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Protein

Kinetochore protein spc7

Gene

spc7

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a component of the NMS (Ndc80-MIND-Spc7) super complex which has a role in kinetochore function during late meiotic prophase and throughout the mitotic cell cycle.

GO - Molecular functioni

  • microtubule plus-end binding Source: PomBase

GO - Biological processi

  • attachment of mitotic spindle microtubules to kinetochore Source: PomBase
  • attachment of spindle microtubules to kinetochore involved in homologous chromosome segregation Source: PomBase
  • Bub1-Bub3 complex localization to kinetochore Source: PomBase
  • cell division Source: UniProtKB-KW
  • deactivation of mitotic spindle assembly checkpoint Source: PomBase
  • microtubule nucleation Source: GO_Central
  • mitotic sister chromatid biorientation Source: PomBase

Keywordsi

Biological processCell cycle, Cell division, Meiosis, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
Kinetochore protein spc7
Alternative name(s):
NMS complex subunit spc7
Gene namesi
Name:spc7
ORF Names:SPCC1020.02
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCC1020.02
PomBaseiSPCC1020.02 spc7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Centromere, Chromosome, Cytoplasm, Cytoskeleton, Kinetochore, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002906441 – 1364Kinetochore protein spc7Add BLAST1364

Proteomic databases

PaxDbiO59757
PRIDEiO59757

PTM databases

iPTMnetiO59757

Interactioni

Subunit structurei

Component of the NMS super complex which consists of mis12, mis13, mis14, ndc80, nnf1, nuf2, sos7, spc7, spc24 and spc25. Interacts (via C-terminus) directly with sos7 (via C-terminus).3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
mal3Q101132EBI-1002205,EBI-1002268

GO - Molecular functioni

  • microtubule plus-end binding Source: PomBase

Protein-protein interaction databases

BioGridi275727, 39 interactors
DIPiDIP-35340N
IntActiO59757, 5 interactors
STRINGi4896.SPCC1020.02.1

Structurei

3D structure databases

ProteinModelPortaliO59757
SMRiO59757
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1071 – 1160Sequence analysisAdd BLAST90

Keywords - Domaini

Coiled coil

Phylogenomic databases

InParanoidiO59757
KOiK11563
OrthoDBiEOG092C001Z
PhylomeDBiO59757

Family and domain databases

InterProiView protein in InterPro
IPR033338 Spc105/Spc7
IPR028972 Spc7_C2
IPR013253 Spc7_domain
PANTHERiPTHR28260 PTHR28260, 1 hit
PfamiView protein in Pfam
PF08317 Spc7, 1 hit
PF15577 Spc7_C2, 1 hit
SMARTiView protein in SMART
SM00787 Spc7, 1 hit

Sequencei

Sequence statusi: Complete.

O59757-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPTSPRRNSI ATTDNVIGRN KSRKRPHSLG GPGALQELKE HTNPAKGILK
60 70 80 90 100
SYSSFSVDPA FTGDEDFNDI HTQINNTVIG ISSNVMAASK RLQMEDLQQL
110 120 130 140 150
SRETSRKSLN RRVSFASHAR VRWYPKDHQS DSEKSTSNHS TPERTFASDA
160 170 180 190 200
KNHSPKGPTT TSFSRNETQS SPHSHSASII SDGSDMDIAS PIRSTESDMV
210 220 230 240 250
SEALNAGHPP PSLYPENDDL SIQNPTKALP EAEKALDVHD ATREQVNDRE
260 270 280 290 300
ETNMDLTIQF QEADSFLSHS ESIKGLSSSE QGTVYSLKAS HDPSNQTQLS
310 320 330 340 350
SPNKSSSPTS IEISDFSKNN ENHDQSENKE EEEDMMLTRP IEIPQHFSPI
360 370 380 390 400
ARPLTSQEAI VDMDITSNNI NLSPVSHFSN GLDLQNLEEA PMNLTRPINA
410 420 430 440 450
NPHLTNHSPN DLTNGEEEMD TTSAFNIENS HLTLLSPIRP SSRSMEEQIM
460 470 480 490 500
DLTQPISSTN APTHLNEDDL NQFTSNISSS SKPRKDNNKT ANSSKPIPDS
510 520 530 540 550
EDFMDITRPF NILSPSKEAL SEEQPMELTS TVFPCENSTS HLEVEEAAMD
560 570 580 590 600
ETVAFQIRGN NVELPSADKE NAEREEIPSY SDKSENFNTT SFTNHERSPN
610 620 630 640 650
GNNNLKFSKD PNSSSPSRHV VATPTDKLGT RKRRLRYSTS SFDQSTLRRN
660 670 680 690 700
RLATIRNARK SISTLNDREL LPVNFFEKKV NSGLYKSVER SENYRLGATP
710 720 730 740 750
LTAEKPFTTE KPLSSLPEEV SRQPTDDKGE QVSNADVDSG LSKTERLTIQ
760 770 780 790 800
QTNEIKHVPT NTTSSVKLPQ QPSNEDEKER ITTADYADST SLERLESQEP
810 820 830 840 850
NRNELVQVGS SNAGNTTSVG MNEHEKSPVK LSKGVSNVDT SLGASTINTN
860 870 880 890 900
ILNQDSGPNE EIPVGNEPEF DTMPTLPNVE PISLSDFLKM TGIEFLDNLT
910 920 930 940 950
IAKRRETLLP NAEENKKCSI QELLESFYIQ FPLLELYKFS CQQLQDYIAE
960 970 980 990 1000
GKDFVTKIEE ETLKENPLLF YEYRKASSDM RVLMDSQFLM MKTFARLQAK
1010 1020 1030 1040 1050
GDWYEWREGL MQGIKHELNL NLTGMQRSLT HLMDVANVIH PYAQEIQERY
1060 1070 1080 1090 1100
NGSITTVQTL KKQKEFANQY DSTLLAQAQE KLEKLKVEVE RRRRLLSEKE
1110 1120 1130 1140 1150
ERRKELAIKI EQVTNSCSDL ELRTNAEQDF YAKNQDFEFD EIKRYEEQLL
1160 1170 1180 1190 1200
NLKNELGWTI VSLTAGGIKL ATNNTALSPY SAEVTVEILR QNFQVNVDIA
1210 1220 1230 1240 1250
CKFPNESNAC SSNVLEHVAS SFSKWHSKVF SRNLRLLKKY LNDVSICWEQ
1260 1270 1280 1290 1300
IVYLVQDFQR LWYHWPFLSV ENDDKSIIIN VELYLRSVSS KVKVVFGLPI
1310 1320 1330 1340 1350
DTIYQTTEVG KFYASTSVAV KQMYAESEGD SYVSEVLNTL SEVVHCTSTY
1360
ALSSACLTVW NKYS
Length:1,364
Mass (Da):153,593
Last modified:August 1, 1998 - v1
Checksum:i829312F81FFB7502
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA Translation: CAA18990.1
PIRiT40839
RefSeqiNP_587958.1, NM_001022949.2

Genome annotation databases

EnsemblFungiiSPCC1020.02.1; SPCC1020.02.1:pep; SPCC1020.02
GeneIDi2539155
KEGGispo:SPCC1020.02

Entry informationi

Entry nameiSPC7_SCHPO
AccessioniPrimary (citable) accession number: O59757
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: August 1, 1998
Last modified: June 20, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names

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