Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Nuclear envelope morphology protein 1

Gene

nem1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic component of the nem1-spo7 complex which acts as a phosphatase and may be required for proper nuclear membrane morphology.By similarity

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear envelope morphology protein 1 (EC:3.1.3.16)
Gene namesi
Name:nem1
ORF Names:SPBC3B8.10c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC3B8.10c
PomBaseiSPBC3B8.10c nem1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei123 – 139HelicalSequence analysisAdd BLAST17

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003159751 – 476Nuclear envelope morphology protein 1Add BLAST476

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi237N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi257N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi284N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi356N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiO59718
PaxDbiO59718
PRIDEiO59718

PTM databases

iPTMnetiO59718

Interactioni

Subunit structurei

Component of the nem1-spo7 complex.By similarity

Protein-protein interaction databases

BioGridi277536, 94 interactors
STRINGi4896.SPBC3B8.10c.1

Structurei

3D structure databases

ProteinModelPortaliO59718
SMRiO59718
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini299 – 460FCP1 homologyPROSITE-ProRule annotationAdd BLAST162

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi158 – 278Ser-richAdd BLAST121

Sequence similaritiesi

Belongs to the Dullard family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiO59718
KOiK17617
OrthoDBiEOG092C5CYS
PhylomeDBiO59718

Family and domain databases

Gene3Di3.40.50.1000, 1 hit
InterProiView protein in InterPro
IPR011948 Dullard_phosphatase
IPR004274 FCP1_dom
IPR036412 HAD-like_sf
IPR023214 HAD_sf
PfamiView protein in Pfam
PF03031 NIF, 1 hit
SMARTiView protein in SMART
SM00577 CPDc, 1 hit
SUPFAMiSSF56784 SSF56784, 1 hit
TIGRFAMsiTIGR02251 HIF-SF_euk, 1 hit
PROSITEiView protein in PROSITE
PS50969 FCP1, 1 hit

Sequencei

Sequence statusi: Complete.

O59718-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNSIARLSDE INKAILATPL DDDEADKEKL ANARGRASSA TLRHYNRRRS
60 70 80 90 100
SYSASSLSSL SSKPTEKEVP TRNEKPKHAN IMRVVVYWIR VFLKRIYTFF
110 120 130 140 150
VHSARVFLYH FLNEEKEFTL ASFFWGLCRF VFFPVLLSYK RREMLPPQPS
160 170 180 190 200
VRRPRFYSSY SYPSSHQDPA YSSFKRHRSS NSYSSSSNGN HVRFQPSIAE
210 220 230 240 250
EEISFNSFSN SLNSEEDVCV SPMKPKEVSL MGKANSNRSG HSHQPQSTQF
260 270 280 290 300
SPPANDNISK LPSSFTIVND PLKSPSSSRL RIRNITLCAD KIPRPLLNSK
310 320 330 340 350
LPRKTLVLDL DETLIHSVSR GSRTTSGQPI EVHVPGEHPI LYYIHKRPHL
360 370 380 390 400
DYFLSNVSQW FRLILFTASV QPYADPIIDY LERDKKIFAK RYYRQHCALV
410 420 430 440 450
DSSFVKDISI CNIHLSRIMI IDNSPASYNA HKENAIPIEG WISDPSDVDL
460 470
LNLLSFLHAL QYVHDVRDLL GLRLAK
Length:476
Mass (Da):54,598
Last modified:August 1, 1998 - v1
Checksum:i012BBD6EF067090F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA Translation: CAA18299.1
PIRiT40330
RefSeqiNP_596404.1, NM_001022323.2

Genome annotation databases

EnsemblFungiiSPBC3B8.10c.1; SPBC3B8.10c.1:pep; SPBC3B8.10c
GeneIDi2541021
KEGGispo:SPBC3B8.10c

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA Translation: CAA18299.1
PIRiT40330
RefSeqiNP_596404.1, NM_001022323.2

3D structure databases

ProteinModelPortaliO59718
SMRiO59718
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi277536, 94 interactors
STRINGi4896.SPBC3B8.10c.1

PTM databases

iPTMnetiO59718

Proteomic databases

MaxQBiO59718
PaxDbiO59718
PRIDEiO59718

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC3B8.10c.1; SPBC3B8.10c.1:pep; SPBC3B8.10c
GeneIDi2541021
KEGGispo:SPBC3B8.10c

Organism-specific databases

EuPathDBiFungiDB:SPBC3B8.10c
PomBaseiSPBC3B8.10c nem1

Phylogenomic databases

InParanoidiO59718
KOiK17617
OrthoDBiEOG092C5CYS
PhylomeDBiO59718

Miscellaneous databases

PROiPR:O59718

Family and domain databases

Gene3Di3.40.50.1000, 1 hit
InterProiView protein in InterPro
IPR011948 Dullard_phosphatase
IPR004274 FCP1_dom
IPR036412 HAD-like_sf
IPR023214 HAD_sf
PfamiView protein in Pfam
PF03031 NIF, 1 hit
SMARTiView protein in SMART
SM00577 CPDc, 1 hit
SUPFAMiSSF56784 SSF56784, 1 hit
TIGRFAMsiTIGR02251 HIF-SF_euk, 1 hit
PROSITEiView protein in PROSITE
PS50969 FCP1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNEM1_SCHPO
AccessioniPrimary (citable) accession number: O59718
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 1, 1998
Last modified: June 20, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again