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Entry version 124 (11 Dec 2019)
Sequence version 1 (01 Aug 1998)
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Protein

G/U mismatch-specific uracil DNA glycosylase

Gene

thp1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Removes uracil from G/U mispairs in ssDNA. Also corrects G/G mispairs. Does not catalyze the removal of thymine from G/T mispairs.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Specifically hydrolyzes mismatched double-stranded DNA and polynucleotides, releasing free uracil. EC:3.2.2.28

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase
Biological processDNA damage, DNA repair

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.2.2.27 5613

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-SPO-110329 Cleavage of the damaged pyrimidine
R-SPO-3108214 SUMOylation of DNA damage response and repair proteins
R-SPO-5221030 TET1,2,3 and TDG demethylate DNA

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
G/U mismatch-specific uracil DNA glycosylase (EC:3.2.2.28)
Alternative name(s):
Uracil mismatch repair protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:thp1
ORF Names:SPCC965.05c
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri284812 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002485 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome III

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
FungiDB:SPCC965.05c

Schizosaccharomyces pombe database

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PomBasei
SPCC965.05c thp1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001857791 – 325G/U mismatch-specific uracil DNA glycosylaseAdd BLAST325

Proteomic databases

MaxQB - The MaxQuant DataBase

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MaxQBi
O59825

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O59825

PRoteomics IDEntifications database

More...
PRIDEi
O59825

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O59825

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
275995, 5 interactors

STRING: functional protein association networks

More...
STRINGi
4896.SPCC965.05c.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O59825

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O59825

KEGG Orthology (KO)

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KOi
K20813

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O59825

Family and domain databases

Conserved Domains Database

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CDDi
cd10028 UDG_F2_MUG, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.470.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR015637 MUG/TDG
IPR003310 TDG
IPR005122 Uracil-DNA_glycosylase-like
IPR036895 Uracil-DNA_glycosylase-like_sf

The PANTHER Classification System

More...
PANTHERi
PTHR12159 PTHR12159, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03167 UDG, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52141 SSF52141, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00584 mug, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O59825-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNDIETRDTG TKNDNSSEFN LSVKSHKRKR SFDDENLELE ESREETSGGI
60 70 80 90 100
LKKAKTQSFS ESLERFRFAH AGSNNEYRKT DVVKNSDTDN GLLKSAVETI
110 120 130 140 150
TLENGLRNRR VNVTKKSTLK ASVKKSTLKK KNEVDPALLQ GVPDYICENP
160 170 180 190 200
YAIIVGLNPG ITSSLKGHAF ASPSNRFWKM LNKSKLLEGN AEFTYLNDKD
210 220 230 240 250
LPAHGLGITN LCARPSSSGA DLRKEEMQDG ARILYEKVKR YRPQVGLFIS
260 270 280 290 300
GKGIWEEMYK MLTGKKLPKT FVFGWQPEKF GDANVFVGIS SSGRAAGYSD
310 320
EKKQNLWNLF AEEVNRHREI VKHAV
Length:325
Mass (Da):36,574
Last modified:August 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0B3F55C43683D92B
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ277958 Genomic DNA Translation: CAB93678.1
AF288481 Genomic DNA Translation: AAG01021.1
CU329672 Genomic DNA Translation: CAA19065.1

Protein sequence database of the Protein Information Resource

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PIRi
T41658

NCBI Reference Sequences

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RefSeqi
NP_588515.1, NM_001023504.2

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
SPCC965.05c.1; SPCC965.05c.1:pep; SPCC965.05c

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2539432

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
spo:SPCC965.05c

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ277958 Genomic DNA Translation: CAB93678.1
AF288481 Genomic DNA Translation: AAG01021.1
CU329672 Genomic DNA Translation: CAA19065.1
PIRiT41658
RefSeqiNP_588515.1, NM_001023504.2

3D structure databases

SMRiO59825
ModBaseiSearch...

Protein-protein interaction databases

BioGridi275995, 5 interactors
STRINGi4896.SPCC965.05c.1

PTM databases

iPTMnetiO59825

Proteomic databases

MaxQBiO59825
PaxDbiO59825
PRIDEiO59825

Genome annotation databases

EnsemblFungiiSPCC965.05c.1; SPCC965.05c.1:pep; SPCC965.05c
GeneIDi2539432
KEGGispo:SPCC965.05c

Organism-specific databases

EuPathDBiFungiDB:SPCC965.05c
PomBaseiSPCC965.05c thp1

Phylogenomic databases

InParanoidiO59825
KOiK20813
PhylomeDBiO59825

Enzyme and pathway databases

BRENDAi3.2.2.27 5613
ReactomeiR-SPO-110329 Cleavage of the damaged pyrimidine
R-SPO-3108214 SUMOylation of DNA damage response and repair proteins
R-SPO-5221030 TET1,2,3 and TDG demethylate DNA

Miscellaneous databases

Protein Ontology

More...
PROi
PR:O59825

Family and domain databases

CDDicd10028 UDG_F2_MUG, 1 hit
Gene3Di3.40.470.10, 1 hit
InterProiView protein in InterPro
IPR015637 MUG/TDG
IPR003310 TDG
IPR005122 Uracil-DNA_glycosylase-like
IPR036895 Uracil-DNA_glycosylase-like_sf
PANTHERiPTHR12159 PTHR12159, 1 hit
PfamiView protein in Pfam
PF03167 UDG, 1 hit
SUPFAMiSSF52141 SSF52141, 1 hit
TIGRFAMsiTIGR00584 mug, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTDG_SCHPO
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O59825
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: August 1, 1998
Last modified: December 11, 2019
This is version 124 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
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