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UniProtKB - O59768 (VCX1_SCHPO)
Protein
Vacuolar calcium ion transporter
Gene
vcx1
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Functioni
Has a role in promoting intracellular calcium ion sequestration via the exchange of calcium ions for hydrogen ions across the vacuolar membrane. Involved also in manganese ion homeostasis via its uptake into the vacuole (By similarity).
By similarityGO - Molecular functioni
- calcium:proton antiporter activity Source: GO_Central
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- calcium ion import into vacuole Source: PomBase
- calcium ion transmembrane transport Source: GO_Central
- cellular calcium ion homeostasis Source: GO_Central
Keywordsi
Biological process | Calcium transport, Ion transport, Transport |
Ligand | Calcium, Manganese, Metal-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Vacuolar calcium ion transporterAlternative name(s): Vacuolar Ca(2+)/H(+) exchanger |
Gene namesi | Name:vcx1 ORF Names:SPCC1795.02c, SPCC895.01 |
Organismi | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
Taxonomic identifieri | 284812 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces › |
Proteomesi |
|
Organism-specific databases
PomBasei | SPCC1795.02c, vcx1 |
VEuPathDBi | FungiDB:SPCC1795.02c |
Subcellular locationi
Vacuole
- Vacuole membrane By similarity; Multi-pass membrane protein By similarity
Endoplasmic reticulum
- Endoplasmic reticulum membrane 1 Publication; Multi-pass membrane protein 1 Publication
Endoplasmic reticulum
- endoplasmic reticulum Source: PomBase
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
Vacuole
- fungal-type vacuole membrane Source: GO_Central
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 55 | CytoplasmicBy similarityAdd BLAST | 55 | |
Transmembranei | 56 – 76 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 77 – 83 | LumenalBy similarity | 7 | |
Transmembranei | 84 – 104 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 105 – 114 | CytoplasmicBy similarity | 10 | |
Transmembranei | 115 – 135 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 136 – 148 | LumenalBy similarityAdd BLAST | 13 | |
Transmembranei | 149 – 169 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 170 – 177 | CytoplasmicBy similarity | 8 | |
Transmembranei | 178 – 198 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 199 – 215 | LumenalBy similarityAdd BLAST | 17 | |
Transmembranei | 216 – 236 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 237 – 264 | CytoplasmicBy similarityAdd BLAST | 28 | |
Transmembranei | 265 – 285 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 286 – 299 | LumenalBy similarityAdd BLAST | 14 | |
Transmembranei | 300 – 320 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 321 – 334 | CytoplasmicBy similarityAdd BLAST | 14 | |
Transmembranei | 335 – 355 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 356 – 358 | LumenalBy similarity | 3 | |
Transmembranei | 359 – 379 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 380 – 389 | CytoplasmicBy similarity | 10 | |
Transmembranei | 390 – 410 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 411 – 412 | LumenalBy similarity | 2 |
Keywords - Cellular componenti
Endoplasmic reticulum, Membrane, VacuolePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000352843 | 1 – 412 | Vacuolar calcium ion transporterAdd BLAST | 412 |
Proteomic databases
PaxDbi | O59768 |
PTM databases
iPTMneti | O59768 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 275958, 2 interactors |
STRINGi | 4896.SPCC1795.02c.1 |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1397, Eukaryota |
HOGENOMi | CLU_008721_2_1_1 |
InParanoidi | O59768 |
OMAi | AAVMITC |
PhylomeDBi | O59768 |
Family and domain databases
Gene3Di | 1.20.1420.30, 1 hit |
InterProi | View protein in InterPro IPR004713, CaH_exchang IPR004798, CAX-like IPR004837, NaCa_Exmemb IPR044880, NCX_ion-bd_dom_sf |
PANTHERi | PTHR31503, PTHR31503, 1 hit |
Pfami | View protein in Pfam PF01699, Na_Ca_ex, 2 hits |
TIGRFAMsi | TIGR00378, cax, 1 hit |
i Sequence
Sequence statusi: Complete.
O59768-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MIERLKIAKN RLEAMNSFNF PAQDRHERAP LLGSEYDHSM ARQLSLLNVV
60 70 80 90 100
GMTKSVLMSS YFNLMLVFVP IGLIAGWFEW NAKSVFILNM LAIIPLASLL
110 120 130 140 150
SFATEQLSII SGPTLGALLN ASFGNAIELI VGVLALKRGE LRIVQSSLLG
160 170 180 190 200
SILSNLLLVF GMCLVTTGIR REITTFNITV AQTMIAMLAL STATILIPAT
210 220 230 240 250
FHYSLPDNAN SENALLHVSR GTAVIVLIVY VLLLVFQLKT HKHVCHDPSE
260 270 280 290 300
VEEETEPRIL GLRSSIAMLA IVTVFVSLCA DYLVGSIDQL VEEVNISKTF
310 320 330 340 350
VGLVILPVVG NAAEHVTAIV VSYRGQMDLA LGVAIGSSIQ IALFLAPFLV
360 370 380 390 400
IVGWIISQPL TLYFESLETV ILFVSVFLVN YLIQDGATHW LEGVQLLALY
410
AIVVLAFFYY PQ
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CU329672 Genomic DNA Translation: CAA18637.1 |
PIRi | T41141 T41639 |
RefSeqi | NP_588042.1, NM_001023034.2 |
Genome annotation databases
EnsemblFungii | SPCC1795.02c.1; SPCC1795.02c.1:pep; SPCC1795.02c |
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CU329672 Genomic DNA Translation: CAA18637.1 |
PIRi | T41141 T41639 |
RefSeqi | NP_588042.1, NM_001023034.2 |
3D structure databases
SMRi | O59768 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 275958, 2 interactors |
STRINGi | 4896.SPCC1795.02c.1 |
PTM databases
iPTMneti | O59768 |
Proteomic databases
PaxDbi | O59768 |
Genome annotation databases
EnsemblFungii | SPCC1795.02c.1; SPCC1795.02c.1:pep; SPCC1795.02c |
Organism-specific databases
PomBasei | SPCC1795.02c, vcx1 |
VEuPathDBi | FungiDB:SPCC1795.02c |
Phylogenomic databases
eggNOGi | KOG1397, Eukaryota |
HOGENOMi | CLU_008721_2_1_1 |
InParanoidi | O59768 |
OMAi | AAVMITC |
PhylomeDBi | O59768 |
Miscellaneous databases
PROi | PR:O59768 |
Family and domain databases
Gene3Di | 1.20.1420.30, 1 hit |
InterProi | View protein in InterPro IPR004713, CaH_exchang IPR004798, CAX-like IPR004837, NaCa_Exmemb IPR044880, NCX_ion-bd_dom_sf |
PANTHERi | PTHR31503, PTHR31503, 1 hit |
Pfami | View protein in Pfam PF01699, Na_Ca_ex, 2 hits |
TIGRFAMsi | TIGR00378, cax, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | VCX1_SCHPO | |
Accessioni | O59768Primary (citable) accession number: O59768 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 4, 2008 |
Last sequence update: | August 1, 1998 | |
Last modified: | February 23, 2022 | |
This is version 126 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Schizosaccharomyces pombe
Schizosaccharomyces pombe: entries and gene names - SIMILARITY comments
Index of protein domains and families