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UniProtKB - O59942 (AAP2_NEUCR)
Protein
Amino-acid permease 2
Gene
aap-2
Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Functioni
GO - Molecular functioni
- transmembrane transporter activity Source: InterPro
GO - Biological processi
- amino acid transport Source: UniProtKB-KW
Keywordsi
Biological process | Amino-acid transport, Transport |
Names & Taxonomyi
Protein namesi | Recommended name: Amino-acid permease 2 |
Gene namesi | Name:aap-2 Synonyms:aap2 ORF Names:90C4.260, NCU00765 |
Organismi | Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) |
Taxonomic identifieri | 367110 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Sordariomycetes › Sordariomycetidae › Sordariales › Sordariaceae › Neurospora › |
Proteomesi |
|
Organism-specific databases
VEuPathDBi | FungiDB:NCU00765 |
Subcellular locationi
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 66 – 86 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 90 – 110 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 139 – 159 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 188 – 208 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 214 – 234 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 255 – 275 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 301 – 321 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 347 – 367 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 399 – 419 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 424 – 444 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 464 – 484 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 496 – 516 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000054182 | 1 – 541 | Amino-acid permease 2Add BLAST | 541 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 43 | DisorderedSequence analysisAdd BLAST | 43 |
Sequence similaritiesi
Belongs to the amino acid-polyamine-organocation (APC) superfamily.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
HOGENOMi | CLU_004495_0_1_1 |
InParanoidi | O59942 |
Family and domain databases
InterProi | View protein in InterPro IPR002293, AA/rel_permease1 IPR004756, AA_permease IPR004840, Amoino_acid_permease_CS |
Pfami | View protein in Pfam PF13520, AA_permease_2, 1 hit |
TIGRFAMsi | TIGR00907, 2A0304, 1 hit |
PROSITEi | View protein in PROSITE PS00218, AMINO_ACID_PERMEASE_1, 1 hit |
i Sequence
Sequence statusi: Complete.
O59942-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSFSPPNKSA DATIQITEMT RQGTPSSGEA AASTPSTSST ESGDKALEAL
60 70 80 90 100
GYTPVFKREF SRWSSFSFAM SISGVYGTLM STWIYGLQAG GAAAIMWSWI
110 120 130 140 150
IGGAGGWALA YSIAEIASAY PSSGAMYFTL KFLAPEEQVP FLCWIAGYLN
160 170 180 190 200
LVGTVAGGAS TEYAASQMLL AAVSITSNFS YVPTPTHVVG VMIGLTTIHA
210 220 230 240 250
MINTLPTAWL NRLTSGYVVF HISVLLGACV TLLVQKRHDM HDLKYAFTNF
260 270 280 290 300
QPSSGWSPPG FAFLFGCLTP AWIMTGCDGT ARIAEEAKNP QMVVPRAIAN
310 320 330 340 350
ATTFTYVIGF FFNLVLVVCM GDPKDLINSP SGQPVAQLFF NGMGRAPAIF
360 370 380 390 400
FTLCGFGVMN LVAIPGIQAG SRTIFALSRD NLLPFSHIWV RISKRSQTPL
410 420 430 440 450
IAVWTYAVLE IIINLLGLAS STAIGAVFNV CTVALNVSYV IPIICKMVYG
460 470 480 490 500
RMQKGPWHMG KYSVWVNAFA VAWNTFMAVI FFFPTRLPVT PENMNYAIVV
510 520 530 540
FFFVLIFALV FWYTHGRHYY TGPLTHSPRA TDMSVRTPVG V
Sequence cautioni
The sequence AAC08355 differs from that shown. Reason: Frameshift.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 70 | M → V in AAC08355 (Ref. 1) Curated | 1 | |
Sequence conflicti | 367 | I → M in AAC08355 (Ref. 1) Curated | 1 | |
Sequence conflicti | 487 | L → V in AAC08355 (Ref. 1) Curated | 1 | |
Sequence conflicti | 507 | F → L in AAC08355 (Ref. 1) Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF053231 mRNA Translation: AAC08355.1 Frameshift. BX842680 Genomic DNA Translation: CAE81952.1 CM002236 Genomic DNA Translation: EAA34926.3 |
RefSeqi | XP_964162.3, XM_959069.3 |
Genome annotation databases
EnsemblFungii | EAA34926; EAA34926; NCU00765 |
GeneIDi | 3880302 |
KEGGi | ncr:NCU00765 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF053231 mRNA Translation: AAC08355.1 Frameshift. BX842680 Genomic DNA Translation: CAE81952.1 CM002236 Genomic DNA Translation: EAA34926.3 |
RefSeqi | XP_964162.3, XM_959069.3 |
3D structure databases
SMRi | O59942 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 5141.EFNCRP00000000617 |
Genome annotation databases
EnsemblFungii | EAA34926; EAA34926; NCU00765 |
GeneIDi | 3880302 |
KEGGi | ncr:NCU00765 |
Organism-specific databases
VEuPathDBi | FungiDB:NCU00765 |
Phylogenomic databases
HOGENOMi | CLU_004495_0_1_1 |
InParanoidi | O59942 |
Family and domain databases
InterProi | View protein in InterPro IPR002293, AA/rel_permease1 IPR004756, AA_permease IPR004840, Amoino_acid_permease_CS |
Pfami | View protein in Pfam PF13520, AA_permease_2, 1 hit |
TIGRFAMsi | TIGR00907, 2A0304, 1 hit |
PROSITEi | View protein in PROSITE PS00218, AMINO_ACID_PERMEASE_1, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | AAP2_NEUCR | |
Accessioni | O59942Primary (citable) accession number: O59942 Secondary accession number(s): Q6MGI6, Q7RVJ9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 15, 1998 |
Last sequence update: | August 31, 2004 | |
Last modified: | February 23, 2022 | |
This is version 109 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families