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UniProtKB - O60100 (IMB4_SCHPO)

Entry version 149 (25 May 2022)
Sequence version 1 (01 Aug 1998)
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Protein

Probable importin subunit beta-4

Gene

kap123

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for nuclear protein import, its predominant substrate seems to be ribosomal proteins. Binds to nucleoporins and the GTP-bound form of gsp1 (Ran) (By similarity).

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein transport, Transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Probable importin subunit beta-4
Alternative name(s):
Importin-123
Karyopherin subunit beta-4
Karyopherin-123
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:kap123
ORF Names:SPBC14F5.03c
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri284812 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002485 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome II

Organism-specific databases

Schizosaccharomyces pombe database

More...PomBasei		SPBC14F5.03c, kap123

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		FungiDB:SPBC14F5.03c

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001207751 – 1067Probable importin subunit beta-4Add BLAST1067

Proteomic databases

MaxQB - The MaxQuant DataBase

More...MaxQBi		O60100

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O60100

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O60100

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		276410, 10 interactors

Database of interacting proteins

More...DIPi		DIP-38714N

Protein interaction database and analysis system

More...IntActi		O60100, 2 interactors

STRING: functional protein association networks

More...STRINGi		4896.SPBC14F5.03c.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		O60100

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O60100

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini27 – 94Importin N-terminalPROSITE-ProRule annotationAdd BLAST68
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati159 – 196HEAT 1Add BLAST38
Repeati379 – 416HEAT 2Add BLAST38
Repeati420 – 457HEAT 3Add BLAST38
Repeati591 – 633HEAT 4Add BLAST43
Repeati890 – 927HEAT 5Add BLAST38
Repeati1013 – 1050HEAT 6Add BLAST38

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the importin beta family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2171, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_003794_1_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O60100

Identification of Orthologs from Complete Genome Data

More...OMAi		VRGNAAY

Database for complete collections of gene phylogenies

More...PhylomeDBi		O60100

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.25.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR021133, HEAT_type_2
IPR001494, Importin-beta_N
IPR040122, Importin_beta

The PANTHER Classification System

More...PANTHERi		PTHR10527, PTHR10527, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF03810, IBN_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00913, IBN_N, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48371, SSF48371, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50077, HEAT_REPEAT, 2 hits
PS50166, IMPORTIN_B_NT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O60100-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDAQFTLELT QLLFQSIAPD TTQITEATRA LETKYLKEPG SLLSLFHIMG 
        60         70         80         90        100
TCENPQVRQL AAIEARKLCH KYWSSVDADV QNQIRSNLLD ITLKEPESIV 
       110        120        130        140        150
RHAFGRVIAA LAKLDLPEGK WNELSAFLVQ ATMDQNDSIR EMAVYVLYSI 
       160        170        180        190        200
AETVDLDNKL LLDFVNLFSQ TITDSSRTVR VTSVQGLGAI AEVLESDDKK 
       210        220        230        240        250
LLHAYRATLP GMLLVLQDVV QVGDVDASKQ VFDVFNTFLI ASGAIISKAL 
       260        270        280        290        300
GNIIEIITGI ANSKQVDDEI RCMALSFIIS CIRFKSRKLQ ALKLGKPLVL 
       310        320        330        340        350
TLMEVATEET TDDIDEDCPA RLALRSIDLL STHLSPSQVF YPMFEAACAF 
       360        370        380        390        400
SQSPQASYRK AALLSIGVAV EGSSESVAGN LPNIFPIIIN GLCDNDMDVR 
       410        420        430        440        450
QAALLALSQI AVEIPTEVSK HHAQLLPLVF ELMSTQGVKV GKSACNCIDA 
       460        470        480        490        500
LLEGLDKSEI SGYLPMLMER LVGLLEFSDT PDIKSCVAAA IGSAAFAAQD 
       510        520        530        540        550
DFIPYFERTM ASLSQCLHTT DDDEGYELRG TVMDTLGAIA NAVGKQAFLP 
       560        570        580        590        600
YTEQLIQLAY EGIQIDHSRL RECSFCFYAV LARVYKEEFA PFLEHIVPAL 
       610        620        630        640        650
FKSIDQDESD ILSERIGAPT AEEISQLLDS VETNEEENDE ELEKAMGVNS 
       660        670        680        690        700
AIAMEKEIAA DALGEICMYV GAPFTPYLEP TVEKLVACTT HFYEGVRKSA 
       710        720        730        740        750
LSSLWRCATT YYKVCNVPQW QPGLPLKVPV PDTVKNIFEA VRKCTFDTLE 
       760        770        780        790        800
EEYEKTVATD ILRNFAESIK TCGPVVLGDD YEKLCEVVME VLQKQHIVQA 
       810        820        830        840        850
GDVFDDDFEE EDIVSNEEVD DTEQDALLID SACDVVIALA VALGGSFADS 
       860        870        880        890        900
FKVFYPQIVK YYMSKNGNER AMAVACVGEV AGGIESAITP FTRDVFSLFM 
       910        920        930        940        950
AALEDSEGEV RSNAAYSMGL LCQFSTEDLS SEYLNILQKL QPFFTQEVFR 
       960        970        980        990       1000
TALDNAIGCI SRLILHNQNA IPVDQVLPIV FSKLPLKEDY LENAPLYHMI 
      1010       1020       1030       1040       1050
LALYRQQNPC LVQHLGELIP VFASVLTGSP EQLNDELRSE LLSMVKEIAP 
      1060 
QYESVVSNYP QLVALLQ
Length:1,067
Mass (Da):117,834
Last modified:August 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0D90A3CB4DE13BB6
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
CU329671 Genomic DNA Translation: CAA19321.1
AB028002 Genomic DNA Translation: BAA87306.1

Protein sequence database of the Protein Information Resource

More...PIRi		T39449

NCBI Reference Sequences

More...RefSeqi		NP_596729.1, NM_001022655.2

Genome annotation databases

Ensembl fungal genome annotation project

More...EnsemblFungii		SPBC14F5.03c.1; SPBC14F5.03c.1:pep; SPBC14F5.03c

Database of genes from NCBI RefSeq genomes

More...GeneIDi		2539863

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		spo:SPBC14F5.03c

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA Translation: CAA19321.1
AB028002 Genomic DNA Translation: BAA87306.1
PIRiT39449
RefSeqiNP_596729.1, NM_001022655.2

3D structure databases

AlphaFoldDBiO60100
SMRiO60100
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi276410, 10 interactors
DIPiDIP-38714N
IntActiO60100, 2 interactors
STRINGi4896.SPBC14F5.03c.1

PTM databases

iPTMnetiO60100

Proteomic databases

MaxQBiO60100
PaxDbiO60100

Genome annotation databases

EnsemblFungiiSPBC14F5.03c.1; SPBC14F5.03c.1:pep; SPBC14F5.03c
GeneIDi2539863
KEGGispo:SPBC14F5.03c

Organism-specific databases

PomBaseiSPBC14F5.03c, kap123
VEuPathDBiFungiDB:SPBC14F5.03c

Phylogenomic databases

eggNOGiKOG2171, Eukaryota
HOGENOMiCLU_003794_1_1_1
InParanoidiO60100
OMAiVRGNAAY
PhylomeDBiO60100

Miscellaneous databases

Protein Ontology

More...PROi		PR:O60100

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR021133, HEAT_type_2
IPR001494, Importin-beta_N
IPR040122, Importin_beta
PANTHERiPTHR10527, PTHR10527, 1 hit
PfamiView protein in Pfam
PF03810, IBN_N, 1 hit
SMARTiView protein in SMART
SM00913, IBN_N, 1 hit
SUPFAMiSSF48371, SSF48371, 2 hits
PROSITEiView protein in PROSITE
PS50077, HEAT_REPEAT, 2 hits
PS50166, IMPORTIN_B_NT, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIMB4_SCHPO
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O60100
Secondary accession number(s): Q9US72
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: August 1, 1998
Last modified: May 25, 2022
This is version 149 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families
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