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Entry version 131 (07 Oct 2020)
Sequence version 2 (03 Oct 2012)
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Protein

Putative anion/proton exchange transporter C19C7.11

Gene

SPBC19C7.11

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Anion/proton exchange transporter involved in iron and copper cation homeostasis.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei218Mediates proton transfer from the outer aqueous phase to the interior of the protein; involved in linking H(+) and Cl(-) transportBy similarity1
Sitei275Mediates proton transfer from the protein to the inner aqueous phaseBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChloride channel, Ion channel
Biological processIon transport, Transport
LigandChloride

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-SPO-2672351, Stimuli-sensing channels

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Putative anion/proton exchange transporter C19C7.11
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:SPBC19C7.11
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri284812 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002485 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome II

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
FungiDB:SPBC19C7.11

Schizosaccharomyces pombe database

More...
PomBasei
SPBC19C7.11

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 78CytoplasmicBy similarityAdd BLAST78
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei79 – 99HelicalSequence analysisAdd BLAST21
Topological domaini100 – 144LumenalBy similarityAdd BLAST45
Transmembranei145 – 165HelicalSequence analysisAdd BLAST21
Topological domaini166 – 167CytoplasmicBy similarity2
Transmembranei168 – 188HelicalSequence analysisAdd BLAST21
Topological domaini189 – 196LumenalBy similarity8
Transmembranei197 – 217HelicalSequence analysisAdd BLAST21
Topological domaini218 – 252CytoplasmicBy similarityAdd BLAST35
Transmembranei253 – 273HelicalSequence analysisAdd BLAST21
Topological domaini274 – 284LumenalBy similarityAdd BLAST11
Transmembranei285 – 305HelicalSequence analysisAdd BLAST21
Topological domaini306 – 322CytoplasmicBy similarityAdd BLAST17
Transmembranei323 – 343HelicalSequence analysisAdd BLAST21
Topological domaini344 – 362LumenalBy similarityAdd BLAST19
Transmembranei363 – 383HelicalSequence analysisAdd BLAST21
Topological domaini384 – 418CytoplasmicBy similarityAdd BLAST35
Transmembranei419 – 439HelicalSequence analysisAdd BLAST21
Topological domaini440 – 442LumenalBy similarity3
Transmembranei443 – 463HelicalSequence analysisAdd BLAST21
Topological domaini464 – 486CytoplasmicBy similarityAdd BLAST23
Transmembranei487 – 507HelicalSequence analysisAdd BLAST21
Topological domaini508 – 520LumenalBy similarityAdd BLAST13
Transmembranei521 – 543HelicalSequence analysisAdd BLAST23
Topological domaini544 – 766CytoplasmicBy similarityAdd BLAST223

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Endosome, Golgi apparatus, Membrane, Vacuole

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003103401 – 766Putative anion/proton exchange transporter C19C7.11Add BLAST766

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O60159

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O60159

PRoteomics IDEntifications database

More...
PRIDEi
O60159

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O60159

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
277272, 1 interactor

STRING: functional protein association networks

More...
STRINGi
4896.SPBC19C7.11.1

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini580 – 641CBS 1PROSITE-ProRule annotationAdd BLAST62
Domaini676 – 734CBS 2PROSITE-ProRule annotationAdd BLAST59

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

CBS domain, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0475, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_003181_2_2_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O60159

KEGG Orthology (KO)

More...
KOi
K05012

Identification of Orthologs from Complete Genome Data

More...
OMAi
FCCWGAE

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.3080.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000644, CBS_dom
IPR014743, Cl-channel_core
IPR001807, Cl-channel_volt-gated

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00571, CBS, 1 hit
PF00654, Voltage_CLC, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00762, CLCHANNEL

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF81340, SSF81340, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51371, CBS, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O60159-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSQKRADSS SSFDQAERRS LDENERKKKY FFNREGSGID NFETDDRVNE
60 70 80 90 100
IINEQNEENV IDQSRWSKLW RIWNVGYSWF ILSIIGTTVG FAAYMLDIVT
110 120 130 140 150
SWLSDIRRGY CTSHWYYNEK FCCWYSETMG SSCTAWKPWT YKFSLNYLIY
160 170 180 190 200
TAFALLFVLC AAIMVRDVAP LAAGSGISEI KCIISGFLRD SFLSFRVMLV
210 220 230 240 250
KCVGLPLAIA SGLSVGKEGP SVHLATTIGH NISKIFKYAR EGSIRYRDIC
260 270 280 290 300
VASAASGVAV AFGSPIGGVL FGIEEMSGGY DPKMIVYSFF CCLSAVGVLH
310 320 330 340 350
MLNPFRTGQV VLFEVRYSGS WHFFELLFFC FLGIFGGLYG EFVMRLFFLI
360 370 380 390 400
QKLRKKYLSR WGVLDAAFVT VITSLVSFLN PWLRLDMTLG MELLFQECKS
410 420 430 440 450
SSSPELINLC DPSLRTKNTI LLLIATFART IFVTFSYGAK VPAGIFVPSM
460 470 480 490 500
AVGASFGYMI GLIAEMIYQR FPNSVLFLAC HGSESCITPG TYALLGAAAS
510 520 530 540 550
LSGIMHLTVT IVVIMFELTG ALNFILPTVL VVALANSIGN MLGKTGIADR
560 570 580 590 600
SIEINGLPLL EPEKSINSSN TINIPITEVM ASNLITIPSI GFTWRKLLGM
610 620 630 640 650
MEGYDFSGYP VVLDSRSNYL IGYLKKSSLK SSFEAAKLEP SFTFDQQLCF
660 670 680 690 700
GKVDSVGDSK SSKFGESDRI DLSAYMDVNP ISVLHTQSIA NVAVLFEVLS
710 720 730 740 750
PSVIFIEKDG NLVGLISKKD LLLASKYYQE DNDLVNPANR HRAVSTERIN
760
DSYENIELKP LKLNIE
Length:766
Mass (Da):85,162
Last modified:October 3, 2012 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i43733DCF104C0AF0
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CU329671 Genomic DNA Translation: CAA19579.2

Protein sequence database of the Protein Information Resource

More...
PIRi
T39817

NCBI Reference Sequences

More...
RefSeqi
NP_596167.2, NM_001022087.2

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
SPBC19C7.11.1; SPBC19C7.11.1:pep; SPBC19C7.11

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2540750

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
spo:SPBC19C7.11

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA Translation: CAA19579.2
PIRiT39817
RefSeqiNP_596167.2, NM_001022087.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi277272, 1 interactor
STRINGi4896.SPBC19C7.11.1

PTM databases

iPTMnetiO60159

Proteomic databases

MaxQBiO60159
PaxDbiO60159
PRIDEiO60159

Genome annotation databases

EnsemblFungiiSPBC19C7.11.1; SPBC19C7.11.1:pep; SPBC19C7.11
GeneIDi2540750
KEGGispo:SPBC19C7.11

Organism-specific databases

EuPathDBiFungiDB:SPBC19C7.11
PomBaseiSPBC19C7.11

Phylogenomic databases

eggNOGiKOG0475, Eukaryota
HOGENOMiCLU_003181_2_2_1
InParanoidiO60159
KOiK05012
OMAiFCCWGAE

Enzyme and pathway databases

ReactomeiR-SPO-2672351, Stimuli-sensing channels

Miscellaneous databases

Protein Ontology

More...
PROi
PR:O60159

Family and domain databases

Gene3Di1.10.3080.10, 1 hit
InterProiView protein in InterPro
IPR000644, CBS_dom
IPR014743, Cl-channel_core
IPR001807, Cl-channel_volt-gated
PfamiView protein in Pfam
PF00571, CBS, 1 hit
PF00654, Voltage_CLC, 1 hit
PRINTSiPR00762, CLCHANNEL
SUPFAMiSSF81340, SSF81340, 1 hit
PROSITEiView protein in PROSITE
PS51371, CBS, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiYHYB_SCHPO
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O60159
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: October 3, 2012
Last modified: October 7, 2020
This is version 131 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families
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