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Protein

Kinetochore protein spc7

Gene

spc7

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a component of the NMS (Ndc80-MIND-Spc7) super complex which has a role in kinetochore function during late meiotic prophase and throughout the mitotic cell cycle.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • microtubule plus-end binding Source: PomBase

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle, Cell division, Meiosis, Mitosis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Kinetochore protein spc7
Alternative name(s):
NMS complex subunit spc7
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:spc7
ORF Names:SPCC1020.02
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri284812 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002485 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome III

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
FungiDB:SPCC1020.02

Schizosaccharomyces pombe database

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PomBasei
SPCC1020.02 spc7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Centromere, Chromosome, Cytoplasm, Cytoskeleton, Kinetochore, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002906441 – 1364Kinetochore protein spc7Add BLAST1364

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
O59757

PRoteomics IDEntifications database

More...
PRIDEi
O59757

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
O59757

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the NMS super complex which consists of mis12, mis13, mis14, ndc80, nnf1, nuf2, sos7, spc7, spc24 and spc25. Interacts (via C-terminus) directly with sos7 (via C-terminus).3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
mal3Q101132EBI-1002205,EBI-1002268

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
275727, 39 interactors

Database of interacting proteins

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DIPi
DIP-35340N

Protein interaction database and analysis system

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IntActi
O59757, 5 interactors

STRING: functional protein association networks

More...
STRINGi
4896.SPCC1020.02.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
O59757

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O59757

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1071 – 1160Sequence analysisAdd BLAST90

Keywords - Domaini

Coiled coil

Phylogenomic databases

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
O59757

KEGG Orthology (KO)

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KOi
K11563

Identification of Orthologs from Complete Genome Data

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OMAi
RIHLQDF

Database of Orthologous Groups

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OrthoDBi
EOG092C001Z

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O59757

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR033338 Spc105/Spc7
IPR028972 Spc7_C2
IPR013253 Spc7_domain

The PANTHER Classification System

More...
PANTHERi
PTHR28260 PTHR28260, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08317 Spc7, 1 hit
PF15577 Spc7_C2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00787 Spc7, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O59757-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPTSPRRNSI ATTDNVIGRN KSRKRPHSLG GPGALQELKE HTNPAKGILK
60 70 80 90 100
SYSSFSVDPA FTGDEDFNDI HTQINNTVIG ISSNVMAASK RLQMEDLQQL
110 120 130 140 150
SRETSRKSLN RRVSFASHAR VRWYPKDHQS DSEKSTSNHS TPERTFASDA
160 170 180 190 200
KNHSPKGPTT TSFSRNETQS SPHSHSASII SDGSDMDIAS PIRSTESDMV
210 220 230 240 250
SEALNAGHPP PSLYPENDDL SIQNPTKALP EAEKALDVHD ATREQVNDRE
260 270 280 290 300
ETNMDLTIQF QEADSFLSHS ESIKGLSSSE QGTVYSLKAS HDPSNQTQLS
310 320 330 340 350
SPNKSSSPTS IEISDFSKNN ENHDQSENKE EEEDMMLTRP IEIPQHFSPI
360 370 380 390 400
ARPLTSQEAI VDMDITSNNI NLSPVSHFSN GLDLQNLEEA PMNLTRPINA
410 420 430 440 450
NPHLTNHSPN DLTNGEEEMD TTSAFNIENS HLTLLSPIRP SSRSMEEQIM
460 470 480 490 500
DLTQPISSTN APTHLNEDDL NQFTSNISSS SKPRKDNNKT ANSSKPIPDS
510 520 530 540 550
EDFMDITRPF NILSPSKEAL SEEQPMELTS TVFPCENSTS HLEVEEAAMD
560 570 580 590 600
ETVAFQIRGN NVELPSADKE NAEREEIPSY SDKSENFNTT SFTNHERSPN
610 620 630 640 650
GNNNLKFSKD PNSSSPSRHV VATPTDKLGT RKRRLRYSTS SFDQSTLRRN
660 670 680 690 700
RLATIRNARK SISTLNDREL LPVNFFEKKV NSGLYKSVER SENYRLGATP
710 720 730 740 750
LTAEKPFTTE KPLSSLPEEV SRQPTDDKGE QVSNADVDSG LSKTERLTIQ
760 770 780 790 800
QTNEIKHVPT NTTSSVKLPQ QPSNEDEKER ITTADYADST SLERLESQEP
810 820 830 840 850
NRNELVQVGS SNAGNTTSVG MNEHEKSPVK LSKGVSNVDT SLGASTINTN
860 870 880 890 900
ILNQDSGPNE EIPVGNEPEF DTMPTLPNVE PISLSDFLKM TGIEFLDNLT
910 920 930 940 950
IAKRRETLLP NAEENKKCSI QELLESFYIQ FPLLELYKFS CQQLQDYIAE
960 970 980 990 1000
GKDFVTKIEE ETLKENPLLF YEYRKASSDM RVLMDSQFLM MKTFARLQAK
1010 1020 1030 1040 1050
GDWYEWREGL MQGIKHELNL NLTGMQRSLT HLMDVANVIH PYAQEIQERY
1060 1070 1080 1090 1100
NGSITTVQTL KKQKEFANQY DSTLLAQAQE KLEKLKVEVE RRRRLLSEKE
1110 1120 1130 1140 1150
ERRKELAIKI EQVTNSCSDL ELRTNAEQDF YAKNQDFEFD EIKRYEEQLL
1160 1170 1180 1190 1200
NLKNELGWTI VSLTAGGIKL ATNNTALSPY SAEVTVEILR QNFQVNVDIA
1210 1220 1230 1240 1250
CKFPNESNAC SSNVLEHVAS SFSKWHSKVF SRNLRLLKKY LNDVSICWEQ
1260 1270 1280 1290 1300
IVYLVQDFQR LWYHWPFLSV ENDDKSIIIN VELYLRSVSS KVKVVFGLPI
1310 1320 1330 1340 1350
DTIYQTTEVG KFYASTSVAV KQMYAESEGD SYVSEVLNTL SEVVHCTSTY
1360
ALSSACLTVW NKYS
Length:1,364
Mass (Da):153,593
Last modified:August 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i829312F81FFB7502
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CU329672 Genomic DNA Translation: CAA18990.1

Protein sequence database of the Protein Information Resource

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PIRi
T40839

NCBI Reference Sequences

More...
RefSeqi
NP_587958.1, NM_001022949.2

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
SPCC1020.02.1; SPCC1020.02.1:pep; SPCC1020.02

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2539155

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
spo:SPCC1020.02

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA Translation: CAA18990.1
PIRiT40839
RefSeqiNP_587958.1, NM_001022949.2

3D structure databases

ProteinModelPortaliO59757
SMRiO59757
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi275727, 39 interactors
DIPiDIP-35340N
IntActiO59757, 5 interactors
STRINGi4896.SPCC1020.02.1

PTM databases

iPTMnetiO59757

Proteomic databases

PaxDbiO59757
PRIDEiO59757

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPCC1020.02.1; SPCC1020.02.1:pep; SPCC1020.02
GeneIDi2539155
KEGGispo:SPCC1020.02

Organism-specific databases

EuPathDBiFungiDB:SPCC1020.02
PomBaseiSPCC1020.02 spc7

Phylogenomic databases

InParanoidiO59757
KOiK11563
OMAiRIHLQDF
OrthoDBiEOG092C001Z
PhylomeDBiO59757

Miscellaneous databases

Protein Ontology

More...
PROi
PR:O59757

Family and domain databases

InterProiView protein in InterPro
IPR033338 Spc105/Spc7
IPR028972 Spc7_C2
IPR013253 Spc7_domain
PANTHERiPTHR28260 PTHR28260, 1 hit
PfamiView protein in Pfam
PF08317 Spc7, 1 hit
PF15577 Spc7_C2, 1 hit
SMARTiView protein in SMART
SM00787 Spc7, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSPC7_SCHPO
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O59757
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: August 1, 1998
Last modified: November 7, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
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