in isoform 4. 1 Publication1
Alternative sequenceiVSP_0289142313Missing in isoform 5. 3 Publications1
Alternative sequenceiVSP_0289152398 – 2985Missing in isoform 5. 3 PublicationsAdd BLAST588

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U94190 mRNA Translation: AAC15791.1
AB011422 mRNA Translation: BAA76314.1
AK125979 mRNA Translation: BAC86373.1
AK131379 mRNA Translation: BAD18530.1
AC022336 Genomic DNA No translation available.
AC069233 Genomic DNA No translation available.
AC080008 Genomic DNA No translation available.
AC112129 Genomic DNA No translation available.
AC117401 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW79410.1
BC026865 mRNA Translation: AAH26865.1
BC058015 mRNA Translation: AAH58015.1 Sequence problems.
AL137629 mRNA Translation: CAB70850.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS3027.1 [O60229-2]
CCDS3028.1 [O60229-4]

Protein sequence database of the Protein Information Resource

More...
PIRi
T46482

NCBI Reference Sequences

More...
RefSeqi
NP_001019831.2, NM_001024660.4
NP_001309917.1, NM_001322988.1
NP_001309918.1, NM_001322989.1
NP_001309923.1, NM_001322994.1
NP_001309924.1, NM_001322995.1
NP_001309925.1, NM_001322996.1
NP_001309926.1, NM_001322997.1
NP_001309927.1, NM_001322998.1
NP_001309928.1, NM_001322999.1
NP_001309929.1, NM_001323000.1
NP_001309930.1, NM_001323001.1
NP_003938.1, NM_003947.5 [O60229-2]
NP_008995.2, NM_007064.4 [O60229-4]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.13281
Hs.8004

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000240874; ENSP00000240874; ENSG00000160145 [O60229-2]
ENST00000291478; ENSP00000291478; ENSG00000160145 [O60229-4]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
8997

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:8997

UCSC genome browser

More...
UCSCi
uc003ehf.2 human [O60229-1]

Keywords - Coding sequence diversityi

Alternative initiation, Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U94190 mRNA Translation: AAC15791.1
AB011422 mRNA Translation: BAA76314.1
AK125979 mRNA Translation: BAC86373.1
AK131379 mRNA Translation: BAD18530.1
AC022336 Genomic DNA No translation available.
AC069233 Genomic DNA No translation available.
AC080008 Genomic DNA No translation available.
AC112129 Genomic DNA No translation available.
AC117401 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW79410.1
BC026865 mRNA Translation: AAH26865.1
BC058015 mRNA Translation: AAH58015.1 Sequence problems.
AL137629 mRNA Translation: CAB70850.1
CCDSiCCDS3027.1 [O60229-2]
CCDS3028.1 [O60229-4]
PIRiT46482
RefSeqiNP_001019831.2, NM_001024660.4
NP_001309917.1, NM_001322988.1
NP_001309918.1, NM_001322989.1
NP_001309923.1, NM_001322994.1
NP_001309924.1, NM_001322995.1
NP_001309925.1, NM_001322996.1
NP_001309926.1, NM_001322997.1
NP_001309927.1, NM_001322998.1
NP_001309928.1, NM_001322999.1
NP_001309929.1, NM_001323000.1
NP_001309930.1, NM_001323001.1
NP_003938.1, NM_003947.5 [O60229-2]
NP_008995.2, NM_007064.4 [O60229-4]
UniGeneiHs.13281
Hs.8004

3D structure databases

ProteinModelPortaliO60229
SMRiO60229
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114478, 16 interactors
IntActiO60229, 12 interactors
STRINGi9606.ENSP00000240874

PTM databases

iPTMnetiO60229
PhosphoSitePlusiO60229
SwissPalmiO60229

Polymorphism and mutation databases

BioMutaiKALRN

Proteomic databases

EPDiO60229
jPOSTiO60229
MaxQBiO60229
PaxDbiO60229
PeptideAtlasiO60229
PRIDEiO60229
ProteomicsDBi49252
49253 [O60229-2]
49254 [O60229-3]
49255 [O60229-4]
49256 [O60229-5]
49257 [O60229-6]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
8997
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000240874; ENSP00000240874; ENSG00000160145 [O60229-2]
ENST00000291478; ENSP00000291478; ENSG00000160145 [O60229-4]
GeneIDi8997
KEGGihsa:8997
UCSCiuc003ehf.2 human [O60229-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8997
DisGeNETi8997
EuPathDBiHostDB:ENSG00000160145.15

GeneCards: human genes, protein and diseases

More...
GeneCardsi
KALRN
HGNCiHGNC:4814 KALRN
HPAiCAB026456
HPA011913
MalaCardsiKALRN
MIMi604605 gene
608901 phenotype
neXtProtiNX_O60229
OpenTargetsiENSG00000160145
PharmGKBiPA29189

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

GeneTreeiENSGT00940000155248
HOGENOMiHOG000044462
HOVERGENiHBG108598
InParanoidiO60229
KOiK15048
OrthoDBi5761at2759
PhylomeDBiO60229
TreeFamiTF318080

Enzyme and pathway databases

ReactomeiR-HSA-193648 NRAGE signals death through JNK
R-HSA-194840 Rho GTPase cycle
R-HSA-3928662 EPHB-mediated forward signaling
R-HSA-416476 G alpha (q) signalling events
R-HSA-416482 G alpha (12/13) signalling events
R-HSA-5687128 MAPK6/MAPK4 signaling
SignaLinkiO60229

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
KALRN human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Kalirin

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
8997

Protein Ontology

More...
PROi
PR:O60229

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000160145 Expressed in 196 organ(s), highest expression level in secondary oocyte
ExpressionAtlasiO60229 baseline and differential
GenevisibleiO60229 HS

Family and domain databases

CDDicd00063 FN3, 1 hit
cd00160 RhoGEF, 2 hits
cd00170 SEC14, 1 hit
Gene3Di1.20.900.10, 2 hits
2.30.29.30, 2 hits
2.60.40.10, 2 hits
3.40.525.10, 1 hit
InterProiView protein in InterPro
IPR001251 CRAL-TRIO_dom
IPR036865 CRAL-TRIO_dom_sf
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR028569 Kalirin
IPR011009 Kinase-like_dom_sf
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR018159 Spectrin/alpha-actinin
IPR002017 Spectrin_repeat
PANTHERiPTHR22826:SF49 PTHR22826:SF49, 6 hits
PfamiView protein in Pfam
PF00650 CRAL_TRIO, 1 hit
PF00041 fn3, 1 hit
PF07679 I-set, 1 hit
PF00169 PH, 1 hit
PF00069 Pkinase, 1 hit
PF00621 RhoGEF, 2 hits
PF00435 Spectrin, 4 hits
SMARTiView protein in SMART
SM00060 FN3, 1 hit
SM00409 IG, 1 hit
SM00408 IGc2, 1 hit
SM00233 PH, 2 hits
SM00325 RhoGEF, 2 hits
SM00220 S_TKc, 1 hit
SM00516 SEC14, 1 hit
SM00326 SH3, 2 hits
SM00150 SPEC, 7 hits
SUPFAMiSSF48065 SSF48065, 2 hits
SSF49265 SSF49265, 1 hit
SSF50044 SSF50044, 2 hits
SSF52087 SSF52087, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50191 CRAL_TRIO, 1 hit
PS50010 DH_2, 2 hits
PS50853 FN3, 1 hit
PS50835 IG_LIKE, 1 hit
PS50003 PH_DOMAIN, 2 hits
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
PS50002 SH3, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKALRN_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O60229
Secondary accession number(s): A8MSI4
, C9JQ37, Q6ZN45, Q8TBQ5, Q9NSZ4, Q9Y2A5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: October 23, 2007
Last modified: February 13, 2019
This is version 191 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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