Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

DNA repair protein rad14

Gene

rhp14

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in nucleotide excision repair (NER). Functional in repair of ultraviolet radiation induced damages and in mitotic mutation avoidance. Binds damaged DNA. Binds specifically to base-base mismatches or small insertion/deletion loops with unpaired nucleotides. Maintains GT repeat stability. Functions as a part of the short-patch excision repair system.3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri116 – 140By similarityAdd BLAST25

GO - Molecular functioni

GO - Biological processi

  • base-excision repair Source: GO_Central
  • nucleotide-excision repair Source: PomBase
  • nucleotide-excision repair, DNA damage recognition Source: PomBase
  • nucleotide-excision repair, DNA incision Source: GO_Central
  • nucleotide-excision repair involved in interstrand cross-link repair Source: PomBase
  • UV-damage excision repair Source: PomBase

Keywordsi

Molecular functionDNA-binding
Biological processDNA damage, DNA repair
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-SPO-5696395 Formation of Incision Complex in GG-NER
R-SPO-5696400 Dual Incision in GG-NER
R-SPO-6781823 Formation of TC-NER Pre-Incision Complex
R-SPO-6782135 Dual incision in TC-NER

Names & Taxonomyi

Protein namesi
Recommended name:
DNA repair protein rad14Curated
Alternative name(s):
XP-A family homolog rhp141 Publication
Gene namesi
Name:rhp141 Publication
Synonyms:rad14Imported
ORF Names:SPBC649.03Imported
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC649.03
PomBaseiSPBC649.03 rhp14

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002742481 – 289DNA repair protein rad14Add BLAST289

Proteomic databases

MaxQBiO59753
PaxDbiO59753
PRIDEiO59753

PTM databases

iPTMnetiO59753

Interactioni

Subunit structurei

Interacts with hrq1.1 Publication

Protein-protein interaction databases

BioGridi277635, 97 interactors
STRINGi4896.SPBC649.03.1

Structurei

3D structure databases

ProteinModelPortaliO59753
SMRiO59753
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the XPA family.Sequence analysis

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri116 – 140By similarityAdd BLAST25

Keywords - Domaini

Zinc-finger

Phylogenomic databases

HOGENOMiHOG000161510
InParanoidiO59753
KOiK10847
OMAiEKPNPHG
OrthoDBiEOG092C44LK
PhylomeDBiO59753

Family and domain databases

Gene3Di3.90.530.10, 1 hit
InterProiView protein in InterPro
IPR009061 DNA-bd_dom_put_sf
IPR000465 XPA
IPR022656 XPA_C
IPR037129 XPA_sf
IPR022652 Znf_XPA_CS
PANTHERiPTHR10142 PTHR10142, 1 hit
PfamiView protein in Pfam
PF05181 XPA_C, 1 hit
PF01286 XPA_N, 1 hit
SUPFAMiSSF46955 SSF46955, 1 hit
TIGRFAMsiTIGR00598 rad14, 1 hit

Sequencei

Sequence statusi: Complete.

O59753-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MENSSIVKSP NPTIEEQRNE IEKLKNLTGI EEVHVDGAKV NKRKRTFDEQ
60 70 80 90 100
SEITKDYIEY DFSKIEDTKG GYLLEEKKVE DLREKPAERE LREQEERQKK
110 120 130 140 150
LRLAPLNLDP ETAPKCFECD SIELDTKYFD IFHCRVCHTC REKYPDKYSL
160 170 180 190 200
LTKTECKLDY LLTEPELQDQ ELLPRLLKAN PHQQGWSNMM LYLRYQVEEF
210 220 230 240 250
AKKKWGSMEA LDAEFERREV QKKEMKEKKF EKQLLELRKR TRTSNYSRMS
260 270 280
IREKRKHVHS YDEEFEKPNE PGVIVQRCKC GLEIEQLEI
Length:289
Mass (Da):34,663
Last modified:August 1, 1998 - v1
Checksum:iF9C2D8B582D30D6F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA Translation: CAA19045.1
PIRiT40596
RefSeqiNP_595222.1, NM_001021128.2

Genome annotation databases

EnsemblFungiiSPBC649.03.1; SPBC649.03.1:pep; SPBC649.03
GeneIDi2541120
KEGGispo:SPBC649.03

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA Translation: CAA19045.1
PIRiT40596
RefSeqiNP_595222.1, NM_001021128.2

3D structure databases

ProteinModelPortaliO59753
SMRiO59753
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi277635, 97 interactors
STRINGi4896.SPBC649.03.1

PTM databases

iPTMnetiO59753

Proteomic databases

MaxQBiO59753
PaxDbiO59753
PRIDEiO59753

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC649.03.1; SPBC649.03.1:pep; SPBC649.03
GeneIDi2541120
KEGGispo:SPBC649.03

Organism-specific databases

EuPathDBiFungiDB:SPBC649.03
PomBaseiSPBC649.03 rhp14

Phylogenomic databases

HOGENOMiHOG000161510
InParanoidiO59753
KOiK10847
OMAiEKPNPHG
OrthoDBiEOG092C44LK
PhylomeDBiO59753

Enzyme and pathway databases

ReactomeiR-SPO-5696395 Formation of Incision Complex in GG-NER
R-SPO-5696400 Dual Incision in GG-NER
R-SPO-6781823 Formation of TC-NER Pre-Incision Complex
R-SPO-6782135 Dual incision in TC-NER

Miscellaneous databases

PROiPR:O59753

Family and domain databases

Gene3Di3.90.530.10, 1 hit
InterProiView protein in InterPro
IPR009061 DNA-bd_dom_put_sf
IPR000465 XPA
IPR022656 XPA_C
IPR037129 XPA_sf
IPR022652 Znf_XPA_CS
PANTHERiPTHR10142 PTHR10142, 1 hit
PfamiView protein in Pfam
PF05181 XPA_C, 1 hit
PF01286 XPA_N, 1 hit
SUPFAMiSSF46955 SSF46955, 1 hit
TIGRFAMsiTIGR00598 rad14, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRAD14_SCHPO
AccessioniPrimary (citable) accession number: O59753
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: August 1, 1998
Last modified: March 28, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again