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UniProtKB - O58796 (TYW31_PYRHO)
Protein
tRNA(Phe) 7-((3-amino-3-carboxypropyl)-4-demethylwyosine(37)-N(4))-methyltransferase 1
Gene
taw3-1
Organism
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Status
Functioni
S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wyosine derivatives biosynthesis pathway. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72.
UniRule annotationCatalytic activityi
- 4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine37 in tRNAPhe + S-adenosyl-L-methionine = 7-[(3S)-3-amino-3-carboxypropyl]wyosine37 in tRNAPhe + H+ + S-adenosyl-L-homocysteineUniRule annotationEC:2.1.1.282UniRule annotation
GO - Molecular functioni
- tRNA methyltransferase activity Source: InterPro
GO - Biological processi
- wybutosine biosynthetic process Source: InterPro
Keywordsi
Molecular function | Methyltransferase, Transferase |
Biological process | tRNA processing |
Ligand | S-adenosyl-L-methionine |
Names & Taxonomyi
Protein namesi | Recommended name: tRNA(Phe) 7-((3-amino-3-carboxypropyl)-4-demethylwyosine(37)-N(4))-methyltransferase 1UniRule annotation (EC:2.1.1.282UniRule annotation)Alternative name(s): tRNA wyosine derivatives biosynthesis protein Taw3 1UniRule annotation |
Gene namesi | Name:taw3-1UniRule annotation Ordered Locus Names:PH1069 |
Organismi | Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3) |
Taxonomic identifieri | 70601 [NCBI] |
Taxonomic lineagei | Archaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Pyrococcus › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000157096 | 1 – 196 | tRNA(Phe) 7-((3-amino-3-carboxypropyl)-4-demethylwyosine(37)-N(4))-methyltransferase 1Add BLAST | 196 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | O58796 |
SMRi | O58796 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | O58796 |
Family & Domainsi
Sequence similaritiesi
Belongs to the TYW3 family.UniRule annotation
Phylogenomic databases
eggNOGi | arCOG04156, Archaea |
OMAi | GKWHHYA |
Family and domain databases
Gene3Di | 3.30.1960.10, 1 hit |
HAMAPi | MF_00266, TYW3_archaea, 1 hit |
InterProi | View protein in InterPro IPR022908, Taw3 IPR003827, tRNA_yW-synthesising IPR036602, tRNA_yW-synthesising-like_sf |
Pfami | View protein in Pfam PF02676, TYW3, 1 hit |
SUPFAMi | SSF111278, SSF111278, 1 hit |
i Sequence
Sequence statusi: Complete.
O58796-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRFTENFERA KKEALMSLEI ALRKGEVDED IIPLLKKINS IENYFTTSSC
60 70 80 90 100
SGRISVMEMP HFGDKVNAKW LGKWHREVSL YEVLEAIKKH RSGQLWFLVR
110 120 130 140 150
SPILHVGAKT LEDAVKLVNL AVSCGFKYSN IKSISNKKLI VEIRSTERMD
160 170 180 190
VLLGENGEIF VGEEYLNKIV EIANDQMRRF KEKLKRLESK INALNR
Sequence cautioni
The sequence BAA30168 differs from that shown. Reason: Erroneous initiation.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BA000001 Genomic DNA Translation: BAA30168.1 Different initiation. |
PIRi | B71101 |
Genome annotation databases
EnsemblBacteriai | BAA30168; BAA30168; BAA30168 |
KEGGi | pho:PH1069 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BA000001 Genomic DNA Translation: BAA30168.1 Different initiation. |
PIRi | B71101 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2DRV | X-ray | 1.60 | A/B | 1-196 | [»] | |
2IT2 | X-ray | 1.50 | A/B | 1-196 | [»] | |
2IT3 | X-ray | 2.10 | A/B | 1-196 | [»] | |
AlphaFoldDBi | O58796 | |||||
SMRi | O58796 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
STRINGi | 70601.3257485 |
Genome annotation databases
EnsemblBacteriai | BAA30168; BAA30168; BAA30168 |
KEGGi | pho:PH1069 |
Phylogenomic databases
eggNOGi | arCOG04156, Archaea |
OMAi | GKWHHYA |
Miscellaneous databases
EvolutionaryTracei | O58796 |
Family and domain databases
Gene3Di | 3.30.1960.10, 1 hit |
HAMAPi | MF_00266, TYW3_archaea, 1 hit |
InterProi | View protein in InterPro IPR022908, Taw3 IPR003827, tRNA_yW-synthesising IPR036602, tRNA_yW-synthesising-like_sf |
Pfami | View protein in Pfam PF02676, TYW3, 1 hit |
SUPFAMi | SSF111278, SSF111278, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | TYW31_PYRHO | |
Accessioni | O58796Primary (citable) accession number: O58796 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 2000 |
Last sequence update: | December 1, 2000 | |
Last modified: | May 25, 2022 | |
This is version 116 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structureDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families