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Entry version 120 (29 Sep 2021)
Sequence version 1 (01 Aug 1998)
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Protein

Septation initiation protein sid4

Gene

sid4

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for activation of the spg1 GTPase signaling cascade which leads to the initiation of septation and the subsequent termination of mitosis. May act as a scaffold at the spindle pole body to which other components of the spg1 signaling cascade attach.

2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • cell cycle Source: UniProtKB-KW
  • cell division Source: UniProtKB-KW
  • negative regulation of septation initiation signaling Source: PomBase

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle, Cell division, Mitosis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Septation initiation protein sid4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:sid4
ORF Names:SPBC244.01c
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri284812 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002485 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome II

Organism-specific databases

Schizosaccharomyces pombe database

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PomBasei
SPBC244.01c, sid4

Eukaryotic Pathogen, Vector and Host Database Resources

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VEuPathDBi
FungiDB:SPBC244.01c

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000977551 – 660Septation initiation protein sid4Add BLAST660

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O60187

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O60187

PRoteomics IDEntifications database

More...
PRIDEi
O60187

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O60187

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
O60187

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

Interacts with cdc11, sad1, plo1 and dma1.

4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
277175, 28 interactors

Protein interaction database and analysis system

More...
IntActi
O60187, 4 interactors

STRING: functional protein association networks

More...
STRINGi
4896.SPBC244.01c.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O60187

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni79 – 243DisorderedSequence analysisAdd BLAST165
Regioni368 – 396DisorderedSequence analysisAdd BLAST29
Regioni459 – 503DisorderedSequence analysisAdd BLAST45

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi79 – 97Polar residuesSequence analysisAdd BLAST19
Compositional biasi107 – 141Polar residuesSequence analysisAdd BLAST35
Compositional biasi151 – 211Polar residuesSequence analysisAdd BLAST61
Compositional biasi226 – 243Polar residuesSequence analysisAdd BLAST18
Compositional biasi382 – 396Basic and acidic residuesSequence analysisAdd BLAST15

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502SVAG, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_415702_0_0_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
LVSKQCL

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O60187

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR021750, Sid4-like

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF11778, SID, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O60187-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDEAFGDSLS TDYRWLGHSH FDSHPSAGDS IYFDSLDEDA DPSRTARIDR
60 70 80 90 100
IAELLDGLND EQISELVNGV NSTTIKENTK KEISNPNDST RLPLEQIPGS
110 120 130 140 150
NNLFLDPRHQ LGDNSQNAQR HHEPSFNSEK ASYTSTPYKN VAPKVIDSPS
160 170 180 190 200
ARHMHSNSPS FPPSQSHTSS YDQSPKGQLR DNISVPNQQD GLDPEVFNQQ
210 220 230 240 250
SKETKKSLQV PPSRNVPPPV TRPNQYNPEP NFSLSSGYPQ QHFSQPELQN
260 270 280 290 300
RNVHLETVPE SYPVPPSGYP LTSSTCVSSI SQPIQSTDCQ KAQENLSNNK
310 320 330 340 350
QMSSNDQDID PFKQAITDLP PSFVNIVLEM NATIQSLSNQ CQQRDKQIEN
360 370 380 390 400
ITKQLLMNQQ DYCPTTMSTT VSTPLCPPKR FPKSTKDFKE QKPDTKQVRS
410 420 430 440 450
ATISNDFNLK GNGRYNEKSQ IAVPSEIRVQ LSTLDAILLQ FEHLRKELTQ
460 470 480 490 500
ARKEIQILRH TSQNGDQESN ESSKNAITTK TTDKGNNKEN TMLNDGSTAP
510 520 530 540 550
AKNDIRNVIN TNNLDAKLSD ESELMIEKNK SYSTPASSTI PTFHTSQPLT
560 570 580 590 600
SLNMPDSRFN LAKEKQLYYR LGLQHIDQQC SVETANMLKT VLVQLNIPFA
610 620 630 640 650
IFPSTIGQVR RQLQQGRRLY QWARNIHYLI YEENMRDGLV SKQCLADMLK
660
KIRELKKRSL
Length:660
Mass (Da):74,473
Last modified:August 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB7791030F3091D94
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF153475 Genomic DNA Translation: AAF69105.1
CU329671 Genomic DNA Translation: CAA19316.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T39964

NCBI Reference Sequences

More...
RefSeqi
NP_596814.1, NM_001023834.2

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
SPBC244.01c.1; SPBC244.01c.1:pep; SPBC244.01c

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2540650

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
spo:SPBC244.01c

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF153475 Genomic DNA Translation: AAF69105.1
CU329671 Genomic DNA Translation: CAA19316.1
PIRiT39964
RefSeqiNP_596814.1, NM_001023834.2

3D structure databases

SMRiO60187
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi277175, 28 interactors
IntActiO60187, 4 interactors
STRINGi4896.SPBC244.01c.1

PTM databases

iPTMnetiO60187
SwissPalmiO60187

Proteomic databases

MaxQBiO60187
PaxDbiO60187
PRIDEiO60187

Genome annotation databases

EnsemblFungiiSPBC244.01c.1; SPBC244.01c.1:pep; SPBC244.01c
GeneIDi2540650
KEGGispo:SPBC244.01c

Organism-specific databases

PomBaseiSPBC244.01c, sid4
VEuPathDBiFungiDB:SPBC244.01c

Phylogenomic databases

eggNOGiENOG502SVAG, Eukaryota
HOGENOMiCLU_415702_0_0_1
OMAiLVSKQCL
PhylomeDBiO60187

Miscellaneous databases

Protein Ontology

More...
PROi
PR:O60187

Family and domain databases

InterProiView protein in InterPro
IPR021750, Sid4-like
PfamiView protein in Pfam
PF11778, SID, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSID4_SCHPO
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O60187
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: August 1, 1998
Last modified: September 29, 2021
This is version 120 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
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