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Protein

Protein SSX4

Gene

SSX4

more
Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Could act as a modulator of transcription.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Protein SSX4
Alternative name(s):
Cancer/testis antigen 5.4
Short name:
CT5.4
Gene namesi
Name:SSX4
Synonyms:SSX4A
AND
Name:SSX4B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000268009.5
HostDB:ENSG00000269791.5
HGNCiHGNC:11338 SSX4
HGNC:16880 SSX4B
MIMi300326 gene
neXtProtiNX_O60224

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi548313
6759
OpenTargetsiENSG00000268009
ENSG00000269791
PharmGKBiPA36162

Polymorphism and mutation databases

BioMutaiSSX4

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001818311 – 188Protein SSX4Add BLAST188

Proteomic databases

PaxDbiO60224
PeptideAtlasiO60224
PRIDEiO60224
ProteomicsDBi49249

PTM databases

iPTMnetiO60224
PhosphoSitePlusiO60224

Expressioni

Gene expression databases

BgeeiENSG00000268009 Expressed in 10 organ(s), highest expression level in right testis
CleanExiHS_SSX4
HS_SSX4B
GenevisibleiO60224 HS

Organism-specific databases

HPAiHPA045683

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ALS2CR12Q96Q35-24EBI-745513,EBI-11533409

Protein-protein interaction databases

BioGridi112637, 4 interactors
IntActiO60224, 9 interactors
MINTiO60224
STRINGi9606.ENSP00000366083

Structurei

3D structure databases

ProteinModelPortaliO60224
SMRiO60224
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 83KRAB-relatedPROSITE-ProRule annotationAdd BLAST64

Sequence similaritiesi

Belongs to the SSX family.Curated

Phylogenomic databases

eggNOGiENOG410JCMU Eukaryota
ENOG4111A52 LUCA
GeneTreeiENSGT00390000012484
HOGENOMiHOG000231461
HOVERGENiHBG002056
InParanoidiO60224
OMAiMNGDNTF
OrthoDBiEOG091G0NPV
PhylomeDBiO60224
TreeFamiTF338517

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR003655 Krueppel-associated_box-rel
IPR028804 SSX
IPR019041 SSXRD_motif
PANTHERiPTHR14112 PTHR14112, 1 hit
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF09514 SSXRD, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SUPFAMiSSF109640 SSF109640, 1 hit
PROSITEiView protein in PROSITE
PS50806 KRAB_RELATED, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: O60224-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNGDDAFARR PRDDAQISEK LRKAFDDIAK YFSKKEWEKM KSSEKIVYVY
60 70 80 90 100
MKLNYEVMTK LGFKVTLPPF MRSKRAADFH GNDFGNDRNH RNQVERPQMT
110 120 130 140 150
FGSLQRIFPK IMPKKPAEEE NGLKEVPEAS GPQNDGKQLC PPGNPSTLEK
160 170 180
INKTSGPKRG KHAWTHRLRE RKQLVVYEEI SDPEEDDE
Length:188
Mass (Da):21,858
Last modified:August 1, 1998 - v1
Checksum:i4ACA2A8737507AE5
GO
Isoform 2 (identifier: O60224-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     111-153: IMPKKPAEEE...NPSTLEKINK → DPKGGNMPGP...NSPRGYDTCP
     154-188: Missing.

Note: No experimental confirmation available.
Show »
Length:153
Mass (Da):17,918
Checksum:i803D9A3205389854
GO

Sequence cautioni

The sequence AAI03865 differs from that shown. Several sequencing errors.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_054114111 – 153IMPKK…EKINK → DPKGGNMPGPTDCVRESSWW FMKRSATLRKMTSNSPRGYD TCP in isoform 2. 1 PublicationAdd BLAST43
Alternative sequenceiVSP_054115154 – 188Missing in isoform 2. 1 PublicationAdd BLAST35

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U90841 mRNA Translation: AAC05820.1
AF196972 Genomic DNA No translation available.
AL606490 Genomic DNA No translation available.
BC005325 mRNA Translation: AAH05325.1
BC103864 mRNA Translation: AAI03865.1 Sequence problems.
BC137394 mRNA Translation: AAI37395.1
BC137395 mRNA Translation: AAI37396.1
CCDSiCCDS35240.1 [O60224-1]
CCDS35241.1 [O60224-1]
CCDS43934.1 [O60224-2]
CCDS43935.1 [O60224-2]
RefSeqiNP_001030004.1, NM_001034832.3 [O60224-1]
NP_001035702.1, NM_001040612.2 [O60224-2]
NP_005627.1, NM_005636.3 [O60224-1]
NP_783856.1, NM_175729.1 [O60224-2]
XP_016885102.1, XM_017029613.1 [O60224-1]
XP_016885248.1, XM_017029759.1 [O60224-1]
UniGeneiHs.558402
Hs.648298

Genome annotation databases

EnsembliENST00000595235; ENSP00000469394; ENSG00000269791 [O60224-1]
ENST00000595689; ENSP00000469011; ENSG00000268009 [O60224-1]
ENST00000619890; ENSP00000481765; ENSG00000269791 [O60224-2]
ENST00000620320; ENSP00000483262; ENSG00000268009 [O60224-2]
GeneIDi548313
6759
KEGGihsa:548313
hsa:6759
UCSCiuc004djf.3 human [O60224-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U90841 mRNA Translation: AAC05820.1
AF196972 Genomic DNA No translation available.
AL606490 Genomic DNA No translation available.
BC005325 mRNA Translation: AAH05325.1
BC103864 mRNA Translation: AAI03865.1 Sequence problems.
BC137394 mRNA Translation: AAI37395.1
BC137395 mRNA Translation: AAI37396.1
CCDSiCCDS35240.1 [O60224-1]
CCDS35241.1 [O60224-1]
CCDS43934.1 [O60224-2]
CCDS43935.1 [O60224-2]
RefSeqiNP_001030004.1, NM_001034832.3 [O60224-1]
NP_001035702.1, NM_001040612.2 [O60224-2]
NP_005627.1, NM_005636.3 [O60224-1]
NP_783856.1, NM_175729.1 [O60224-2]
XP_016885102.1, XM_017029613.1 [O60224-1]
XP_016885248.1, XM_017029759.1 [O60224-1]
UniGeneiHs.558402
Hs.648298

3D structure databases

ProteinModelPortaliO60224
SMRiO60224
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112637, 4 interactors
IntActiO60224, 9 interactors
MINTiO60224
STRINGi9606.ENSP00000366083

PTM databases

iPTMnetiO60224
PhosphoSitePlusiO60224

Polymorphism and mutation databases

BioMutaiSSX4

Proteomic databases

PaxDbiO60224
PeptideAtlasiO60224
PRIDEiO60224
ProteomicsDBi49249

Protocols and materials databases

DNASUi548313
6759
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000595235; ENSP00000469394; ENSG00000269791 [O60224-1]
ENST00000595689; ENSP00000469011; ENSG00000268009 [O60224-1]
ENST00000619890; ENSP00000481765; ENSG00000269791 [O60224-2]
ENST00000620320; ENSP00000483262; ENSG00000268009 [O60224-2]
GeneIDi548313
6759
KEGGihsa:548313
hsa:6759
UCSCiuc004djf.3 human [O60224-1]

Organism-specific databases

CTDi548313
6759
DisGeNETi548313
6759
EuPathDBiHostDB:ENSG00000268009.5
HostDB:ENSG00000269791.5
GeneCardsiSSX4
SSX4B
HGNCiHGNC:11338 SSX4
HGNC:16880 SSX4B
HPAiHPA045683
MIMi300326 gene
neXtProtiNX_O60224
OpenTargetsiENSG00000268009
ENSG00000269791
PharmGKBiPA36162
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JCMU Eukaryota
ENOG4111A52 LUCA
GeneTreeiENSGT00390000012484
HOGENOMiHOG000231461
HOVERGENiHBG002056
InParanoidiO60224
OMAiMNGDNTF
OrthoDBiEOG091G0NPV
PhylomeDBiO60224
TreeFamiTF338517

Miscellaneous databases

ChiTaRSiSSX4B human
GeneWikiiSSX4_(gene)
PROiPR:O60224
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000268009 Expressed in 10 organ(s), highest expression level in right testis
CleanExiHS_SSX4
HS_SSX4B
GenevisibleiO60224 HS

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR003655 Krueppel-associated_box-rel
IPR028804 SSX
IPR019041 SSXRD_motif
PANTHERiPTHR14112 PTHR14112, 1 hit
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF09514 SSXRD, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SUPFAMiSSF109640 SSF109640, 1 hit
PROSITEiView protein in PROSITE
PS50806 KRAB_RELATED, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSSX4_HUMAN
AccessioniPrimary (citable) accession number: O60224
Secondary accession number(s): A8MYD4
, B2RPE3, Q3SYD4, Q5JQZ0, Q9UJU9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: August 1, 1998
Last modified: November 7, 2018
This is version 147 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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