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UniProtKB - O59737 (GYP1_SCHPO)
Protein
GTPase-activating protein gyp1
Gene
gyp1
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Functioni
Stimulates specifically the GTPase activity of ypt1. Functions on the Golgi as a negative regulator of ypt1 (By similarity).
By similarityGO - Molecular functioni
- GTPase activator activity Source: PomBase
GO - Biological processi
- activation of GTPase activity Source: GO_Central
- intracellular protein transport Source: GO_Central
- vesicle-mediated transport Source: PomBase
Keywordsi
Molecular function | GTPase activation |
Names & Taxonomyi
Protein namesi | Recommended name: GTPase-activating protein gyp1Alternative name(s): GAP for ypt1 |
Gene namesi | Name:gyp1Imported ORF Names:SPBC530.01 |
Organismi | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
Taxonomic identifieri | 284812 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces › |
Proteomesi |
|
Organism-specific databases
PomBasei | SPBC530.01, gyp1 |
VEuPathDBi | FungiDB:SPBC530.01 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Golgi apparatus
- Golgi stack By similarity
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Cytosol
- cytosol Source: PomBase
Golgi apparatus
- Golgi apparatus Source: GO_Central
- Golgi stack Source: UniProtKB-SubCell
Nucleus
- nucleus Source: PomBase
Other locations
- cytoplasm Source: PomBase
Keywords - Cellular componenti
Cytoplasm, Golgi apparatus, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000312835 | 1 – 514 | GTPase-activating protein gyp1Add BLAST | 514 |
Proteomic databases
MaxQBi | O59737 |
PaxDbi | O59737 |
PTM databases
iPTMneti | O59737 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 277408, 67 interactors |
STRINGi | 4896.SPBC530.01.1 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 216 – 443 | Rab-GAP TBCPROSITE-ProRule annotationAdd BLAST | 228 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 17 – 65 | DisorderedSequence analysisAdd BLAST | 49 | |
Regioni | 130 – 164 | DisorderedSequence analysisAdd BLAST | 35 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 17 – 31 | Polar residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 130 – 163 | Polar residuesSequence analysisAdd BLAST | 34 |
Phylogenomic databases
eggNOGi | KOG1092, Eukaryota |
HOGENOMi | CLU_018687_4_1_1 |
InParanoidi | O59737 |
OMAi | SAKLPGX |
PhylomeDBi | O59737 |
Family and domain databases
InterProi | View protein in InterPro IPR000195, Rab-GTPase-TBC_dom IPR035969, Rab-GTPase_TBC_sf |
Pfami | View protein in Pfam PF00566, RabGAP-TBC, 1 hit |
SMARTi | View protein in SMART SM00164, TBC, 1 hit |
SUPFAMi | SSF47923, SSF47923, 2 hits |
PROSITEi | View protein in PROSITE PS50086, TBC_RABGAP, 1 hit |
i Sequence
Sequence statusi: Complete.
O59737-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MESQSKKSSA LKTLSSLWNG SSSATSDPVT VLDRSRTHHH RGRSTSSKAQ
60 70 80 90 100
PFRLDDSVYS DQPPKDHISL ARSITRPESA SESKIYAPSA RSSLSLEAVV
110 120 130 140 150
GKKVSAKFAK YLSQTDDDWG VSNIKASKSL PRMARSTTPN SSSRSLFPQN
160 170 180 190 200
GVDTTTSRQK LHSSGRFPLP AKLAHRSVEV EVAESNALVS RIKKFSRILD
210 220 230 240 250
APIVDLNALR TLAWNGIPSE HRPIVWKYLL GYLPCNASRR EVTLKRKRDE
260 270 280 290 300
YNAAKDSCFN TNTEPPPLDQ TIWRQIVLDV PRTNPSILLY QNPLTQRMLE
310 320 330 340 350
RILYVWASRH PASGYVQGIS DLVTPFIQVF LSEYIGDKDP MTYDIALLDE
360 370 380 390 400
TNRNDIEADA YWCLSKLLDG IQDNYIHAQP GIRRQVNNLR ELTLRIDEPL
410 420 430 440 450
VKHLQMEGVD FLQFSFRWMN CLLMRELSIS NIIRMWDTYM AEGVQGFSEF
460 470 480 490 500
HLYVCAAFLV KWSSELQKME FQDILIFLQS IPTKDWSTKD IEILLSEAFL
510
WKSLYSGAGA HLKR
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CU329671 Genomic DNA Translation: CAA19167.1 |
PIRi | T40517 |
RefSeqi | NP_595314.1, NM_001021221.2 |
Genome annotation databases
EnsemblFungii | SPBC530.01.1; SPBC530.01.1:pep; SPBC530.01 |
GeneIDi | 2540892 |
KEGGi | spo:SPBC530.01 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CU329671 Genomic DNA Translation: CAA19167.1 |
PIRi | T40517 |
RefSeqi | NP_595314.1, NM_001021221.2 |
3D structure databases
SMRi | O59737 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 277408, 67 interactors |
STRINGi | 4896.SPBC530.01.1 |
PTM databases
iPTMneti | O59737 |
Proteomic databases
MaxQBi | O59737 |
PaxDbi | O59737 |
Genome annotation databases
EnsemblFungii | SPBC530.01.1; SPBC530.01.1:pep; SPBC530.01 |
GeneIDi | 2540892 |
KEGGi | spo:SPBC530.01 |
Organism-specific databases
PomBasei | SPBC530.01, gyp1 |
VEuPathDBi | FungiDB:SPBC530.01 |
Phylogenomic databases
eggNOGi | KOG1092, Eukaryota |
HOGENOMi | CLU_018687_4_1_1 |
InParanoidi | O59737 |
OMAi | SAKLPGX |
PhylomeDBi | O59737 |
Miscellaneous databases
PROi | PR:O59737 |
Family and domain databases
InterProi | View protein in InterPro IPR000195, Rab-GTPase-TBC_dom IPR035969, Rab-GTPase_TBC_sf |
Pfami | View protein in Pfam PF00566, RabGAP-TBC, 1 hit |
SMARTi | View protein in SMART SM00164, TBC, 1 hit |
SUPFAMi | SSF47923, SSF47923, 2 hits |
PROSITEi | View protein in PROSITE PS50086, TBC_RABGAP, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | GYP1_SCHPO | |
Accessioni | O59737Primary (citable) accession number: O59737 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 4, 2007 |
Last sequence update: | August 1, 1998 | |
Last modified: | February 23, 2022 | |
This is version 115 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Schizosaccharomyces pombe
Schizosaccharomyces pombe: entries and gene names