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Protein

60S ribosomal protein L5

Gene

rpl-5

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.By similarity

GO - Molecular functioni

  • 5S rRNA binding Source: GO_Central
  • structural constituent of ribosome Source: InterPro

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein, RNA-binding, rRNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L5
Alternative name(s):
CPR4
Gene namesi
Name:rpl-5
Synonyms:crp-4
ORF Names:B7H23.350, NCU04331
OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Taxonomic identifieri367110 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
Proteomesi
  • UP000001805 Componenti: Chromosome 2, Linkage Group V

Organism-specific databases

EuPathDBiFungiDB:NCU04331

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001314511 – 30160S ribosomal protein L5Add BLAST301

Proteomic databases

PRIDEiO59953

Interactioni

Subunit structurei

Component of the large ribosomal subunit (LSU).By similarity

Structurei

3D structure databases

ProteinModelPortaliO59953
SMRiO59953
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000105947
InParanoidiO59953
KOiK02932
OMAiVAEYMES
OrthoDBiEOG092C44EY

Family and domain databases

HAMAPiMF_01337_A Ribosomal_L18_A, 1 hit
InterProiView protein in InterPro
IPR005485 Rbsml_L5_euk/L18_arc
IPR025607 Rbsml_L5e/L18P_C
PANTHERiPTHR23410 PTHR23410, 1 hit
PfamiView protein in Pfam
PF14204 Ribosomal_L18_c, 1 hit
PF17144 Ribosomal_L5e, 1 hit
PRINTSiPR00058 RIBOSOMALL5

Sequencei

Sequence statusi: Complete.

O59953-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAFHKLVKNS AYYSRFQTKY KRRREGKTDY YARKRLITQA KNKYNAPKYR
60 70 80 90 100
LVVRFTNRDI ILQIVSSEIT GDKVFASAYS HELKAYGIEH GLTNWAAAYA
110 120 130 140 150
TGLLLARRVL KKLGLDETFK GVEEADGEYK LTEAAETDDG ERRPFKAFLD
160 170 180 190 200
VGLARTSTGA RVFGAMKGAS DGGIFIPHSE NRFPGYDMES EELDAETLKK
210 220 230 240 250
YIFGGHVAEY METLADDDEE RYKSQFNRYI EDDLEADGLE DLYAEAHAAI
260 270 280 290 300
REDPFKKAES EAPKKTKEEW KAESLKYKKS KLTREQRAAG VQERIAALRS

E
Length:301
Mass (Da):34,412
Last modified:August 1, 1998 - v1
Checksum:i289B0F0D1672A5F9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF054907 Genomic DNA Translation: AAC09000.1
BX294026 Genomic DNA Translation: CAD71058.1
CM002240 Genomic DNA Translation: EAA31342.1
RefSeqiXP_960578.1, XM_955485.3

Genome annotation databases

EnsemblFungiiEAA31342; EAA31342; NCU04331
GeneIDi3876725
KEGGincr:NCU04331

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF054907 Genomic DNA Translation: AAC09000.1
BX294026 Genomic DNA Translation: CAD71058.1
CM002240 Genomic DNA Translation: EAA31342.1
RefSeqiXP_960578.1, XM_955485.3

3D structure databases

ProteinModelPortaliO59953
SMRiO59953
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiO59953

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEAA31342; EAA31342; NCU04331
GeneIDi3876725
KEGGincr:NCU04331

Organism-specific databases

EuPathDBiFungiDB:NCU04331

Phylogenomic databases

HOGENOMiHOG000105947
InParanoidiO59953
KOiK02932
OMAiVAEYMES
OrthoDBiEOG092C44EY

Family and domain databases

HAMAPiMF_01337_A Ribosomal_L18_A, 1 hit
InterProiView protein in InterPro
IPR005485 Rbsml_L5_euk/L18_arc
IPR025607 Rbsml_L5e/L18P_C
PANTHERiPTHR23410 PTHR23410, 1 hit
PfamiView protein in Pfam
PF14204 Ribosomal_L18_c, 1 hit
PF17144 Ribosomal_L5e, 1 hit
PRINTSiPR00058 RIBOSOMALL5
ProtoNetiSearch...

Entry informationi

Entry nameiRL5_NEUCR
AccessioniPrimary (citable) accession number: O59953
Secondary accession number(s): Q7RVB8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: August 1, 1998
Last modified: November 7, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
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Main funding by: National Institutes of Health

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