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Entry version 105 (11 Dec 2019)
Sequence version 1 (01 Aug 1998)
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Protein

2-(3-amino-3-carboxypropyl)histidine synthase subunit 1

Gene

dph1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: peptidyl-diphthamide biosynthesis

This protein is involved in the pathway peptidyl-diphthamide biosynthesis, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway peptidyl-diphthamide biosynthesis and in Protein modification.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-SPO-5358493 Synthesis of diphthamide-EEF2

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00559

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
2-(3-amino-3-carboxypropyl)histidine synthase subunit 1Curated (EC:2.5.1.108By similarity)
Alternative name(s):
Diphthamide biosynthesis protein 1
Diphtheria toxin resistance protein 1Curated
S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 1Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:dph1
ORF Names:SPBC3B8.05
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri284812 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002485 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome II

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
FungiDB:SPBC3B8.05

Schizosaccharomyces pombe database

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PomBasei
SPBC3B8.05 dph1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000833781 – 4362-(3-amino-3-carboxypropyl)histidine synthase subunit 1Add BLAST436

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O59713

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O59713

PRoteomics IDEntifications database

More...
PRIDEi
O59713

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
276826, 14 interactors

STRING: functional protein association networks

More...
STRINGi
4896.SPBC3B8.05.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O59713

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DPH1/DPH2 family. DPH1 subfamily.Curated

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000164743

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O59713

KEGG Orthology (KO)

More...
KOi
K07561

Identification of Orthologs from Complete Genome Data

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OMAi
PGQVLGC

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O59713

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.11840, 1 hit
3.40.50.11850, 1 hit
3.40.50.11860, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016435 DPH1/DPH2
IPR042263 DPH1/DPH2_1
IPR042264 DPH1/DPH2_2
IPR042265 DPH1/DPH2_3
IPR035435 DPH1/DPH2_euk_archaea

The PANTHER Classification System

More...
PANTHERi
PTHR10762 PTHR10762, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01866 Diphthamide_syn, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF004967 DPH1, 1 hit

Structure-Function Linkage Database

More...
SFLDi
SFLDS00032 Radical_SAM_3-amino-3-carboxyp, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00322 diphth2_R, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O59713-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEVKKSIPK RRFVGKKNRK ENNLDGSNRD VENAALVTIN SKRSAGRVAT
60 70 80 90 100
QIPEDILNDK AINEAIKLLP QNYNFEIHKT IWHIRLRKAK RVALQLPEGL
110 120 130 140 150
LMFGCILSDI FEQFCQVETI VMGDVTYGAC CIDDFTARAL DCDFLVHYGH
160 170 180 190 200
SCLIPVDQTP IKVLYVFVDI KIDLQHVVSS LKHNLPSNSR LALVGTIQFV
210 220 230 240 250
GSLNSIKDAL QIQDEDGKGG FYVVIPQAKP LSPGEALGCT SPYIEKGSVD
260 270 280 290 300
ALIYIGDGRF HLESVMIANP DLPAYRYDPY SHKLSIESYA HEEMKSIRYS
310 320 330 340 350
AVEKARTAKK FGLIQGTLGR QGSPKVLENL KNTLRKNNKD FVCVLMSEIF
360 370 380 390 400
PSRLGQFSDI DAWIQVACPR LSIDWGYAFP APLLTPYEAS AAFNVVPWKE
410 420 430
VYPMDFYATN SLGNWTPNNP ENRPLPNRKK TGPVSS
Length:436
Mass (Da):48,795
Last modified:August 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i01A544115C69ACC4
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
CU329671 Genomic DNA Translation: CAA18294.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T40335

NCBI Reference Sequences

More...
RefSeqi
NP_596409.1, NM_001022328.2

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
SPBC3B8.05.1; SPBC3B8.05.1:pep; SPBC3B8.05

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2540295

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
spo:SPBC3B8.05

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA Translation: CAA18294.1
PIRiT40335
RefSeqiNP_596409.1, NM_001022328.2

3D structure databases

SMRiO59713
ModBaseiSearch...

Protein-protein interaction databases

BioGridi276826, 14 interactors
STRINGi4896.SPBC3B8.05.1

Proteomic databases

MaxQBiO59713
PaxDbiO59713
PRIDEiO59713

Genome annotation databases

EnsemblFungiiSPBC3B8.05.1; SPBC3B8.05.1:pep; SPBC3B8.05
GeneIDi2540295
KEGGispo:SPBC3B8.05

Organism-specific databases

EuPathDBiFungiDB:SPBC3B8.05
PomBaseiSPBC3B8.05 dph1

Phylogenomic databases

HOGENOMiHOG000164743
InParanoidiO59713
KOiK07561
OMAiPGQVLGC
PhylomeDBiO59713

Enzyme and pathway databases

UniPathwayiUPA00559
ReactomeiR-SPO-5358493 Synthesis of diphthamide-EEF2

Miscellaneous databases

Protein Ontology

More...
PROi
PR:O59713

Family and domain databases

Gene3Di3.40.50.11840, 1 hit
3.40.50.11850, 1 hit
3.40.50.11860, 1 hit
InterProiView protein in InterPro
IPR016435 DPH1/DPH2
IPR042263 DPH1/DPH2_1
IPR042264 DPH1/DPH2_2
IPR042265 DPH1/DPH2_3
IPR035435 DPH1/DPH2_euk_archaea
PANTHERiPTHR10762 PTHR10762, 1 hit
PfamiView protein in Pfam
PF01866 Diphthamide_syn, 1 hit
PIRSFiPIRSF004967 DPH1, 1 hit
SFLDiSFLDS00032 Radical_SAM_3-amino-3-carboxyp, 1 hit
TIGRFAMsiTIGR00322 diphth2_R, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDPH1_SCHPO
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O59713
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: August 1, 1998
Last modified: December 11, 2019
This is version 105 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
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